AutismKB 2.0

Annotation Detail for GRM6


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Basic Information Top
Gene Symbol:GRM6 ( CSNB1B,DKFZp686H1993,GPRC1F,MGLUR6,mGlu6 )
Gene Full Name: glutamate receptor, metabotropic 6
Band: 5q35.3
Quick LinksEntrez ID:2916; OMIM: 604096; Uniprot ID:GRM6_HUMAN; ENSEMBL ID: ENSG00000113262; HGNC ID: 4598
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Night blindness, congenital stationary, type 1B
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GRM6 mRNAincreases expression 18648102
D004390 Chlorpyrifos Chlorpyrifos results in decreased expression of GRM6 mRNAdecreases expression 19440498
D003976 Diazinon Diazinon results in increased expression of GRM6 mRNAincreases expression 19440498
D004051 Diethylhexyl Phthalate Diethylhexyl Phthalate results in decreased expression of GRM6 mRNAdecreases expression 15620428
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GRM6 exonincreases mutagenesis 17430614
C025256 nonylphenol nonylphenol results in decreased expression of GRM6 mRNAdecreases expression 15620428
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Diethylhexyl Phthalate 5.036734493
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.543712494
MESH:D000236 Adenoma Ethylnitrosourea 7.546695378
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 10.7616611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 10.7616487989
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001927 Brain Diseases Ethylnitrosourea 5.1914991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.5916357521 18412241 15144691 16651633 16436596
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.777296757 3581430
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.717505956
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 7.7116003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.5017160924
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2118759878 12868966 11906362 11298694 14531868 8156756 8970840 2524372
MESH:D003876 Dermatitis, Atopic Diethylhexyl Phthalate 4.1716882537
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 2.036482804 9328219 6679447 1440618 8291058 9653073 7440962 18289764 9022650 18692083 16192314 18648102 11289319
MESH:D004417 Dyspnea Diazinon 5.3216487989
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.5018357618
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0216436596
MESH:D005910 Glioma Ethylnitrosourea 3.5916357521 18412241 16651633
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 10.886705139
MESH:D006505 Hepatitis Diazinon 10.8816487989
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007248 Infertility, Male Diazinon 4.0212948887 16466525
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.616582329
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 8.6117379185
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008107 Liver Diseases Chlorpyrifos 3.1315991261
MESH:D008113 Liver Neoplasms Diethylhexyl Phthalate 3.5311940454
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.71598648 1399818 3712494 6587162
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6317703301 16271038 6695378 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 4.1615790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.4715375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.7018041768 10767621 10838139
MESH:D008579 Meningioma Ethylnitrosourea 6.5017943659
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.8216707424
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.106679447
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.8816003739 16651423 17160924
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3715081274
OMIM:257270 NIGHT BLINDNESS, CONGENITAL STATIONARY, TYPE 1B marker/mechanism
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.5017160924
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D011041 Poisoning Diazinon 4.7017603234
MESH:D012135 Respiratory Sounds Chlorpyrifos 5.0517119214 16611668 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.4117119214 16611668
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.616418539
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.6215790496
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.121399818 6582329 3712494 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.378074119
MESH:D014570 Urologic Diseases Diazinon 5.8016487989
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28995
    • No data
    Releated disease ID Related disease Name
    PA445129Night Blindness
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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