AutismKB 2.0

Annotation Detail for CARD10


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Basic Information Top
Gene Symbol:CARD10 ( BIMP1,CARMA3,MGC142219 )
Gene Full Name: caspase recruitment domain family, member 10
Band: 22q13.1
Quick LinksEntrez ID:29775; OMIM: 607209; Uniprot ID:CAR10_HUMAN; ENSEMBL ID: ENSG00000100065; HGNC ID: 16422
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1859Ovarian cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of CARD10 mRNAdecreases expression 19933214
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of CARD10 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of CARD10 mRNAaffects expression 17562736
D001151 Arsenic Arsenic results in increased expression of CARD10 mRNAincreases expression 19945496
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of CARD10 mRNAincreases expression 20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CARD10 mRNAdecreases expression 19150397
D020111 Chlorodiphenyl (54% Chlorine) Chlorodiphenyl (54% Chlorine) results in decreased expression of CARD10 mRNAdecreases expression 16934159
D016572 Cyclosporine Cyclosporine results in decreased expression of CARD10 mRNAdecreases expression 20106945
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of CARD10 mRNAincreases expression 18691550
D004052 Diethylnitrosamine IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CARD10 mRNA]decreases reaction|increases expression 18691550
D004052 Diethylnitrosamine MAPK14 protein inhibits the reaction [Diethylnitrosamine results in increased expression of CARD10 mRNA]decreases reaction|increases expression 18691550
D004958 Estradiol Estradiol inhibits the reaction [Etoposide results in increased expression of CARD10 mRNA]decreases reaction|increases expression 19426747
D004958 Estradiol Estradiol results in decreased expression of CARD10 mRNAdecreases expression 19426747
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of CARD10 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of CARD10 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CARD10 mRNAaffects cotreatment|increases expression 17942748
D005047 Etoposide Estradiol inhibits the reaction [Etoposide results in increased expression of CARD10 mRNA]decreases reaction|increases expression 19426747
D005047 Etoposide Etoposide results in increased expression of CARD10 mRNAincreases expression 19426747
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CARD10 mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of CARD10 mRNAincreases expression 19482888
D020849 Raloxifene Raloxifene affects the expression of CARD10 mRNAaffects expression 14699072
D013629 Tamoxifen Tamoxifen affects the expression of CARD10 mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of CARD10 mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CARD10 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of CARD10 mRNAdecreases expression 19933214
D014635 Valproic Acid Valproic Acid results in increased expression of CARD10 mRNAincreases expression 19101580
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.5514745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 14.166195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 14.1611752688 14514962 15322242
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 14.168875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.9119490988
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 6.9720464547 20127859
MESH:D000230 Adenocarcinoma Estradiol 6.9711473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 6.9714692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.596695378
MESH:D000236 Adenoma Diethylnitrosamine 6.596695378 10737359
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 17.3118056438 19061943 16434500 17620307 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Phenobarbital 17.3117620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 17.3116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.2117306315
MESH:D000419 Albuminuria Raloxifene 4.5817308373 17451421
MESH:D000544 Alzheimer Disease Raloxifene 2.5415800139
MESH:D000550 Amblyopia Valproic Acid 5.2317688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9311748828
MESH:D000799 Angioedema Acetaminophen 3.8410982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.5517497229
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0619183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8616835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6515885639
MESH:D050197 Atherosclerosis Arsenic 3.2419371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8515238991 18558336 18316065 18396377 17507914 19460635 20603192 17688650 17157402 18985861 16609825 18177632 18775368 19232924 18940202
MESH:D001714 Bipolar Disorder Valproic Acid 3.0617594078 20046352
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.9815746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.988888407
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.1614601052
MESH:D001930 Brain Injuries Raloxifene 4.4616580743
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 3.7620146248 17474063
MESH:D001943 Breast Neoplasms Diethylnitrosamine 3.7617474063
MESH:D001943 Breast Neoplasms Estradiol 3.7617261762 17018787 17289903 14630087 19861407 16675129 12948864 18497071
MESH:D001943 Breast Neoplasms Etoposide 3.7616322251
MESH:D001943 Breast Neoplasms Raloxifene 3.7616912660 17261762 15572757 17595753 17049068 17952589 15758505 17242785 17440819 15775269 17893378 16837676
MESH:D001943 Breast Neoplasms Tamoxifen 3.7620859285 15668708 18984771 19221464 18425577 19142967 21152245 19189212 19487384 19189210 19115204 18629630 16873071 16202921 20005174 19084267 17440819 19011961 19103187 18855134 20390343 15565566 19410462 17893378 17049068 18815881 19200415 16273361 17261762 18351453 20544844 20135344 19288272 19289846 21138602 19059307 19066611 19244106 16818667 18997820 20065188 19155303 11161223 17242785 18821012
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 3.7620435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.4516111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7816835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5817687452 15504454
