AutismKB 2.0

Annotation Detail for GRPR


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Basic Information Top
Gene Symbol:GRPR ( - )
Gene Full Name: gastrin-releasing peptide receptor
Band: Xp22.2
Quick LinksEntrez ID:2925; OMIM: 305670; Uniprot ID:GRPR_HUMAN; ENSEMBL ID: ENSG00000126010; HGNC ID: 4609
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04080Neuroactive ligand-receptor interaction
hsa04020Calcium signaling pathway
Pathway IDPathway Name
Signaling by GPCR
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GRPR mRNAaffects expression 16483693
D000728 Androgens Androgens affects the expression of GRPR proteinaffects expression 17204703
D001761 Bleomycin Bleomycin results in decreased expression of GRPR mRNAdecreases expression 15808516
C071363 bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)- bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)- binds to and results in decreased activity of GRPR proteinaffects binding|decreases activity 17097693
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of GRPR geneincreases mutagenesis 16495775
D008070 Lipopolysaccharides Lipopolysaccharides results in decreased expression of GRPR mRNAdecreases expression 12057914
C025256 nonylphenol nonylphenol results in decreased expression of GRPR mRNAdecreases expression 15620428
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRPR mRNAaffects binding|decreases expression|increases activity 19710929
D014415 Tunicamycin Tunicamycin results in increased expression of GRPR mRNAincreases expression 17127020
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.8418287403
MESH:D055371 Acute Lung Injury Bleomycin 16.7417118201
MESH:D055371 Acute Lung Injury Lipopolysaccharides 16.7411850527 18653653
MESH:D055371 Acute Lung Injury pirinixic acid 16.7418653653
MESH:D000236 Adenoma Ethylnitrosourea 3.836695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000544 Alzheimer Disease Androgens 3.6517917157 17182789
MESH:D000860 Anoxia Bleomycin 5.6915782499
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001927 Brain Diseases Ethylnitrosourea 5.0714991843
MESH:D001932 Brain Neoplasms Ethylnitrosourea 4.4818412241 16651633 16436596 16357521 15144691
MESH:D001943 Breast Neoplasms Androgens 3.7217018787
MESH:D002294 Carcinoma, Squamous Cell Bleomycin 3.646189445
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 3.8616003739
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 6.3017160924
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D016638 Critical Illness Androgens 6.3416670151
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 6.3018357618
MESH:D004487 Edema Bleomycin 7.9117118201
MESH:D004487 Edema pirinixic acid 7.9112083418
MESH:D019446 Endotoxemia Lipopolysaccharides 4.6815328337 15821434 17637181
MESH:D005234 Fatty Liver pirinixic acid 2.9720131406 19236843
MESH:D005334 Fever Lipopolysaccharides 4.219205823 11852909
MESH:D005909 Glioblastoma Ethylnitrosourea 3.9516436596
MESH:D005910 Glioma Ethylnitrosourea 3.5618412241 16357521 16651633
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.5816366002
MESH:D006529 Hepatomegaly pirinixic acid 3.2516221962 18467677 19176532 19772884
MESH:D006628 Hirsutism Androgens 6.4016914592 17019078
MESH:D006689 Hodgkin Disease Bleomycin 4.5517606976 18501091 15147373
MESH:D017588 Hyperandrogenism Androgens 6.0517019078
MESH:D006943 Hyperglycemia pirinixic acid 3.3820558911
MESH:D007249 Inflammation Bleomycin 6.0917118201
MESH:D007249 Inflammation Lipopolysaccharides 6.0912878042 17963957 17237260 9205823 17255318
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8517255318
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 4.1017379185
MESH:D007970 Leukopenia Lipopolysaccharides 4.9815821434
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 2.5612878042
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5615474484
MESH:D008113 Liver Neoplasms pirinixic acid 1.8820007298 16377806 15890375
MESH:D055370 Lung Injury Lipopolysaccharides 4.2621114838
MESH:D008175 Lung Neoplasms Bleomycin 3.316189445
MESH:D008175 Lung Neoplasms Ethylnitrosourea 3.3117703301 16271038 6695378 16019985
MESH:D008223 Lymphoma Ethylnitrosourea 4.0815790496
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 5.3115375218
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 3.6318041768 10767621 10838139
MESH:D008545 Melanoma Bleomycin 3.2715577320
MESH:D008569 Memory Disorders marker/mechanism 17097693
MESH:D008569 Memory Disorders bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)- 7.0617097693
MESH:D008579 Meningioma Ethylnitrosourea 6.3017943659
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2119151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.1016411023
MESH:D009369 Neoplasms pirinixic acid 2.0317405874
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 4.6616707424
MESH:D009442 Neurilemmoma Ethylnitrosourea 5.7016003739 17160924 16651423
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 6.3017160924
MESH:D011014 Pneumonia Bleomycin 12.4517071938 18024389 16317386
MESH:D011014 Pneumonia Lipopolysaccharides 12.4512224865 11605937
MESH:D011471 Prostatic Neoplasms marker/mechanism 17204703
MESH:D011471 Prostatic Neoplasms Androgens 4.6415389811 17909013 16998812
MESH:D011654 Pulmonary Edema Bleomycin 5.6315808516
MESH:D011658 Pulmonary Fibrosis Bleomycin 3.9312574379 16314464 18008008 16115399 21435439 15541506 15322207 17241526 17434272 14609568 18162602 12624602 17177178 11554783
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8610835634
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3615821434
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 5.4515790496
MESH:D015431 Weight Loss Bleomycin 5.9312624602
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
KEGG:04080 Neuroactive ligand-receptor interaction
REACT:14797 Signaling by GPCR
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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