AutismKB 2.0

Annotation Detail for GTF3C1


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Basic Information Top
Gene Symbol:GTF3C1 ( DKFZp686A111,TFIIIC,TFIIIC220,TFIIICalpha )
Gene Full Name: general transcription factor IIIC, polypeptide 1, alpha 220kDa
Band: 16p12.1
Quick LinksEntrez ID:2975; OMIM: 603246; Uniprot ID:TF3C1_HUMAN; ENSEMBL ID: ENSG00000077235; HGNC ID: 4664
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GTF3C1 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of GTF3C1 mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GTF3C1 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GTF3C1 mRNAdecreases expression 20127859
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTF3C1 mRNAdecreases expression 19150397
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GTF3C1 mRNAaffects expression 12734012
D002251 Carbon Tetrachloride Carbon Tetrachloride results in decreased expression of GTF3C1 mRNAdecreases expression 16239168
D003520 Cyclophosphamide [Doxorubicin co-treated with Cyclophosphamide] affects the expression of GTF3C1 mRNAaffects cotreatment|affects expression 16322899
D004317 Doxorubicin [Doxorubicin co-treated with Cyclophosphamide] affects the expression of GTF3C1 mRNAaffects cotreatment|affects expression 16322899
C008493 methylselenic acid methylselenic acid results in decreased expression of GTF3C1 mRNAdecreases expression 18548127
D005996 Nitroglycerin Nitroglycerin results in increased expression of GTF3C1 mRNAincreases expression 12102619
C006253 pirinixic acid pirinixic acid results in increased expression of GTF3C1 mRNAincreases expression 18301758
D012643 Selenium Selenium results in increased expression of GTF3C1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2318653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5420127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 4.5417418594
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.803712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.806695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.6316434500
MESH:D000419 Albuminuria Doxorubicin 4.6721441931
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.7415014928
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.191440618 11289319
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2619483382
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.8714601052
MESH:D001932 Brain Neoplasms Doxorubicin 3.9117150277
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0220146248 17474063
MESH:D001943 Breast Neoplasms Cyclophosphamide 2.0212006526 17388661 15093573 11325840 18323546 15136595 16978400 18234424 17020986
MESH:D001943 Breast Neoplasms Doxorubicin 2.0211325840 15692762 15994142 16096432 15567936 18628466 17426702 18695136 16322301 15136595 18382427 15939500 16115903 19526202 15993339 16264153 16595493 17369602 18234424 17983394 15668708 15634643 16826403 16935488
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9215721981 15673190 15700767 16227642 16050911 18705752 16097048 16011737 16124888 10355542 3786805 16192424
MESH:D002276 Carcinoid Tumor Doxorubicin 4.9816051944
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0616705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 9.067296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 9.0618788625
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 9.0619701751
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 9.0618059187 16023760 17876044 16234567
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.0416152834
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 11.137296757
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 11.1316201981
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 11.1316201981 1485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.7920419170
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 4.796189445
MESH:D009202 Cardiomyopathies Doxorubicin 3.6016731534 16242529 17329180 17007740 17351982 16455267 18627295 17924179 15476868 16952015 17519947 16612575 16651473 17974986 17131338 15792986 17308081 17928571 16269455 16364871 17382496 15811867 15505089 16278810 16109756
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.9816243910 17334414
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 11.616135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.617505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 11.6120889678
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 8.1119486331 9022650
MESH:D002779 Cholestasis pirinixic acid 8.1119176532
MESH:D003092 Colitis Selenium 3.9217936198
MESH:D015179 Colorectal Neoplasms Doxorubicin 2.1418802399 18259882
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.1618551238
MESH:D003556 Cystitis Cyclophosphamide 5.1617010015 18093676 10700343 10498854 17979934 18433785 18295254 12913760 12161096 15643279 18483878 16413132 16989017 16614059 18710439 12388444 11948286 18372110 16651033 15276878
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.9411298694 12868966 2524372 18759878 11906362 8156756 14531868 8970840
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4718249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.613621924 2952479
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.1611751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2518772604
