AutismKB 2.0

Annotation Detail for MSH6


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Basic Information Top
Gene Symbol:MSH6 ( GTBP,HNPCC5,HSAP )
Gene Full Name: mutS homolog 6 (E. coli)
Band: 2p16.3
Quick LinksEntrez ID:2956; OMIM: 600678; Uniprot ID:MSH6_HUMAN; ENSEMBL ID: ENSG00000116062; HGNC ID: 7329
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03430Mismatch repair
hsa05210Colorectal cancer
hsa05200Pathways in cancer
No data
No data
No data
No data
Related Diseases/Disorders Top
Desease IDDesease Name
Cancers
Cancers of the digestive system
H00020Colorectal cancer
Desease IDDesease Name
1712Yersinia infection
1781Rheumatoid arthritis
1807Autoimmune disease
1934Cancer
Desease Name
colorectal cancer
CANCER
endometrial cancer
No data
Desease Name
Endometrial cancer, familial
Mismatch repair cancer syndrome
Colorectal cancer, hereditary nonpolyposis, type 5
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D006710 Homocysteine Homocysteine results in decreased expression of MSH6 mRNAdecreases expression 17326132
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MSH6 mRNAdecreases expression 20382639
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of MSH6 mRNAdecreases expression 15336504
D004317 Doxorubicin Doxorubicin results in decreased expression of MSH6 mRNAdecreases expression 16404146
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of MSH6 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSH6 mRNAaffects cotreatment|increases expression 17942748
D005038 Ethylnitrosourea MSH6 gene mutant form results in decreased susceptibility to Ethylnitrosoureadecreases response to substance 18522974
D005038 Ethylnitrosourea Ethylnitrosourea results in increased mutagenesis of MSH6 geneincreases mutagenesis 18417481
16495775
C106014 gedunin gedunin results in decreased expression of MSH6 mRNAdecreases expression 17010675
C015329 lycopene lycopene results in increased expression of MSH6 mRNAincreases expression 16886892
D008345 Manganese Manganese results in decreased expression of MSH6 mRNAdecreases expression 17175027
C025340 manganese chloride manganese chloride results in decreased expression of MSH6 mRNAdecreases expression 17175027
D008770 Methylnitrosourea MSH6 gene mutant form results in decreased susceptibility to Methylnitrosoureadecreases response to substance 18522974
D008770 Methylnitrosourea Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]affects binding|increases reaction 16204460
D010634 Phenobarbital Phenobarbital results in increased expression of MSH6 mRNAincreases expression 19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of MSH6 mRNAdecreases expression 18445702
C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of MSH6 mRNAdecreases expression 16678137
C017947 sodium arsenite sodium arsenite results in decreased expression of MSH6 mRNAdecreases expression 16014739
C017947 sodium arsenite sodium arsenite results in increased expression of MSH6 proteinincreases expression 19072884
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSH6 mRNAaffects cotreatment|increases expression 17942748
C496197 trans-10,cis-12-conjugated linoleic acid trans-10,cis-12-conjugated linoleic acid results in decreased expression of MSH6 mRNAdecreases expression 17951470
C050414 tripterine tripterine results in decreased expression of MSH6 mRNAdecreases expression 17010675
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.186195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.1814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.0818653653
MESH:D000230 Adenocarcinoma Doxorubicin 7.1617418594
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1614692618
MESH:D000230 Adenocarcinoma Methylnitrosourea 7.1615688392 15113128
MESH:D000236 Adenoma Ethylnitrosourea 3.696695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.0917620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 17.0916434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.0916835633
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.6715276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 4.8716712894 17306315
MESH:D000419 Albuminuria Doxorubicin 4.5021441931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000756 Anemia, Sideroblastic Manganese 10.8916910769
MESH:D000756 Anemia, Sideroblastic manganese chloride 10.8916910769
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D001321 Autistic Disorder Homocysteine 3.0420468076 16297937
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6319483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.6312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.6714601052
MESH:D001927 Brain Diseases Ethylnitrosourea 4.8414991843
MESH:D001932 Brain Neoplasms Doxorubicin 8.9617150277
MESH:D001932 Brain Neoplasms Ethylnitrosourea 8.9616357521 16651633 18412241 16436596 15144691
