AutismKB 2.0

Annotation Detail for BLNK


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:BLNK ( AGM4,BASH,BLNK-S,LY57,MGC111051,SLP-65,SLP65 )
Gene Full Name: B-cell linker
Band: 10q24.1
Quick LinksEntrez ID:29760; OMIM: 604515; Uniprot ID:BLNK_HUMAN; ENSEMBL ID: ENSG00000095585; HGNC ID: 14211
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05340Primary immunodeficiency
hsa04662B cell receptor signaling pathway
Pathway IDPathway Name
Signaling in Immune system
Pathway IDPathway Name
200005BCR signaling pathway
Pathway IDPathway Name
P00010B cell activation
No data
Related Diseases/Disorders Top
Desease IDDesease Name
H00085Agammaglobulinemias
Immune system diseases
Primary immunodeficiency
No data
No data
No data
Desease Name
Agammaglobulinemia 4
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of BLNK mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of BLNK proteinaffects expression 20106945
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BLNK mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene affects the expression of BLNK mRNAaffects expression 20106945
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of BLNK mRNAincreases expression 14729362
D016572 Cyclosporine Cyclosporine results in decreased expression of BLNK mRNAdecreases expression 20106945
D004040 Dietary Carbohydrates Dietary Carbohydrates results in increased expression of BLNK mRNAincreases expression 17490981
D004041 Dietary Fats Dietary Fats results in increased expression of BLNK mRNAincreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BLNK mRNAaffects cotreatment|increases expression 18164116
D004958 Estradiol [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BLNK mRNAaffects cotreatment|increases expression 19619570
D004958 Estradiol Estradiol results in decreased expression of BLNK mRNAdecreases expression 20106945
D004958 Estradiol Estradiol results in increased expression of BLNK mRNAincreases expression 19619570
D006861 Hydrogen Peroxide Hydrogen Peroxide results in increased expression of BLNK mRNAincreases expression 14729362
C041786 palm oil palm oil results in increased expression of BLNK mRNAincreases expression 18042831
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of BLNK mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of BLNK mRNAincreases expression 19482888
19270015
C006253 pirinixic acid pirinixic acid results in decreased expression of BLNK mRNAdecreases expression 17426115
D013749 Tetrachlorodibenzodioxin [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of BLNK mRNAaffects cotreatment|increases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of BLNK mRNAdecreases expression 20106945
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BLNK mRNAincreases expression 19619570
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of BLNK mRNAincreases expression 17035482
D014212 Tretinoin Tretinoin results in increased expression of BLNK mRNAincreases expression 16249480
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.366195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.3615322242 14514962 11752688
MESH:D055371 Acute Lung Injury pirinixic acid 3.1218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.2820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 4.2811473722
MESH:D000236 Adenoma Benzo(a)pyrene 11.226695378
MESH:D000236 Adenoma beta-Naphthoflavone 11.2219389873
MESH:D000236 Adenoma Diethylnitrosamine 11.226695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 25.0619061943 17620307 16434500 18056438 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 25.0617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 25.0616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 25.0616835633
MESH:D000361 Agammaglobulinemia marker/mechanism
MESH:D000505 Alopecia Tretinoin 3.6215955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9511748828
MESH:D000799 Angioedema Acetaminophen 3.8710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0919183758
MESH:D001161 Arteriosclerosis Dietary Fats 3.9015238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2616292516
MESH:D001249 Asthma Tretinoin 2.3416456186
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001471 Barrett Esophagus Tretinoin 4.4116935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 15.3019483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 15.3012125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 15.3016206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8215340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7615746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.9520146248 17474063
MESH:D001943 Breast Neoplasms Dietary Fats 2.9520435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.9517474063
MESH:D001943 Breast Neoplasms Estradiol 2.9516675129 12948864 19861407 17289903 18497071 14630087 17018787 17261762
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.9520435547
