AutismKB 2.0

Annotation Detail for BRF1


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Basic Information Top
Gene Symbol:BRF1 ( BRF,FLJ42674,FLJ43034,GTF3B,MGC105048,TAF3B2,TAF3C,TAFIII90,TF3B90,TFIIIB90,hBRF )
Gene Full Name: BRF1 homolog, subunit of RNA polymerase III transcription initiation factor IIIB (S. cerevisiae)
Band: 14q32.33
Quick LinksEntrez ID:2972; OMIM: 604902; Uniprot ID:TF3B_HUMAN; ENSEMBL ID: ENSG00000185024; HGNC ID: 11551
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
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Pathway IDPathway Name
Transcription
No data
Pathway IDPathway Name
P00023General transcription regulation
P00055Transcription regulation by bZIP transcription factor
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of BRF1 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of BRF1 mRNAaffects expression 17562736
D002330 Carmustine Carmustine results in decreased expression of BRF1 mRNAdecreases expression 15980968
D004610 Ellagic Acid Ellagic Acid results in decreased expression of BRF1 mRNAdecreases expression 12002526
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of BRF1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRF1 mRNAaffects cotreatment|increases expression 17942748
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of BRF1 mRNAaffects binding|increases activity|increases expression 19710929
C059514 resveratrol resveratrol results in decreased expression of BRF1 mRNAdecreases expression 12569576
12002526
D012402 Rotenone Rotenone results in decreased expression of BRF1 mRNAdecreases expression 19013527
D018038 Sodium Selenite Sodium Selenite results in decreased expression of BRF1 mRNAdecreases expression 18175754
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of BRF1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.0814514962 15322242 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D058186 Acute Kidney Injury resveratrol 4.0216538975
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 7.153712494
MESH:D000236 Adenoma resveratrol 7.1515688382
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7116434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.7116835633
MESH:D000544 Alzheimer Disease resveratrol 2.6016183991 16162502
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1111748828
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.7015885639
MESH:D001169 Arthritis, Experimental resveratrol 7.7017115116
MESH:D050197 Atherosclerosis resveratrol 3.3716873680 17967414
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.2811289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 9.3519483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.3512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.0615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8715746008
MESH:D002545 Brain Ischemia resveratrol 4.5217600658
MESH:D001932 Brain Neoplasms Carmustine 4.5516187019
MESH:D001943 Breast Neoplasms resveratrol 2.1217534123 17651959 16393696
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.1220435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9316835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.717296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.713084413
MESH:D006528 Carcinoma, Hepatocellular resveratrol 4.7116227395 19321006
MESH:D018827 Carcinoma, Lewis Lung resveratrol 4.8316675471
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.757296757
MESH:D002294 Carcinoma, Squamous Cell resveratrol 2.7516227395
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases resveratrol 3.5915458977
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.877505956
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.1219486331 9022650
MESH:D002779 Cholestasis Ethinyl Estradiol 14.1217681005 17333356 16105132 15861022 11677210 17110522 16919318
MESH:D002779 Cholestasis pirinixic acid 14.1219176532
MESH:D019457 Chromosome Breakage Sodium Selenite 4.9715894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1615668235 12621046 8697196 15340226 16354765
MESH:D003092 Colitis resveratrol 4.3416474422
MESH:D003110 Colonic Neoplasms resveratrol 2.4816338953
MESH:D015179 Colorectal Neoplasms resveratrol 2.2216550006
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2114669216 17141729
MESH:D003327 Coronary Disease resveratrol 3.8516507316
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2610048152 15322242 20055451
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0112868966 14531868 8156756 18759878 11906362 2524372 11298694 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.672952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9316285004
MESH:D003921 Diabetes Mellitus, Experimental resveratrol 3.9116873680
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7017107852
MESH:D003928 Diabetic Nephropathies resveratrol 4.1116286809
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.339022650 18692083 7440962 9328219 11289319 6679447 8291058 18648102 1440618 9653073 6482804 18289764 16192314
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 9.3312392966 14725611 11421492 16227642 17562736 16781746 16485898 16109766 17522070 11461765 16393943 18071297 19370779 19416960 15619225 16081117 15968718 14986274 10774834 12958197 14550746 19085960 17906064 12705907 12594235 16177239 12540782 11834606 10915739 10663392 11287661 11743745 2444490 18713872 19420014 12153990 19739265 11529661 11739529 19164858 19923254
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 9.3315131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 9.3320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8911462148
MESH:D004487 Edema pirinixic acid 12.4512083418
MESH:D004487 Edema resveratrol 12.458985016
MESH:D004487 Edema Tetrachlorodibenzodioxin 12.4511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.1716714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.7912538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental resveratrol 9.7917872969
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.1810568697 9294722
MESH:D020345 Enterocolitis, Necrotizing resveratrol 5.0617923197
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.143581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1411564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.1215345470
MESH:D005234 Fatty Liver pirinixic acid 8.1219236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.6711858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.286705139
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.1620067830