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4919066611
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 14.0616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 14.063084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 14.0617306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 14.0618785209 18665156 19418558 20432363 18978308 20101231 19335982 16569478 19394651 18971187 20512989 19919837 3581430 18691550 20084675 20214788 19519916 16681979 16698587 18788625 20935162 20727157 11831363 19107877 17428255 16935385 16830150 18056438 16540662 20514400 20524982 18494052 16807293 10737359 19539802 10672840 17138121 17761372 21159647 3084413 16288022 19383236 20007298 16878318 16779866 18393292 17978847 17055752 17173139 16328049 19701751 17162532 19822196 19208518 19052882 16502159 18210153 19171122 18506893
MESH:D006528 Carcinoma, Hepatocellular Estradiol 14.0616924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 14.0617173139 20935162 20007298 6705139 1701930
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 14.0616924424
MESH:D002294 Carcinoma, Squamous Cell Arsenic 4.6918922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6920419170
MESH:D002295 Carcinoma, Transitional Cell Arsenic 15.8218640142
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 15.8217572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 15.8217572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3518670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 7.5115738583 19152805 17938729
MESH:D002318 Cardiovascular Diseases Raloxifene 7.5115775269
MESH:D002340 Carotid Artery Diseases Arsenic 4.2916973168 18022660
MESH:D002386 Cataract Acetaminophen 2.5710977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 15.8920889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 15.8912371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 15.8917174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 15.8918566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.244080065
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.7020734317
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.2619052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.2616835633
MESH:D002779 Cholestasis Cyclosporine 7.7219486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.7215861022 11677210 17110522 17681005 16919318 17333356 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0916354765 8697196 12621046 15340226 15668235
MESH:D003072 Cognition Disorders Raloxifene 4.6015800139
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0414669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.4715322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities Valproic Acid 2.4717688650 16575769 8888407
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0018551238
MESH:D003711 Demyelinating Diseases Tamoxifen 4.3519031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.1417474826
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 4.2020387270
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.2017107852
MESH:D003928 Diabetic Nephropathies Estradiol 14.9219279558
MESH:D003928 Diabetic Nephropathies Raloxifene 14.9217308373 17451421 15920148
MESH:D003928 Diabetic Nephropathies Tamoxifen 14.9219279558
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 15.2018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 15.2010663392 17522070 11743745 11421492 16781746 16109766 14550746 10915739 18713872 15968718 14725611 11287661 17562736 19739265 16485898 19416960 12705907 16081117 12392966 17906064 16393943 16177239 11529661 16227642 18071297 12594235 11739529 15619225 11461765 14986274 12153990 19420014 19370779 19085960 12540782 2444490 19923254 11834606 19164858 10774834 12958197
MESH:D056486 Drug-Induced Liver Injury Chlorodiphenyl (54% Chlorine) 15.2017851650
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 15.2019107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 15.2020420201
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 15.201733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1019426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7411462148
MESH:D004421 Dystonia Phenobarbital 10.381851702
MESH:D004421 Dystonia Valproic Acid 10.381851702
MESH:D004487 Edema Raloxifene 6.7915860553
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.7912711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9016714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 15.2612538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 15.2615845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 15.2619031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.3418566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.3416202921 20544844 19155303 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.009294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 10.753659116
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 10.753659116 17275665
MESH:D004828 Epilepsies, Partial Phenobarbital 9.9811558140 3922381
MESH:D004828 Epilepsies, Partial Valproic Acid 9.9816628512 3922381
MESH:D004827 Epilepsy Phenobarbital 6.6320417680
MESH:D004827 Epilepsy Valproic Acid 6.6320417680 18234410
MESH:D004832 Epilepsy, Absence Phenobarbital 8.806401628
MESH:D004832 Epilepsy, Absence Valproic Acid 8.806254150 7562514 6426943
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 11.267750514
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 11.267750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 10.453659116
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 10.453659116
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.3320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.3316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0011564622
MESH:D005234 Fatty Liver Cyclosporine 30.5319224547
MESH:D005234 Fatty Liver Diethylnitrosamine 30.5321071580 20387270
MESH:D005234 Fatty Liver Ethinyl Estradiol 30.5315345470
MESH:D005234 Fatty Liver Raloxifene 30.5317473493
MESH:D005234 Fatty Liver Tamoxifen 30.5314986274 19224547
MESH:D005234 Fatty Liver Valproic Acid 30.5319224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2216709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4411858732
