AutismKB 2.0

Annotation Detail for GSTT2


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Basic Information Top
Gene Symbol:GSTT2 ( GSTT2B,MGC182032 )
Gene Full Name: glutathione S-transferase theta 2
Band: 22q11.23
Quick LinksEntrez ID:2953; OMIM: 600437; Uniprot ID:GSTT2_HUMAN; ENSEMBL ID: ENSG00000099984; HGNC ID: 4642
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4061glutathione-mediated detoxification
Pathway IDPathway Name
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
Desease IDDesease Name
2053Colon cancer
Desease Name
colorectal cancer
CANCER
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C008348 1-menaphthyl sulfate GSTT2 protein affects the metabolism of 1-menaphthyl sulfateaffects metabolic processing 9037717
C008348 1-menaphthyl sulfate GSTT2 protein affects the metabolism of 1-menaphthyl sulfateaffects metabolic processing 8645195
C008348 1-menaphthyl sulfate GSTT2 protein affects the metabolism of 1-menaphthyl sulfateaffects metabolic processing 2114406
C008348 1-menaphthyl sulfate GSTT2 protein results in increased metabolism of 1-menaphthyl sulfateincreases metabolic processing 12054768
C110057 4-nitrophenethyl bromide GSTT2 protein results in increased metabolism of 4-nitrophenethyl bromideincreases metabolic processing 12054768
C453681 7-amino-4-chloromethylcoumarin GSTT2 protein results in increased metabolism of 7-amino-4-chloromethylcoumarinincreases metabolic processing 17011574
D016604 Aflatoxin B1 GSTT2 protein affects the metabolism of and results in increased oxidation of Aflatoxin B1affects metabolic processing|increases oxidation 8951341
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GSTT2 mRNAaffects expression 16483693
C526219 apple polyphenol extract apple polyphenol extract results in increased expression of GSTT2 mRNAincreases expression 16369997
18351577
C039726 artesunate GSTT2 mRNA affects the susceptibility to artesunateaffects response to substance 15796179
D001241 Aspirin Aspirin results in increased expression of GSTT2 proteinincreases expression 9729437
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GSTT2 mRNAdecreases expression 20127859
D002087 Butyrates Butyrates results in increased expression of GSTT2 mRNAincreases expression 15746163
C055494 caffeic acid phenethyl ester caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTT2 mRNA]decreases reaction|increases expression 20360939
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GSTT2 mRNAdecreases expression 16644059
D002713 Chlorine [Ozone co-treated with Chlorine] results in increased expression of GSTT2 mRNAaffects cotreatment|increases expression 18636392
D004390 Chlorpyrifos Chlorpyrifos results in increased expression of GSTT2 mRNAincreases expression 19440498
D019826 Cholic Acid Cholic Acid results in increased expression of GSTT2 mRNAincreases expression 17521389
C007164 cumene hydroperoxide GSTT2 protein affects the metabolism of cumene hydroperoxideaffects metabolic processing 2114406
D003976 Diazinon Diazinon results in increased expression of GSTT2 mRNAincreases expression 19440498
D004041 Dietary Fats Dietary Fats results in decreased expression of GSTT2 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTT2 mRNA]decreases reaction|increases expression 20360939
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of GSTT2 mRNAincreases expression 20360939
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of GSTT2 mRNAincreases expression 15289156
D004137 Dinitrochlorobenzene GSTT2 protein affects the metabolism of Dinitrochlorobenzeneaffects metabolic processing 8645195
D004137 Dinitrochlorobenzene GSTT2 protein results in increased metabolism of Dinitrochlorobenzeneincreases metabolic processing 12054768
D004958 Estradiol Estradiol affects the expression of GSTT2 mRNAaffects expression 15598610
D004958 Estradiol Estradiol results in increased expression of GSTT2 mRNAincreases expression 15289156
D004976 Ethacrynic Acid GSTT2 protein affects the metabolism of Ethacrynic Acidaffects metabolic processing 2114406
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of GSTT2 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GSTT2 mRNAdecreases expression 14976129
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of GSTT2 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTT2 mRNAaffects cotreatment|increases expression 17942748
D005047 Etoposide GSTT2 protein affects the susceptibility to Etoposideaffects response to substance 16217747
D011345 Fenofibrate Fenofibrate results in increased expression of GSTT2 mRNAincreases expression 11798191
D005419 Flavonoids Flavonoids results in decreased expression of GSTT2 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in increased expression of GSTT2 mRNAincreases expression 15289156
D006016 Glycolates Glycolates analog binds to and results in decreased activity of GSTT2 proteinaffects binding|decreases activity 6686184
D006540 Herbicides Herbicides binds to and results in decreased activity of GSTT2 proteinaffects binding|decreases activity 6686184
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of GSTT2 mRNAaffects cotreatment|increases expression 17183730
C029424 hydrazine hydrazine results in increased expression of GSTT2 mRNAincreases expression 15282401
D007052 Ibuprofen Ibuprofen results in increased expression of GSTT2 proteinincreases expression 9729437
D007213 Indomethacin Indomethacin results in increased expression of GSTT2 proteinincreases expression 9729437
D015735 Mifepristone Mifepristone results in decreased expression of GSTT2 mRNAdecreases expression 17584828
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of GSTT2 mRNAdecreases expression 17616710
C025589 ochratoxin A ochratoxin A results in decreased expression of GSTT2 mRNAdecreases expression 16251485
D010126 Ozone [Ozone co-treated with Chlorine] results in increased expression of GSTT2 mRNAaffects cotreatment|increases expression 18636392
C041786 palm oil palm oil results in decreased expression of GSTT2 mRNAdecreases expression 18042831
