AutismKB 2.0

Annotation Detail for GSK3B


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Basic Information Top
Gene Symbol:GSK3B ( - )
Gene Full Name: glycogen synthase kinase 3 beta
Band: 3q13.33
Quick LinksEntrez ID:2932; OMIM: 605004; Uniprot ID:GSK3B_HUMAN; ENSEMBL ID: ENSG00000082701; HGNC ID: 4617
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05160Hepatitis C
hsa04910Insulin signaling pathway
hsa04916Melanogenesis
hsa04012ErbB signaling pathway
hsa04360Axon guidance
hsa04310Wnt signaling pathway
hsa05010Alzheimer's disease
hsa04722Neurotrophin signaling pathway
hsa04110Cell cycle
hsa04340Hedgehog signaling pathway
hsa05213Endometrial cancer
hsa05210Colorectal cancer
hsa05217Basal cell carcinoma
hsa05215Prostate cancer
hsa04510Focal adhesion
hsa04062Chemokine signaling pathway
hsa05200Pathways in cancer
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Signaling by Wnt
Signalling by NGF
Axon guidance
Pathway IDPathway Name
200123BMP receptor signaling
200183Trk receptor signaling mediated by PI3K and PLC-gamma
200156Signaling events mediated by Stem cell factor receptor (c-Kit)
200061LKB1 signaling events
200093C-MYC pathway
200175p53 pathway
200077Glucocorticoid receptor regulatory network
200076Role of Calcineurin-dependent NFAT signaling in lymphocytes
200169Class I PI3K signaling events mediated by Akt
200168Insulin-mediated glucose transport
200166Aurora A signaling
200011LPA receptor mediated events
200147Hedgehog signaling events mediated by Gli proteins
200102Regulation of Androgen receptor activity
200052Presenilin action in Notch and Wnt signaling
200051Reelin signaling pathway
200057CDC42 signaling events
Pathway IDPathway Name
P00026Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00033Insulin/IGF pathway-protein kinase B signaling cascade
P00005Angiogenesis
P00004Alzheimer disease-presenilin pathway
P00012Cadherin signaling pathway
P00025Hedgehog signaling pathway
P00048PI3 kinase pathway
P00047PDGF signaling pathway
P00036Interleukin signaling pathway
P04393Ras Pathway
P00057Wnt signaling pathway
Pathway IDPathway Name
500077CRMPs in Sema3A signaling
Related Diseases/Disorders Top
No data
No data
Desease Name
bipolar disorder
PSYCH
NEUROLOGICAL
Alzheimers disease
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Neomycin results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 15800129
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 19814765
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 19814765
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B proteindecreases phosphorylation|increases activity 15942663
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]decreases reaction|increases activity|increases phosphorylation 17928571
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 15845746
C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 16179367
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GSK3B mRNAaffects expression 21346803
C076996 27-hydroxycholesterol 27-hydroxycholesterol results in decreased expression of GSK3B proteindecreases expression 20157255
C029955 2-nitrotoluene 2-nitrotoluene affects the expression of GSK3B mRNAaffects expression 16460773
C417520 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B proteindecreases activity 19486905
C417520 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B proteindecreases activity 19159680
C417520 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione [3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 proteindecreases activity|increases expression 19159680
C417520 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione results in decreased activity of GSK3B proteindecreases activity 15942663
C027576 4-hydroxy-2-nonenal 4-hydroxy-2-nonenal results in decreased expression of GSK3B mRNAdecreases expression 12419474
C471843 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine results in decreased activity of GSK3B proteindecreases activity 15958644
C483321 6-bromoindirubin-3'-oxime 6-bromoindirubin-3'-oxime results in decreased activity of GSK3B proteindecreases activity 18624906
D000082 Acetaminophen Acetaminophen affects the expression of GSK3B mRNAaffects expression 16701773
D000242 Cyclic AMP GSK3B protein affects the reaction [Deamino Arginine Vasopressin results in increased abundance of Cyclic AMP]affects reaction|increases abundance 20056751
D043582 5-alpha-Dihydroprogesterone 5-alpha-Dihydroprogesterone results in decreased expression of GSK3B proteindecreases expression 17443805
C120793 alsterpaullone alsterpaullone results in decreased activity of GSK3B proteindecreases activity 16055726
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GSK3B mRNAaffects expression 16483693
D000661 Amphetamine Amphetamine results in decreased expression of GSK3B proteindecreases expression 16144542
C526219 apple polyphenol extract apple polyphenol extract results in decreased activity of GSK3B proteindecreases activity 16968061
C526219 apple polyphenol extract apple polyphenol extract results in increased expression of GSK3B proteinincreases expression 16968061
C015001 arsenite arsenite metabolite results in increased expression of GSK3B mRNAincreases expression 18242949
D001241 Aspirin Aspirin results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 11593435
D001241 Aspirin Aspirin results in increased phosphorylation of GSK3B proteinincreases phosphorylation 12813129
D001554 Benzene Benzene analog results in decreased activity of GSK3B proteindecreases activity 17764934
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of GSK3B mRNAaffects expression 20382639
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GSK3B mRNAdecreases expression 19150397
C070515 bisindolylmaleimide I bisindolylmaleimide I results in decreased activity of GSK3B proteindecreases activity 16055726
C467001 bisindolylmaleimide IX bisindolylmaleimide IX results in decreased activity of GSK3B proteindecreases activity 16055726
C099813 bromochloroacetic acid bromochloroacetic acid affects the expression of GSK3B mRNAaffects expression 16460773
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of GSK3B mRNAincreases expression 15336504
D002110 Caffeine Caffeine results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 15126379
D002118 Calcium Calcium results in increased phosphorylation of GSK3B proteinincreases phosphorylation 15800129
C059041 calyculin A calyculin A promotes the reaction [Lithium Chloride results in increased phosphorylation of GSK3B protein]increases phosphorylation|increases reaction 12813129
D002248 Carbon Monoxide Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]decreases phosphorylation|decreases reaction 18037988
D003024 Clozapine Clozapine results in increased phosphorylation of GSK3B proteinincreases phosphorylation 19440698
D003024 Clozapine Clozapine results in increased expression of GSK3B proteinincreases expression 16144542
19359144
D003024 Clozapine DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein]affects reaction|increases expression 16144542
D003474 Curcumin Curcumin results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 18790744
D003474 Curcumin Curcumin results in increased expression of GSK3B proteinincreases expression 19573523
D003474 Curcumin Curcumin results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 18006147
D003513 Cycloheximide Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSK3B mRNA]decreases expression|decreases reaction 11007951
D003894 Deamino Arginine Vasopressin GSK3B protein affects the reaction [Deamino Arginine Vasopressin results in increased abundance of Cyclic AMP]affects reaction|increases abundance 20056751
C107676 deguelin deguelin results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 19336726
C007262 deoxynivalenol deoxynivalenol results in increased phosphorylation of GSK3B proteinincreases phosphorylation 15976193
D004041 Dietary Fats Dietary Fats results in decreased expression of GSK3B mRNAdecreases expression 18042831
D004052 Diethylnitrosamine CTNNB1 protein inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 20583210
D004052 Diethylnitrosamine Diethylnitrosamine results in increased phosphorylation of GSK3B proteinincreases phosphorylation 20583210
D004280 Dobutamine GSK3B gene mutant form affects the susceptibility to Dobutamineaffects response to substance 17901358
D004317 Doxorubicin Doxorubicin results in increased phosphorylation of GSK3B proteinincreases phosphorylation 17339365
D004317 Doxorubicin methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17339365
D004317 Doxorubicin Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17339365
D004317 Doxorubicin Carbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]decreases phosphorylation|decreases reaction 18037988
D004317 Doxorubicin Doxorubicin results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 18037988
C045651 epigallocatechin gallate epigallocatechin gallate results in increased phosphorylation of GSK3B proteinincreases phosphorylation 16968065
D004958 Estradiol Estradiol results in increased phosphorylation of GSK3B proteinincreases phosphorylation 16076840
D004958 Estradiol wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 16076840
D004958 Estradiol 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 15845746
D004958 Estradiol Estradiol results in increased phosphorylation of GSK3B proteinincreases phosphorylation 15845746
D004958 Estradiol Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 15845746
D004958 Estradiol Estradiol inhibits the reaction [Progesterone results in decreased expression of GSK3B mRNA]decreases expression|decreases reaction 17170212
D000431 Ethanol ALDH2 protein inhibits the reaction [Ethanol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 19332462
D000431 Ethanol Ethanol results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 18377926
D000431 Ethanol Ethanol results in increased phosphorylation of GSK3B proteinincreases phosphorylation 19332462
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GSK3B mRNAincreases expression 12655037
15576828
D005047 Etoposide BCL2 protein affects the reaction [[Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 protein]affects reaction|increases activity 19408126
D005047 Etoposide Etoposide results in increased activity of GSK3B proteinincreases activity 19408126
D005047 Etoposide [Etoposide results in increased activity of GSK3B protein] which results in increased activity of CASP3 proteinincreases activity 19408126
D005473 Fluoxetine Fluoxetine results in increased expression of GSK3B proteinincreases expression 19359144
D019833 Genistein Genistein results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 18431742
C007845 gingerol GSK3B protein affects the reaction [gingerol results in increased expression of GDF15 protein]affects reaction|increases expression 18058799
D006220 Haloperidol DRD2 protein affects the reaction [Haloperidol results in increased expression of GSK3B protein]affects reaction|increases expression 16144542
D006220 Haloperidol Haloperidol results in increased expression of GSK3B mRNAincreases expression 19359144
D006220 Haloperidol Haloperidol results in increased expression of GSK3B proteinincreases expression 16144542
19359144
D006581 Hexachlorobenzene Hexachlorobenzene results in decreased activity of GSK3B proteindecreases activity 16679308
