AutismKB 2.0

Annotation Detail for PARVB


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Basic Information Top
Gene Symbol:PARVB ( CGI-56 )
Gene Full Name: parvin, beta
Band: 22q13.31
Quick LinksEntrez ID:29780; OMIM: 608121; Uniprot ID:PARVB_HUMAN; ENSEMBL ID: ENSG00000188677; HGNC ID: 14653
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04510Focal adhesion
Pathway IDPathway Name
Cell junction organization
No data
Pathway IDPathway Name
P00034Integrin signalling pathway
Pathway IDPathway Name
500125Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1934Cancer
1944Breast cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of PARVB mRNAaffects expression 21346803
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PARVB mRNAdecreases expression 20018196
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of PARVB mRNAaffects expression 17484886
D012402 Rotenone Rotenone results in increased expression of PARVB mRNAincreases expression 19013527
D012645 Selenomethionine Selenomethionine affects the expression of PARVB mRNAaffects expression 17222674
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.2616097048 3786805 16124888 10355542 16011737 15700767 15721981 18705752 16192424 15673190 16227642 16050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 3.1116705839
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 3.1118788625
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.446135515
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7.4420889678
MESH:D003110 Colonic Neoplasms marker/mechanism 19050079
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.1618551238 21346803
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 4.167120509 21278145 6884620 16177239 3732212 7440962 15968718 16227642 15998439 19085960 19336974 10915739 11566570 2869522 15027814 4309450 6623471 7179309 3786805 9327722 10092053 17522070
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1420426865
MESH:D005234 Fatty Liver Carbon Tetrachloride 3.5419224547 12795759 15959796 12631006 17595544 16045604 61145 16239168
MESH:D005355 Fibrosis Carbon Tetrachloride 3.9418705752
MESH:D006505 Hepatitis Carbon Tetrachloride 4.0319110552 19900420
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 5.0716899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.5715338365
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.9811408273 17174718 17157831 16239168 16943688 11903743 16221502 17334410 21278145
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7516027843 15338365 17565644 16136751 20821823 17631135 18481824 17698563 18054572 15673190 14724832 16192424 18420326 17557913 18156304 12546737 18263696 18472332 14716833 17766677 18418968 18277467 18339082 18472094 18429990 13678700 15959796 17714472 15057751 15818738 17525996 18210741 17976157 17805973 11481614 18376398 15362042 12898905 18395095 17823541 18205269 15931870 18317297 14512876 16015684 17481882 15876570 18187930 15123356 14748882 12445421 16638106 17640975 17708605 12586293 12632514 18705752 14620537 16097048 17869086 12609069 12958196 12667390 18251166 17900296 12666154 17944888 18412020 18279442 12389079 15650968 15925388 16033810 12649538 12445418 17761835 17721639 12632512 15052691 18006644 16011737 18395914 10355542 16248980 12741479 15370692 18166357 17922224 16116963 15730626 15996030 15893842 14716496
MESH:D008107 Liver Diseases Carbon Tetrachloride 2.1515830285 15720792 16246199 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.6515123358
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 4.0416899240 14706259
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.927678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 4.9219294768
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.612876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.6112014681 15583823
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009364 Neoplasm Recurrence, Local marker/mechanism 19050079
MESH:D009410 Nerve Degeneration Rotenone 4.1517356569 18619942 15790535
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010300 Parkinson Disease Rotenone 3.0816140633 11535288 18619942 15451049 16412576 18191903 11445065 19114014 19232380
MESH:D020734 Parkinsonian Disorders Rotenone 4.4215927086 18197244 15795934 15574749
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7618551238
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
Pathway ID Pathway Name
REACT:20676 Cell junction organization
KEGG:04510 Focal adhesion
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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