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.3621346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 12.361440618 16192314 8291058 7440962 9653073 18692083 6679447 18289764 9328219 9022650 11289319 18648102 6482804
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.363732212 4309450 7179309 7440962 3786805 16177239 15027814 21278145 10092053 17522070 10915739 16227642 7120509 19085960 11566570 2869522 6884620 15968718 6623471 9327722 15998439 19336974
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 12.3617416283
MESH:D056486 Drug-Induced Liver Injury Selenium 12.3615131321
MESH:D004362 Drug Toxicity Doxorubicin 3.7518602426
MESH:D004487 Edema pirinixic acid 2.5912083418
MESH:D016889 Endometrial Neoplasms Doxorubicin 3.5217359293
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 5.3318037988
MESH:D004802 Eosinophilia Cyclophosphamide 4.3511006010
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 7.343581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.3420426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 7.3416530937
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.0412631006 16239168 15959796 19224547 17595544 61145 16045604 12795759
MESH:D005234 Fatty Liver pirinixic acid 8.0420131406 19236843
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.196705139
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 4.7419069698
MESH:D005355 Fibrosis Carbon Tetrachloride 3.5918705752
MESH:D005909 Glioblastoma Doxorubicin 3.4217150277
MESH:D018316 Gliosarcoma Cyclophosphamide 5.6711389073
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.157505956
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.1716376943 11014644 15172196
MESH:D006261 Headache Nitroglycerin 5.3611554966 11284996
MESH:D006258 Head and Neck Neoplasms Doxorubicin 3.6015692506
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006331 Heart Diseases Doxorubicin 3.5616495754 16330681 16879835 17888722 14766674 16244371 16244372 16707910 18006777 12587719 17875725 18674790 16144979
MESH:D006333 Heart Failure Doxorubicin 12.1917481944
MESH:D006333 Heart Failure pirinixic acid 12.1920558911
MESH:D006333 Heart Failure Selenium 12.1917162251
MESH:D006394 Hemangiosarcoma Doxorubicin 4.0115692506
MESH:D006467 Hemophilia A Cyclophosphamide 5.4311918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.7114986274
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 9.656705139
MESH:D006505 Hepatitis Carbon Tetrachloride 9.6519900420 19110552
MESH:D006529 Hepatomegaly pirinixic acid 3.1319176532 16221962 19772884 18467677
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.0317606976 16135485
MESH:D006689 Hodgkin Disease Doxorubicin 8.0317606976 15147373 18501091
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.6916899240
MESH:D006943 Hyperglycemia pirinixic acid 3.2920558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.0815034207
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.2315338365
MESH:D007154 Immune System Diseases Cyclophosphamide 5.5116076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.6916517039 7193160
MESH:D007251 Influenza, Human Selenium 4.3716624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7016306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.198074119 9022650
MESH:D007674 Kidney Diseases Doxorubicin 3.1115699352 15369732 16775033
MESH:D007676 Kidney Failure, Chronic Doxorubicin 10.3516707910
MESH:D007676 Kidney Failure, Chronic Selenium 10.3516518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.6716705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.676582329
MESH:D007938 Leukemia Cyclophosphamide 3.5410602166
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 5.3316085563
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5418172266 17802794 17296974 17008537 17658394 18587576
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.1710373061
MESH:D007970 Leukopenia Cyclophosphamide 5.1210052129 11830472
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8616239168 16943688 17334410 11408273 17174718 16221502 21278145 11903743 17157831
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2615034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 3.5713678700 14716496 18395914 17698563 12632512 15925388 18418968 12389079 12667390 17922224 16192424 18277467 12445421 17714472 18187930 14620537 17525996 15931870 17640975 18472332 18156304 16638106 15876570 18376398 17766677 17823541 17631135 17557913 17721639 14748882 17900296 15730626 10355542 18412020 12741479 16136751 20821823 16015684 11481614 17708605 15052691 12632514 15893842 17805973 18263696 12445418 15650968 18006644 12958196 18251166 14724832 18210741 15996030 17481882 15959796 15370692 16033810 12898905 16027843 17869086 18205269 18420326 15057751 15338365 18705752 17976157 16116963 18395095 18279442 16011737 17944888 18054572 15123356 16248980 18317297 17761835 16097048 14512876 17565644 12546737 18429990 12609069 18339082 15818738 14716833 12649538 15362042 12666154 18166357 18472094 18481824 15673190 12586293
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 3.5716439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5715474484
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1015720792 16964402 17285989 16246199 15830285
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3015123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 3.7916899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.007678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.0020195826 21137059