D006581 Hexachlorobenzene [Hexachlorobenzene results in decreased activity of GSK3B protein] which results in decreased expression of CDH1 proteindecreases activity|decreases expression 16679308
C477872 IC 87114 IC 87114 results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 16179367
D007093 Imidazoles Imidazoles analog results in decreased activity of GSK3B proteindecreases activity 17764934
D007213 Indomethacin Indomethacin results in increased expression of GSK3B mRNAincreases expression 18299717
C510621 KCC 009 KCC 009 results in decreased expression of GSK3B proteindecreases expression 16170020
C510621 KCC 009 KCC 009 results in decreased phosphorylation of and results in increased activity of GSK3B proteindecreases phosphorylation|increases activity 16170020
C119620 kenpaullone kenpaullone results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 17993264
C119620 kenpaullone kenpaullone results in decreased activity of GSK3B proteindecreases activity 18624906
D008094 Lithium Lithium results in decreased activity of GSK3B proteindecreases activity 19932742
D008094 Lithium Lithium results in increased phosphorylation of GSK3B proteinincreases phosphorylation 19440698
D008094 Lithium Lithium results in decreased activity of GSK3B proteindecreases activity 19621015
D008094 Lithium Lithium results in decreased activity of GSK3B proteindecreases activity 16288908
D008094 Lithium Lithium results in increased expression of GSK3B mRNAincreases expression 19359144
D008094 Lithium Lithium results in increased expression of GSK3B proteinincreases expression 19359144
D018021 Lithium Chloride Lithium Chloride results in decreased activity of GSK3B proteindecreases activity 19486905
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of SCN9A mRNAdecreases activity|increases expression 19486905
D018021 Lithium Chloride CTNNB1 protein affects the reaction [[Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 protein]affects reaction|decreases activity|decreases expression 19274078
D018021 Lithium Chloride Lithium Chloride results in decreased activity of GSK3B proteindecreases activity 19101580
19274078
19823589
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 mRNAdecreases activity|decreases expression 19274078
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in decreased expression of CDH11 proteindecreases activity|decreases expression 19274078
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of STARD7 mRNAdecreases activity|increases expression 19679347
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of STARD7 proteindecreases activity|increases expression 19679347
D018021 Lithium Chloride Lithium Chloride results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 20093106
D018021 Lithium Chloride Lithium Chloride results in increased expression of and results in increased phosphorylation of and results in decreased activity of GSK3B proteindecreases activity|increases expression|increases phosphorylation 19196980
D018021 Lithium Chloride Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B proteindecreases activity|increases phosphorylation 17868649
19679347
D018021 Lithium Chloride Lithium Chloride results in increased phosphorylation of GSK3B proteinincreases phosphorylation 18830594
D018021 Lithium Chloride PIK3CA protein affects the reaction [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein]affects reaction|decreases activity|increases phosphorylation 19196980
D018021 Lithium Chloride Lithium Chloride results in decreased activity of GSK3B proteindecreases activity 15364539
19442631
D018021 Lithium Chloride Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B proteindecreases activity|increases phosphorylation 19582394
19440036
D018021 Lithium Chloride [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in decreased expression of SNAI1 proteindecreases activity|decreases expression|increases phosphorylation 19440036
D018021 Lithium Chloride [Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 proteindecreases activity|increases localization|increases phosphorylation 19582394
D018021 Lithium Chloride [[Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B protein] which results in increased localization of CTNNB1 protein] which results in increased expression of GIP mRNAdecreases activity|increases expression|increases localization|increases phosphorylation 19582394
D018021 Lithium Chloride Lithium Chloride results in increased stability of GSK3B proteinincreases stability 19448134
D018021 Lithium Chloride calyculin A promotes the reaction [Lithium Chloride results in increased phosphorylation of GSK3B protein]increases phosphorylation|increases reaction 12813129
D018021 Lithium Chloride Lithium Chloride results in decreased activity of GSK3B proteindecreases activity 18972237
15247282
D018021 Lithium Chloride [Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 proteindecreases activity|increases expression 18972237
D018021 Lithium Chloride [[Lithium Chloride results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 protein] which affects the expression of GJA1 proteinaffects expression|decreases activity|increases expression 18972237
D018021 Lithium Chloride Lithium Chloride results in decreased expression of GSK3B mRNAdecreases expression 18932008
D018021 Lithium Chloride Lithium Chloride results in increased phosphorylation of and results in decreased activity of GSK3B proteindecreases activity|increases phosphorylation 12813129
D018021 Lithium Chloride Lithium Chloride results in decreased activity of [GSK3A protein binds to GSK3B protein]affects binding|decreases activity 16076840
D018021 Lithium Chloride Lithium Chloride results in decreased activity of GSK3B proteindecreases activity 17210701
16055726
18624906
C010480 lupeol lupeol binds to GSK3B proteinaffects binding 18222664
D008701 Methapyrilene Methapyrilene results in increased expression of GSK3B mRNAincreases expression 16393664
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GSK3B mRNAincreases expression 19285098
D018817 N-Methyl-3,4-methylenedioxyamphetamine N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GSK3B proteinincreases expression 19285098
C008493 methylselenic acid methylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17339365
C008493 methylselenic acid methylselenic acid results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 17339365
D015735 Mifepristone Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 16882987
C008542 monodansylcadaverine monodansylcadaverine results in decreased expression of GSK3B proteindecreases expression 16170020
C479831 N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea results in decreased activity of GSK3B proteindecreases activity 16202587
D009355 Neomycin 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Neomycin results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 15800129
D009355 Neomycin Neomycin results in increased phosphorylation of GSK3B proteinincreases phosphorylation 15800129
D009583 Nitrofurazone Nitrofurazone binds to GSK3B proteinaffects binding 18222664
C404397 NSC 680410 NSC 680410 results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 14647418
C076029 olanzapine olanzapine results in increased phosphorylation of GSK3B proteinincreases phosphorylation 19440698
D009942 Organometallic Compounds Organometallic Compounds results in decreased activity of GSK3B proteindecreases activity 17210701
C041786 palm oil palm oil results in decreased expression of GSK3B mRNAdecreases expression 18042831
D010656 Phenylephrine Phenylephrine results in increased phosphorylation of GSK3B proteinincreases phosphorylation 15795328
D010656 Phenylephrine SGK1 protein promotes the reaction [Phenylephrine results in increased phosphorylation of GSK3B protein]increases phosphorylation|increases reaction 15795328
D010693 Phloretin Phloretin results in decreased activity of GSK3B proteindecreases activity 16968061
D010743 Phospholipids Phospholipids results in increased phosphorylation of GSK3B proteinincreases phosphorylation 15956784
D011280 Pregnanolone Pregnanolone results in decreased expression of GSK3B proteindecreases expression 17443805
D011374 Progesterone Mifepristone inhibits the reaction [Progesterone results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 16882987
D011374 Progesterone Progesterone results in increased phosphorylation of GSK3B proteinincreases phosphorylation 16882987
D011374 Progesterone Progesterone inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 15845746
D011374 Progesterone Estradiol inhibits the reaction [Progesterone results in decreased expression of GSK3B mRNA]decreases expression|decreases reaction 17170212
D011374 Progesterone Progesterone results in decreased expression of GSK3B mRNAdecreases expression 17170212
D011374 Progesterone Progesterone results in decreased expression of GSK3B proteindecreases expression 17443805
D011374 Progesterone Progesterone results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 17443805
C008704 pyrithione AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]affects cotreatment|increases activity|increases phosphorylation|increases reaction 17098228
C008704 pyrithione GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]affects cotreatment|increases phosphorylation|increases reaction 17098228
C008704 pyrithione [Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B proteinaffects cotreatment|increases activity|increases phosphorylation 17098228
D011794 Quercetin Quercetin results in decreased activity of GSK3B proteindecreases activity 16968061
D011794 Quercetin Quercetin results in decreased expression of GSK3B proteindecreases expression 16968065
C052785 rebamipide rebamipide results in increased expression of GSK3B mRNAincreases expression 18299717
C059514 resveratrol resveratrol results in increased activity of GSK3B proteinincreases activity 17868649
C059514 resveratrol resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B proteindecreases activity|increases phosphorylation 16860989
D018967 Risperidone DRD2 protein affects the reaction [Risperidone results in increased expression of GSK3B protein]affects reaction|increases expression 16144542
D018967 Risperidone Risperidone results in increased expression of GSK3B proteinincreases expression 16144542
C089730 rosiglitazone rosiglitazone results in decreased activity of GSK3B proteindecreases activity 19621015
D012428 Ruthenium Ruthenium results in decreased activity of GSK3B proteindecreases activity 17210701
D017975 Ruthenium Compounds Ruthenium Compounds results in decreased activity of GSK3B proteindecreases activity 16858717
17210701
C010327 salinomycin salinomycin results in decreased expression of GSK3B mRNAdecreases expression 19682730
C093642 SB 203580 SB 203580 inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 19814765
C093642 SB 203580 SB 203580 inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 19814765
C417521 SB 216763 SB 216763 results in decreased activity of GSK3B proteindecreases activity 19486905
C417521 SB 216763 PIK3CA protein affects the reaction [SB 216763 results in increased phosphorylation of and results in decreased activity of GSK3B protein]affects reaction|decreases activity|increases phosphorylation 19196980
