AutismKB 2.0

Annotation Detail for GTF2A2


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Basic Information Top
Gene Symbol:GTF2A2 ( HsT18745,TF2A2,TFIIA )
Gene Full Name: general transcription factor IIA, 2, 12kDa
Band: 15q22.2
Quick LinksEntrez ID:2958; OMIM: 600519; Uniprot ID:T2AG_HUMAN; ENSEMBL ID: ENSG00000140307; HGNC ID: 4647
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03022Basal transcription factors
Pathway IDPathway Name
Transcription
Gene Expression
HIV Infection
No data
Pathway IDPathway Name
P00023General transcription regulation
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GTF2A2 mRNAdecreases expression 18648102
C105260 4-tert-octylphenol 4-tert-octylphenol results in increased expression of GTF2A2 mRNAincreases expression 17011747
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GTF2A2 mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of GTF2A2 mRNAincreases expression 17011747
D000431 Ethanol Ethanol results in increased expression of GTF2A2 mRNAincreases expression 17920746
D017239 Paclitaxel Paclitaxel analog results in increased expression of GTF2A2 mRNAincreases expression 15585946
D017239 Paclitaxel Paclitaxel results in increased expression of GTF2A2 mRNAincreases expression 15585946
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GTF2A2 mRNAaffects binding|decreases expression|increases activity 19710929
C017947 sodium arsenite sodium arsenite results in increased expression of GTF2A2 mRNAincreases expression 20308225
C052342 topiramate topiramate results in increased expression of GTF2A2 mRNAincreases expression 16979414
D014212 Tretinoin Tretinoin results in decreased expression of GTF2A2 proteindecreases expression 16646664
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.1517676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 11.2818287403
MESH:D000138 Acidosis Ethanol 11.2811192467
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.843712494
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 4.9615276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.1716712894 17306315
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.5815451040 15451039
MESH:D000437 Alcoholism topiramate 5.1617925516 18552399 19331489
MESH:D000505 Alopecia Tretinoin 3.7515955085
MESH:D000686 Amyloidosis Diethylstilbestrol 4.6815469931
MESH:D000853 Anophthalmos Ethanol 5.0415513904
MESH:D001008 Anxiety Disorders Ethanol 4.1411141031
MESH:D001169 Arthritis, Experimental Tretinoin 3.1816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3016292516
MESH:D001249 Asthma Tretinoin 2.3916456186
MESH:D001471 Barrett Esophagus Tretinoin 4.6016935849
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.5519483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.5516197459 16206674
MESH:D001859 Bone Neoplasms Paclitaxel 4.7515867366
MESH:D001943 Breast Neoplasms Diethylstilbestrol 2.0515324884 17129689
MESH:D001943 Breast Neoplasms Paclitaxel 2.0518323546 11325840 16273361 16115903 15136595 18223236 16244791 18234424
MESH:D001943 Breast Neoplasms Tretinoin 2.0516443354 16873071 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.8316813970
MESH:D002056 Burns Ethanol 4.8716374292
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.4216168501
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 11.737296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 11.7316924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Ethanol 11.7315763234 15289165 18788625
MESH:D006528 Carcinoma, Hepatocellular Paclitaxel 11.7316313753
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 11.7316507464 15276417 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.731917145
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 4.8318572023
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.8316096774 16051514
MESH:D006332 Cardiomegaly Ethanol 3.5219332462
MESH:D002386 Cataract Tretinoin 3.1917460283
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.127505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.1220056578 19524636
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.8316129372
MESH:D002659 Child Development Disorders, Pervasive topiramate 4.1515650499
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.2719486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.2719176532
MESH:D002822 Choriocarcinoma Tretinoin 5.4216461808
MESH:D002971 Cleft Lip Ethanol 3.6615513904
MESH:D002972 Cleft Palate Ethanol 6.3715513904
MESH:D002972 Cleft Palate Tretinoin 6.379407595
MESH:D003092 Colitis Tretinoin 3.9217035595
MESH:D015179 Colorectal Neoplasms Paclitaxel 2.4418802399
MESH:D019465 Craniofacial Abnormalities Ethanol 2.8815451040 11873399 15513904 15451039 10194807 19302082 11198716