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of GSTT2 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of GSTT2 mRNA]increases expression|increases reaction 18467677
D010634 Phenobarbital Phenobarbital affects the expression of GSTT2 mRNAaffects expression 19136022
D010634 Phenobarbital Phenobarbital results in increased expression of GSTT2 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid affects the expression of GSTT2 mRNAaffects expression 19136022
C006253 pirinixic acid pirinixic acid results in decreased expression of GSTT2 mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of GSTT2 mRNAincreases expression 18301758
17426115
D010936 Plant Extracts Plant Extracts results in increased expression of GSTT2 mRNAincreases expression 18351577
D012643 Selenium Selenium deficiency results in increased expression of GSTT2 mRNAincreases expression 16170372
D012643 Selenium Selenium results in increased expression of GSTT2 mRNAincreases expression 16170372
C017947 sodium arsenite sodium arsenite results in increased expression of GSTT2 mRNAincreases expression 14691202
D013629 Tamoxifen Tamoxifen affects the expression of GSTT2 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTT2 mRNA]affects reaction|increases expression 19474220
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTT2 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of GSTT2 mRNAincreases expression 19474220
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of GSTT2 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.0314745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 11.276195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 11.2715322242 14514962 11752688
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 11.278875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.4719490988
MESH:D000138 Acidosis Ammonium Chloride 3.0518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.4217505938
MESH:D058186 Acute Kidney Injury Ibuprofen 4.006375363
MESH:D055371 Acute Lung Injury Chlorine 7.6020601635
MESH:D055371 Acute Lung Injury pirinixic acid 7.6018653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 15.0720127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 15.0711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 15.0714692618
MESH:D000230 Adenocarcinoma Genistein 15.0711473722
MESH:D000230 Adenocarcinoma Ibuprofen 15.0710697514
MESH:D000230 Adenocarcinoma Indomethacin 15.0716537180
MESH:D000236 Adenoma Benzo(a)pyrene 9.416695378
MESH:D000236 Adenoma Diethylnitrosamine 9.416695378 10737359
MESH:D000236 Adenoma Indomethacin 9.4111497255
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 20.6919061943 18056438 19052882 17162532 17620307 16434500
MESH:D018248 Adenoma, Liver Cell Phenobarbital 20.6917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 20.6916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 20.6916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.1815276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.3816712894 17306315
MESH:D000382 Agricultural Workers' Diseases Chlorpyrifos 7.5016611668 11874814 17119214
MESH:D000382 Agricultural Workers' Diseases Diazinon 7.5016487989
MESH:D016301 Alveolar Bone Loss Indomethacin 4.8517225004
MESH:D000544 Alzheimer Disease Ibuprofen 8.3418351690
MESH:D000544 Alzheimer Disease Indomethacin 8.3415579461 17627676
MESH:D000544 Alzheimer Disease Ozone 8.3415513908
MESH:D000544 Alzheimer Disease Plant Extracts 8.3416962711
MESH:D000550 Amblyopia Valproic Acid 4.7117688650
MESH:D000686 Amyloidosis Diethylstilbestrol 4.0015469931
MESH:D000707 Anaphylaxis Ibuprofen 4.759532969
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.5111748828
MESH:D001008 Anxiety Disorders Valproic Acid 3.1717497229
MESH:D001014 Aortic Aneurysm Indomethacin 4.3710231640
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 10.0619183758
MESH:D017544 Aortic Aneurysm, Abdominal Indomethacin 10.0610388637
MESH:D001161 Arteriosclerosis Dietary Fats 8.2615238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.2611256880
MESH:D018771 Arthralgia Indomethacin 4.652160914
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.4315885639
MESH:D001169 Arthritis, Experimental Plant Extracts 6.4314686799
MESH:D001172 Arthritis, Rheumatoid Indomethacin 4.3811248219
MESH:D001172 Arthritis, Rheumatoid Ozone 4.3815570426
MESH:D001249 Asthma Ozone 2.4717854713 16373670
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.2820485159 12372130
MESH:D001321 Autistic Disorder Valproic Acid 2.0716609825 18558336 19232924 17507914 18775368 18316065 17688650 18396377 18177632 15238991 17157402 20603192 18940202 18985861 19460635
MESH:D001477 Bartter Syndrome Indomethacin 4.4910684365
MESH:D001714 Bipolar Disorder Valproic Acid 2.8017594078 20046352
MESH:D001778 Blood Coagulation Disorders pirinixic acid 7.2619483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 7.2612125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.2715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 6.9015746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 6.908888407
MESH:D019046 Bone Marrow Neoplasms Etoposide 4.6414601052
MESH:D001929 Brain Edema Indomethacin 4.5111481608
MESH:D002545 Brain Ischemia Ibuprofen 14.3115837124
MESH:D002545 Brain Ischemia Indomethacin 14.3112524144
MESH:D002545 Brain Ischemia Plant Extracts 14.3116041641
MESH:D001932 Brain Neoplasms Aspirin 3.9815481559
MESH:D001943 Breast Neoplasms Aspirin 8.7715161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.7717474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 8.7720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 8.7717474063
MESH:D001943 Breast Neoplasms Diethylstilbestrol 8.7717129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 8.7717289903 17261762 12948864 19861407 16675129 17018787 18497071 14630087
MESH:D001943 Breast Neoplasms Etoposide 8.7716322251
MESH:D001943 Breast Neoplasms Genistein 8.7716873071 17200150 16541309
MESH:D001943 Breast Neoplasms Indomethacin 8.7717401462