C417521 SB 216763 SB 216763 results in decreased activity of GSK3B proteindecreases activity 19823589
C417521 SB 216763 SB 216763 results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 16170020
C417521 SB 216763 SB 216763 results in increased expression of and results in increased phosphorylation of and results in decreased activity of GSK3B proteindecreases activity|increases expression|increases phosphorylation 19196980
C417521 SB 216763 SB 216763 results in decreased activity of GSK3B proteindecreases activity 19159680
C417521 SB 216763 [SB 216763 results in decreased activity of GSK3B protein] which results in increased expression of CTNNB1 proteindecreases activity|increases expression 19159680
C417521 SB 216763 SB 216763 results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 19448134
C417521 SB 216763 SB 216763 results in decreased activity of GSK3B proteindecreases activity 16288908
C417521 SB 216763 SB 216763 binds to and results in decreased activity of GSK3B proteinaffects binding|decreases activity 15958644
C417521 SB 216763 SB 216763 results in decreased activity of GSK3B proteindecreases activity 17210701
17339365
D012643 Selenium [Selenium co-treated with Vitamin E] results in increased expression of GSK3B mRNAaffects cotreatment|increases expression 19244175
D012643 Selenium Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17339365
D012643 Selenium Selenium results in decreased expression of GSK3B mRNAdecreases expression 19244175
D012643 Selenium Selenium results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 17339365
D020123 Sirolimus Sirolimus inhibits the reaction [TSC1 gene mutant form results in decreased phosphorylation of GSK3B protein]decreases phosphorylation|decreases reaction 18495876
D018038 Sodium Selenite Sodium Selenite results in decreased expression of GSK3B mRNAdecreases expression 18175754
D013467 Sulindac Sulindac results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 11593435
C004648 testosterone enanthate testosterone enanthate affects the expression of GSK3B mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSK3B mRNA]decreases expression|decreases reaction 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of GSK3B mRNAdecreases expression 11007951
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B proteinincreases phosphorylation 18996433
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased phosphorylation of GSK3B proteinincreases phosphorylation 17993264
D013755 Tetradecanoylphorbol Acetate U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17993264
D014212 Tretinoin Tretinoin results in decreased phosphorylation of GSK3B proteindecreases phosphorylation 16288212
D014212 Tretinoin Tretinoin results in increased phosphorylation of GSK3B proteinincreases phosphorylation 16288212
C113580 U 0126 U 0126 inhibits the reaction [EDN1 protein results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17993264
C113580 U 0126 U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 17993264
D014635 Valproic Acid Valproic Acid results in decreased activity of GSK3B proteindecreases activity 19101580
D014635 Valproic Acid Valproic Acid results in increased phosphorylation of GSK3B proteinincreases phosphorylation 19440698
D014635 Valproic Acid Valproic Acid results in decreased expression of GSK3B mRNAdecreases expression 19359144
C025643 vinclozolin vinclozolin affects the expression of GSK3B mRNAaffects expression 19015723
D014810 Vitamin E [Selenium co-treated with Vitamin E] results in increased expression of GSK3B mRNAaffects cotreatment|increases expression 19244175
D014810 Vitamin E Vitamin E results in decreased expression of GSK3B mRNAdecreases expression 19244175
C009687 wortmannin wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]decreases reaction|increases phosphorylation 16076840
D015032 Zinc AKT1 protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B protein]affects cotreatment|increases activity|increases phosphorylation|increases reaction 17098228
D015032 Zinc GSK3B protein promotes the reaction [[Zinc co-treated with pyrithione] results in increased phosphorylation of MAPT protein]affects cotreatment|increases phosphorylation|increases reaction 17098228
D015032 Zinc [Zinc co-treated with pyrithione] results in increased phosphorylation of and results in increased activity of GSK3B proteinaffects cotreatment|increases activity|increases phosphorylation 17098228
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Sulindac 4.6314745880
MESH:D000014 Abnormalities, Drug-Induced Ethanol 9.4018926900 17676605
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 9.4011752688 15322242 14514962
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 9.408875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.1519490988
MESH:D000138 Acidosis Ammonium Chloride 7.6518287403
MESH:D000138 Acidosis Ethanol 7.6511192467
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.0817505938
MESH:D000168 Acrocephalosyndactylia U 0126 4.6517694057
MESH:D000169 Acrodermatitis Zinc 4.5516889938 17190629 17202136
MESH:D058186 Acute Kidney Injury resveratrol 6.4616538975
MESH:D058186 Acute Kidney Injury Sulindac 6.467897758
MESH:D000230 Adenocarcinoma Doxorubicin 12.9117418594
MESH:D000230 Adenocarcinoma Estradiol 12.9111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9114692618
MESH:D000230 Adenocarcinoma Genistein 12.9111473722
MESH:D000230 Adenocarcinoma Indomethacin 12.9116537180
MESH:D000230 Adenocarcinoma Sulindac 12.9111910360
MESH:D000236 Adenoma Diethylnitrosamine 11.3810737359 6695378
MESH:D000236 Adenoma Indomethacin 11.3811497255
MESH:D000236 Adenoma resveratrol 11.3815688382
MESH:D000236 Adenoma Sulindac 11.3810223192
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 7.2417620307 17162532 19061943 18056438 19052882 16434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 7.2416835633
MESH:D011125 Adenomatous Polyposis Coli Sulindac 3.8411535846 16460482 11874996 17611924 15623613 12394442 19003578
MESH:D000380 Agranulocytosis Clozapine 4.2214617031 16160616 12649775
MESH:D000419 Albuminuria Doxorubicin 3.7321441931
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 4.4515451039 15451040
MESH:D019973 Alcohol-Related Disorders Curcumin 4.2117887948
MESH:D000505 Alopecia Tretinoin 2.9115955085
MESH:D016301 Alveolar Bone Loss Indomethacin 4.5017225004
MESH:D000544 Alzheimer Disease 27-hydroxycholesterol 14.7514523054 20157255
MESH:D000544 Alzheimer Disease Curcumin 14.7515590663
MESH:D000544 Alzheimer Disease Indomethacin 14.7517627676 15579461
MESH:D000544 Alzheimer Disease Lithium 14.7519621015
MESH:D000544 Alzheimer Disease resveratrol 14.7516183991 16162502
MESH:D000544 Alzheimer Disease rosiglitazone 14.7519621015
MESH:D000544 Alzheimer Disease Zinc 14.7516580781 16325427 16410023 17119284
MESH:D000550 Amblyopia Valproic Acid 4.3617688650
MESH:D019969 Amphetamine-Related Disorders Amphetamine 5.2015010207 18475255 16916582 16459022
MESH:D000690 Amyotrophic Lateral Sclerosis 4-hydroxy-2-nonenal 3.5110965797
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.2011748828
MESH:D000741 Anemia, Aplastic Benzene 3.6711369114 14761424 17661222
MESH:D000743 Anemia, Hemolytic Quercetin 3.4617084956
MESH:D000755 Anemia, Sickle Cell Zinc 4.0816916123
MESH:D000799 Angioedema Acetaminophen 2.9810982225
MESH:D000853 Anophthalmos Ethanol 3.9815513904
MESH:D000855 Anorexia Amphetamine 8.1416101753 16084549 12183048 12005258
MESH:D000855 Anorexia N-Methyl-3,4-methylenedioxyamphetamine 8.1415146954
MESH:D001008 Anxiety Disorders Ethanol 15.4011141031
MESH:D001008 Anxiety Disorders Fluoxetine 15.4018083778
MESH:D001008 Anxiety Disorders Valproic Acid 15.4017497229
MESH:D001008 Anxiety Disorders vinclozolin 15.4019015723
MESH:D001014 Aortic Aneurysm Indomethacin 4.0310231640
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 4.0410388637
MESH:D001145 Arrhythmias, Cardiac Phenylephrine 3.3617460149
MESH:D001161 Arteriosclerosis Dietary Fats 7.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 7.1511256880
MESH:D018771 Arthralgia Indomethacin 4.302160914
MESH:D001169 Arthritis, Experimental marker/mechanism 16713974
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 8.8215885639
MESH:D001169 Arthritis, Experimental resveratrol 8.8217115116
MESH:D001169 Arthritis, Experimental Tretinoin 8.8216412693
MESH:D001172 Arthritis, Rheumatoid Curcumin 5.7116807698
MESH:D001172 Arthritis, Rheumatoid Indomethacin 5.7111248219
MESH:D001172 Arthritis, Rheumatoid Tretinoin 5.7116292516
MESH:D020817 Asperger Syndrome Risperidone 4.7416401163
MESH:D001249 Asthma epigallocatechin gallate 5.9516516891
MESH:D001249 Asthma Tretinoin 5.9516456186
MESH:D001249 Asthma Zinc 5.9517085522
MESH:D055963 Asthma, Aspirin-Induced Aspirin 3.9720485159 12372130
MESH:D001260 Ataxia Telangiectasia Quercetin 4.1215336622
MESH:D050197 Atherosclerosis 27-hydroxycholesterol 7.919059518 11166758
MESH:D050197 Atherosclerosis Curcumin 7.9118704882
MESH:D050197 Atherosclerosis resveratrol 7.9116873680 17967414
MESH:D001289 Attention Deficit Disorder with Hyperactivity Risperidone 4.1618349709
MESH:D001321 Autistic Disorder Acetaminophen 4.5818445737
MESH:D001321 Autistic Disorder Fluoxetine 4.5819232924 18775368
MESH:D001321 Autistic Disorder Haloperidol 4.5818080171 19368416
MESH:D001321 Autistic Disorder olanzapine 4.5818685284 17069543
MESH:D001321 Autistic Disorder Risperidone 4.5818026891 16948927 19013209 15543515 19368416 17929164 16239862 16730335 17069546 19232924 16379507 19154706 18278980 18349709 16601648 15930063 18775368 15994720 15492353 17019624 18080171
MESH:D001321 Autistic Disorder Sirolimus 4.5821115397
MESH:D001321 Autistic Disorder Valproic Acid 4.5818940202 17688650 16609825 18177632 19460635 15238991 17157402 18985861 19232924 20603192 18396377 17507914 18775368 18558336 18316065
MESH:D001327 Autoimmune Diseases Curcumin 13.3819761891
MESH:D001327 Autoimmune Diseases epigallocatechin gallate 13.3819761891
MESH:D001327 Autoimmune Diseases Quercetin 13.3819761891
MESH:D001471 Barrett Esophagus Tretinoin 3.5816935849
MESH:D001477 Bartter Syndrome Indomethacin 4.1510684365
MESH:D001714 Bipolar Disorder Lithium 9.1920338123 17594078 19153942 20046352
MESH:D001714 Bipolar Disorder Risperidone 9.1918278980 19154706
MESH:D001714 Bipolar Disorder Valproic Acid 9.1917594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 6.3712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 6.3716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 2.9215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 5.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 5.988888407
MESH:D001855 Bone Marrow Diseases Benzene 4.3616183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 9.2814601052
MESH:D019046 Bone Marrow Neoplasms Etoposide 9.2814601052
MESH:D001913 Bowen's Disease Sulindac 4.4911207687
MESH:D001919 Bradycardia Phenylephrine 3.7015306635
MESH:D001929 Brain Edema Indomethacin 4.1611481608
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 4.4717868700
MESH:D001930 Brain Injuries Pregnanolone 13.8915665606 15380490
MESH:D001930 Brain Injuries Progesterone 13.8915380490 15665606 15845082
MESH:D001930 Brain Injuries Zinc 13.8917109824
MESH:D002545 Brain Ischemia Curcumin 12.2116770732
MESH:D002545 Brain Ischemia Indomethacin 12.2112524144