MESH:D001943 Breast Neoplasms Tretinoin 2.9516166294 16443354 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.6116813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4816111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8016835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.1916168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.413084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.4121507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 11.4116540662 17138121 20727157 19394651 16569478 18393292 19107877 19701751 18494052 20514400 16698587 17761372 20101231 19519916 16830150 10672840 16878318 20084675 19383236 16807293 17162532 19171122 16935385 19335982 16328049 20935162 20214788 17428255 18788625 17978847 19919837 18210153 19208518 3084413 16502159 17055752 18978308 17173139 16779866 18506893 11831363 18785209 21159647 19539802 19418558 19052882 19822196 3581430 20512989 16288022 18665156 10737359 20524982 18056438 18691550 16681979 20007298 20432363 18971187
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.4116924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 11.416705139 20007298 20935162 1701930 17173139
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 11.411917145
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.5720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.5716096774 16051514
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3718850075 16120746 18670907
MESH:D002318 Cardiovascular Diseases Hydrogen Peroxide 3.5116936243
MESH:D002386 Cataract Acetaminophen 7.2310977129
MESH:D002386 Cataract Tretinoin 7.2317460283
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.1712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.177505956 2727394 17174075 21159647
MESH:D002471 Cell Transformation, Neoplastic Estradiol 11.1718566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.264080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.6116129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.3319052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.3316835633
MESH:D002779 Cholestasis Cyclosporine 7.7619486331
MESH:D002779 Cholestasis pirinixic acid 7.7619176532
MESH:D002822 Choriocarcinoma Tretinoin 5.1916461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.778697196 16354765 15668235 12621046 15340226
MESH:D002972 Cleft Palate Tretinoin 5.779407595
MESH:D003092 Colitis Tretinoin 3.7217035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0614669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4515322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.459142499 10589399 9224671 17551590 16925845 14991402 9211117 8800419 9664655 9125849
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4318249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2220387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2217107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.4119279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.1312153990 14986274 10915739 16227642 14550746 11834606 11529661 19416960 10663392 11461765 12540782 18071297 11287661 19739265 12705907 16781746 17906064 14725611 19085960 11421492 11739529 17522070 12392966 12958197 12594235 15968718 2444490 16109766 16177239 11743745 18713872 16081117 19370779 16485898 17562736 19164858 10774834 16393943 19923254 15619225 19420014
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.1319107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.1320420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1319426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7611462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4518367378
MESH:D004421 Dystonia Phenobarbital 4.011851702
MESH:D004487 Edema pirinixic acid 6.5512083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.5511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 12.0515322242 16714409 18230668
MESH:D004489 Edema, Cardiac Tretinoin 12.0518230668
MESH:D016889 Endometrial Neoplasms Estradiol 7.4211473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Tretinoin 7.4216569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.0210568697 9294722
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.123659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.903922381 11558140
MESH:D004827 Epilepsy Phenobarbital 2.8920417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.546401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.043659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1516302075
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0116530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.8411564622
MESH:D005124 Eye Abnormalities Tretinoin 8.849664655 16938888
MESH:D005234 Fatty Liver Cyclosporine 18.8119224547
MESH:D005234 Fatty Liver Dietary Fats 18.8119551842 17967931 18296743 19004024
MESH:D005234 Fatty Liver Diethylnitrosamine 18.8120387270 21071580
MESH:D005234 Fatty Liver pirinixic acid 18.8119236843 20131406
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4711858732
MESH:D005355 Fibrosis Cyclosporine 21.2712168785 12639820
MESH:D005355 Fibrosis Dietary Fats 21.2718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 21.2720067830
MESH:D005355 Fibrosis Tretinoin 21.2717994277
MESH:D005756 Gastritis Acetaminophen 3.7116983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.248708960