MESH:D001943 Breast Neoplasms ochratoxin A 8.7711921183
MESH:D001943 Breast Neoplasms Tamoxifen 8.7719011961 19244106 19221464 16273361 21138602 17261762 18815881 17049068 15565566 21152245 19115204 19200415 19142967 16873071 19084267 20390343 16202921 19059307 19155303 17440819 18629630 20005174 19410462 18984771 11161223 20859285 17893378 19487384 19189212 19103187 19189210 19288272 15668708 20065188 20135344 19066611 18855134 18821012 20544844 18997820 18351453 18425577 17242785 19289846 16818667
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.7720435547
MESH:D016535 Bronchial Hyperreactivity Ozone 3.2815516495 17626835 18417511 16777450 18315731 19059883 14754758
MESH:D002056 Burns Indomethacin 4.2110459503
MESH:D002057 Burns, Chemical Plant Extracts 4.829625245
MESH:D002100 Cachexia Ibuprofen 18.2015141370
MESH:D002100 Cachexia Indomethacin 18.2015141370 16537180 11239499 15625704
MESH:D002100 Cachexia Ozone 18.2016183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 3.9516111702
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.2918705752 16192424 3786805 15721981 10355542 15700767 16097048 16227642 16124888 15673190 16050911 16011737
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.4016835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.0119066611
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 23.5912619106 21507988 12907637
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 23.5918788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 23.5916569478 17978847 10672840 17173139 16502159 11831363 16328049 16779866 16878318 19171122 19208518 16288022 19919837 17138121 3084413 18506893 17055752 18691550 18788625 16681979 19701751 20432363 17761372 19822196 20514400 18665156 18210153 18971187 16935385 20101231 19052882 10737359 20214788 18056438 19539802 19418558 18393292 20524982 20727157 16830150 19335982 19383236 17162532 17428255 16807293 20007298 19394651 18785209 18494052 20935162 21159647 16698587 20084675 20512989 19107877 16540662 3581430 19519916 18978308
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 23.5916924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 23.5916924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 23.5916924424
MESH:D006528 Carcinoma, Hepatocellular Indomethacin 23.5916391822
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 23.5917173139 20935162 6705139 1701930 20007298
MESH:D006528 Carcinoma, Hepatocellular Plant Extracts 23.5918834353
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 23.5917306315 16507464 15276417
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 23.5916924424
MESH:D018827 Carcinoma, Lewis Lung Indomethacin 4.2211053908
MESH:D018276 Carcinoma, Medullary Indomethacin 4.8411352223 14736730 18791128
MESH:D002292 Carcinoma, Renal Cell Indomethacin 3.1217341418
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 6.5620419170
MESH:D002294 Carcinoma, Squamous Cell Indomethacin 6.5615482327 12636206
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 6.5618572023
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.1717572228
MESH:D006332 Cardiomegaly Plant Extracts 5.9817645561
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 5.9818670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 2.9516332659
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 9.1417174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 9.1418566989
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 9.1420056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 3.764080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.5120734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 7.9019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 7.9016835633
MESH:D002764 Cholecystitis Indomethacin 4.6511181007
MESH:D002779 Cholestasis Ethinyl Estradiol 6.4716919318 11677210 17681005 17333356 16105132 15861022 17110522
MESH:D002779 Cholestasis pirinixic acid 6.4719176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 1.8715668235 15340226 12621046 8697196 16354765
MESH:D003092 Colitis Selenium 3.2917936198
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.6619159591 17373747
MESH:D003110 Colonic Neoplasms Aspirin 7.4012411196
MESH:D003110 Colonic Neoplasms Butyrates 7.4015936596
MESH:D003110 Colonic Neoplasms Genistein 7.4017182828
MESH:D003110 Colonic Neoplasms Indomethacin 7.4011260862 15625704 15637740 15786552 15936596 15963497
MESH:D015179 Colorectal Neoplasms Aspirin 2.8617047198
MESH:D015179 Colorectal Neoplasms Indomethacin 2.8617054584 12606626 11197048 18059344
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.6314669216 17141729
MESH:D018352 Coronavirus Infections Indomethacin 5.2017302372
MESH:D019465 Craniofacial Abnormalities ochratoxin A 3.5520036863
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5520055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.558888407 17688650 16575769
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.0712952375 16002989
MESH:D003711 Demyelinating Diseases Tamoxifen 3.8719031437
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 3.7315491423
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.1718249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.2120387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.2116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.2117107852
MESH:D003928 Diabetic Nephropathies Estradiol 12.6119279558
MESH:D003928 Diabetic Nephropathies Plant Extracts 12.6119706694
MESH:D003928 Diabetic Nephropathies Tamoxifen 12.6119279558
MESH:D003967 Diarrhea Indomethacin 3.337237001 7907874
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 10.0910915739 19336974 16177239 3732212 19085960 11566570 4309450 6884620 7440962 3786805 16227642 15998439 15968718 6623471 9327722 7179309 17522070 7120509 2869522 21278145 15027814 10092053
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 10.0919107877
MESH:D056486 Drug-Induced Liver Injury Selenium 10.0915131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 10.0920420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 10.0919641884 1733752