MESH:D002545 Brain Ischemia resveratrol 12.2117600658
MESH:D001932 Brain Neoplasms Aspirin 19.4115481559
MESH:D001932 Brain Neoplasms Curcumin 19.4117596214
MESH:D001932 Brain Neoplasms Doxorubicin 19.4117150277
MESH:D001932 Brain Neoplasms KCC 009 19.4116170020
MESH:D001932 Brain Neoplasms monodansylcadaverine 19.4116170020
MESH:D001943 Breast Neoplasms Aspirin 19.2215161893
MESH:D001943 Breast Neoplasms Benzene 19.2211921183 17162533
MESH:D001943 Breast Neoplasms Curcumin 19.2218462866 18593918 16243823 19250217
MESH:D001943 Breast Neoplasms deguelin 19.2218593368 17035597
MESH:D001943 Breast Neoplasms Dietary Fats 19.2220435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 19.2217474063
MESH:D001943 Breast Neoplasms Doxorubicin 19.2217426702 15939500 17369602 15567936 17983394 16264153 15994142 15136595 15634643 18695136 15668708 19526202 18628466 16096432 16935488 15692762 16322301 18234424 15993339 16826403 11325840 16115903 18382427 16595493
MESH:D001943 Breast Neoplasms Estradiol 19.2212948864 18497071 17018787 19861407 17261762 14630087 17289903 16675129
MESH:D001943 Breast Neoplasms Etoposide 19.2216322251
MESH:D001943 Breast Neoplasms Genistein 19.2216873071 17200150 16541309
MESH:D001943 Breast Neoplasms gingerol 19.2217683926
MESH:D001943 Breast Neoplasms Hexachlorobenzene 19.2215061365 12709520
MESH:D001943 Breast Neoplasms Indomethacin 19.2217401462
MESH:D001943 Breast Neoplasms Progesterone 19.2215562024 16175315 17614352
MESH:D001943 Breast Neoplasms Quercetin 19.2218628248
MESH:D001943 Breast Neoplasms resveratrol 19.2216393696 17651959 17534123
MESH:D001943 Breast Neoplasms salinomycin 19.2219682730
MESH:D001943 Breast Neoplasms Sulindac 19.2216642371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 19.2220435547
MESH:D001943 Breast Neoplasms Tretinoin 19.2216166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 3.7416813970
MESH:D002056 Burns Ethanol 8.6216374292
MESH:D002056 Burns Indomethacin 8.6210459503
MESH:D002100 Cachexia Indomethacin 4.1515625704 16537180 11239499 15141370
MESH:D002105 Cadmium Poisoning Quercetin 4.6716962696
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.6116111702
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 3.1016050911
MESH:D002276 Carcinoid Tumor Doxorubicin 3.9416051944
MESH:D002277 Carcinoma Curcumin 5.9518593918
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 5.9516835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.2916168501
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 26.0616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 26.063084413
MESH:D006528 Carcinoma, Hepatocellular deguelin 26.0618575727
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 26.0619701751 19383236 19052882 18978308 16502159 16807293 19919837 19418558 18788625 19107877 16878318 10737359 16328049 16830150 20727157 18056438 18393292 21159647 19539802 19822196 18506893 18691550 17055752 18665156 16935385 19335982 3084413 11831363 20214788 20512989 18210153 3581430 16569478 18494052 10672840 20084675 20514400 17162532 17761372 20101231 19171122 16779866 17173139 17428255 20935162 18971187 17138121 20432363 17978847 19519916 16288022 20524982 16698587 19394651 19208518 16540662 16681979 20007298 18785209
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 26.0618059187 16234567 16023760 17876044
MESH:D006528 Carcinoma, Hepatocellular Estradiol 26.0616924424
MESH:D006528 Carcinoma, Hepatocellular Ethanol 26.0618788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Genistein 26.0616924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 26.0616391822
MESH:D006528 Carcinoma, Hepatocellular Quercetin 26.0619519916 12508355
MESH:D006528 Carcinoma, Hepatocellular resveratrol 26.0616227395 19321006
MESH:D006528 Carcinoma, Hepatocellular Sirolimus 26.0619335982
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 26.061917145
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 8.6011053908
MESH:D018827 Carcinoma, Lewis Lung resveratrol 8.6016675471
MESH:D018276 Carcinoma, Medullary Indomethacin 4.5014736730 11352223 18791128
MESH:D002289 Carcinoma, Non-Small-Cell Lung Curcumin 2.6118414057
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.1217234771
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 5.161485588 16201981
MESH:D002292 Carcinoma, Renal Cell Indomethacin 5.1617341418
MESH:D002294 Carcinoma, Squamous Cell Curcumin 19.7518462866
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 19.756189445
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 19.7515482327 12636206
MESH:D002294 Carcinoma, Squamous Cell resveratrol 19.7516227395
MESH:D002294 Carcinoma, Squamous Cell Sirolimus 19.7519435901
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 19.7518922899
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 19.7516096774 16051514
MESH:D002294 Carcinoma, Squamous Cell Zinc 19.7516543248
MESH:D006332 Cardiomegaly marker/mechanism 17901358
MESH:D006332 Cardiomegaly Ethanol 11.8119332462
MESH:D006332 Cardiomegaly Phenylephrine 11.8117124262 16170337 15728586 17287366 11754973 11179087
MESH:D006332 Cardiomegaly Quercetin 11.8119794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 11.8118670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 2.9217924179 17928571 16612575 17131338 17382496 16364871 16278810 18627295 17974986 16109756 17007740 16731534 16952015 17351982 15811867 15476868 15792986 16651473 16242529 17519947 16455267 15505089 17308081 17329180 16269455
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.5716243910 17334414
MESH:D002318 Cardiovascular Diseases Genistein 8.5716332659
MESH:D002318 Cardiovascular Diseases resveratrol 8.5715458977
MESH:D002318 Cardiovascular Diseases Zinc 8.5716936243
MESH:D002375 Catalepsy Haloperidol 4.0615215559 1977408
MESH:D002386 Cataract Acetaminophen 5.3110977129
MESH:D002386 Cataract Tretinoin 5.3117460283
MESH:D002389 Catatonia olanzapine 5.3818071103 16772815
MESH:D002430 Cecal Neoplasms 2-nitrotoluene 4.9014688030
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.796135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.7920889678
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 10.7917174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.7918566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 3.7416129372
MESH:D014355 Chagas Disease Nitrofurazone 6.3111354658
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.3220734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 6.8619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 6.8616835633
MESH:D002764 Cholecystitis Indomethacin 4.3011181007
MESH:D002779 Cholestasis Ethinyl Estradiol 2.2117110522 17333356 17681005 15861022 16105132 11677210 16919318
MESH:D002822 Choriocarcinoma Tretinoin 4.2916461808
MESH:D019457 Chromosome Breakage Sodium Selenite 3.9115894690
MESH:D002971 Cleft Lip Ethanol 3.0615513904
MESH:D002972 Cleft Palate Ethanol 7.1915513904
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 7.1916354765 15340226 12621046 8697196 15668235
MESH:D002972 Cleft Palate Tretinoin 7.199407595
MESH:D003072 Cognition Disorders Clozapine 4.1317123785
MESH:D003092 Colitis Carbon Monoxide 21.2116365149
MESH:D003092 Colitis Curcumin 21.2116804969 18200517 16782535
MESH:D003092 Colitis resveratrol 21.2116474422
MESH:D003092 Colitis Selenium 21.2117936198
MESH:D003092 Colitis Tretinoin 21.2117035595
MESH:D003103 Coloboma Curcumin 3.7718809619
MESH:D003110 Colonic Neoplasms 6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine 18.8215958644
MESH:D003110 Colonic Neoplasms arsenite 18.8215037631
MESH:D003110 Colonic Neoplasms Aspirin 18.8212411196
MESH:D003110 Colonic Neoplasms Curcumin 18.8216340194 19359593
MESH:D003110 Colonic Neoplasms Genistein 18.8217182828
MESH:D003110 Colonic Neoplasms Indomethacin 18.8211260862 15786552 15936596 15625704 15637740 15963497
MESH:D003110 Colonic Neoplasms Quercetin 18.8217148506 11134977 19056647 16640504 17191121 15741050 19440933
MESH:D003110 Colonic Neoplasms resveratrol 18.8216338953
MESH:D003110 Colonic Neoplasms Sulindac 18.8212458338 12902858
MESH:D015179 Colorectal Neoplasms Aspirin 6.4817047198
MESH:D015179 Colorectal Neoplasms Doxorubicin 6.4818259882 18802399
MESH:D015179 Colorectal Neoplasms Indomethacin 6.4812606626 17054584 18059344 11197048
MESH:D015179 Colorectal Neoplasms Quercetin 6.4818852136 18095365
MESH:D015179 Colorectal Neoplasms resveratrol 6.4816550006
MESH:D015179 Colorectal Neoplasms Sulindac 6.4811076880 18059344 11197048 10666051
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.3217141729 14669216
MESH:D016510 Corneal Neovascularization Curcumin 4.0618497527
MESH:D003327 Coronary Disease resveratrol 3.1416507316
MESH:D018352 Coronavirus Infections Indomethacin 4.8517302372
MESH:D019465 Craniofacial Abnormalities Benzene 9.2015643154
MESH:D019465 Craniofacial Abnormalities Ethanol 9.2010194807 19302082 15513904 15451039 11198716 11873399 15451040
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 9.2015322242 10048152 20055451
MESH:D019465 Craniofacial Abnormalities Tretinoin 9.209125849 10589399 9664655 17551590 9142499 9211117 8800419 16925845 9224671 14991402
MESH:D019465 Craniofacial Abnormalities Valproic Acid 9.2017688650 16575769 8888407
MESH:D019465 Craniofacial Abnormalities Vitamin E 9.2019769572
MESH:D019465 Craniofacial Abnormalities Zinc 9.2019302082
MESH:D003456 Cryptorchidism vinclozolin 3.5214966744
MESH:D003490 Cyanosis 2,6-dinitrotoluene 3.1818551238
MESH:D007644 Darier Disease Lithium 5.0620338123
MESH:D016757 Death, Sudden, Cardiac Haloperidol 8.8120210726
MESH:D016757 Death, Sudden, Cardiac Risperidone 8.8120210726
MESH:D003704 Dementia Haloperidol 7.9711575062
MESH:D003704 Dementia Risperidone 7.9711575062
MESH:D003715 Dengue 27-hydroxycholesterol 4.8319427377
MESH:D003866 Depressive Disorder Fluoxetine 3.9615014590
MESH:D003872 Dermatitis Benzene 3.9315902427
MESH:D002658 Developmental Disabilities olanzapine 4.0617069543
MESH:D018500 Diabetes Insipidus, Nephrogenic Lithium 4.9119244398
MESH:D003920 Diabetes Mellitus rosiglitazone 11.2617446233
MESH:D003920 Diabetes Mellitus Sodium Selenite 11.2616285004
MESH:D003920 Diabetes Mellitus Zinc 11.2616479319
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 6.1719496084
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 6.1716873680
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 16.1016402076
MESH:D003924 Diabetes Mellitus, Type 2 Curcumin 16.1018403477
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 16.1020387270
MESH:D003924 Diabetes Mellitus, Type 2 epigallocatechin gallate 16.1016988119
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 16.1016647724
MESH:D003924 Diabetes Mellitus, Type 2 rosiglitazone 16.1012642470
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 16.1017107852
MESH:D003928 Diabetic Nephropathies Curcumin 10.8318204486
MESH:D003928 Diabetic Nephropathies Estradiol 10.8319279558
MESH:D003928 Diabetic Nephropathies resveratrol 10.8316286809
MESH:D003929 Diabetic Neuropathies Pregnanolone 9.6717187935
MESH:D003929 Diabetic Neuropathies Progesterone 9.6717187935
MESH:D003930 Diabetic Retinopathy Sulindac 4.3617621415 12861449
MESH:D003967 Diarrhea Indomethacin 3.027237001 7907874
MESH:D006970 Disorders of Excessive Somnolence Clozapine 11.5615331141
MESH:D006970 Disorders of Excessive Somnolence Risperidone 11.5616379507
