AutismKB 2.0

Annotation Detail for GRM7


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Basic Information Top
Gene Symbol:GRM7 ( FLJ40498,GLUR7,GPRC1G,MGLU7,MGLUR7 )
Gene Full Name: glutamate receptor, metabotropic 7
Band: 3p26.1
Quick LinksEntrez ID:2917; OMIM: 604101; Uniprot ID:GRM7_HUMAN; ENSEMBL ID: ENSG00000196277; HGNC ID: 4599
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CHEMDEPENDENCY
PSYCH
smoking cessation
major depressive disorder (broad)
panic disorder
Desease Name
Panic disorder
Major depressive disorder (broad)
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRM7 mRNAaffects expression 16483693
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of GRM7 mRNAaffects expression 17331233
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GRM7 mRNAaffects cotreatment|decreases expression 18164116
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GRM7 mRNAincreases expression 17452286
D003976 Diazinon Diazinon results in increased expression of GRM7 mRNAincreases expression 17452286
D003993 Dibutyl Phthalate Dibutyl Phthalate results in decreased expression of GRM7 mRNAdecreases expression 15620428
C036042 dicyclohexyl phthalate dicyclohexyl phthalate results in increased expression of GRM7 mRNAincreases expression 15620428
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GRM7 mRNAaffects cotreatment|decreases expression 18164116
D013654 Taurine Taurine results in decreased expression of GRM7 mRNAdecreases expression 16579726
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D000236 Adenoma beta-Naphthoflavone 7.2519389873
MESH:D000236 Adenoma Diethylnitrosamine 7.2510737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.1817162532 17620307 16434500 19052882 18056438 19061943
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 10.1416611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 10.1416487989
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2117474063
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 1.8618971187 17761372 18978308 17173139 19335982 17138121 16681979 17978847 20512989 17428255 20432363 16288022 19418558 20935162 10737359 19171122 11831363 3084413 19107877 20514400 16779866 20214788 17162532 18788625 18691550 16935385 19394651 16328049 21159647 19919837 20524982 16878318 19519916 19052882 16830150 20727157 19822196 18506893 16540662 16502159 18494052 18393292 16807293 19539802 18056438 18210153 18665156 17055752 3581430 16569478 18785209 10672840 16698587 19701751 20007298 19208518 20084675 20101231 19383236
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.992727394 17174075 7505956 21159647
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8719052882
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.6916037377
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D058065 Diabetic Cardiomyopathies Taurine 6.3416025228
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 4.6519107877
MESH:D056486 Drug-Induced Liver Injury Taurine 4.659328219
MESH:D004417 Dyspnea Diazinon 5.1216487989
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4416302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.3921071580 20387270
MESH:D006505 Hepatitis Diazinon 4.8116487989
MESH:D007248 Infertility, Male Diazinon 3.9516466525 12948887
MESH:D007249 Inflammation Diethylnitrosamine 2.4718785209
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9318407596 18665156 19638242 18522880 20032147
MESH:D008106 Liver Cirrhosis, Experimental Taurine 3.2715931870 15893842
MESH:D008107 Liver Diseases Chlorpyrifos 4.5815991261
MESH:D008107 Liver Diseases Diethylnitrosamine 4.5817034775
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 4.9919389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 4.9919254457 20583210 18648771 19090486 19638242 19850985 18754104 19255062 19294768 16942905 18644402 19642983 18977376 2422723 19690152 19833225 20101389 20405173 19426721 21167192 21278145 18978307 19499222 19996281 19812893 20501860 12112319 21047994 12771043 15175105 19256749 20492335 20137499 15885732 9163691 19551842 20452335 10737359 19073162 21071580 2862719 20118626 19427195 20434301
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.5418164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.5416842330 16267830 18308698 19539802 18164116 19009564 18253720 18079962 3124819 18544905 17942915 18775883 9362446 17174075 19519916 2563599 19126423 18093689 18282651 21159647 17854601 19004024
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.2817365036
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 21163286 6695378
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2518303189 16966607 16166281
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.649029167 3581430
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.5120387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4420387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 4.3015081274
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4816540662
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.1510923243
MESH:D011041 Poisoning Diazinon 4.5717603234
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.732563599
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.0917365031 17975199 17322281 15814490
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.8916611668 17119214 11874814
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 5.2116611668 17119214
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 6.416418539
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.147505956
MESH:D014570 Urologic Diseases Diazinon 5.5916487989
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28996
    • No data
    Releated disease ID Related disease Name
    PA447212Panic Disorder
    PA447216Schizophrenia
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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