AutismKB 2.0

Annotation Detail for GRM8


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Basic Information Top
Gene Symbol:GRM8 ( FLJ41058,GLUR8,GPRC1H,MGC126724,MGLUR8,mGlu8 )
Gene Full Name: glutamate receptor, metabotropic 8
Band: 7q31.33
Quick LinksEntrez ID:2918; OMIM: 601116; Uniprot ID:GRM8_HUMAN; ENSEMBL ID: ENSG00000179603; HGNC ID: 4600
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
Pathway IDPathway Name
Signaling by GPCR
No data
Pathway IDPathway Name
P00039Metabotropic glutamate receptor group III pathway
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00027Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
CARDIOVASCULAR
Carotid atherosclerosis in HIV infection
PSYCH
schizophrenia
plasma chemerin levels
Desease Name
Depression--quantitative trait
Plasma chemerin levels
Carotid atherosclerosis in HIV infection
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRM8 mRNAaffects expression 16483693
D003913 Dextroamphetamine Dextroamphetamine results in increased expression of GRM8 mRNAincreases expression 18255232
D017638 Asbestos, Crocidolite Asbestos, Crocidolite affects the expression of GRM8 mRNAaffects expression 17331233
D003976 Diazinon Diazinon results in decreased expression of GRM8 mRNAdecreases expression 17452286
D003993 Dibutyl Phthalate Dibutyl Phthalate results in increased expression of GRM8 mRNAincreases expression 15620428
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GRM8 geneincreases mutagenesis 16495775
D010634 Phenobarbital Phenobarbital results in increased expression of GRM8 mRNAincreases expression 19482888
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.836195326
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma Ethylnitrosourea 3.866695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3717620307
MESH:D000382 Agricultural Workers' Diseases Diazinon 4.7316487989
MESH:D001321 Autistic Disorder marker/mechanism 12676915
MESH:D001927 Brain Diseases Ethylnitrosourea 5.1514991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.5518412241 16436596 15144691 16651633 16357521
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 1.946705139 17173139 20007298 20935162 1701930
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.9016003739
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.614080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.4317160924
MESH:D003456 Cryptorchidism Dibutyl Phthalate 5.7816037377
MESH:D004417 Dyspnea Diazinon 5.2416487989
MESH:D004421 Dystonia Phenobarbital 4.311851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.4318357618
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.473659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.313922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.796401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.617750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.413659116
MESH:D005909 Glioblastoma Ethylnitrosourea 4.0016436596
MESH:D005910 Glioma Ethylnitrosourea 3.5816357521 18412241 16651633
MESH:D006505 Hepatitis Diazinon 4.9016487989
MESH:D006529 Hepatomegaly Phenobarbital 3.8416109766
MESH:D007248 Infertility, Male Diazinon 3.9916466525 12948887
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.1617379185
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0321047994
MESH:D008107 Liver Diseases Phenobarbital 2.2219363144
MESH:D008113 Liver Neoplasms Phenobarbital 2.3921047994 19812893 19482888 19073162 15975961 8742319
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 2.866150874 17172636 18308698 1399818 2563599
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.3817365036
MESH:D008175 Lung Neoplasms Ethylnitrosourea 2.6316271038 6695378 16019985 17703301
MESH:D008223 Lymphoma Ethylnitrosourea 4.1315790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.4115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6718041768 10767621 10838139
MESH:D008579 Meningioma Ethylnitrosourea 6.4317943659
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2718303189 16966607 16166281
MESH:D009041 Motion Sickness Dextroamphetamine 5.961613127
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8717484760
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.7616707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.8116003739 17160924 16651423
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.4317160924
MESH:D010018 Osteomalacia Phenobarbital 4.7617016548
MESH:D010190 Pancreatic Neoplasms Phenobarbital 2.5716965848
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 5.2510923243
MESH:D011041 Poisoning Diazinon 4.6517603234
MESH:D011230 Precancerous Conditions Phenobarbital 3.872563599
MESH:D019310 Pseudolymphoma Phenobarbital 4.9412752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 3.1115814490 17975199 17322281 17365031
MESH:D012640 Seizures Phenobarbital 2.874039156 3137016 16876388 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.226407741
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.5615790496
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.261399818
MESH:D014570 Urologic Diseases Diazinon 5.7216487989
Pathway ID Pathway Name
KEGG:04724 Glutamatergic synapse
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA28997
    • No data
    No data
    Releated drug ID Related drug Name
    PA450626nicotine
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
    No data
    No data
    No data

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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