AutismKB 2.0

Annotation Detail for VPREB3


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Basic Information Top
Gene Symbol:VPREB3 ( 8HS20,N27C7-2 )
Gene Full Name: pre-B lymphocyte 3
Band: 22q11.23
Quick LinksEntrez ID:29802; OMIM: 605017; Uniprot ID:VPRE3_HUMAN; ENSEMBL ID: ENSG00000128218; HGNC ID: 12710
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of VPREB3 mRNAaffects expression 18281256
D000082 Acetaminophen Acetaminophen affects the expression of VPREB3 mRNAaffects expression 17562736
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of VPREB3 mRNAdecreases expression 20106945
D005472 Fluorouracil Fluorouracil affects the expression of VPREB3 mRNAaffects expression 16584549
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.6620127859 20464547
MESH:D000230 Adenocarcinoma Fluorouracil 4.6617638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.866695378
MESH:D000740 Anemia Fluorouracil 4.1116511603 17963324 15504547
MESH:D000799 Angioedema Acetaminophen 4.5710982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.6419183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.1420146248 17474063
MESH:D001943 Breast Neoplasms Fluorouracil 2.1419217205 18608205 16595493 16110121 16557594 18357371 15136595
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 3.083084413
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 3.0817971768 16332177 18930000 17088986 17045692 16799960
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.1718695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.9520419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.9516280240 17066447 18986760 16757204
MESH:D002386 Cataract Acetaminophen 2.7910977129
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2817725105 18772588 15001691 17016597 16510598 17287894 17018589 16340194 17169374 17172411
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0014970324 16303861 18288408 16331619 17094418 18509181 15289873 17695437 17594712 15148649 18949393 18383874 17255274 20501625 17016601 18448328 17454858 16524972 16391804 17401013 18802399 16282729
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6714725611 16177239 10915739 11421492 11739529 16081117 17906064 19923254 11743745 17522070 14550746 2444490 19164858 16109766 19739265 12958197 18713872 19085960 19420014 11834606 12705907 15968718 11529661 16393943 19416960 16485898 10663392 19370779 15619225 16227642 12594235 17562736 12153990 14986274 11461765 10774834 12540782 12392966 16781746 18071297 11287661
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.8219426721
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.7516530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7515173087 16785472 16337965 16481741 17638652
MESH:D005756 Gastritis Acetaminophen 4.4016983495
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6415162350 18337622 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.8320471113
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 5.3116109766
MESH:D006930 Hyperalgesia Acetaminophen 3.0216870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4015629191 12587719
MESH:D007680 Kidney Neoplasms Fluorouracil 3.6516985049
MESH:D008107 Liver Diseases Acetaminophen 1.7019014921 12969438 16610002 16611625 19784758 11587558 12587719 19460945
MESH:D017114 Liver Failure, Acute Acetaminophen 3.6317185352 16871587
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.0221137059 20195826
MESH:D008113 Liver Neoplasms Fluorouracil 5.0215113037 18383874 16603448 17045692
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5517053015 20064080 20464547 18816296 20869020 18569708 6695378 18520028 20135361
MESH:D008175 Lung Neoplasms Fluorouracil 2.5515246190
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D008546 Melanoma, Experimental Acetaminophen 4.1319513568
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 9.5716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 9.5718986760 16757204
MESH:D009369 Neoplasms Benzo(a)pyrene 5.6311141357
MESH:D009369 Neoplasms Fluorouracil 5.6318239605 16928823 18600527
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.2118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D010146 Pain Acetaminophen 2.7316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7716929163 15113037 16500647 19003803
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.1517292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.1519082440 18626508
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3818286688 18722050 16160472 15538739
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.5210029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.492093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 2.4917172411 16951190 19084572 18567086 15786421 19015929 17498489 17522103 16424979 18396642
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 2.3017053015
MESH:D014581 Urticaria Acetaminophen 3.4410982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.2716803524
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA37325
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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