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.3811462148
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 11.5416133044 18446180 18450898
MESH:D004374 Ductus Arteriosus, Patent Indomethacin 11.5416326151 18446180 12774134 18043480 16133044 17190690
MESH:D004381 Duodenal Ulcer Indomethacin 3.6617202747 17045617 11595415 17151854 16699067 11535926 11595431 17329845 11991626 10671773 17351913
MESH:D050171 Dyslipidemias Dietary Fats 7.7118367378
MESH:D050171 Dyslipidemias Fenofibrate 7.7116707586
MESH:D004417 Dyspnea Chlorine 8.9620016425
MESH:D004417 Dyspnea Diazinon 8.9616487989
MESH:D004421 Dystonia Phenobarbital 8.881851702
MESH:D004421 Dystonia Valproic Acid 8.881851702
MESH:D004487 Edema Aspirin 21.2217259670
MESH:D004487 Edema Indomethacin 21.227907874 19703484 16100529 8985016 8273558 7990266 10653021
MESH:D004487 Edema perfluorooctanoic acid 21.2217259670 12083418
MESH:D004487 Edema pirinixic acid 21.2212083418
MESH:D004487 Edema Plant Extracts 21.2212787963
MESH:D004487 Edema Tetrachlorodibenzodioxin 21.2211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.3816714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 7.3512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 7.3519031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 10.2016402032
MESH:D004714 Endometrial Hyperplasia Genistein 10.2016402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 19.7215700306 16804899
MESH:D016889 Endometrial Neoplasms Estradiol 19.7219148513 11473722 18566989
MESH:D016889 Endometrial Neoplasms Fenofibrate 19.7216569247
MESH:D016889 Endometrial Neoplasms Genistein 19.7211473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 19.7220544844 17893378 19155303 16202921
MESH:D004715 Endometriosis Ibuprofen 18.2815652904
MESH:D004715 Endometriosis Indomethacin 18.2815652904
MESH:D004715 Endometriosis Mifepristone 18.2816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 18.289294722 10568697
MESH:D004719 Endomyocardial Fibrosis Plant Extracts 5.1615268973
MESH:D019446 Endotoxemia Ibuprofen 9.1711545620
MESH:D019446 Endotoxemia Indomethacin 9.1718509659
MESH:D004751 Enteritis Indomethacin 4.2310567023 16328016 17763956
MESH:D020345 Enterocolitis, Necrotizing Indomethacin 4.4917980183
MESH:D004802 Eosinophilia Indomethacin 3.5611298111
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 9.153659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 9.1517275665 3659116
MESH:D004828 Epilepsies, Partial Phenobarbital 8.263922381 11558140
MESH:D004828 Epilepsies, Partial Valproic Acid 8.2616628512 3922381
MESH:D004827 Epilepsy Phenobarbital 9.4920417680
MESH:D004827 Epilepsy Plant Extracts 9.4919439326 19700373
MESH:D004827 Epilepsy Valproic Acid 9.4918234410 20417680
MESH:D004832 Epilepsy, Absence Phenobarbital 7.446401628
MESH:D004832 Epilepsy, Absence Valproic Acid 7.446254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 9.657750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 9.657750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 8.793659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 8.793659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.6016302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.4416530937
MESH:D004938 Esophageal Neoplasms Indomethacin 6.4411005569
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 6.4416704527 15547733 16805852 15264214 15150132 16510608 15623463 15878914 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.6311564622
MESH:D005234 Fatty Liver Carbon Tetrachloride 35.3712631006 19224547 15959796 61145 12795759 16239168 16045604 17595544
MESH:D005234 Fatty Liver Dietary Fats 35.3718296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 35.3720387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 35.3715345470
MESH:D005234 Fatty Liver pirinixic acid 35.3720131406 19236843
MESH:D005234 Fatty Liver Plant Extracts 35.3715975614
MESH:D005234 Fatty Liver Tamoxifen 35.3719224547 14986274
MESH:D005234 Fatty Liver Valproic Acid 35.3719224547 14986274
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.1316534752 16513791 16002989 16611131 15751030
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.1316709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 2.9611858732
MESH:D005315 Fetal Diseases Valproic Acid 4.3716575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.658888407 18558336
MESH:D005334 Fever Ibuprofen 8.1016997862
MESH:D005334 Fever Indomethacin 8.1010431976 11852909 17627676
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.0214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.6719069698
MESH:D005354 Fibrosarcoma Indomethacin 4.3910962813
MESH:D005355 Fibrosis Carbon Tetrachloride 17.1218705752
MESH:D005355 Fibrosis Dietary Fats 17.1218296743
MESH:D005355 Fibrosis Indomethacin 17.1217994277
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 17.1220067830
MESH:D005499 Folliculitis Indomethacin 4.6511298111
MESH:D005739 Gas Poisoning Chlorine 4.4920016425
MESH:D005756 Gastritis Indomethacin 4.2315046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 11.1216452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 11.1216452187
MESH:D005909 Glioblastoma Aspirin 10.1012870263
MESH:D005909 Glioblastoma Genistein 10.1016598420
MESH:D005909 Glioblastoma Indomethacin 10.1012870263
MESH:D005910 Glioma Indomethacin 3.0116487511 18371953
MESH:D005923 Glomerulosclerosis, Focal Segmental Indomethacin 3.8811849393
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.0810696789
MESH:D006073 Gout Indomethacin 4.8411248219
MESH:D006261 Headache Aspirin 4.4415240983
MESH:D006258 Head and Neck Neoplasms Indomethacin 3.3915482327
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 5.4920471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 5.4910048152 11294989
MESH:D006333 Heart Failure pirinixic acid 9.9820558911
MESH:D006333 Heart Failure Plant Extracts 9.9818097624
MESH:D006333 Heart Failure Selenium 9.9817162251