MESH:D053207 Diurnal Enuresis Risperidone 5.8017822346
MESH:D004314 Down Syndrome Risperidone 4.4118349709
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 18.6718551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 18.6712392966 16781746 10774834 14725611 19420014 12705907 11739529 19416960 12153990 11421492 14550746 11529661 12594235 18071297 15619225 12958197 19164858 17906064 16485898 11287661 10663392 16109766 19370779 16227642 17562736 19085960 2444490 11461765 18713872 16177239 12540782 19739265 16393943 16081117 19923254 15968718 11743745 17522070 11834606 10915739 14986274
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 18.6719107877
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 18.6717416283
MESH:D056486 Drug-Induced Liver Injury Ethanol 18.6711566570
MESH:D056486 Drug-Induced Liver Injury Selenium 18.6715131321
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 18.6715131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 18.6720420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 18.6719641884 1733752
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.2319426721
MESH:D004362 Drug Toxicity Doxorubicin 5.8718602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 5.8711462148
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 4.2918446180 17190690 18043480 16326151 16133044 12774134
MESH:D004381 Duodenal Ulcer Curcumin 6.7417351913
MESH:D004381 Duodenal Ulcer Indomethacin 6.7411595431 11595415 17045617 10671773 11535926 17202747 17151854 16699067 17351913 17329845 11991626
MESH:D050171 Dyslipidemias Clozapine 6.6616402076
MESH:D050171 Dyslipidemias Dietary Fats 6.6618367378
MESH:D004421 Dystonia Valproic Acid 3.251851702
MESH:C538011 Eales disease Vitamin E 3.849068938
MESH:D004487 Edema Aspirin 24.9517259670
MESH:D004487 Edema bisindolylmaleimide I 24.958273558
MESH:D004487 Edema Fluoxetine 24.9512798668
MESH:D004487 Edema Indomethacin 24.9516100529 8985016 19703484 7907874 10653021 8273558 7990266
MESH:D004487 Edema resveratrol 24.958985016
MESH:D004487 Edema rosiglitazone 24.9512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 24.9511000095 12711302
MESH:D004487 Edema Tetradecanoylphorbol Acetate 24.958113982 16716910 9599246 11698051 7812673 15177302 8273558
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 9.0715322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 9.0718230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental 27-hydroxycholesterol 15.4017410599
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.4012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 15.4017692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 15.4017872969
MESH:D004714 Endometrial Hyperplasia Genistein 3.7416402032
MESH:D016889 Endometrial Neoplasms Doxorubicin 12.7317359293
MESH:D016889 Endometrial Neoplasms Estradiol 12.7318566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 12.7311473722
MESH:D016889 Endometrial Neoplasms Tretinoin 12.7316569247
MESH:D004715 Endometriosis Indomethacin 20.6715652904
MESH:D004715 Endometriosis Mifepristone 20.6716134523
MESH:D004715 Endometriosis Progesterone 20.6716134523
MESH:D004715 Endometriosis Sulindac 20.6715652904
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 20.6710568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.2918037988
MESH:D019446 Endotoxemia Indomethacin 3.6618509659
MESH:D004751 Enteritis Indomethacin 3.8810567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 9.6017980183
MESH:D020345 Enterocolitis, Necrotizing resveratrol 9.6017923197
MESH:D004802 Eosinophilia Indomethacin 3.2411298111
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.3217275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.063922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.4320417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 2.866426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 3.467750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.223659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.2516302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3720426865
MESH:D004938 Esophageal Neoplasms Ethanol 10.3716704527
MESH:D004938 Esophageal Neoplasms Indomethacin 10.3711005569
MESH:D004938 Esophageal Neoplasms Sulindac 10.3712235107
MESH:D004938 Esophageal Neoplasms Zinc 10.3716543248
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 6.5811564622
MESH:D005124 Eye Abnormalities Tretinoin 6.5816938888 9664655
MESH:D005221 Fatigue Amphetamine 4.7519890266
MESH:D005234 Fatty Liver arsenite 29.9018296743
MESH:D005234 Fatty Liver Curcumin 29.9019297423
MESH:D005234 Fatty Liver Dietary Fats 29.9017967931 19004024 18296743 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 29.9021071580 20387270
MESH:D005234 Fatty Liver Ethanol 29.9018620774 19236843 16409862
MESH:D005234 Fatty Liver Ethinyl Estradiol 29.9015345470
MESH:D005234 Fatty Liver rosiglitazone 29.9019196556
MESH:D005234 Fatty Liver Valproic Acid 29.9014986274 19224547
MESH:D005235 Fatty Liver, Alcoholic Ethanol 4.7917920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 4.4415513904 16946407 15451040 10194807
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.6211858732
MESH:D005315 Fetal Diseases Valproic Acid 4.0216575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.328888407 18558336
MESH:D005334 Fever Indomethacin 3.3711852909 17627676 10431976
MESH:D018221 Fibromatosis, Abdominal Sulindac 4.6214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 8.9719069698
MESH:D018222 Fibromatosis, Aggressive Sulindac 8.9719069698
MESH:D005354 Fibrosarcoma Indomethacin 4.0410962813
MESH:D005355 Fibrosis arsenite 28.9218296743
MESH:D005355 Fibrosis Curcumin 28.9218705752
MESH:D005355 Fibrosis Dietary Fats 28.9218296743
MESH:D005355 Fibrosis Indomethacin 28.9217994277
MESH:D005355 Fibrosis Quercetin 28.9219474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 28.9220067830
MESH:D005355 Fibrosis Tretinoin 28.9217994277
MESH:D005499 Folliculitis Indomethacin 4.3011298111
MESH:D005756 Gastritis Acetaminophen 20.2616983495
MESH:D005756 Gastritis Ethanol 20.2615046732
MESH:D005756 Gastritis Indomethacin 20.2615046732
MESH:D005756 Gastritis Zinc 20.2617241300
MESH:D005764 Gastroesophageal Reflux Sulindac 4.1911910360
MESH:D005770 Gastrointestinal Neoplasms Curcumin 3.8618462866
MESH:D030342 Genetic Diseases, Inborn vinclozolin 4.0816973722
MESH:D005832 Genital Diseases, Male vinclozolin 4.4316417039
MESH:D005909 Glioblastoma Aspirin 33.0812870263
MESH:D005909 Glioblastoma Curcumin 33.0817596214
MESH:D005909 Glioblastoma Doxorubicin 33.0817150277
MESH:D005909 Glioblastoma Genistein 33.0816598420
MESH:D005909 Glioblastoma Indomethacin 33.0812870263
MESH:D005909 Glioblastoma KCC 009 33.0816170020
MESH:D005909 Glioblastoma monodansylcadaverine 33.0816170020
MESH:D005909 Glioblastoma Quercetin 33.0819804834
MESH:D005909 Glioblastoma Tretinoin 33.0817312396
MESH:D005910 Glioma Indomethacin 4.8616487511 18371953
MESH:D005910 Glioma Quercetin 4.8617643826
MESH:D005922 Glomerulonephritis, IGA deoxynivalenol 4.3115173396 16524712
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.5711849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 3.7210696789
MESH:D006073 Gout Indomethacin 4.5011248219
MESH:D006130 Growth Disorders Zinc 3.3517217573
MESH:D006261 Headache Aspirin 4.1015240983
MESH:D006258 Head and Neck Neoplasms Curcumin 17.5518829502 18462866
MESH:D006258 Head and Neck Neoplasms Doxorubicin 17.5515692506
MESH:D006258 Head and Neck Neoplasms Indomethacin 17.5515482327
MESH:D006258 Head and Neck Neoplasms Sirolimus 17.5519435901
MESH:D006258 Head and Neck Neoplasms Tretinoin 17.5516096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.2916084493
MESH:D006330 Heart Defects, Congenital Lithium 11.6419638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.6410048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 11.6414991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 11.6416080930
MESH:D006331 Heart Diseases Doxorubicin 2.8516144979 12587719 16244371 17888722 14766674 16330681 16495754 16707910 18006777 18674790 16879835 17875725 16244372
MESH:D006333 Heart Failure marker/mechanism 17901358
MESH:D006333 Heart Failure Dobutamine 12.1117440445
MESH:D006333 Heart Failure Doxorubicin 12.1117481944
MESH:D006333 Heart Failure Selenium 12.1117162251
MESH:D006333 Heart Failure Zinc 12.1117162251
MESH:D006335 Heart Injuries Zinc 4.9017074742
MESH:D016481 Helicobacter Infections Zinc 3.7417241300
MESH:D006394 Hemangiosarcoma 2-nitrotoluene 7.0913678655
MESH:D006394 Hemangiosarcoma Doxorubicin 7.0915692506
MESH:D006402 Hematologic Diseases Benzene 3.8616183116
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.5611000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 3.7915633222
MESH:D006505 Hepatitis Caffeine 4.1711394713
MESH:D019698 Hepatitis C, Chronic Indomethacin 3.8715135802
MESH:D006527 Hepatolenticular Degeneration Zinc 3.8617276780
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.0816120746 15340226 12621046
MESH:D015417 Hereditary Sensory and Motor Neuropathy Curcumin 4.2017701891
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.3216863852 16490937
MESH:D006558 Herpes Genitalis Estradiol 4.1615709030
MESH:D006561 Herpes Simplex Etoposide 7.2910809021
MESH:D006561 Herpes Simplex resveratrol 7.2916876885
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 4.8817440010
MESH:D006689 Hodgkin Disease Doxorubicin 5.3418501091 15147373 17606976
MESH:D006689 Hodgkin Disease Etoposide 5.3418180244 17606976 16200630 16135485 15147373
MESH:D019584 Hot Flashes Estradiol 12.2417088409
MESH:D019584 Hot Flashes Fluoxetine 12.2414716179
MESH:D019584 Hot Flashes Vitamin E 12.2414716179
MESH:D006849 Hydrocephalus Valproic Acid 4.0117688650
MESH:D006869 Hydronephrosis Lithium Chloride 10.1519797860
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 10.1516354765 8697196 16959395 18606429 15340226
MESH:D012001 Hyperacusis Aspirin 4.8915240983
MESH:D006930 Hyperalgesia Acetaminophen 17.1116870215
MESH:D006930 Hyperalgesia Ethanol 17.1118783367
MESH:D006930 Hyperalgesia Indomethacin 17.1112727271
MESH:D006930 Hyperalgesia rosiglitazone 17.1112083418
MESH:D006930 Hyperalgesia Tretinoin 17.1116870215
MESH:D034321 Hyperamylasemia Indomethacin 4.8517883296
MESH:D006937 Hypercholesterolemia 27-hydroxycholesterol 20.4817873880
MESH:D006937 Hypercholesterolemia Curcumin 20.4818704882
MESH:D006937 Hypercholesterolemia Dietary Fats 20.4821332399
MESH:D006937 Hypercholesterolemia lupeol 20.4816933029
MESH:D006937 Hypercholesterolemia resveratrol 20.4817188708
MESH:D006940 Hyperemia Indomethacin 4.1512524144
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 3.7316778211
MESH:D006943 Hyperglycemia Quercetin 7.4618262572 11834736
MESH:D006943 Hyperglycemia Risperidone 7.4618278980
MESH:D006948 Hyperkinesis Amphetamine 8.9814960337 1977408
MESH:D006948 Hyperkinesis Clozapine 8.9816046005
MESH:D006949 Hyperlipidemias Dietary Fats 10.9421332399
MESH:D006949 Hyperlipidemias Indomethacin 10.9417546600
MESH:D006949 Hyperlipidemias resveratrol 10.9416873680
MESH:D006963 Hyperphagia olanzapine 5.3717933447
MESH:D006973 Hypertension Benzene 8.9117940673
MESH:D006973 Hypertension Phenylephrine 8.9112717712 8949925
MESH:D006973 Hypertension Quercetin 8.9118356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.9118850075 18670907