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 11.0019294768
MESH:D008113 Liver Neoplasms pirinixic acid 11.0015890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 14.702876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.70598648 6587162 1399818 3712494
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 14.7012014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 14.7016842330 17085340
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5420464547 18520028 18569708 20135361 18816296 6695378 17053015 20869020 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 2.5417418594 6189445
MESH:D008223 Lymphoma Cyclophosphamide 8.1412854902
MESH:D008223 Lymphoma Doxorubicin 8.1416098063
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7116675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 9.3011911406
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 9.3017654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.7015621674
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 6.4215458769
MESH:D008325 Mammary Neoplasms, Experimental Selenium 6.4215318939
MESH:D008545 Melanoma Doxorubicin 2.3016827129
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.9416388313
MESH:D008654 Mesothelioma Doxorubicin 6.4217638057
MESH:D008654 Mesothelioma Selenium 6.4215107826
MESH:D008708 Methemoglobinemia Nitroglycerin 4.853537620
MESH:D020326 Migraine without Aura Nitroglycerin 5.2514659530
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.6115792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D052016 Mucositis Doxorubicin 4.9417415656
MESH:D009135 Muscular Diseases pirinixic acid 3.6416239165
MESH:D009203 Myocardial Infarction Doxorubicin 9.8619429709 15857846
MESH:D009203 Myocardial Infarction Nitroglycerin 9.8614729435
MESH:D009203 Myocardial Infarction pirinixic acid 9.8619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0316411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.0118551238 7678174
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.983581430
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.9818259882
MESH:D009369 Neoplasms Benzo(a)pyrene 8.5911141357
MESH:D009369 Neoplasms Cyclophosphamide 8.5918854779
MESH:D009369 Neoplasms pirinixic acid 8.5917405874
MESH:D009401 Nephrosis Doxorubicin 4.9116636307 16899518
MESH:D009404 Nephrotic Syndrome Doxorubicin 4.1015640375 16889571
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.986679447
MESH:D009447 Neuroblastoma Cyclophosphamide 7.398761367 15176712 16115947
MESH:D009447 Neuroblastoma Doxorubicin 7.3915555623
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.0412837982 8761367
MESH:D009503 Neutropenia Cyclophosphamide 4.448291058
MESH:D009765 Obesity pirinixic acid 1.8420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 9.236482804 4026338
MESH:D009845 Oligospermia Cyclophosphamide 4.8616517039
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.193988306
MESH:D012516 Osteosarcoma Doxorubicin 4.2015930896
MESH:D010146 Pain Cyclophosphamide 3.7118093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 3.2211332152
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.627296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.646228378
MESH:D003557 Phyllodes Tumor Doxorubicin 5.3317983394
MESH:D010954 Plasmacytoma Selenium 5.0615087411
MESH:D010997 Pleural Neoplasms Doxorubicin 5.3317638057
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8621297632
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.1317292933
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1317136230
MESH:D011471 Prostatic Neoplasms Doxorubicin 2.1315897917 16888761 18437689 16868541 16729912 15749863
MESH:D011471 Prostatic Neoplasms methylselenic acid 2.1316205645
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3216636934
MESH:D051437 Renal Insufficiency Doxorubicin 4.3617922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.4319058328
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.463692021
MESH:D012509 Sarcoma Doxorubicin 4.0915675481 15625365 17203757 17710206 18313854 16767912
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.3716326096 14601052
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.9417846226
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.9416636934
MESH:D012640 Seizures 2,6-dinitrotoluene 2.6118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.9719755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 5.9715692506
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.7017203757 16767912 15625365
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.6716517039
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2112837982
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.547505956 6582329 6587162 1399818 3712494
MESH:D013964 Thyroid Neoplasms Doxorubicin 7.5416010429 17909728
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 16.2516049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 16.258074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 16.2517053015
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 16.2514692829
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 16.2517653716
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.4710091137
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.3617638931 17678736 16364871 17334414
Pathway ID Pathway Name
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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