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 2.8811000095
MESH:D006501 Hepatic Encephalopathy Indomethacin 4.1115633222
MESH:D006505 Hepatitis Carbon Tetrachloride 8.0219110552 19900420
MESH:D006505 Hepatitis Diazinon 8.0216487989
MESH:D019698 Hepatitis C, Chronic Indomethacin 4.2015135802
MESH:D006529 Hepatomegaly perfluorooctanoic acid 16.643609246
MESH:D006529 Hepatomegaly Phenobarbital 16.6416109766
MESH:D006529 Hepatomegaly pirinixic acid 16.6418467677 16221962 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 16.6415340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.5115709030
MESH:D006561 Herpes Simplex Etoposide 8.5810809021
MESH:D006561 Herpes Simplex Plant Extracts 8.5810715843
MESH:D015658 HIV Infections Plant Extracts 3.4012878215
MESH:D006689 Hodgkin Disease Etoposide 6.2415147373 18180244 16200630 17606976 16135485
MESH:D006689 Hodgkin Disease sodium arsenite 6.2412676792
MESH:D019584 Hot Flashes Estradiol 8.6217088409
MESH:D019584 Hot Flashes Plant Extracts 8.6214716179 16566672 17454163
MESH:D006849 Hydrocephalus Valproic Acid 4.3617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.538697196 18606429 15340226 16354765 16959395
MESH:D012001 Hyperacusis Aspirin 5.2415240983
MESH:D006930 Hyperalgesia Indomethacin 6.9212727271
MESH:D006930 Hyperalgesia perfluorooctanoic acid 6.9212083418
MESH:D034321 Hyperamylasemia Indomethacin 5.2017883296
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.0216899240
MESH:D006937 Hypercholesterolemia Dietary Fats 3.1421332399
MESH:D006940 Hyperemia Indomethacin 4.5012524144
MESH:D006943 Hyperglycemia pirinixic acid 2.7420558911
MESH:D020138 Hyperhomocysteinemia Plant Extracts 4.0416484555
MESH:D006949 Hyperlipidemias Dietary Fats 12.8721332399
MESH:D006949 Hyperlipidemias Indomethacin 12.8717546600
MESH:D006949 Hyperlipidemias Plant Extracts 12.8715268973 15975614
MESH:D006965 Hyperplasia Diethylstilbestrol 3.9412960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.7018850075 18670907
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 3.5915338365
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.1316612254
MESH:D006984 Hypertrophy Ibuprofen 4.5216672835
MESH:D007021 Hypospadias Diethylstilbestrol 9.5916002989
MESH:D007021 Hypospadias Ethinyl Estradiol 9.5916569931 16945680
MESH:D007077 Ileal Diseases Indomethacin 4.5118306037 10574470
MESH:D007079 Ileitis Indomethacin 4.8410651667 10647630 16133968
MESH:D007235 Infant, Premature, Diseases Ibuprofen 12.4716133044
MESH:D007235 Infant, Premature, Diseases Indomethacin 12.4716133044
MESH:D007246 Infertility Diethylstilbestrol 3.8715036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 2.9912013081
MESH:D007248 Infertility, Male Diazinon 9.2916466525 12948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 9.2917937319
MESH:D007248 Infertility, Male sodium arsenite 9.2912646999 15346721
MESH:D007249 Inflammation Dietary Fats 27.5420412841
MESH:D007249 Inflammation Diethylnitrosamine 27.5418785209
MESH:D007249 Inflammation Flavonoids 27.5417296493
MESH:D007249 Inflammation Ibuprofen 27.543291741
MESH:D007249 Inflammation Indomethacin 27.547812673 3291741 12568917
MESH:D007249 Inflammation perfluorooctanoic acid 27.5412083418
MESH:D007249 Inflammation Plant Extracts 27.5416366677 12787963 19332304 15997105
MESH:D007249 Inflammation Tamoxifen 27.5419457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 27.5412200463 12878042
MESH:D007251 Influenza, Human Selenium 3.6816624496
MESH:D007333 Insulin Resistance Dietary Fats 10.3018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 10.3016393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 10.3016306350
MESH:D007410 Intestinal Diseases Indomethacin 3.8310210152 17329856 17994277 11713966 15610444 15831440 18236018 11855677 11686837
MESH:D007414 Intestinal Neoplasms caffeic acid phenethyl ester 8.7810783313
MESH:D007414 Intestinal Neoplasms Plant Extracts 8.7812584176 12628509 12351151
MESH:D019586 Intracranial Hypertension Indomethacin 4.8515241188
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 2.8816580747
MESH:D007579 Jejunal Diseases Indomethacin 4.5110574470 16133968 18306037
MESH:D007674 Kidney Diseases caffeic acid phenethyl ester 15.8215369732
MESH:D007674 Kidney Diseases Estradiol 15.8215618244
MESH:D007674 Kidney Diseases Indomethacin 15.8217190690
MESH:D007674 Kidney Diseases ochratoxin A 15.8211409539
MESH:D007674 Kidney Diseases sodium arsenite 15.8220008137
MESH:D007676 Kidney Failure, Chronic Selenium 3.4316518626
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 14.4615003126 16762066 14681315
MESH:D007680 Kidney Neoplasms Estradiol 14.4615610895
MESH:D007680 Kidney Neoplasms ochratoxin A 14.4616251485
MESH:D007680 Kidney Neoplasms Tamoxifen 14.4618625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.5717184923
MESH:D016773 Leishmaniasis, Cutaneous Indomethacin 3.4911703811 12228301 10320625
MESH:D007938 Leukemia Genistein 2.7617468513 18980019
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Indomethacin 3.5410785260 15631656 16572323
MESH:D015470 Leukemia, Myeloid, Acute Indomethacin 3.7118360721
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 3.7116294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute caffeic acid phenethyl ester 3.6516766008
MESH:D007964 Leukocytosis Indomethacin 4.8516537180
MESH:D007969 Leukomalacia, Periventricular Indomethacin 5.2017980183
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 4.728812269
MESH:D008064 Lipidoses Tamoxifen 2.7917567588 15342952
MESH:D008101 Liver Abscess, Amebic Indomethacin 5.2011479899
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 17.5817334410 16943688 16239168 11408273 21278145 17157831 16221502 11903743 17174718
MESH:D008103 Liver Cirrhosis Dietary Fats 17.5818296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 17.5818407596 19638242 18522880 18665156 20032147
MESH:D008103 Liver Cirrhosis Phenobarbital 17.5821047994
MESH:D008103 Liver Cirrhosis Plant Extracts 17.5817157831
