AutismKB 2.0

Annotation Detail for YPEL1


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Basic Information Top
Gene Symbol:YPEL1 ( MGC64992 )
Gene Full Name: yippee-like 1 (Drosophila)
Band: 22q11.21-q11.22
Quick LinksEntrez ID:29799; OMIM: 608082; Uniprot ID:YPEL1_HUMAN; ENSEMBL ID: ENSG00000100027; HGNC ID: 12845
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C014211 2,3,7,8-tetrachlorodibenzofuran 2,3,7,8-tetrachlorodibenzofuran affects the expression of YPEL1 mRNAaffects expression 18343893
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of YPEL1 mRNAdecreases expression 16788091
D001151 Arsenic Arsenic affects the expression of YPEL1 mRNAaffects expression 18414638
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of YPEL1 mRNAdecreases expression 15336504
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YPEL1 mRNAaffects cotreatment|increases expression 17942748
D018038 Sodium Selenite Sodium Selenite results in increased expression of YPEL1 mRNAincreases expression 18175754
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin affects the expression of YPEL1 mRNAaffects expression 18343893
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of YPEL1 mRNAaffects cotreatment|increases expression 17942748
D014212 Tretinoin Tretinoin results in decreased expression of YPEL1 mRNAdecreases expression 16788091
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1815322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3217505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8614692618
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7116835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.5917306315
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1711748828
MESH:D020261 Arsenic Poisoning Arsenic 2.9216251483 18414634 12569548 16835338
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7711256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 7.6715885639
MESH:D001169 Arthritis, Experimental Tretinoin 7.6716412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
MESH:D050197 Atherosclerosis Arsenic 3.3812928151 19371607
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 9.7612125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 9.7616197459 16206674
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1715340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9115746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9620435547
MESH:D001943 Breast Neoplasms Tretinoin 1.9616873071 16443354 16166294
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.7117687452 15504454
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2916507464 17306315
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 3.291917145
MESH:D002294 Carcinoma, Squamous Cell Arsenic 5.0018922899 17687452 15504454
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0016096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.3018640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4916120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.6117938729 15738583 19152805
MESH:D002340 Carotid Artery Diseases Arsenic 4.5216973168 18022660
MESH:D002386 Cataract Tretinoin 3.2217460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3816835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0517333356 17110522 16919318 15861022 16105132 17681005 11677210
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0615894690
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.0512621046 8697196 15668235 15340226 16354765
MESH:D002972 Cleft Palate Tretinoin 6.059407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2714669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.5020055451 15322242 10048152
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.509211117 17551590 9142499 10589399 16925845 9125849 9224671 8800419 9664655 14991402
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9916285004
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.7117107852
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0115131321
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 4.0120420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9311462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 13.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 13.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4712538720
MESH:D016889 Endometrial Neoplasms Tretinoin 3.2516569247
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.259294722 10568697
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 9.4311564622
MESH:D005124 Eye Abnormalities Tretinoin 9.439664655 16938888
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0515345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7611858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.6620067830
MESH:D005355 Fibrosis Tretinoin 9.6617994277
MESH:D005534 Foot Diseases Arsenic 5.946392382
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9710696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital 2,3,7,8-tetrachlorodibenzofuran 11.9511294989
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 11.9511294989 10048152
MESH:D006330 Heart Defects, Congenital Tretinoin 11.959664655 14991402
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5811000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2016120746 12621046 15340226
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.428697196 18606429 15340226 16354765 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.4016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.6817050553
MESH:D006973 Hypertension Arsenic 5.4911953799 9931084 16076760
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.4918670907 18850075
MESH:D006987 Hypesthesia Arsenic 5.9416093927
MESH:D007021 Hypospadias Ethinyl Estradiol 4.1216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6417937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9612878042 12200463
MESH:D007333 Insulin Resistance Sodium Selenite 3.4214714311
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.7616580747
MESH:D007569 Jaw Abnormalities Tretinoin 10.7615992940 17551590
MESH:D007642 Keratosis Arsenic 5.3316930632 12749816
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1119850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 8.2617339181
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 8.2616331271 9834237 17368321 19642359 16823087 17712046 17301526 19035177 17361223 16140955 16766008 17107899 19029980 16788101 19225113 17217047 15748426 19075265 17339181 16935935 17294898 17649720 12679006 17506722 16891316
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 2.3612878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.3618397230 16248980
MESH:D008107 Liver Diseases Arsenic 2.5911134558
MESH:D008113 Liver Neoplasms Arsenic 4.8216368122
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8216984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2412151625
MESH:D008175 Lung Neoplasms Arsenic 2.4819168569 17306315 17976673
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 2.4819555203 11884234
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3214737004
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tretinoin 1.9716752155
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D017202 Myocardial Ischemia Arsenic 9.6515371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 9.6512213967
MESH:D009369 Neoplasms Tretinoin 2.5116594593 16946489
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 10.4714600291
MESH:D009421 Nervous System Malformations Tretinoin 10.479125849
MESH:D009436 Neural Tube Defects Arsenic 7.9216620997
MESH:D009436 Neural Tube Defects Tretinoin 7.929142499
MESH:D020078 Neurogenic Inflammation Arsenic 4.6417056641
MESH:D010051 Ovarian Neoplasms Arsenic 5.2117306315
MESH:D010051 Ovarian Neoplasms Tretinoin 5.2116936753
MESH:D010146 Pain Tretinoin 3.1016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5315976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.4616093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.3315371236 16905509 6392382
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8418163543
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.5311896295 11399792 11118676 11222880
MESH:D011471 Prostatic Neoplasms Arsenic 3.4016140617
MESH:D011471 Prostatic Neoplasms Sodium Selenite 3.4018760546
MESH:D011507 Proteinuria Arsenic 10.1621343184
MESH:D011507 Proteinuria Tretinoin 10.1616636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.6515861022 16919318
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1218990726
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616283617 16116481
MESH:D012871 Skin Diseases Arsenic 2.8017548696 16353154 15952646 16702368 17453740 16759981 17050553 19834688 17938729 18709164 6392382
MESH:D012878 Skin Neoplasms Arsenic 14.4119538983 16251483 15504454 17029826 17976673 17050553
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 14.418532709
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 14.4116192470
MESH:D012878 Skin Neoplasms Tretinoin 14.4116467112
MESH:D013088 Spermatocele Ethinyl Estradiol 4.3216709447
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3715669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2812697716
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2116026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8917976673 11144890 15987713 19429237 17306315 19322015 18640142
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5814692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D014652 Vascular Diseases Arsenic 5.0717056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7814671159 15869587
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6215886252
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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