MESH:D005315 Fetal Diseases Valproic Acid 4.8916575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 4.118888407 18558336
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.1719069698
MESH:D005355 Fibrosis Cyclosporine 8.4412639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.4420067830
MESH:D005534 Foot Diseases Arsenic 5.566392382
MESH:D005756 Gastritis Acetaminophen 3.6816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.218708960
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5910696789
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.4120471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.4110048152 11294989
MESH:D006331 Heart Diseases Raloxifene 3.5211110106
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3211000095
MESH:D006529 Hepatomegaly Phenobarbital 8.4016109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.4012621046 15340226 16120746
MESH:D006558 Herpes Genitalis Estradiol 5.0315709030
MESH:D006561 Herpes Simplex Etoposide 4.5510809021
MESH:D006689 Hodgkin Disease Etoposide 3.8515147373 18180244 17606976 16135485 16200630
MESH:D019584 Hot Flashes Estradiol 3.7517088409
MESH:D006849 Hydrocephalus Valproic Acid 4.8617688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0516959395 18606429 8697196 15340226 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.6816870215
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4417050553
MESH:D006973 Hypertension Arsenic 12.329931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 12.3210903974
MESH:D006973 Hypertension Raloxifene 12.3215787275 17577099
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 12.3218670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.5616093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8016569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4412013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4717937319
MESH:D007249 Inflammation Diethylnitrosamine 8.2018785209
MESH:D007249 Inflammation Tamoxifen 8.2019457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.2012200463 12878042
MESH:D007333 Insulin Resistance Estradiol 2.9516627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3216580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4415604871
MESH:D007642 Keratosis Arsenic 4.9812749816 16930632
MESH:D007674 Kidney Diseases Acetaminophen 9.9015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 9.9018776723 8314463 10903974
MESH:D007674 Kidney Diseases Estradiol 9.9015618244
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 17.6016705839
MESH:D007680 Kidney Neoplasms Cyclosporine 17.6012371664
MESH:D007680 Kidney Neoplasms Estradiol 17.6015610895
MESH:D007680 Kidney Neoplasms Tamoxifen 17.6018625569
MESH:D007889 Leiomyoma Raloxifene 4.4816973256
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1516294345 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5417339181
MESH:D008064 Lipidoses Tamoxifen 3.1415342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.6019638242 20032147 18407596 18665156 18522880
MESH:D008103 Liver Cirrhosis Phenobarbital 6.6021047994
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.4214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.4218564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.4212878042
MESH:D008107 Liver Diseases Acetaminophen 9.3519784758 12969438 12587719 16611625 11587558 19460945 19014921 16610002
MESH:D008107 Liver Diseases Arsenic 9.3511134558
MESH:D008107 Liver Diseases Diethylnitrosamine 9.3517034775
MESH:D008107 Liver Diseases Phenobarbital 9.3519363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2216871587 17185352
MESH:D008113 Liver Neoplasms Arsenic 17.8916368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 17.8921137059 20195826
MESH:D008113 Liver Neoplasms Diethylnitrosamine 17.8919812893 21071580 20501860 21047994 15175105 21167192 20434301 19642983 18644402 2862719 19090486 20492335 2422723 10737359 19254457 20405173 19294768 19256749 20452335 20583210 18978307 19255062 18977376 9163691 15885732 19996281 18648771 19690152 20118626 12771043 20101389 21278145 19850985 12112319 19551842 19499222 20137499 18754104 19426721 16942905 19833225 19638242 19073162 19427195
MESH:D008113 Liver Neoplasms Phenobarbital 17.898742319 19073162 19482888 21047994 15975961 19812893
MESH:D008113 Liver Neoplasms Tamoxifen 17.8916684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 17.8916984957
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 9.7318093689 17854601 19126423 21159647 19519916 19009564 18308698 18544905 3124819 18079962 9362446 19539802 16842330 19004024 17942915 17174075 2563599 16267830 18282651 18775883 18164116 18253720
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 9.732563599 17172636 6150874 1399818 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 9.7312151625
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 4.2617228818
MESH:D008175 Lung Neoplasms Arsenic 6.5619168569 17976673 17306315
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5620869020 18520028 20135361 17053015 18569708 20464547 18816296 20064080 6695378
MESH:D008175 Lung Neoplasms Diethylnitrosamine 6.5620970405 20512841 21163286 6695378
MESH:D008175 Lung Neoplasms Tamoxifen 6.5618625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5619555203 11884234
MESH:D008223 Lymphoma Etoposide 3.9112854902 12556972
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.7519428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 5.9211408345 11807958 16891317 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 5.9214580682 19196723 11731420 19196722 16827153
MESH:D020149 Manganese Poisoning Estradiol 12.6519453300
MESH:D020149 Manganese Poisoning Tamoxifen 12.6519453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5519513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7916801185
MESH:D008881 Migraine Disorders Valproic Acid 3.1718765137 18803445
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.5515863610
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1716381670
MESH:D009101 Multiple Myeloma Raloxifene 3.4216497877