MESH:D006984 Hypertrophy Phenylephrine 8.4318502941 12791704
MESH:D006984 Hypertrophy Sirolimus 8.4319211884
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 3.5417488730
MESH:D007021 Hypospadias Ethinyl Estradiol 2.9816945680 16569931
MESH:D007077 Ileal Diseases Indomethacin 4.1610574470 18306037
MESH:D007079 Ileitis Indomethacin 4.5010647630 10651667 16133968
MESH:D007235 Infant, Premature, Diseases Indomethacin 4.5016133044
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 8.7215869954
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 8.7217600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.6712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 4.6017937319
MESH:D007248 Infertility, Male vinclozolin 4.6016467254
MESH:D007249 Inflammation bisindolylmaleimide I 33.368273558
MESH:D007249 Inflammation Curcumin 33.3616956363 17151092 18403477
MESH:D007249 Inflammation Dietary Fats 33.3620412841
MESH:D007249 Inflammation Diethylnitrosamine 33.3618785209
MESH:D007249 Inflammation Fluoxetine 33.3612798668
MESH:D007249 Inflammation Indomethacin 33.363291741 12568917 7812673
MESH:D007249 Inflammation Progesterone 33.3615869954
MESH:D007249 Inflammation resveratrol 33.3616366677
MESH:D007249 Inflammation rosiglitazone 33.3612083418
MESH:D007249 Inflammation Sulindac 33.363291741
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 33.3612878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 33.3615177302 8273558 11698051 7812673 7562506
MESH:D015212 Inflammatory Bowel Diseases Curcumin 2.7818596194 18200517
MESH:D007251 Influenza, Human Quercetin 19.5816624496
MESH:D007251 Influenza, Human resveratrol 19.5816624496
MESH:D007251 Influenza, Human Selenium 19.5816624496
MESH:D007251 Influenza, Human Vitamin E 19.5816624496
MESH:D007333 Insulin Resistance Dietary Fats 12.6311836018 18457598
MESH:D007333 Insulin Resistance Estradiol 12.6316627594 16393666
MESH:D007333 Insulin Resistance rosiglitazone 12.6316306350
MESH:D007333 Insulin Resistance Sodium Selenite 12.6314714311
MESH:D007410 Intestinal Diseases Indomethacin 11.8317994277 15831440 11686837 17329856 15610444 11713966 11855677 10210152 18236018
MESH:D007410 Intestinal Diseases rebamipide 11.8311686837
MESH:D007410 Intestinal Diseases Tretinoin 11.8317994277
MESH:D007414 Intestinal Neoplasms Curcumin 7.6010783313
MESH:D007414 Intestinal Neoplasms Sulindac 7.6012628509 12584176 10213222 12351151 10223192 12663524
MESH:D007417 Intestinal Polyps Sulindac 4.1911245490 12394442
MESH:D019586 Intracranial Hypertension Indomethacin 4.5015241188
MESH:D007511 Ischemia Zinc 3.8016584753
MESH:D007569 Jaw Abnormalities Ethanol 12.7015513904
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 12.7016580747
MESH:D007569 Jaw Abnormalities Tretinoin 12.7015992940 17551590
MESH:D007579 Jejunal Diseases Indomethacin 4.1618306037 16133968 10574470
MESH:D007627 Keloid Quercetin 4.1217086741
MESH:D007674 Kidney Diseases Acetaminophen 20.2115629191 12587719
MESH:D007674 Kidney Diseases Doxorubicin 20.2115369732 16775033 15699352
MESH:D007674 Kidney Diseases Estradiol 20.2115618244
MESH:D007674 Kidney Diseases Indomethacin 20.2117190690
MESH:D007674 Kidney Diseases Quercetin 20.2116962696
MESH:D007674 Kidney Diseases Vitamin E 20.2112488133
MESH:D007674 Kidney Diseases Zinc 20.2116960431
MESH:D007676 Kidney Failure, Chronic Doxorubicin 12.2916707910
MESH:D007676 Kidney Failure, Chronic Selenium 12.2916518626
MESH:D007676 Kidney Failure, Chronic Zinc 12.2916518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 5.0116705839
MESH:D007680 Kidney Neoplasms Estradiol 5.0115610895
MESH:D007683 Kidney Tubular Necrosis, Acute Calcium 4.1816316344
MESH:D007859 Learning Disorders Ethanol 3.3915451040
MESH:D007889 Leiomyoma Curcumin 3.7718555241
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.1910320625 12228301 11703811
MESH:D007938 Leukemia 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 17.9812970779
MESH:D007938 Leukemia Benzene 17.9815935818 14694614 17119257 18335105
MESH:D007938 Leukemia Curcumin 17.9818462866
MESH:D007938 Leukemia Genistein 17.9817468513 18980019
MESH:D007938 Leukemia Quercetin 17.9817468513
MESH:D007938 Leukemia Tretinoin 17.9817143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.2916085563
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Curcumin 3.4316106398
MESH:D007948 Leukemia, Monocytic, Acute U 0126 4.4616972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.2615631656 10785260 16572323
MESH:D007951 Leukemia, Myeloid Benzene 7.1117506065
MESH:D007951 Leukemia, Myeloid Tretinoin 7.1116482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Benzene 6.6919478238
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 6.6918360721
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 6.6916294345 19850784 17596541
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 6.6916294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 5.7116087638
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 5.7116788101 17217047 19035177 17506722 19642359 12679006 17339181 16331271 17107899 19225113 17649720 15748426 17361223 16766008 16891316 16935935 16823087 17368321 19075265 19029980 9834237 17301526 17294898 16140955 17712046
MESH:D015458 Leukemia, T-Cell Curcumin 3.9416106398
MESH:D007964 Leukocytosis Indomethacin 4.5016537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 4.8517980183
MESH:D007984 Leydig Cell Tumor vinclozolin 3.8816417039
MESH:D017880 Limb Deformities, Congenital Ethanol 6.1217676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 6.129224671
MESH:D008064 Lipidoses Clozapine 6.4417567588
MESH:D008064 Lipidoses Fluoxetine 6.4415342952 17567588
MESH:D008101 Liver Abscess, Amebic Indomethacin 4.8511479899
MESH:D008103 Liver Cirrhosis arsenite 11.2818296743
MESH:D008103 Liver Cirrhosis Dietary Fats 11.2818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.2818522880 18407596 20032147 19638242 18665156
MESH:D008103 Liver Cirrhosis Ethanol 11.2815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.2418295389
MESH:D008105 Liver Cirrhosis, Biliary Sulindac 3.6212468960
MESH:D008106 Liver Cirrhosis, Experimental Curcumin 21.0118705752 17355460 18006644
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 21.0116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental epigallocatechin gallate 21.0117481882
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 21.0114716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 21.0118166357
MESH:D008106 Liver Cirrhosis, Experimental Genistein 21.0117823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 21.0118194892
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 21.0112741479
MESH:D008106 Liver Cirrhosis, Experimental rosiglitazone 21.0117347453 15980055
MESH:D008106 Liver Cirrhosis, Experimental Sirolimus 21.0117050028
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 21.0112878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 21.0118397230 16248980
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 21.0116169303
MESH:D008107 Liver Diseases Acetaminophen 9.0719784758 12587719 19460945 11587558 12969438 16611625 19014921 16610002
MESH:D008107 Liver Diseases Carbon Monoxide 9.0717173083
MESH:D008107 Liver Diseases Curcumin 9.0716956363
MESH:D008107 Liver Diseases Diethylnitrosamine 9.0717034775
MESH:D008107 Liver Diseases Sulindac 9.0714986274 16867024
MESH:D008108 Liver Diseases, Alcoholic Ethanol 3.8217347304 17207112
MESH:D017114 Liver Failure, Acute Acetaminophen 2.4816871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 12.467678174
MESH:D008113 Liver Neoplasms Diethylnitrosamine 12.4619996281 18754104 19073162 19499222 15885732 19638242 15175105 18977376 21071580 18648771 19090486 19690152 20501860 19294768 2422723 19426721 21047994 21278145 19427195 18644402 20434301 20101389 21167192 19812893 18978307 20137499 19551842 19256749 2862719 19833225 16942905 20452335 9163691 12112319 19255062 12771043 20492335 20583210 19254457 19642983 19850985 20118626 20405173 10737359
MESH:D008113 Liver Neoplasms Methapyrilene 12.4615890375
MESH:D008113 Liver Neoplasms Quercetin 12.4618980244
MESH:D008113 Liver Neoplasms resveratrol 12.4620405173 19812893 19321006 19073162
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 12.4616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 19.172876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Benzene 19.1712562636
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.1718775883 17854601 18544905 21159647 18079962 19126423 16267830 2563599 19539802 18164116 19009564 3124819 19004024 18093689 16842330 18308698 18253720 9362446 18282651 17942915 17174075 19519916
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 19.1716842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Hexachlorobenzene 19.171423854
MESH:D008114 Liver Neoplasms, Experimental Quercetin 19.1719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.1712151625
MESH:D008133 Long QT Syndrome Dobutamine 6.8519353679
MESH:D008133 Long QT Syndrome olanzapine 6.8520210726
MESH:D008171 Lung Diseases Dobutamine 5.8516638327
MESH:D008171 Lung Diseases Vitamin E 5.8516863852
MESH:D017563 Lung Diseases, Interstitial Benzene 8.5114698565
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 8.5117228818
MESH:D008175 Lung Neoplasms arsenite 18.2716809336
MESH:D008175 Lung Neoplasms Benzene 18.2712562636
MESH:D008175 Lung Neoplasms Curcumin 18.2719359593 18462866 16243823
MESH:D008175 Lung Neoplasms deguelin 18.2719336726 16288123
MESH:D008175 Lung Neoplasms Diethylnitrosamine 18.2720512841 20970405 21163286 6695378
MESH:D008175 Lung Neoplasms Doxorubicin 18.276189445 17418594
MESH:D008175 Lung Neoplasms Indomethacin 18.2711053908 16537180 11497255
MESH:D008175 Lung Neoplasms Quercetin 18.2716280456
MESH:D008175 Lung Neoplasms Sulindac 18.2715713900 19359593
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 18.2719555203 11884234
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 18.2711807781
MESH:D008175 Lung Neoplasms Vitamin E 18.2711062179
MESH:D008223 Lymphoma Benzene 12.5817119257 17584886
MESH:D008223 Lymphoma Curcumin 12.5818462866
MESH:D008223 Lymphoma Doxorubicin 12.5816098063
MESH:D008223 Lymphoma Etoposide 12.5812854902 12556972
MESH:D016393 Lymphoma, B-Cell resveratrol 7.6417088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 7.6414737004
MESH:D020522 Lymphoma, Mantle-Cell marker/mechanism 18787224
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 6.4917654614
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 6.4914749477
MESH:D016399 Lymphoma, T-Cell Curcumin 8.8016173963
MESH:D016399 Lymphoma, T-Cell Doxorubicin 8.8015621674
MESH:D015674 Mammary Neoplasms, Animal Benzene 7.4412562636
MESH:D015674 Mammary Neoplasms, Animal resveratrol 7.4415688416
MESH:D008325 Mammary Neoplasms, Experimental Benzene 34.6811921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 34.6815458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 34.6811807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 34.6814578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 34.6817203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 34.6811606380 8985016
MESH:D008325 Mammary Neoplasms, Experimental rosiglitazone 34.6816827153
MESH:D008325 Mammary Neoplasms, Experimental salinomycin 34.6819682730
MESH:D008325 Mammary Neoplasms, Experimental Selenium 34.6815318939