MESH:D001943 Breast Neoplasms Doxorubicin 2.0115668708 19526202 15993339 17426702 18234424 15567936 18382427 15136595 15994142 18695136 16935488 16264153 16096432 15939500 16595493 15692762 17369602 11325840 18628466 16115903 15634643 16826403 17983394 16322301
MESH:D001943 Breast Neoplasms Methylnitrosourea 2.0116253758 14633655 11306469
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.0120435547
OMIM:604370 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 marker/mechanism
MESH:D002276 Carcinoid Tumor Doxorubicin 4.7816051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 4.6317876044 18059187 16023760 16234567
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.6317173139 1701930 6705139 20007298 20935162
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.6317306315 15276417 16507464
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 3.141485588 16201981
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.776189445
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.7718572023
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 16120746 18850075
MESH:D009202 Cardiomyopathies Doxorubicin 3.5015792986 17351982 17924179 18627295 15811867 17329180 16612575 15505089 16455267 16364871 17007740 17519947 16242529 16278810 17382496 16109756 16269455 15476868 16731534 17974986 16952015 17131338 17308081 16651473 17928571
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9317334414 16243910
MESH:D002386 Cataract Methylnitrosourea 3.9612484553
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.8720889678
MESH:D002471 Cell Transformation, Neoplastic Ethylnitrosourea 15.8716003739
MESH:D002471 Cell Transformation, Neoplastic Methylnitrosourea 15.872727394 7505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 15.8720056578 19524636
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.214080065
MESH:D016543 Central Nervous System Neoplasms Ethylnitrosourea 5.9617160924
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6316919318 17110522 17681005 15861022 16105132 17333356 11677210
MESH:D002779 Cholestasis pirinixic acid 7.6319176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0815668235 15340226 12621046 8697196 16354765
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D003123 Colorectal Neoplasms, Hereditary Nonpolyposis marker/mechanism 18417481
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0214669216 17141729
MESH:D003324 Coronary Artery Disease Homocysteine 3.7416379339
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4018249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 3.8317416283
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.8320420201
MESH:D004362 Drug Toxicity Doxorubicin 8.0018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 8.0011462148
MESH:D004421 Dystonia Phenobarbital 3.961851702
MESH:D004476 Ectodermal Dysplasia Ethylnitrosourea 5.9618357618
MESH:D004487 Edema pirinixic acid 6.4012083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.4012711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8718230668 15322242 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D016889 Endometrial Neoplasms marker/mechanism
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.4217359293
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.1318037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.073659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.843922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8720417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.506401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.217750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.983659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.0620426865
MESH:D017889 Exfoliation Syndrome Homocysteine 5.6716504073
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.4115345470
MESH:D005234 Fatty Liver pirinixic acid 7.4120131406 19236843
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.5519069698
MESH:D005354 Fibrosarcoma Methylnitrosourea 5.2011555667
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 2.9120067830
MESH:D005833 Genital Neoplasms, Female sodium arsenite 4.6416452187
MESH:D005901 Glaucoma Homocysteine 5.2516504073
MESH:D005909 Glioblastoma Doxorubicin 11.9617150277
MESH:D005909 Glioblastoma Ethylnitrosourea 11.9616436596
MESH:D005909 Glioblastoma Manganese 11.9617043766
MESH:D005910 Glioma Ethylnitrosourea 6.5516357521 16651633 18412241
MESH:D005910 Glioma Methylnitrosourea 6.559825942
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.5015692506
MESH:D006330 Heart Defects, Congenital Homocysteine 6.8719638421
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.8711294989 10048152
MESH:D006331 Heart Diseases Doxorubicin 3.4516144979 16244372 16330681 18006777 17888722 16495754 12587719 16879835 16244371 17875725 18674790 14766674 16707910