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.8816925845 9142499 17551590 9664655 10589399 9224671 8800419 9211117 14991402 9125849
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.7512952375 16002989
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0112868966 11298694 8156756 8970840 11906362 14531868 18759878 2524372
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.673621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 topiramate 3.7316979414
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.239328219 18692083 7440962 18289764 9653073 6482804 18648102 9022650 16192314 6679447 8291058 11289319 1440618
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.2311566570
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004489 Edema, Cardiac Tretinoin 4.7318230668
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 4.9316402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 7.9515700306 16804899
MESH:D016889 Endometrial Neoplasms Tretinoin 7.9516569247
MESH:D004827 Epilepsy topiramate 4.4019148780
MESH:D004833 Epilepsy, Temporal Lobe topiramate 6.5416499746
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.623581430
MESH:D004938 Esophageal Neoplasms Ethanol 7.6216704527
MESH:D004938 Esophageal Neoplasms Paclitaxel 7.6216481741
MESH:D005124 Eye Abnormalities Tretinoin 3.7016938888 9664655
MESH:D005234 Fatty Liver Ethanol 8.4619236843 16409862 18620774
MESH:D005234 Fatty Liver pirinixic acid 8.4619236843 20131406
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.9317920746
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.7515751030 16513791 16534752 16611131 16002989
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.5415513904 16946407 15451040 10194807
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tretinoin 3.7317994277
MESH:D005756 Gastritis Ethanol 4.9615046732
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 13.6216452187
MESH:D005833 Genital Neoplasms, Female sodium arsenite 13.6216452187
MESH:D005909 Glioblastoma Tretinoin 3.1117312396
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.2916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.4216084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.989664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 3.2118467677 16221962 19772884 19176532
MESH:D006689 Hodgkin Disease sodium arsenite 3.3012676792
MESH:D006930 Hyperalgesia Ethanol 8.4618783367
MESH:D006930 Hyperalgesia Tretinoin 8.4616870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.7816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 11.5715034207
MESH:D006965 Hyperplasia Diethylstilbestrol 11.5712960047 14722030
MESH:D007021 Hypospadias Diethylstilbestrol 4.7916002989
MESH:D007246 Infertility Diethylstilbestrol 4.5515036965
MESH:D007248 Infertility, Male sodium arsenite 3.1015346721 12646999
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007410 Intestinal Diseases Tretinoin 3.9817994277
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.289022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 10.9115513904
MESH:D007569 Jaw Abnormalities Tretinoin 10.9117551590 15992940
MESH:D007674 Kidney Diseases sodium arsenite 2.8920008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.026582329
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.0215003126 16762066 14681315
MESH:D007859 Learning Disorders Diethylstilbestrol 10.5217184923
MESH:D007859 Learning Disorders Ethanol 10.5215451040
MESH:D007938 Leukemia Tretinoin 2.8417143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.8716482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1017596541 16294345 19850784
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.2617368321 17361223 16140955 16823087 19225113 19075265 17217047 9834237 12679006 16788101 19029980 17712046 16331271 19035177 17506722 17294898 15748426 17107899 16766008 17339181 16935935 17649720 17301526 16891316 19642359
MESH:D017880 Limb Deformities, Congenital Ethanol 8.7217676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.729224671
MESH:D008080 Liposarcoma Paclitaxel 5.0117353645
MESH:D008103 Liver Cirrhosis Ethanol 3.4615289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.3318295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 3.6318166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.6315474484
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 3.6316248980 18397230
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.8717347304 17207112
MESH:D008113 Liver Neoplasms Diethylstilbestrol 7.8216712894 15890375
MESH:D008113 Liver Neoplasms pirinixic acid 7.8220007298 16377806 15890375
MESH:D008113 Liver Neoplasms sodium arsenite 7.8216712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.633712494 6587162 1399818 598648