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 34.688985016
MESH:D008325 Mammary Neoplasms, Experimental Zinc 34.6812773700
MESH:D020149 Manganese Poisoning Estradiol 3.6119453300
MESH:D008527 Medulloblastoma Tretinoin 2.3617453147
MESH:D008545 Melanoma Curcumin 19.3117885582 18462866
MESH:D008545 Melanoma Doxorubicin 19.3116827129
MESH:D008545 Melanoma epigallocatechin gallate 19.3117992120 11746506
MESH:D008545 Melanoma Organometallic Compounds 19.3117210701
MESH:D008545 Melanoma resveratrol 19.3117992120
MESH:D008545 Melanoma Ruthenium 19.3117210701
MESH:D008545 Melanoma Ruthenium Compounds 19.3117210701
MESH:D008545 Melanoma Sirolimus 19.3119282848
MESH:D008545 Melanoma Sulindac 19.3116642371
MESH:D008545 Melanoma Tretinoin 19.3116752155
MESH:D008546 Melanoma, Experimental Acetaminophen 2.7319513568
MESH:D008569 Memory Disorders Curcumin 7.0617263510
MESH:D008569 Memory Disorders Ethanol 7.0618411066 15451040
MESH:D008591 Meningomyelocele Tretinoin 3.5916940565
MESH:D001523 Mental Disorders Clozapine 15.7116856516
MESH:D001523 Mental Disorders Fluoxetine 15.7116856516
MESH:D001523 Mental Disorders Haloperidol 15.7116856516
MESH:D001523 Mental Disorders olanzapine 15.7116856516
MESH:D001523 Mental Disorders Risperidone 15.7116856516 16596465
MESH:D008607 Mental Retardation Risperidone 3.7418349709
MESH:D008654 Mesothelioma Doxorubicin 4.8317638057
MESH:D008654 Mesothelioma Selenium 4.8315107826
MESH:D008659 Metabolic Diseases olanzapine 8.4219142110
MESH:D008659 Metabolic Diseases resveratrol 8.4217112576
MESH:D024821 Metabolic Syndrome X Clozapine 12.0019142101
MESH:D024821 Metabolic Syndrome X Risperidone 12.0019142101
MESH:D024821 Metabolic Syndrome X rosiglitazone 12.0017261469
MESH:D008881 Migraine Disorders Aspirin 8.9215240983
MESH:D008881 Migraine Disorders Indomethacin 8.9211903285
MESH:D008881 Migraine Disorders Valproic Acid 8.9218765137 18803445
MESH:D020326 Migraine without Aura Cyclic AMP 4.3411304026
MESH:D028361 Mitochondrial Diseases Doxorubicin 3.7215792986
MESH:D019964 Mood Disorders Risperidone 5.0017019624
MESH:D009062 Mouth Neoplasms Indomethacin 6.9212636206
MESH:D009062 Mouth Neoplasms Sirolimus 6.9219435901
MESH:D052016 Mucositis Doxorubicin 3.9417415656
MESH:D009101 Multiple Myeloma Benzene 8.4917119195
MESH:D009101 Multiple Myeloma Curcumin 8.4919372569
MESH:D009101 Multiple Myeloma resveratrol 8.4917049120 17935668 16490592 17164350 16267019 14749477
MESH:D019042 Muscle Neoplasms 2-nitrotoluene 5.8113678655
MESH:D009134 Muscular Atrophy, Spinal Curcumin 16.2417962980
MESH:D009134 Muscular Atrophy, Spinal epigallocatechin gallate 16.2417962980
MESH:D009134 Muscular Atrophy, Spinal resveratrol 16.2417962980
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.258888407
MESH:D009190 Myelodysplastic Syndromes Tretinoin 5.5117596541
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 5.5117596541
MESH:D009203 Myocardial Infarction Aspirin 20.1912692751
MESH:D009203 Myocardial Infarction Doxorubicin 20.1919429709 15857846
MESH:D009203 Myocardial Infarction Genistein 20.1917141266
MESH:D009203 Myocardial Infarction Lithium 20.1916288908
MESH:D009203 Myocardial Infarction Quercetin 20.1919595682
MESH:D009203 Myocardial Infarction resveratrol 20.1916456233 17188708 16317513 16525036 17125593 17015251
MESH:D009203 Myocardial Infarction SB 216763 20.1916288908
MESH:D017202 Myocardial Ischemia Dobutamine 11.3612447174
MESH:D017202 Myocardial Ischemia resveratrol 11.3617015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 11.3612213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 10.2916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 10.2917141266
MESH:D015428 Myocardial Reperfusion Injury Quercetin 10.2919207477
MESH:D009205 Myocarditis resveratrol 3.9117322642
MESH:D009207 Myoclonus Fluoxetine 5.028041377
MESH:D009325 Nausea Aspirin 4.3515240983
MESH:D009336 Necrosis 2,6-dinitrotoluene 3.017678174 18551238
MESH:D009361 Neoplasm Invasiveness Curcumin 3.5618495463
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 7.039029167 3581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 7.0318259882
MESH:D009362 Neoplasm Metastasis Indomethacin 7.0311239499 11053908 16537180
MESH:D009369 Neoplasms deguelin 7.9017764071
MESH:D009369 Neoplasms Nitrofurazone 7.9015488632
MESH:D009369 Neoplasms Quercetin 7.9015185748
MESH:D009369 Neoplasms Tretinoin 7.9016946489 16594593
MESH:D009374 Neoplasms, Experimental Indomethacin 6.6615625704 10663608
MESH:D009374 Neoplasms, Experimental resveratrol 6.668985016
MESH:D009376 Neoplasms, Hormone-Dependent Curcumin 3.6712497104
MESH:D009389 Neovascularization, Pathologic arsenite 7.3415738583
MESH:D009389 Neovascularization, Pathologic Estradiol 7.3417289903
MESH:D009401 Nephrosis Doxorubicin 3.9316899518 16636307
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.2616889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 16.8111399458 16427766
MESH:D009421 Nervous System Malformations Genistein 16.8116427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.8114600291
MESH:D009421 Nervous System Malformations Tretinoin 16.819125849
MESH:D009423 Nervous System Neoplasms Curcumin 4.7618462866
MESH:D009436 Neural Tube Defects Benzene 8.6515643154
MESH:D009436 Neural Tube Defects Tretinoin 8.659142499
MESH:D009436 Neural Tube Defects Valproic Acid 8.6516359493 8888407
MESH:D009447 Neuroblastoma Doxorubicin 2.7515555623
MESH:D019636 Neurodegenerative Diseases Acetaminophen 23.5418514411
MESH:D019636 Neurodegenerative Diseases Amphetamine 23.5415183010
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 23.5420387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 23.5412349958
MESH:D019636 Neurodegenerative Diseases resveratrol 23.5417652729
MESH:D019636 Neurodegenerative Diseases Sulindac 23.5416850258 17266991
MESH:D020078 Neurogenic Inflammation Quercetin 8.0517929310
MESH:D020078 Neurogenic Inflammation resveratrol 8.0517929310
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.2520387270
MESH:D053206 Nocturnal Enuresis Risperidone 5.4617822346
MESH:D009765 Obesity Clozapine 8.1418515891 19142110
MESH:D009765 Obesity Curcumin 8.1419297423
MESH:D009765 Obesity Dietary Fats 8.1417217161 18457598 21332399 16723640 18674790 20132043 19632207 20518802 11836018
MESH:D009765 Obesity olanzapine 8.1418515891
MESH:D009771 Obsessive-Compulsive Disorder Fluoxetine 4.6620418887
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.306374098
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 6.6516049721
MESH:D009784 Occupational Diseases Benzene 6.6515935809 17178637 15727169 15576619 15913788 17479406 16737584 17119257 15612468
MESH:D010003 Osteoarthritis Aspirin 6.067009135
MESH:D010003 Osteoarthritis Indomethacin 6.067009135
MESH:D010024 Osteoporosis Calcium 8.5717882678
MESH:D010024 Osteoporosis Curcumin 8.5718719352
MESH:D010024 Osteoporosis Genistein 8.5719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 12.3216169203
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 12.3219495926
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 12.3217513867
MESH:D012516 Osteosarcoma Doxorubicin 3.4015930896
MESH:D010051 Ovarian Neoplasms 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 31.3216211241
MESH:D010051 Ovarian Neoplasms Benzene 31.3212562636
MESH:D010051 Ovarian Neoplasms Curcumin 31.3219020741 18462866
MESH:D010051 Ovarian Neoplasms Estradiol 31.3219401270
MESH:D010051 Ovarian Neoplasms Genistein 31.3219005980
MESH:D010051 Ovarian Neoplasms Mifepristone 31.3216525653
MESH:D010051 Ovarian Neoplasms Nitrofurazone 31.3211026599
MESH:D010051 Ovarian Neoplasms Progesterone 31.3216525653 17393432
MESH:D010051 Ovarian Neoplasms Quercetin 31.3219005980
MESH:D010051 Ovarian Neoplasms Tretinoin 31.3216936753
MESH:D010051 Ovarian Neoplasms U 0126 31.3216211241
MESH:D010146 Pain Acetaminophen 17.3416870215
MESH:D010146 Pain Aspirin 17.346363464 6995502
MESH:D010146 Pain Fluoxetine 17.3412798668
MESH:D010146 Pain Indomethacin 17.343291741 17627676 13679232 17440234
MESH:D010146 Pain Sulindac 17.343291741
MESH:D010146 Pain Tretinoin 17.3416870215
MESH:D010149 Pain, Postoperative Indomethacin 3.8212538197 18702446
MESH:D010190 Pancreatic Neoplasms Curcumin 22.1219401701 17440100 19196508
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 22.1216540662
MESH:D010190 Pancreatic Neoplasms Ethanol 22.1212384795
MESH:D010190 Pancreatic Neoplasms Etoposide 22.1219003803
MESH:D010190 Pancreatic Neoplasms Quercetin 22.1216965848
MESH:D010190 Pancreatic Neoplasms Sulindac 22.1211504793 16820089
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 22.1215976015
MESH:D010190 Pancreatic Neoplasms Tretinoin 22.1215976015
MESH:D010195 Pancreatitis Indomethacin 3.1517883296 15028970
MESH:D016584 Panic Disorder Ethinyl Estradiol 2.8911578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 3.4718922899 12065085 8330346 18404319
MESH:D010257 Paraneoplastic Syndromes Indomethacin 4.8516537180
MESH:D010300 Parkinson Disease Sirolimus 3.3619682553
MESH:D020734 Parkinsonian Disorders Indomethacin 3.3712349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 4.8511903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.3812520081
MESH:D010437 Peptic Ulcer Indomethacin 4.2911148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 4.6911156591
MESH:D010518 Periodontitis Indomethacin 4.0517225004
MESH:D010538 Peritonitis marker/mechanism 16713974
MESH:D020795 Photophobia Aspirin 4.8915240983
MESH:D010787 Photosensitivity Disorders 4-hydroxy-2-nonenal 4.6311550810
MESH:D003557 Phyllodes Tumor Doxorubicin 4.2917983394
MESH:D020774 Pick Disease of the Brain Fluoxetine 5.168041377
MESH:D010954 Plasmacytoma Selenium 4.0215087411
MESH:D010997 Pleural Neoplasms Doxorubicin 4.2917638057
MESH:D011141 Polyuria Lithium Chloride 5.1419692487
MESH:D017119 Porphyria Cutanea Tarda Hexachlorobenzene 8.409918132
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 8.4018163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 6.772563599
MESH:D011230 Precancerous Conditions Quercetin 6.7719056647
MESH:D011225 Pre-Eclampsia Zinc 3.4817114810
MESH:D047928 Premature Birth Indomethacin 4.2917000239
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 16.3416679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 16.3411399792 11222880 11896295 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 16.3420603192
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 16.3418220299 18042343 19015723
MESH:D011469 Prostatic Diseases vinclozolin 4.0818220299
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.1120887781
MESH:D011471 Prostatic Neoplasms marker/mechanism 16421604
MESH:D011471 Prostatic Neoplasms Curcumin 3.3818226269 11398177 18769126 10851300 12497104 15129424 18156803
MESH:D011471 Prostatic Neoplasms Doxorubicin 3.3816868541 16729912 15749863 15897917 18437689 16888761
MESH:D011471 Prostatic Neoplasms Estradiol 3.3816740699
MESH:D011471 Prostatic Neoplasms Etoposide 3.3817172428
MESH:D011471 Prostatic Neoplasms Genistein 3.3816925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms methylselenic acid 3.3816205645
MESH:D011471 Prostatic Neoplasms Quercetin 3.3814715546 17292933
MESH:D011471 Prostatic Neoplasms resveratrol 3.3817804756 15767336 17636462 17718901 17675339 16731767
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.3818760546
