AutismKB 2.0

Annotation Detail for OLA1


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Basic Information Top
Gene Symbol:OLA1 ( DKFZp313H1942,DOC45,GBP45,GTPBP9 )
Gene Full Name: Obg-like ATPase 1
Band: 2q31.1
Quick LinksEntrez ID:29789; OMIM: 611175; Uniprot ID:OLA1_HUMAN; ENSEMBL ID: ENSG00000138430; HGNC ID: 28833
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of OLA1 mRNAaffects expression 17562736
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in increased expression of OLA1 mRNAincreases expression 15336504
D002995 Clofibric Acid Clofibric Acid affects the expression of OLA1 mRNAaffects expression 17602206
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of OLA1 mRNAaffects cotreatment|affects expression 17602206
C014347 decitabine decitabine results in decreased expression of OLA1 mRNAdecreases expression 19363521
C014347 decitabine TP53 protein affects the reaction [decitabine results in decreased expression of OLA1 mRNA]affects reaction|decreases expression 19363521
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of OLA1 mRNAaffects cotreatment|affects expression 17602206
D007657 Ketone Bodies Ketone Bodies results in increased expression of OLA1 mRNAincreases expression 16807920
C037219 quinoline quinoline analog results in decreased expression of OLA1 proteindecreases expression 18645022
D012643 Selenium Selenium results in decreased expression of OLA1 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma Diethylnitrosamine 2.9810737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.2418056438 19061943 17162532 17620307 19052882 16434500
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms decitabine 2.2618320071 19208741
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2617474063
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.913084413
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.9117055752 20084675 11831363 20432363 20524982 17162532 18393292 20514400 17761372 19383236 19208518 20935162 16779866 18971187 19919837 18494052 17978847 20101231 17173139 18785209 18506893 19418558 16569478 19822196 10672840 16878318 19052882 18665156 16288022 18788625 17138121 16540662 20214788 18056438 16935385 19107877 19171122 19335982 18210153 20512989 19701751 19519916 16328049 20727157 20007298 17428255 3084413 18978308 19539802 16681979 16502159 16830150 10737359 16698587 19394651 16807293 3581430 18691550 21159647
MESH:D006528 Carcinoma, Hepatocellular quinoline 4.91598648
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0117174075 21159647 2727394 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9019052882
MESH:D003092 Colitis Selenium 4.0917936198
MESH:D003110 Colonic Neoplasms decitabine 2.3717616700
MESH:D015179 Colorectal Neoplasms decitabine 2.1018981723
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2320387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.5715619225 16109766 11529661 16177239 2444490 12540782 12958197 19085960 12392966 15968718 18713872 14550746 16393943 11834606 19164858 12705907 12594235 19739265 19370779 16781746 17522070 16081117 17562736 11743745 14986274 18071297 11421492 16227642 19923254 17906064 12153990 10915739 10774834 14725611 10663392 11287661 16485898 11461765 19420014 19416960 11739529
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.5719107877
MESH:D056486 Drug-Induced Liver Injury Selenium 6.5715131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.4916302075
MESH:D005234 Fatty Liver Diethylnitrosamine 3.4321071580 20387270
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006333 Heart Failure Selenium 3.2117162251
MESH:D006390 Hemangioendothelioma quinoline 6.28598648
MESH:D006394 Hemangiosarcoma quinoline 5.24598648
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D007248 Infertility, Male decitabine 3.3517581917
MESH:D007249 Inflammation Diethylnitrosamine 2.4818785209
MESH:D007251 Influenza, Human Selenium 4.5716624496
MESH:D007674 Kidney Diseases Acetaminophen 2.3212587719 15629191
MESH:D007676 Kidney Failure, Chronic Selenium 4.1316518626
MESH:D007938 Leukemia decitabine 3.1819235587 18980019
MESH:D007951 Leukemia, Myeloid decitabine 4.2419117987 17236224 18454857
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4119387464 19010910 18460780 17679729 18206229 18704418
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.9419638242 20032147 18407596 18522880 18665156
MESH:D008107 Liver Diseases Acetaminophen 4.0812969438 12587719 19460945 16610002 19784758 16611625 19014921 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.0817034775
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4616871587 17185352
MESH:D008113 Liver Neoplasms Clofibric Acid 5.0217602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 5.0212771043 15885732 19690152 19642983 19812893 2422723 19254457 19833225 20137499 18978307 19426721 20583210 12112319 10737359 19638242 19551842 20452335 20434301 20101389 20405173 18648771 19996281 19499222 21071580 19073162 20492335 18977376 19256749 18754104 19294768 19427195 21167192 16942905 19850985 18644402 19255062 21278145 19090486 15175105 9163691 2862719 21047994 20118626 20501860
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 2.7718253720 17854601 18544905 3124819 18079962 17174075 19126423 19009564 18164116 18308698 18775883 16267830 19004024 17942915 19519916 9362446 21159647 18282651 16842330 19539802 18093689 2563599
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620512841 20970405 6695378 21163286
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9015318939
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008654 Mesothelioma Selenium 2.8715107826
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119010910 18608210 19157545 16882708
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 6.569029167 3581430
MESH:D009362 Neoplasm Metastasis quinoline 6.56598648
MESH:D009369 Neoplasms decitabine 2.8119116145 17925555 19470736
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.8618514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.8620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.4920387270
MESH:D010051 Ovarian Neoplasms decitabine 2.7119331143 19259094
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms decitabine 5.6119294695
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 5.6116540662
MESH:D010954 Plasmacytoma Selenium 5.2715087411
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.772563599
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 2.798532709
MESH:D013274 Stomach Neoplasms decitabine 2.5819037991
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 2.5818456281
MESH:D013964 Thyroid Neoplasms decitabine 7.8917967635
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 7.897505956
MESH:D001749 Urinary Bladder Neoplasms decitabine 2.8019087683 17616700
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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