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005909 Glioblastoma Carmustine 4.0316187019
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.227505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.8610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4111294989 10048152
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5111000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.716705139
MESH:D006529 Hepatomegaly pirinixic acid 8.9916221962 19772884 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9915340226 12621046 16120746
MESH:D006561 Herpes Simplex resveratrol 4.4216876885
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3116959395 16354765 8697196 18606429 15340226
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006937 Hypercholesterolemia resveratrol 4.1817188708
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006949 Hyperlipidemias resveratrol 4.2116873680
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.1515034207
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9618850075 18670907
MESH:D017379 Hypertrophy, Left Ventricular resveratrol 4.4617488730
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery resveratrol 4.8617600658
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5917937319
MESH:D007249 Inflammation resveratrol 5.3416366677
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 5.3412200463 12878042
MESH:D007251 Influenza, Human resveratrol 4.8116624496
MESH:D007333 Insulin Resistance pirinixic acid 7.6716306350
MESH:D007333 Insulin Resistance Sodium Selenite 7.6714714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.288074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5116580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2915629191 12587719
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.116582329
MESH:D015473 Leukemia, Promyelocytic, Acute resveratrol 3.6816087638
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.309327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.1815474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.1812878042
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19784758 19014921 12587719 12969438 16610002 19460945 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4017185352 16871587
MESH:D008113 Liver Neoplasms pirinixic acid 7.7416377806 20007298 15890375
MESH:D008113 Liver Neoplasms resveratrol 7.7419073162 19321006 19812893 20405173
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.7416984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.07598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.0712151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D016393 Lymphoma, B-Cell resveratrol 10.9017088997
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 10.9014737004
MESH:D008228 Lymphoma, Non-Hodgkin resveratrol 4.0114749477
MESH:D015674 Mammary Neoplasms, Animal resveratrol 4.4815688416
MESH:D008325 Mammary Neoplasms, Experimental resveratrol 3.218985016 11606380
MESH:D008545 Melanoma Carmustine 3.8912393984
MESH:D008545 Melanoma resveratrol 3.8917992120
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008659 Metabolic Diseases resveratrol 4.5517112576
MESH:D009101 Multiple Myeloma resveratrol 3.5817164350 16490592 14749477 16267019 17049120 17935668
MESH:D009134 Muscular Atrophy, Spinal resveratrol 5.1117962980
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 5.9519151258
MESH:D009203 Myocardial Infarction resveratrol 5.9516525036 16317513 17125593 16456233 17188708 17015251
MESH:D017202 Myocardial Ischemia resveratrol 9.4717015251 17125593
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.4712213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009205 Myocarditis resveratrol 5.0017322642
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.533581430
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009374 Neoplasms, Experimental resveratrol 4.218985016
MESH:D009410 Nerve Degeneration Rotenone 4.0117356569 15790535 18619942
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4114600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.026679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8418514411
MESH:D019636 Neurodegenerative Diseases resveratrol 8.8417652729
MESH:D020078 Neurogenic Inflammation resveratrol 4.5817929310
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.584026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.283988306
MESH:D015663 Osteoporosis, Postmenopausal resveratrol 4.4417513867
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.707296757
MESH:D010300 Parkinson Disease Rotenone 3.0319114014 19232380 18191903 11535288 15451049 11445065 16412576 16140633 18619942
MESH:D020734 Parkinsonian Disorders Rotenone 4.2415795934 18197244 15574749 15927086
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.736228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.7618163543
MESH:D011297 Prenatal Exposure Delayed Effects resveratrol 10.4016679765
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.4011896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms resveratrol 3.4316731767 17675339 17718901 17636462 15767336 17804756
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4318760546
MESH:D011537 Pruritus Ethinyl Estradiol 3.5516919318 15861022
MESH:D051436 Renal Insufficiency, Chronic resveratrol 5.8516325855
MESH:D015427 Reperfusion Injury pirinixic acid 6.8319058328
MESH:D015427 Reperfusion Injury resveratrol 6.8317058453 16314181 16317513 17520802 15827377
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.503692021
MESH:D012878 Skin Neoplasms resveratrol 5.968985016 15837718
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.9616192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
OMIM:601367 STROKE, ISCHEMIC resveratrol 4.6416321402
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.1712697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.011399818 6587162 7505956 6582329 3712494
MESH:D014062 Tongue Neoplasms resveratrol 4.3716227395
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.338074119
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms resveratrol 4.2617473185
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.1714692618
MESH:D014594 Uterine Neoplasms resveratrol 10.1717044934
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.8612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7114671159 15869587
MESH:D018487 Ventricular Dysfunction, Left resveratrol 4.5217488730
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5115886252
Pathway ID Pathway Name
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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