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 14.0312649538 15893842 15931870 20821823 18263696 18395095 17922224 18187930 16136751 18317297 15959796 17640975 14716833 15650968 12445418 12741479 17869086 17766677 18054572 18420326 18472094 11481614 16638106 14724832 17481882 17805973 17698563 18166357 15925388 16011737 15818738 13678700 17761835 17900296 14620537 15876570 15673190 18339082 18472332 18156304 14748882 16027843 12898905 18279442 18006644 12586293 16248980 17565644 17557913 10355542 12546737 17631135 16015684 18481824 15730626 17721639 17708605 12667390 12666154 18412020 17823541 16033810 14512876 18429990 15370692 17944888 18210741 12958196 18395914 17525996 18251166 15996030 18376398 18705752 17714472 15338365 18277467 12609069 12389079 16097048 12632514 16116963 14716496 18205269 18418968 15057751 12632512 15362042 12445421 15052691 16192424 17976157 15123356
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 14.0314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Fenofibrate 14.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Genistein 14.0317823541
MESH:D008106 Liver Cirrhosis, Experimental Indomethacin 14.0318194892
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 14.0315474484
MESH:D008106 Liver Cirrhosis, Experimental Plant Extracts 14.0315479170
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 14.0318564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 14.0312878042
MESH:D008107 Liver Diseases Carbon Tetrachloride 10.8416246199 16964402 15830285 15720792 17285989
MESH:D008107 Liver Diseases Chlorpyrifos 10.8415991261
MESH:D008107 Liver Diseases Diethylnitrosamine 10.8417034775
MESH:D008107 Liver Diseases Phenobarbital 10.8419363144
MESH:D008107 Liver Diseases Plant Extracts 10.8417034775
MESH:D017093 Liver Failure Carbon Tetrachloride 3.6715123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.2514706259 16899240
MESH:D008113 Liver Neoplasms Aflatoxin B1 41.742125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 41.7421137059 20195826
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 41.7419294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 41.7419996281 20452335 19090486 18648771 21167192 19426721 21047994 20101389 19255062 19254457 2862719 19812893 19427195 18644402 19551842 18754104 19833225 19294768 16942905 15175105 10737359 18977376 19642983 19690152 9163691 12112319 21071580 19499222 18978307 19073162 20405173 12771043 20583210 21278145 20492335 19638242 19850985 20137499 2422723 20434301 15885732 20501860 20118626 19256749
MESH:D008113 Liver Neoplasms Diethylstilbestrol 41.7416712894 15890375
MESH:D008113 Liver Neoplasms Fenofibrate 41.7418978307
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 41.7414757943 18709148
MESH:D008113 Liver Neoplasms Phenobarbital 41.7419812893 19073162 21047994 8742319 19482888 15975961
MESH:D008113 Liver Neoplasms pirinixic acid 41.7420007298 16377806 15890375
MESH:D008113 Liver Neoplasms Plant Extracts 41.7419168119
MESH:D008113 Liver Neoplasms sodium arsenite 41.7416712894 15276417
MESH:D008113 Liver Neoplasms Tamoxifen 41.7416684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 41.7416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 19.088603461
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 19.0815583823 12014681
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 19.0818775883 17942915 19539802 3124819 16267830 19009564 18544905 17174075 18079962 17854601 16842330 18164116 19519916 9362446 2563599 19126423 18093689 19004024 21159647 18308698 18253720 18282651
MESH:D008114 Liver Neoplasms, Experimental Fenofibrate 19.0818775883 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 19.0818308698 2563599 17172636 6150874 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 19.0812151625
MESH:D008171 Lung Diseases Ozone 6.3519066396 8266340
MESH:D008171 Lung Diseases sodium arsenite 6.3519095001
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 3.7417228818
MESH:D055370 Lung Injury Ozone 3.3620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 13.7614755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 13.7620464547 20135361 18816296 6695378 18569708 18520028 20869020 17053015 20064080
MESH:D008175 Lung Neoplasms Diethylnitrosamine 13.7620970405 20512841 6695378 21163286
MESH:D008175 Lung Neoplasms Indomethacin 13.7616537180 11497255 11053908
MESH:D008175 Lung Neoplasms Ozone 13.767614698 8597069
MESH:D008175 Lung Neoplasms Plant Extracts 13.7620869020
MESH:D008175 Lung Neoplasms sodium arsenite 13.7615276417 17306315 19931552 16712894 17077188
MESH:D008175 Lung Neoplasms Tamoxifen 13.7618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 13.7611884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.6415166399
MESH:D008223 Lymphoma Diethylstilbestrol 6.6915700306
MESH:D008223 Lymphoma Etoposide 6.6912854902 12556972
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.0016002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.2619428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 19.1916891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Genistein 19.1914578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 19.1910697514
MESH:D008325 Mammary Neoplasms, Experimental ochratoxin A 19.1911921183
MESH:D008325 Mammary Neoplasms, Experimental Selenium 19.1915318939
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 19.1914580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 10.9219453300
MESH:D020149 Manganese Poisoning Tamoxifen 10.9219453300
MESH:D008545 Melanoma artesunate 6.5216273263
MESH:D008545 Melanoma Dinitrochlorobenzene 6.5212202904 17334785
MESH:D008545 Melanoma sodium arsenite 6.5219082730 16487513
MESH:D008545 Melanoma Tamoxifen 6.5212393984 19393235
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.6715990972
MESH:D008654 Mesothelioma Selenium 2.5715107826
MESH:D008679 Metaplasia Ozone 4.5910496685
MESH:D008850 Microphthalmos ochratoxin A 5.3120036863
MESH:D008881 Migraine Disorders Aspirin 10.5715240983
MESH:D008881 Migraine Disorders Indomethacin 10.5711903285
MESH:D008881 Migraine Disorders Valproic Acid 10.5718765137 18803445