MESH:D006333 Heart Failure Doxorubicin 6.9617481944
MESH:D006333 Heart Failure pirinixic acid 6.9620558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.8615692506
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006529 Hepatomegaly Phenobarbital 14.1616109766
MESH:D006529 Hepatomegaly pirinixic acid 14.1619772884 19176532 18467677 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.1616120746 15340226 12621046
MESH:D006689 Hodgkin Disease Doxorubicin 7.3517606976 15147373 18501091
MESH:D006689 Hodgkin Disease sodium arsenite 7.3512676792
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0216354765 15340226 18606429 8697196 16959395
MESH:D006943 Hyperglycemia pirinixic acid 3.1420558911
MESH:D020138 Hyperhomocysteinemia Homocysteine 4.6717292331 18234410 17369066
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.8918850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 11.1417937319
MESH:D007248 Infertility, Male Methylnitrosourea 11.147193160
MESH:D007248 Infertility, Male sodium arsenite 11.1415346721 12646999
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.8312878042 12200463
MESH:D007333 Insulin Resistance pirinixic acid 2.6016306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007674 Kidney Diseases Doxorubicin 6.1915369732 16775033 15699352
MESH:D007674 Kidney Diseases sodium arsenite 6.1920008137
MESH:D007676 Kidney Failure, Chronic Doxorubicin 4.1116707910
MESH:D007680 Kidney Neoplasms Ethylnitrosourea 3.8917379185
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.1316085563
MESH:D017880 Limb Deformities, Congenital Methylnitrosourea 4.1715526292
MESH:D008103 Liver Cirrhosis Phenobarbital 2.8721047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.4116595196 16439617
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.4115474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4112878042
MESH:D008107 Liver Diseases Phenobarbital 2.1619363144
MESH:D008113 Liver Neoplasms Phenobarbital 10.5519073162 19482888 15975961 8742319 19812893 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 10.5520007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 10.5516712894 15276417
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 10.5516984957
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 9.7016842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.7017172636 2563599 1399818 18308698 6150874
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7012151625
MESH:D038061 Lower Extremity Deformities, Congenital Methylnitrosourea 5.4216080182
MESH:D008171 Lung Diseases sodium arsenite 3.1419095001
MESH:D008175 Lung Neoplasms Doxorubicin 6.5717418594 6189445
MESH:D008175 Lung Neoplasms Ethylnitrosourea 6.5717703301 16271038 6695378 16019985
MESH:D008175 Lung Neoplasms Methylnitrosourea 6.5718062963
MESH:D008175 Lung Neoplasms sodium arsenite 6.5719931552 16712894 17077188 17306315 15276417
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5719555203 11884234
MESH:D008223 Lymphoma Doxorubicin 12.6016098063
MESH:D008223 Lymphoma Ethylnitrosourea 12.6015790496
MESH:D008223 Lymphoma Methylnitrosourea 12.6011418001 16257854
MESH:D016393 Lymphoma, B-Cell Methylnitrosourea 4.7314633661
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.7517654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 11.5615621674
MESH:D016399 Lymphoma, T-Cell Ethylnitrosourea 11.5615375218
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 10.0915458769
MESH:D008325 Mammary Neoplasms, Experimental Ethylnitrosourea 10.0910767621 18041768 10838139
MESH:D008325 Mammary Neoplasms, Experimental Methylnitrosourea 10.0916944150 16827153 17131329 15113128 12931682 15313902 10838139 16051031 14999141 19196723 15688392 14633655 17020996 11751437 10767621 16619500 11807958
MESH:D020149 Manganese Poisoning Manganese 5.4919453300 16551646 16568477
MESH:D008545 Melanoma Doxorubicin 3.4416827129
MESH:D008545 Melanoma sodium arsenite 3.4419082730 16487513
MESH:D008579 Meningioma Ethylnitrosourea 5.9617943659
MESH:D008591 Meningomyelocele Homocysteine 5.5016602021
MESH:D008654 Mesothelioma Doxorubicin 3.0417638057
OMIM:276300 MISMATCH REPAIR CANCER SYNDROME marker/mechanism
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.4615792986
MESH:D009069 Movement Disorders Manganese 4.9716551646
MESH:D052016 Mucositis Doxorubicin 4.7517415656
MESH:D009135 Muscular Diseases pirinixic acid 3.4716239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.5019429709 15857846
MESH:D009203 Myocardial Infarction Homocysteine 9.5017412321
MESH:D009203 Myocardial Infarction pirinixic acid 9.5019151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.9812213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.9116411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4417484760
