Annotation Detail for GUCY1A2
Basic Information Top
| Gene Symbol: | GUCY1A2 ( GC-SA2,GUC1A2 ) |
|---|---|
| Gene Full Name: | guanylate cyclase 1, soluble, alpha 2 |
| Band: | 11q22.3 |
| Quick Links | Entrez ID:2977; OMIM: 601244; Uniprot ID:GCYA2_HUMAN; ENSEMBL ID: ENSG00000152402; HGNC ID: 4684 |
| Relate to Another Database: | SFARIGene; denovo-db |
Related Diseases/Disorders| Chemical ID | Chemical Name | Interaction | Interaction Action | Publication |
|---|---|---|---|---|
| D000638 | Amiodarone | Amiodarone results in increased expression of GUCY1A2 mRNA | increases expression | 19774075 |
| D000643 | Ammonium Chloride | Ammonium Chloride affects the expression of GUCY1A2 mRNA | affects expression | 16483693 |
| D001104 | Arbutin | Arbutin results in decreased expression of GUCY1A2 mRNA | decreases expression | 17103032 |
| D001564 | Benzo(a)pyrene | Benzo(a)pyrene results in increased expression of GUCY1A2 mRNA | increases expression | 17879257 |
| D005419 | Flavonoids | Flavonoids results in increased expression of GUCY1A2 mRNA | increases expression | 18035473 |
| C011890 | kojic acid | kojic acid results in decreased expression of GUCY1A2 mRNA | decreases expression | 16595896 |
| Disease ID | Disease Name | Direct Evidence | Inference Chemical Name | Inference Score | Publication |
|---|---|---|---|---|---|
| MESH:D000138 | Acidosis | Ammonium Chloride | 4.02 | 18287403 | |
| MESH:D000230 | Adenocarcinoma | Benzo(a)pyrene | 2.04 | 20127859 20464547 | |
| MESH:D000236 | Adenoma | Benzo(a)pyrene | 2.82 | 6695378 | |
| MESH:D017544 | Aortic Aneurysm, Abdominal | Benzo(a)pyrene | 4.49 | 19183758 | |
| MESH:D001145 | Arrhythmias, Cardiac | Amiodarone | 4.11 | 18218290 18057881 20041841 | |
| MESH:D001281 | Atrial Fibrillation | Amiodarone | 4.13 | 19698954 18651412 | |
| MESH:D001778 | Blood Coagulation Disorders | Amiodarone | 4.22 | 19483382 | |
| MESH:D001943 | Breast Neoplasms | marker/mechanism | 18507500 | ||
| MESH:D001943 | Breast Neoplasms | Benzo(a)pyrene | 2.00 | 20146248 17474063 | |
| MESH:D002294 | Carcinoma, Squamous Cell | Benzo(a)pyrene | 2.12 | 20419170 | |
| MESH:D002311 | Cardiomyopathy, Dilated | Amiodarone | 2.98 | 19225199 15710769 | |
| MESH:D002341 | Carotid Artery Thrombosis | Amiodarone | 5.55 | 18974383 | |
| MESH:D015179 | Colorectal Neoplasms | marker/mechanism | 21278247 18507500 | ||
| MESH:D056486 | Drug-Induced Liver Injury | Amiodarone | 2.46 | 15265979 18218290 | |
| MESH:D004938 | Esophageal Neoplasms | Benzo(a)pyrene | 2.07 | 16530937 | |
| MESH:D005234 | Fatty Liver | Amiodarone | 3.84 | 14986274 | |
| MESH:D006330 | Heart Defects, Congenital | Benzo(a)pyrene | 2.80 | 20471113 | |
| MESH:D006529 | Hepatomegaly | Amiodarone | 4.16 | 15265979 | |
| MESH:D006937 | Hypercholesterolemia | Amiodarone | 4.20 | 8137927 9751232 | |
| MESH:D007037 | Hypothyroidism | Amiodarone | 4.93 | 18020914 17991464 | |
| MESH:D007249 | Inflammation | Flavonoids | 2.79 | 17296493 | |
| MESH:D008064 | Lipidoses | Amiodarone | 3.73 | 15342952 17567588 | |
| MESH:D008113 | Liver Neoplasms | Benzo(a)pyrene | 2.13 | 20195826 21137059 | |
| MESH:D008114 | Liver Neoplasms, Experimental | kojic acid | 3.51 | 18544905 | |
| MESH:D008133 | Long QT Syndrome | Amiodarone | 3.82 | 15350150 11989578 17391786 | |
| MESH:D008171 | Lung Diseases | Amiodarone | 3.57 | 12587719 | |
| MESH:D017563 | Lung Diseases, Interstitial | Amiodarone | 5.00 | 18516814 | |
| MESH:D008175 | Lung Neoplasms | Benzo(a)pyrene | 1.57 | 18816296 6695378 18569708 18520028 20464547 20064080 17053015 20869020 20135361 | |
| MESH:D009062 | Mouth Neoplasms | Benzo(a)pyrene | 3.43 | 16381670 | |
| MESH:D009181 | Mycoses | Amiodarone | 5.42 | 12754197 17974566 | |
| MESH:D009369 | Neoplasms | Benzo(a)pyrene | 2.30 | 11141357 | |
| MESH:D011471 | Prostatic Neoplasms | Benzo(a)pyrene | 2.92 | 17292933 | |
| MESH:D011658 | Pulmonary Fibrosis | Amiodarone | 2.95 | 12832656 12490602 11597910 | |
| OMIM:609620 | SHORT QT SYNDROME 1 | Amiodarone | 5.55 | 18724381 | |
| MESH:D012878 | Skin Neoplasms | Benzo(a)pyrene | 2.49 | 10029692 19755658 | |
| MESH:D013274 | Stomach Neoplasms | Benzo(a)pyrene | 1.56 | 20155912 2093021 | |
| MESH:D013276 | Stomach Ulcer | Amiodarone | 3.64 | 18087811 | |
| MESH:D013610 | Tachycardia | Amiodarone | 4.67 | 11238279 | |
| MESH:D017180 | Tachycardia, Ventricular | Amiodarone | 4.57 | 19225199 | |
| MESH:D013959 | Thyroid Diseases | Amiodarone | 5.28 | 19731979 | |
| MESH:D013971 | Thyrotoxicosis | Amiodarone | 5.28 | 18020914 19584973 | |
| MESH:D016171 | Torsades de Pointes | Amiodarone | 4.65 | 17467628 11989578 | |
| MESH:D001749 | Urinary Bladder Neoplasms | Benzo(a)pyrene | 2.28 | 17053015 |
| Pathway ID | Pathway Name |
|---|---|
| KEGG:04540 | Gap junction |
| REACT:604 | Hemostasis |
| KEGG:04730 | Long-term depression |
| KEGG:00230 | Purine metabolism |
| KEGG:04970 | Salivary secretion |
| KEGG:04270 | Vascular smooth muscle contraction |