MESH:D005909 Glioblastoma Tretinoin 3.0117312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6210696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.1916084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 11.1020471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.1011294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.109664655 14991402
MESH:D006333 Heart Failure pirinixic acid 2.5420558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4415720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3411000095
MESH:D006529 Hepatomegaly Phenobarbital 14.4716109766
MESH:D006529 Hepatomegaly pirinixic acid 14.4718467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 14.4715340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.0615709030
MESH:D019584 Hot Flashes Estradiol 3.7817088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0816354765 15340226 8697196 18606429 16959395
MESH:D006930 Hyperalgesia Acetaminophen 7.6316870215
MESH:D006930 Hyperalgesia Tretinoin 7.6316870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6021332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.5816778211
MESH:D006943 Hyperglycemia pirinixic acid 3.1920558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.6221332399
MESH:D006973 Hypertension Cyclosporine 4.9510903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9518670907 18850075
MESH:D007249 Inflammation Dietary Fats 8.2920412841
MESH:D007249 Inflammation Diethylnitrosamine 8.2918785209
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 12.3018457598 11836018
MESH:D007333 Insulin Resistance Estradiol 12.3016627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 12.3016306350
MESH:D007410 Intestinal Diseases Tretinoin 3.7817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.9516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.9517551590 15992940
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4715604871
MESH:D007674 Kidney Diseases Acetaminophen 9.9815629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.988314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 9.9815618244
MESH:D007676 Kidney Failure, Chronic Hydrogen Peroxide 4.2816518626
MESH:D007680 Kidney Neoplasms Cyclosporine 7.2812371664
MESH:D007680 Kidney Neoplasms Estradiol 7.2815610895
MESH:D007938 Leukemia Tretinoin 2.7717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.7016932348 16482212 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.0817596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.1517361223 12679006 16891316 17649720 19075265 16788101 17712046 16823087 9834237 17506722 17294898 16140955 19642359 17107899 19029980 19225113 15748426 17339181 17368321 16331271 16766008 17301526 16935935 17217047 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.319224671
MESH:D008103 Liver Cirrhosis Dietary Fats 11.0418296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.0418665156 18522880 20032147 19638242 18407596
MESH:D008103 Liver Cirrhosis Phenobarbital 11.0421047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 4.9214659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 4.9215474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 4.9212878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 4.9216248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 6.4912587719 11587558 19784758 16610002 12969438 16611625 19460945 19014921
MESH:D008107 Liver Diseases Diethylnitrosamine 6.4917034775
MESH:D008107 Liver Diseases Phenobarbital 6.4919363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2416871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 21.949163691 18177683 2125692 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 21.9421137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 21.9421295105 19389873
MESH:D008113 Liver Neoplasms Diethylnitrosamine 21.9419427195 21167192 19073162 18648771 21071580 20583210 19642983 20101389 2422723 15885732 18978307 18977376 20118626 19996281 19551842 19294768 20434301 19255062 20501860 15175105 19850985 19254457 16942905 18644402 19090486 9163691 2862719 19690152 12771043 19812893 20492335 19256749 20137499 19638242 19833225 18754104 12112319 21047994 10737359 21278145 19499222 20452335 20405173 19426721
MESH:D008113 Liver Neoplasms Phenobarbital 21.948742319 19812893 21047994 15975961 19482888 19073162
MESH:D008113 Liver Neoplasms pirinixic acid 21.9415890375 20007298 16377806
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 21.9416984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 18.688603461
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 18.6818164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 18.6819539802 18093689 16267830 18079962 18282651 17942915 21159647 3124819 16842330 18544905 18308698 19009564 18253720 18775883 18164116 2563599 17854601 17174075 9362446 19126423 19004024 19519916
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 18.686150874 1399818 18308698 2563599 17172636
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 18.6812151625
MESH:D008175 Lung Neoplasms Aflatoxin B1 4.8314755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 4.8318816296 18520028 18569708 6695378 20064080 20464547 20869020 20135361 17053015
MESH:D008175 Lung Neoplasms Diethylnitrosamine 4.8320512841 6695378 21163286 20970405
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 4.8319555203 11884234