MESH:D009362 Neoplasm Metastasis Doxorubicin 2.9318259882
MESH:D009369 Neoplasms lycopene 11.7917051425
MESH:D009369 Neoplasms Methylnitrosourea 11.7915533788
MESH:D009369 Neoplasms pirinixic acid 11.7917405874
MESH:D009369 Neoplasms sodium arsenite 11.7911559025
MESH:D009374 Neoplasms, Experimental Ethylnitrosourea 15.2416707424
MESH:D009374 Neoplasms, Experimental Methylnitrosourea 15.2412696579
MESH:D009374 Neoplasms, Experimental sodium arsenite 15.2420056578
MESH:D009401 Nephrosis Doxorubicin 4.7316636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 3.9615640375 16889571
MESH:D009410 Nerve Degeneration Manganese 4.2416551646
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects sodium arsenite 3.1112854658
MESH:D009442 Neurilemmoma Ethylnitrosourea 13.1616003739 17160924 16651423
MESH:D009442 Neurilemmoma Methylnitrosourea 13.1611555667
MESH:D009447 Neuroblastoma Doxorubicin 3.2415555623
MESH:D009765 Obesity pirinixic acid 1.8020558911
MESH:D009837 Oligodendroglioma Ethylnitrosourea 5.9617160924
MESH:D010018 Osteomalacia Phenobarbital 4.3317016548
MESH:D012516 Osteosarcoma Doxorubicin 4.0815930896
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.4217306315 15276417
MESH:D010190 Pancreatic Neoplasms Methylnitrosourea 5.5516965848
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.5516965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010300 Parkinson Disease Homocysteine 5.9516275827
MESH:D010300 Parkinson Disease Manganese 5.9511181820
MESH:D020734 Parkinsonian Disorders Manganese 4.4316140633
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D003557 Phyllodes Tumor Doxorubicin 5.1317983394
MESH:D010997 Pleural Neoplasms Doxorubicin 5.1317638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.582563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611222880 11896295 11399792 11118676
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.2116888761 16729912 16868541 15897917 15749863 18437689
MESH:D011471 Prostatic Neoplasms lycopene 2.2117337101 15084515
MESH:D011471 Prostatic Neoplasms Methylnitrosourea 2.2115682402 12376480
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.2116039940
MESH:D011537 Pruritus Ethinyl Estradiol 3.2816919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 4.4712752131
MESH:D051437 Renal Insufficiency Doxorubicin 4.1817922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.3619058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012162 Retinal Degeneration Methylnitrosourea 4.3818172121 18155124
MESH:D012175 Retinoblastoma Methylnitrosourea 5.4511555667
MESH:D012509 Sarcoma Doxorubicin 3.9517710206 15625365 15675481 16767912 18313854 17203757
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.2014601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.7517846226
MESH:D012559 Schizophrenia Homocysteine 3.1016641680
MESH:D012640 Seizures Phenobarbital 2.664039156 16876388 11442880 3137016
MESH:D003294 Seizures, Febrile Phenobarbital 4.796407741
MESH:D012878 Skin Neoplasms Doxorubicin 13.4115692506
MESH:D012878 Skin Neoplasms sodium arsenite 13.4119524636 18572023
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 13.418532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.4116192470
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.5316767912 17203757 15625365
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.7612854658
MESH:D013274 Stomach Neoplasms Methylnitrosourea 2.6916257854 15930296 18593901
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013953 Thymus Neoplasms Ethylnitrosourea 12.1815790496
MESH:D013953 Thymus Neoplasms Methylnitrosourea 12.1811418001
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D013964 Thyroid Neoplasms Doxorubicin 11.9517909728 16010429
MESH:D013964 Thyroid Neoplasms Methylnitrosourea 11.957505956 3078959
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.951399818
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 5.2117653716
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.2116452187 16712894 17306315 11723127
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 3.7311813266
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014652 Vascular Diseases sodium arsenite 4.3917056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5015869587 14671159
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.1817638931 17334414 16364871 17678736
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
Pathway ID Pathway Name
KEGG:05210 Colorectal cancer
KEGG:03430 Mismatch repair
KEGG:05200 Pathways in cancer
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA184
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA451100prednisone
    PA452621antineoplastic agents
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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