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 7.3516381670
MESH:D009062 Mouth Neoplasms Indomethacin 7.3512636206
MESH:D009135 Muscular Diseases pirinixic acid 3.0116239165
MESH:D020391 Muscular Dystrophy, Facioscapulohumeral marker/mechanism 12868502
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.578888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 2.8517596541
MESH:D009203 Myocardial Infarction Aspirin 8.1912692751
MESH:D009203 Myocardial Infarction Genistein 8.1917141266
MESH:D009203 Myocardial Infarction pirinixic acid 8.1919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.6112213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 11.8916810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 11.8917141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 11.8916411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 3.9717484760
MESH:D009325 Nausea Aspirin 4.7015240983
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 8.223581430 9029167
MESH:D009362 Neoplasm Metastasis Indomethacin 8.2216537180 11239499 11053908
MESH:D009362 Neoplasm Metastasis Tamoxifen 8.2219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.3319410462
MESH:D009369 Neoplasms Benzo(a)pyrene 9.6111141357
MESH:D009369 Neoplasms Diethylstilbestrol 9.6115313581
MESH:D009369 Neoplasms pirinixic acid 9.6117405874
MESH:D009369 Neoplasms sodium arsenite 9.6111559025
MESH:D009374 Neoplasms, Experimental Indomethacin 7.6415625704 10663608
MESH:D009374 Neoplasms, Experimental sodium arsenite 7.6420056578
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.4819196722 19189210 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.2317289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 4.476375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.0010961664
MESH:D009421 Nervous System Malformations Diethylstilbestrol 19.5011399458
MESH:D009421 Nervous System Malformations Estradiol 19.5011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 19.5016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 19.5014600291
MESH:D009436 Neural Tube Defects ochratoxin A 10.3520036863
MESH:D009436 Neural Tube Defects sodium arsenite 10.3512854658
MESH:D009436 Neural Tube Defects Valproic Acid 10.358888407 16359493
MESH:D019954 Neurobehavioral Manifestations Plant Extracts 4.6917168769
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.2020387270
MESH:D019636 Neurodegenerative Diseases Indomethacin 7.2012349958
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.6020387270
MESH:D020258 Neurotoxicity Syndromes Chlorpyrifos 3.8215081274
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.469802331
MESH:D009765 Obesity Dietary Fats 6.5811836018 21332399 20132043 20518802 19632207 16723640 18674790 18457598 17217161
MESH:D009765 Obesity pirinixic acid 6.5820558911
MESH:D009765 Obesity Plant Extracts 6.5820132043 19056576
MESH:D007752 Obstetric Labor, Premature Indomethacin 4.656374098
MESH:D010003 Osteoarthritis Aspirin 10.937009135
MESH:D010003 Osteoarthritis Ibuprofen 10.937009135
MESH:D010003 Osteoarthritis Indomethacin 10.937009135
MESH:D010018 Osteomalacia Phenobarbital 3.8617016548
MESH:D010024 Osteoporosis Genistein 2.9319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.6216169203
MESH:D010051 Ovarian Neoplasms Estradiol 9.7819401270
MESH:D010051 Ovarian Neoplasms Genistein 9.7819005980
MESH:D010051 Ovarian Neoplasms Mifepristone 9.7816525653
MESH:D010051 Ovarian Neoplasms sodium arsenite 9.7815276417 17306315
MESH:D010146 Pain Aspirin 9.236363464 6995502
MESH:D010146 Pain Ibuprofen 9.233291741
MESH:D010146 Pain Indomethacin 9.2317440234 3291741 17627676 13679232
MESH:D010149 Pain, Postoperative Ibuprofen 9.7616678543
MESH:D010149 Pain, Postoperative Indomethacin 9.7618702446 12538197
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 10.6816540662
MESH:D010190 Pancreatic Neoplasms Etoposide 10.6819003803
MESH:D010190 Pancreatic Neoplasms Ibuprofen 10.6812384795
MESH:D010190 Pancreatic Neoplasms Phenobarbital 10.6816965848
MESH:D010195 Pancreatitis Indomethacin 3.4615028970 17883296
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.2211578682
MESH:D010212 Papilloma cumene hydroperoxide 8.5012065085 17234724
MESH:D010212 Papilloma Plant Extracts 8.5015173996 16517061
MESH:D010257 Paraneoplastic Syndromes Indomethacin 5.2016537180
MESH:D020734 Parkinsonian Disorders Indomethacin 3.6812349958
MESH:D051302 Paroxysmal Hemicrania Indomethacin 5.2011903285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.7312520081
MESH:D010437 Peptic Ulcer Indomethacin 4.6411148446
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.0311156591
MESH:D010518 Periodontitis Indomethacin 4.4017225004
MESH:D010538 Peritonitis Ozone 3.6416369182
MESH:D020795 Photophobia Aspirin 5.2415240983
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.6514722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.1715687265 16977796
MESH:D010954 Plasmacytoma Selenium 4.3715087411
MESH:D011014 Pneumonia Ozone 3.8918007984 18381685 18929643
MESH:D011041 Poisoning Diazinon 3.8917603234
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.0818163543
MESH:D011230 Precancerous Conditions Diethylnitrosamine 7.672563599
MESH:D011230 Precancerous Conditions Phenobarbital 7.672563599
MESH:D047928 Premature Birth Indomethacin 4.6317000239
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 19.1117184923
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 19.1117132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 19.1111399792 11222880 11118676 11896295
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 19.1120603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.4320887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.7217292933
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.7217136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.7216740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.7217172428
MESH:D011471 Prostatic Neoplasms Genistein 2.7216925846 15256057 15378649