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 4.018888407
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.1417596541
MESH:D017202 Myocardial Ischemia Arsenic 8.9415371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.9412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.2616810080
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.4717484760
MESH:D009232 Myxoma Raloxifene 5.5516343187
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.8518551238
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.703581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.7019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5119410462
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1611141357
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0019189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 3.7217289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2719348381 18481113
MESH:D009421 Nervous System Malformations Estradiol 9.4111399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.4114600291
MESH:D009436 Neural Tube Defects Arsenic 7.4116620997
MESH:D009436 Neural Tube Defects Valproic Acid 7.4116359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.1218514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.1220387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.3617056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1220387270
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4116049721 12819281
MESH:D010018 Osteomalacia Phenobarbital 4.3617016548
MESH:D010024 Osteoporosis Raloxifene 3.3819059307 17882678 15775268
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.2115758505 15579764 17823083 17893378
MESH:D010051 Ovarian Neoplasms Arsenic 4.9317306315
MESH:D010051 Ovarian Neoplasms Estradiol 4.9319401270
MESH:D010146 Pain Acetaminophen 2.3716870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 8.6816540662
MESH:D010190 Pancreatic Neoplasms Etoposide 8.6819003803
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.6816965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6711578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2512520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.986392382 15371236 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5418163543
MESH:D011230 Precancerous Conditions Cyclosporine 15.1712371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 15.172563599
MESH:D011230 Precancerous Conditions Phenobarbital 15.172563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 9.4411118676 11896295 11399792 11222880
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 9.4420603192
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.8720887781
MESH:D011471 Prostatic Neoplasms Arsenic 1.8916140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Etoposide 1.8917172428
MESH:D011471 Prostatic Neoplasms Raloxifene 1.8915731164 16536755 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011507 Proteinuria Arsenic 3.9921343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.3016919318 15861022
MESH:D019310 Pseudolymphoma Phenobarbital 12.1912752131
MESH:D019310 Pseudolymphoma Valproic Acid 12.1912752131 11422049
MESH:D011565 Psoriasis Cyclosporine 2.2216882103
MESH:D011693 Purpura Raloxifene 5.5515770314
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 4.1619155313
MESH:D012512 Sarcoma, Ewing's Etoposide 4.6914601052
MESH:D012559 Schizophrenia Valproic Acid 2.0719110320 15737665
MESH:D012640 Seizures 2,4-dinitrotoluene 9.7518551238
MESH:D012640 Seizures Phenobarbital 9.754039156 3137016 16876388 11442880
MESH:D012640 Seizures Valproic Acid 9.7511738929 16876388 3137016 1511512 17978042 15475178 11044598 14763951
MESH:D003294 Seizures, Febrile Phenobarbital 4.816407741
MESH:D012871 Skin Diseases Arsenic 2.7419834688 16759981 18709164 16353154 15952646 17938729 17548696 17050553 17453740 6392382 16702368
MESH:D012878 Skin Neoplasms Arsenic 9.3815504454 17029826 17976673 16251483 19538983 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 9.3819755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 9.3816192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.5616709447
MESH:D013088 Spermatocele Tamoxifen 11.5616709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0319457130
MESH:D016135 Spinal Dysraphism Valproic Acid 3.7619490988
MESH:D013226 Status Epilepticus Valproic Acid 4.5412833885
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.332093021 20155912
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.3318456281
MESH:D020521 Stroke Raloxifene 3.8016837676
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9012697716
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.127505956
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.121399818
MESH:D013978 Tibial Fractures Estradiol 13.7119048282
MESH:D013978 Tibial Fractures Raloxifene 13.7119048282
MESH:D014178 Translocation, Genetic Valproic Acid 5.2317262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.513119515
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 15.7316049721
MESH:D001749 Urinary Bladder Neoplasms Arsenic 15.7317306315 19322015 19429237 11144890 18640142 17976673 15987713
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 15.7317053015
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 15.7317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 15.7317572228 8653321 16712894
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.638888407
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.3110091137
MESH:D014581 Urticaria Acetaminophen 2.9610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2814692618
MESH:D014605 Uveitis Cyclosporine 3.981336536
MESH:D014652 Vascular Diseases Arsenic 4.7317056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5912125929
MESH:D054556 Venous Thromboembolism Raloxifene 5.2116837676
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5214671159 15869587
MESH:D014846 Vulvar Neoplasms Raloxifene 5.5516343187
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2515886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4417120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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