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3815084515
MESH:D011471 Prostatic Neoplasms Zinc 3.3816606632 12429649 16700911 16517595
MESH:D011472 Prostatitis vinclozolin 4.0818629315
MESH:D011507 Proteinuria Indomethacin 6.7111849393
MESH:D011507 Proteinuria Tretinoin 6.7116636307
MESH:D011537 Pruritus Ethinyl Estradiol 2.4716919318 15861022
MESH:D019310 Pseudolymphoma Valproic Acid 3.6711422049 12752131
MESH:D011595 Psychomotor Agitation Haloperidol 9.0511575062
MESH:D011595 Psychomotor Agitation olanzapine 9.0518685284
MESH:D011618 Psychotic Disorders Clozapine 6.9515331141
MESH:D011618 Psychotic Disorders Haloperidol 6.9511575062
MESH:D011625 Pterygium Tretinoin 3.9416723453
MESH:D011649 Pulmonary Alveolar Proteinosis 27-hydroxycholesterol 5.5215466366
MESH:D011656 Pulmonary Emphysema Curcumin 3.7619168576
MESH:D051437 Renal Insufficiency Doxorubicin 3.3917922066
MESH:D051436 Renal Insufficiency, Chronic resveratrol 4.7116325855
MESH:D015427 Reperfusion Injury resveratrol 2.7815827377 17520802 16314181 16317513 17058453
MESH:D012128 Respiratory Distress Syndrome, Adult Curcumin 3.2410666014 18379247
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.0218990726
MESH:D012162 Retinal Degeneration Zinc 3.4516584753
MESH:D012208 Rhabdomyosarcoma Tretinoin 8.2216116481 16283617
MESH:D012208 Rhabdomyosarcoma Valproic Acid 8.2219155313
MESH:D012220 Rhinitis Aspirin 3.6312372130
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.4718045962
MESH:D012509 Sarcoma Curcumin 7.0618462866
MESH:D012509 Sarcoma Doxorubicin 7.0616767912 17710206 15625365 15675481 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 7.8514601052 16326096
MESH:D012512 Sarcoma, Ewing's Etoposide 7.8514601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 3.9417846226
MESH:D012554 Schistosomiasis japonica Quercetin 4.6716862918
MESH:D012559 Schizophrenia marker/mechanism 14745448
MESH:D012559 Schizophrenia Clozapine 8.2417726453 17123785 20107430 17667964 20521326 11151749 20580759 16141801 18855531 20521320 20452607 20168265 11763009 19369910 18806925
MESH:D012559 Schizophrenia Haloperidol 8.2419369910 20107430 1830565 18513383
MESH:D012559 Schizophrenia olanzapine 8.2420521326 20107430 17726453
MESH:D012559 Schizophrenia Risperidone 8.2419154706 20107430 18278980
MESH:D012559 Schizophrenia Valproic Acid 8.2419110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 9.0218551238
MESH:D012640 Seizures Ethanol 9.029754883
MESH:D012640 Seizures Lithium 9.0219660546
MESH:D012640 Seizures Valproic Acid 9.0211044598 1511512 11738929 3137016 15475178 14763951 17978042 16876388
MESH:D018805 Sepsis Curcumin 3.3518389075
MESH:D020230 Serotonin Syndrome Fluoxetine 5.038704074
MESH:D012852 Sinusitis Phenylephrine 3.857327846
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.4312269725
MESH:D012871 Skin Diseases Vitamin E 2.1518709164
MESH:D012878 Skin Neoplasms deguelin 23.3716041863
MESH:D012878 Skin Neoplasms Doxorubicin 23.3715692506
MESH:D012878 Skin Neoplasms gingerol 23.3719481070
MESH:D012878 Skin Neoplasms resveratrol 23.3715837718 8985016
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 23.378532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 23.3716192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 23.3718404319 8985016 8330346 12065085 11807781
MESH:D012878 Skin Neoplasms Tretinoin 23.3716467112
MESH:D012893 Sleep Disorders Caffeine 8.6719395429
MESH:D012893 Sleep Disorders Risperidone 8.6718278980
MESH:D007319 Sleep Initiation and Maintenance Disorders Caffeine 4.2517225163
MESH:D019082 Smith-Lemli-Opitz Syndrome 27-hydroxycholesterol 5.1711254748
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 3.7315625365 17203757 16767912
OMIM:270800 SPASTIC PARAPLEGIA 5A, AUTOSOMAL RECESSIVE 27-hydroxycholesterol 5.5219812052
MESH:D013088 Spermatocele Ethinyl Estradiol 3.0816709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.4315862959 16503802
MESH:D016135 Spinal Dysraphism Valproic Acid 3.0919490988
MESH:D013226 Status Epilepticus Lithium 9.7919951488 19430551 19570321
MESH:D013226 Status Epilepticus Valproic Acid 9.7912833885
MESH:D019956 Stereotypic Movement Disorder Amphetamine 5.551977408
MESH:D013272 Stomach Diseases Indomethacin 7.9117638125 15472012 18545984 10486359 16184426 10192188 16113693 17207306 16280098 15038085 18209964 17160473 10215738
MESH:D013272 Stomach Diseases rebamipide 7.9116184426
MESH:D013274 Stomach Neoplasms Benzene 6.3312562636
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 6.3318456281
MESH:D013274 Stomach Neoplasms Ethanol 6.3318456281
MESH:D013274 Stomach Neoplasms Indomethacin 6.3315609394
MESH:D013274 Stomach Neoplasms rebamipide 6.3315993841
MESH:D013274 Stomach Neoplasms Tretinoin 6.3317261132
MESH:D013276 Stomach Ulcer Curcumin 7.8116631530 19188055
MESH:D013276 Stomach Ulcer Ethanol 7.8117918041 9211565 11906479 17189318 16755016 9562338
MESH:D013276 Stomach Ulcer Indomethacin 7.8115255614 18431645 16252198 10750652 18726076 17627676 18299717 16755016 18181030 1323529 11595415 16397915 16169175 17135157 12787963 17977527 12467913 17918041 14567935 15104355 18237397 10878458 11523592 16631530 11729361 12077510 11145282 16150113 17657623 15138204 12500499 17895592 18087811 18543354 18193104 10423059 12498302 11906479 17654042 16934674 18209962 11595431
MESH:D020521 Stroke Aspirin 6.5716403987
MESH:D020521 Stroke Vitamin E 6.5716517955
OMIM:601367 STROKE, ISCHEMIC resveratrol 3.7216321402
MESH:D013375 Substance Withdrawal Syndrome Ethanol 3.509754883
MESH:D017180 Tachycardia, Ventricular Haloperidol 12.9820210726
MESH:D017180 Tachycardia, Ventricular olanzapine 12.9820210726
MESH:D017180 Tachycardia, Ventricular Risperidone 12.9820210726
MESH:D019851 Thrombophilia Ethinyl Estradiol 2.8211994571
MESH:D013927 Thrombosis Aspirin 6.7417672075
MESH:D013927 Thrombosis Ethinyl Estradiol 6.7415669648
MESH:D013953 Thymus Neoplasms Benzene 4.1010850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.0312697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.567505956
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.5617909728 16010429
MESH:D013964 Thyroid Neoplasms Indomethacin 11.5618791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Tretinoin 11.5616026305 17045167
MESH:D013978 Tibial Fractures Estradiol 3.8219048282
MESH:D014062 Tongue Neoplasms resveratrol 12.2616227395
MESH:D014062 Tongue Neoplasms Tretinoin 12.2616051514
MESH:D014062 Tongue Neoplasms Zinc 12.2616543248
MESH:D016171 Torsades de Pointes Dobutamine 4.5019353679
MESH:D005879 Tourette Syndrome Risperidone 5.1119154706
MESH:D014178 Translocation, Genetic Valproic Acid 4.3617262798
MESH:D014376 Tuberculosis Tretinoin 2.6316040207
MESH:D014402 Tuberous Sclerosis Sirolimus 4.7521115397 18495876
MESH:D014456 Ulcer Indomethacin 4.0417380554 10574470
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 3.673119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.3916049721
MESH:D001749 Urinary Bladder Neoplasms Curcumin 8.3918593936
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 8.3917653716
MESH:D001749 Urinary Bladder Neoplasms Quercetin 8.3916720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 3.818888407
MESH:D014565 Urogenital Neoplasms Curcumin 4.4118462866
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 3.4710091137
MESH:D014581 Urticaria Acetaminophen 6.2910982225
MESH:D014581 Urticaria Aspirin 6.2920485159 10982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 7.0217473185
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 7.0216129372
MESH:D014594 Uterine Neoplasms Benzene 16.3312562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 16.3314692618
MESH:D014594 Uterine Neoplasms resveratrol 16.3317044934
MESH:D014594 Uterine Neoplasms Sulindac 16.3318645019
MESH:D014604 Uveal Neoplasms Tretinoin 3.7416752155
MESH:D014605 Uveitis Sirolimus 4.761336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 3.7212125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 2.7614671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 7.5817334414 17638931 17678736 16364871
MESH:D018487 Ventricular Dysfunction, Left resveratrol 7.5817488730
MESH:D014820 Vitiligo Tretinoin 3.2416761959
MESH:D014839 Vomiting Indomethacin 3.8811897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.3815886252
MESH:D015430 Weight Gain Clozapine 17.1920564506 17502770 16402076 20107430 20521320 16141801
MESH:D015430 Weight Gain Dietary Fats 17.1916723640
MESH:D015430 Weight Gain olanzapine 17.1919434072 20107430 17933447
MESH:D015430 Weight Gain Risperidone 17.1916379507 20564506
MESH:D015431 Weight Loss Clozapine 4.2217933447
MESH:D009396 Wilms Tumor Tretinoin 3.2216287080
MESH:D014947 Wounds and Injuries lupeol 7.7518222664
MESH:D014947 Wounds and Injuries Nitrofurazone 7.7518222664 18440737
Pathway ID Pathway Name
KEGG:05010 Alzheimer's disease
REACT:18266 Axon guidance
KEGG:04360 Axon guidance
KEGG:05217 Basal cell carcinoma
KEGG:04662 B cell receptor signaling pathway
KEGG:04110 Cell cycle
KEGG:04062 Chemokine signaling pathway
KEGG:05210 Colorectal cancer
KEGG:05213 Endometrial cancer
KEGG:04012 ErbB signaling pathway
KEGG:04510 Focal adhesion
KEGG:04340 Hedgehog signaling pathway
KEGG:05160 Hepatitis C
KEGG:04910 Insulin signaling pathway
KEGG:05162 Measles
KEGG:04916 Melanogenesis
KEGG:04722 Neurotrophin signaling pathway
KEGG:05200 Pathways in cancer
KEGG:05215 Prostate cancer
REACT:11045 Signaling by Wnt
REACT:11061 Signalling by NGF
KEGG:04660 T cell receptor signaling pathway
KEGG:04310 Wnt signaling pathway
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29009
    • No data
    Releated disease ID Related disease Name
    PA444750Leukemia
    PA447278Depression
    PA447321Depressive Disorder, Major
    PA447062Parkinsonian Disorders
    PA443560Breast Neoplasms
    PA445084Wilms Tumor
    Releated drug ID Related drug Name
    PA449167cyclosporine
    PA449015citalopram
    PA449673fluoxetine
    PA10804imatinib
    PA449773glucose
    PA152241909PP2
    PA451578tacrolimus
    PA451365sirolimus
    PA450243lithium
    PA451283rosiglitazone
    PA164749238exenatide
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB01356 antagonist Lithium
    DB01772 - 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione
    DB01793 - I-5
    DB01950 - N-(4-Methoxybenzyl)-N'-(5-Nitro-1,3-Thiazol-2-Yl)Urea
    DB02010 - Staurosporine Enzyme Inhibitors
    DB02052 - Indirubin-3'-Monoxime
    DB03431 - Adenosine-5'-Diphosphate
    DB03444 - (3e)-6'-Bromo-2,3'-Biindole-2',3(1h,1'h)-Dione 3-Oxime
    DB04014 - Alsterpaullone
    DB04395 - Phosphoaminophosphonic Acid-Adenylate Ester
    DB07014 - 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole
    DB07058 - 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione
    DB07149 - (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one
    DB07584 - N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
    DB07585 - 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
    DB07676 - 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one
    DB07812 - N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide
    DB07859 - 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE
    DB07947 - ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE
    DB08073 - (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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