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.7217409433
MESH:D011471 Prostatic Neoplasms Plant Extracts 2.7217804756 14666653
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.7216039940
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.7215067354
MESH:D011507 Proteinuria Ibuprofen 8.166375363
MESH:D011507 Proteinuria Indomethacin 8.1611849393
MESH:D011537 Pruritus Ethinyl Estradiol 2.8116919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 10.4712752131
MESH:D019310 Pseudolymphoma Valproic Acid 10.4711422049 12752131
MESH:D015427 Reperfusion Injury pirinixic acid 2.1219058328
MESH:D012120 Respiration Disorders Chlorine 4.6918579056
MESH:D012135 Respiratory Sounds Chlorpyrifos 4.1411874814 16611668 17119214
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.3518990726
MESH:D012140 Respiratory Tract Diseases Chlorpyrifos 4.3816611668 17119214
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.7119155313
MESH:D012220 Rhinitis Aspirin 3.9412372130
MESH:D012512 Sarcoma, Ewing's Etoposide 4.2214601052
MESH:D012559 Schizophrenia Valproic Acid 1.9915737665 19110320
MESH:D012640 Seizures Phenobarbital 4.8411442880 4039156 3137016 16876388
MESH:D012640 Seizures Valproic Acid 4.841511512 16876388 3137016 15475178 14763951 11738929 11044598 17978042
MESH:D003294 Seizures, Febrile Phenobarbital 4.316407741
MESH:D012729 Sex Chromosome Aberrations Chlorpyrifos 5.576418539
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 4.7712269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 15.1710029692 19755658
MESH:D012878 Skin Neoplasms cumene hydroperoxide 15.178532709 12065085 17234724
MESH:D012878 Skin Neoplasms Plant Extracts 15.1715173996 16517061
MESH:D012878 Skin Neoplasms sodium arsenite 15.1719524636 18572023
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 15.1716192470
MESH:D013088 Spermatocele Diethylstilbestrol 17.1316002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 17.1316709447
MESH:D013088 Spermatocele Tamoxifen 17.1316709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.5319457130
MESH:D016135 Spinal Dysraphism sodium arsenite 8.2312854658
MESH:D016135 Spinal Dysraphism Valproic Acid 8.2319490988
MESH:D013226 Status Epilepticus Valproic Acid 4.0212833885
MESH:D013272 Stomach Diseases Indomethacin 3.9117638125 10215738 16280098 15472012 10192188 15038085 16184426 10486359 18209964 17160473 18545984 16113693 17207306
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.2220155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 4.2218456281
MESH:D013274 Stomach Neoplasms Indomethacin 4.2215609394
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 4.2212958204 17575124
MESH:D013276 Stomach Ulcer Indomethacin 6.2416631530 17657623 1323529 11523592 17627676 11595431 17977527 16169175 16150113 18087811 18431645 18299717 15138204 17654042 10423059 16252198 10878458 11145282 12077510 18193104 16397915 18209962 15104355 14567935 17918041 15255614 17895592 11595415 11906479 12498302 12467913 18181030 17135157 18726076 16755016 16934674 10750652 11729361 18543354 18237397 12500499 12787963
MESH:D013276 Stomach Ulcer Plant Extracts 6.2418237397 17135157 18193104 12787963 15255614
MESH:D020521 Stroke Aspirin 3.9716403987
MESH:D013705 Temporomandibular Joint Disorders Plant Extracts 4.9617997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.1511994571
MESH:D013927 Thrombosis Aspirin 7.7717672075
MESH:D013927 Thrombosis Ethinyl Estradiol 7.7715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.3812697716
MESH:D013964 Thyroid Neoplasms Butyrates 13.9817967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 13.987505956
MESH:D013964 Thyroid Neoplasms Indomethacin 13.9818791128 14736730 11352223
MESH:D013964 Thyroid Neoplasms Phenobarbital 13.981399818
MESH:D013978 Tibial Fractures Estradiol 4.1719048282
MESH:D014178 Translocation, Genetic Valproic Acid 4.7117262798
MESH:D014456 Ulcer Indomethacin 4.3910574470 17380554
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.013119515
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 10.0817053015
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 10.0816452187 17306315 16712894
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 10.0817306315 11723127 16712894 16452187
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 10.0816712894 8653321 17572228
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.158888407
MESH:D014570 Urologic Diseases Diazinon 4.7616487989
MESH:D014581 Urticaria Aspirin 3.9810982225 20485159
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 8.0716175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 8.0711813266
MESH:D014591 Uterine Diseases Diethylstilbestrol 4.6514652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 7.8815809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 7.8814692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 3.9416513791 16002989
MESH:D014652 Vascular Diseases sodium arsenite 3.9217056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.0812125929
MESH:D020301 Vasospasm, Intracranial Ibuprofen 4.6819057314
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.0814671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Plant Extracts 4.2518097624
MESH:D020257 Ventricular Remodeling Plant Extracts 4.8118097624
MESH:D014839 Vomiting Indomethacin 4.2311897121
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.7315886252
MESH:D015430 Weight Gain Dietary Fats 3.3116723640
MESH:D014947 Wounds and Injuries Plant Extracts 3.8420213670 19894650
Pathway ID Pathway Name
KEGG:00982 Drug metabolism - cytochrome P450
KEGG:00480 Glutathione metabolism
KEGG:00980 Metabolism of xenobiotics by cytochrome P450
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29030
    • No data
    Releated disease ID Related disease Name
    PA444818Lung Neoplasms
    PA443622Carcinoma, Non-Small-Cell Lung
    Releated drug ID Related drug Name
    PA449014cisplatin
    PA449383docetaxel
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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