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 2.5611807958 11408345 16891317 17203775
MESH:D020149 Manganese Poisoning Estradiol 4.5119453300
MESH:D008527 Medulloblastoma Tretinoin 2.7817453147
MESH:D008545 Melanoma Tretinoin 1.9416752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5819513568
MESH:D008591 Meningomyelocele Tretinoin 4.4416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8216801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1916381670
MESH:D009135 Muscular Diseases pirinixic acid 3.5216239165
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.0817596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1419151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0212213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.2616810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.2616411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5017484760
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.573581430 9029167
MESH:D009369 Neoplasms Benzo(a)pyrene 8.2011141357
MESH:D009369 Neoplasms pirinixic acid 8.2017405874
MESH:D009369 Neoplasms Tretinoin 8.2016594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4717954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2918481113 19348381
MESH:D009421 Nervous System Malformations Estradiol 16.3916427766 11399458
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 16.3914600291
MESH:D009421 Nervous System Malformations Tretinoin 16.399125849
MESH:D009436 Neural Tube Defects Tretinoin 3.059142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1920387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1520387270
MESH:D009765 Obesity Dietary Fats 4.4416723640 17217161 18457598 21332399 11836018 18674790 20518802 19632207 20132043
MESH:D009765 Obesity pirinixic acid 4.4420558911
MESH:D010018 Osteomalacia Phenobarbital 4.3817016548
MESH:D010051 Ovarian Neoplasms Estradiol 4.8119401270
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8116936753
MESH:D010146 Pain Acetaminophen 6.5916870215
MESH:D010146 Pain Tretinoin 6.5916870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.6216540662
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.6216965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.6215976015
MESH:D010212 Papilloma Hydrogen Peroxide 4.1012065085
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2812520081
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5718163543
MESH:D011230 Precancerous Conditions Cyclosporine 15.2912371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.292563599
MESH:D011230 Precancerous Conditions Phenobarbital 15.292563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2111222880 11896295 11399792 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1117292933
MESH:D011471 Prostatic Neoplasms Estradiol 3.1116740699
MESH:D011507 Proteinuria Tretinoin 3.6116636307
MESH:D019310 Pseudolymphoma Phenobarbital 4.5312752131
MESH:D011565 Psoriasis Cyclosporine 2.2316882103
MESH:D011625 Pterygium Tretinoin 4.8116723453
MESH:D015427 Reperfusion Injury pirinixic acid 2.3919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8518990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.1116116481 16283617
MESH:D012640 Seizures Phenobarbital 2.6911442880 16876388 3137016 4039156
MESH:D003294 Seizures, Febrile Phenobarbital 4.846407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 17.9419755658 10029692
MESH:D012878 Skin Neoplasms Hydrogen Peroxide 17.9412065085
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 17.948532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 17.9416192470
MESH:D012878 Skin Neoplasms Tretinoin 17.9416467112
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.3320155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 3.3318456281
MESH:D013274 Stomach Neoplasms Tretinoin 3.3317261132
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9312697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 11.997505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 11.991399818
MESH:D013964 Thyroid Neoplasms Tretinoin 11.9917045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.7219048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.7916051514
MESH:D014376 Tuberculosis Tretinoin 3.2316040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.1817053015
MESH:D014581 Urticaria Acetaminophen 2.9810982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.6816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.6416752155
MESH:D014605 Uveitis Cyclosporine 4.011336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6212125929
MESH:D014820 Vitiligo Tretinoin 4.0716761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2815886252
MESH:D015430 Weight Gain Dietary Fats 3.7416723640
MESH:D009396 Wilms Tumor Tretinoin 3.9716287080
MESH:D014985 Xerophthalmia Cyclosporine 4.4717120751
Pathway ID Pathway Name
KEGG:04662 B cell receptor signaling pathway
KEGG:04380 Osteoclast differentiation
KEGG:05340 Primary immunodeficiency
REACT:6900 Signaling in Immune system
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA25371
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA449177cytarabine
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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