MESH:D008171 Lung Diseases sodium arsenite 3.2819095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.8917306315 17077188 19931552 15276417 16712894
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.3915166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.5915700306
MESH:D008228 Lymphoma, Non-Hodgkin Paclitaxel 4.2314749477
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.7816002989
MESH:D008527 Medulloblastoma Tretinoin 2.8417453147
MESH:D008545 Melanoma Paclitaxel 5.3512040289 16342250 12025231
MESH:D008545 Melanoma sodium arsenite 5.3519082730 16487513
MESH:D008545 Melanoma Tretinoin 5.3516752155
MESH:D008569 Memory Disorders Ethanol 4.3915451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.6416940565
MESH:D008881 Migraine Disorders topiramate 4.7018803445 16942474 18765137 18759728
MESH:D009101 Multiple Myeloma Paclitaxel 3.8114749477
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.1717596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 6.163581430
MESH:D009362 Neoplasm Metastasis Paclitaxel 6.1615867366
MESH:D009369 Neoplasms Diethylstilbestrol 12.5315313581
MESH:D009369 Neoplasms pirinixic acid 12.5317405874
MESH:D009369 Neoplasms sodium arsenite 12.5311559025
MESH:D009369 Neoplasms Tretinoin 12.5316946489 16594593
MESH:D009374 Neoplasms, Experimental sodium arsenite 3.8820056578
MESH:D009421 Nervous System Malformations Diethylstilbestrol 10.5211399458
MESH:D009421 Nervous System Malformations Tretinoin 10.529125849
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 12.766679447
MESH:D009436 Neural Tube Defects sodium arsenite 12.7612854658
MESH:D009436 Neural Tube Defects Tretinoin 12.769142499
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D010014 Osteolysis Paclitaxel 5.2215867366
MESH:D010051 Ovarian Neoplasms Paclitaxel 8.2611161223
MESH:D010051 Ovarian Neoplasms sodium arsenite 8.2615276417 17306315
MESH:D010051 Ovarian Neoplasms Tretinoin 8.2616936753
MESH:D010146 Pain Tretinoin 3.0416870215
MESH:D010190 Pancreatic Neoplasms Ethanol 5.6312384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.6315976015
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.4314722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.8915687265 16977796
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 4.3517184923
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.6815046698 17136230 15846301
MESH:D011471 Prostatic Neoplasms Paclitaxel 2.6816356831 17172428 16729912 17136230
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.6816039940
MESH:D011507 Proteinuria Tretinoin 3.7916636307
MESH:D011625 Pterygium Tretinoin 5.0316723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.2816283617 16116481
MESH:D012640 Seizures Ethanol 7.079754883
MESH:D012640 Seizures topiramate 7.0716499746
MESH:D012878 Skin Neoplasms sodium arsenite 6.0418572023 19524636
MESH:D012878 Skin Neoplasms Tretinoin 6.0416467112
MESH:D013088 Spermatocele Diethylstilbestrol 4.9816002989 16709447
MESH:D016135 Spinal Dysraphism sodium arsenite 3.9312854658
MESH:D013274 Stomach Neoplasms Ethanol 3.6018456281
MESH:D013274 Stomach Neoplasms Paclitaxel 3.6018506536 18396642
MESH:D013274 Stomach Neoplasms Tretinoin 3.6017261132
MESH:D013276 Stomach Ulcer Ethanol 3.7017918041 9211565 16755016 17189318 11906479 9562338
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.429754883
MESH:D024801 Tauopathies Paclitaxel 5.0516930453
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.571399818 6582329 3712494 6587162 7505956
MESH:D013964 Thyroid Neoplasms Tretinoin 7.5717045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.9516051514
MESH:D014376 Tuberculosis Tretinoin 3.3316040207
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 8.738074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 8.7317306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.7316712894 11723127 17306315 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 16.8516175088
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 16.8511813266
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 16.8516129372
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.4314652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 4.2715809267 16690809
MESH:D014604 Uveal Neoplasms Tretinoin 4.8816752155
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.6516002989 16513791
MESH:D014652 Vascular Diseases sodium arsenite 4.6617056641
MESH:D014820 Vitiligo Tretinoin 4.2516761959
MESH:D009396 Wilms Tumor Tretinoin 4.1216287080
Pathway ID Pathway Name
KEGG:03022 Basal transcription factors
REACT:71 Gene Expression
REACT:6185 HIV Infection
REACT:1788 Transcription
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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