AutismKB 2.0

Annotation Detail for SLC25A6


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Basic Information Top
Gene Symbol:SLC25A6 ( AAC3,ANT3,ANT3Y,MGC17525 )
Gene Full Name: solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
Band: Xp22.32 and Yp11.3
Quick LinksEntrez ID:293; OMIM: 300151,403000; Uniprot ID:ADT3_HUMAN; ENSEMBL ID: ENSG00000169100; HGNC ID: 10992
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04020Calcium signaling pathway
hsa05016Huntington's disease
hsa05012Parkinson's disease
Pathway IDPathway Name
Diabetes pathways
Influenza Infection
Integration of energy metabolism
HIV Infection
No data
No data
Pathway IDPathway Name
500929Influenza Virus Induced Apoptosis
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of SLC25A6 mRNAdecreases expression 12958071
C099555 CD 437 CD 437 results in decreased expression of SLC25A6 mRNAdecreases expression 12958071
D004040 Dietary Carbohydrates Dietary Carbohydrates results in decreased expression of SLC25A6 mRNAdecreases expression 17490981
D015741 Metribolone Metribolone promotes the reaction [NDRG1 protein binds to SLC25A6 protein]affects binding|increases reaction 17220478
D012643 Selenium Selenium results in increased expression of SLC25A6 mRNAincreases expression 19244175
C066340 tolcapone tolcapone binds to SLC25A6 proteinaffects binding 19783845
D014212 Tretinoin SLC25A6 protein results in increased susceptibility to Tretinoinincreases response to substance 16556444
D014501 Uranium Uranium affects the expression of SLC25A6 mRNAaffects expression 15672453
C005460 uranyl acetate uranyl acetate affects the expression of SLC25A6 mRNAaffects expression 15672453
D014810 Vitamin E Vitamin E results in increased expression of SLC25A6 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D017109 Akathisia, Drug-Induced tolcapone 6.5611080934
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000544 Alzheimer Disease tolcapone 3.3120150427
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.7816206674 16197459
MESH:D001943 Breast Neoplasms Tretinoin 2.2516166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.1516050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.901917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3316051514 16096774
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002972 Cleft Palate Tretinoin 2.739407595
MESH:D003092 Colitis Selenium 10.2317936198
MESH:D003092 Colitis Tretinoin 10.2317035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7317551590 9211117 8800419 9224671 16925845 14991402 9125849 9664655 10589399 9142499
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7319769572
MESH:D003866 Depressive Disorder tolcapone 4.427768276 11224284
MESH:D003865 Depressive Disorder, Major tolcapone 5.0510440460
MESH:D056486 Drug-Induced Liver Injury Selenium 4.5415131321
MESH:D056486 Drug-Induced Liver Injury tolcapone 4.5416604736 19783845
MESH:D004409 Dyskinesia, Drug-Induced tolcapone 5.6611455177
MESH:C538011 Eales disease Vitamin E 4.979068938
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2116569247
MESH:D054908 Extensively Drug-Resistant Tuberculosis tolcapone 6.2119578428
MESH:D005124 Eye Abnormalities Tretinoin 3.709664655 16938888
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 7.0514991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 7.0516080930
MESH:D006333 Heart Failure Selenium 3.1717162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7516863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.2414716179
MESH:D006930 Hyperalgesia Tretinoin 3.3516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D007251 Influenza, Human Selenium 11.8616624496
MESH:D007251 Influenza, Human Vitamin E 11.8616624496
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.0715992940 17551590
MESH:D007674 Kidney Diseases Vitamin E 2.8912488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.0616518626
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1016294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2619225113 17649720 12679006 16140955 19029980 9834237 17301526 17712046 17361223 17107899 17506722 17368321 16766008 19642359 19075265 16891316 16935935 17339181 16331271 17217047 15748426 17294898 16823087 16788101 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.439224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.5916248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.5916169303
MESH:D008171 Lung Diseases Vitamin E 3.2916863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.8615318939
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Tretinoin 1.9616752155
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008654 Mesothelioma Selenium 2.8515107826
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009369 Neoplasms Tretinoin 2.4816946489 16594593
MESH:D009421 Nervous System Malformations Tretinoin 3.989125849
MESH:D009436 Neural Tube Defects Tretinoin 3.169142499
MESH:D010051 Ovarian Neoplasms CD 437 5.3617474084
MESH:D010051 Ovarian Neoplasms Tretinoin 5.3616936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5115976015
MESH:D010300 Parkinson Disease tolcapone 3.6511586115 1977408 11746615 8739811 11432539 16758261 18328768 8635184 20334432 9333106 19578428 9754991 20216409 19783845 11793426 9305320 17089403 7566641 9591521 9708959 10651109
MESH:D010954 Plasmacytoma Selenium 5.1515087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2815084515
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816116481 16283617
MESH:D012871 Skin Diseases Vitamin E 2.4818709164
MESH:D012878 Skin Neoplasms Tretinoin 2.6816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Vitamin E 3.6616517955
MESH:D013964 Thyroid Neoplasms Tretinoin 3.1517045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D018088 Tuberculosis, Multidrug-Resistant tolcapone 6.2119578428
MESH:D001749 Urinary Bladder Neoplasms CD 437 3.4416720286
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.8416129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014820 Vitiligo tolcapone 11.7710573327
MESH:D014820 Vitiligo Tretinoin 11.7716761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:04020 Calcium signaling pathway
REACT:15380 Diabetes pathways
REACT:6185 HIV Infection
KEGG:05016 Huntington's disease
REACT:6167 Influenza Infection
REACT:1505 Integration of energy metabolism
KEGG:05012 Parkinson's disease
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA35868
  • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB00720 antagonist Clodronate Antineoplastic Agents;Antihypocalcemic Agents;Bisphosphonates;Osteoporosis Prophylactic;Bone Density Conservation Agents
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018