AutismKB 2.0

Annotation Detail for REPIN1


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Basic Information Top
Gene Symbol:REPIN1 ( AP4,RIP60,ZNF464,Zfp464 )
Gene Full Name: replication initiator 1
Band: 7q36.1
Quick LinksEntrez ID:29803; OMIM: NA; Uniprot ID:REPI1_HUMAN; ENSEMBL ID: ENSG00000214022; HGNC ID: 17922
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of REPIN1 mRNAdecreases expression 18648102
D000638 Amiodarone Amiodarone results in increased expression of REPIN1 mRNAincreases expression 19774075
C006632 arsenic trioxide arsenic trioxide results in increased expression of REPIN1 mRNAincreases expression 20458559
D002857 Chromium Chromium results in decreased expression of REPIN1 mRNAdecreases expression 17547211
D019800 Phenol Phenol results in decreased expression of REPIN1 mRNAdecreases expression 17547211
D011192 Potassium Dichromate Potassium Dichromate results in decreased expression of REPIN1 mRNAdecreases expression 17547211
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma arsenic trioxide 2.3411798837 19825857
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.923712494
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.1118218290 20041841 18057881
MESH:D001281 Atrial Fibrillation Amiodarone 4.1319698954 18651412
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.541440618 11289319
MESH:D001778 Blood Coagulation Disorders Amiodarone 10.3819483382
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 10.3816206674
MESH:D001859 Bone Neoplasms Phenol 5.5610556009
MESH:D001913 Bowen's Disease Phenol 6.2719293009
MESH:D001943 Breast Neoplasms Chromium 3.4315986119
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.6811589617
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.143581430 7296757
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 3.1416217749 11135700 14691202 15073043 15553829
MESH:D002291 Carcinoma, Papillary arsenic trioxide 5.4019014326
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.807296757
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 4.4212490120
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.9819225199 15710769
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.5518974383
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.967505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.389022650 19486331
MESH:D015179 Colorectal Neoplasms arsenic trioxide 1.8620501625
MESH:D023903 Coronary Restenosis arsenic trioxide 4.5712609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 1.8910525206
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 4.4515213294
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 8.7912868966 11906362 8156756 8970840 14531868 11298694 18759878 2524372
MESH:D017449 Dermatitis, Allergic Contact Potassium Dichromate 8.7916823706
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.843621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.2616192314 11289319 6679447 18648102 18289764 9328219 7440962 6482804 9653073 8291058 18692083 1440618 9022650
MESH:D056486 Drug-Induced Liver Injury Amiodarone 4.2618218290 15265979
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.693581430
MESH:D004938 Esophageal Neoplasms arsenic trioxide 4.6912903497
MESH:D005234 Fatty Liver Amiodarone 9.1014986274
MESH:D005234 Fatty Liver arsenic trioxide 9.1015073043
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.546705139
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 4.6416904648
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.397505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.896705139
MESH:D006529 Hepatomegaly Amiodarone 4.1615265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.208137927 9751232
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.3615034207
MESH:D007037 Hypothyroidism Amiodarone 4.9317991464 18020914
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.549022650 8074119
MESH:D055623 Keratosis, Actinic Phenol 6.9619293009
MESH:D007674 Kidney Diseases Chromium 7.6117934191
MESH:D007674 Kidney Diseases Potassium Dichromate 7.6119665454
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.236582329
MESH:D007938 Leukemia arsenic trioxide 2.9615070760
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 4.1212560223 17077332
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 4.7716972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.6614633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 4.0919077051
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 2.1816467208 20471514 19850784 17050201 16968895
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 3.4116331271 17649720 19225113 15336539 12679006 17712046 16966277 9834237 16330433 12712474 19075265 19642359 11161223 15213294 17869043 16891316 15622746 11468182 15748426 16823087 16112521 17217047 17107899 12018890 19035177
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.7316882451
MESH:D008064 Lipidoses Amiodarone 3.7317567588 15342952
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.389327722 15034207
MESH:D008113 Liver Neoplasms arsenic trioxide 2.4314682389
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.576587162 3712494 1399818 598648
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 6.5720377131
MESH:D008133 Long QT Syndrome Amiodarone 9.0117391786 15350150 11989578
MESH:D008133 Long QT Syndrome arsenic trioxide 9.0115213294
MESH:D008171 Lung Diseases Amiodarone 3.5712587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.0018516814
MESH:D008175 Lung Neoplasms arsenic trioxide 1.8711798837 19825857
MESH:D009101 Multiple Myeloma arsenic trioxide 3.3214977855 19549372 15949261 11468182 19417148
MESH:D009181 Mycoses Amiodarone 5.4217974566 12754197
MESH:D009182 Mycosis Fungoides arsenic trioxide 5.1918349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 3.3016882451 16105982
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 4.3416624393
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.573581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.906679447
MESH:D009436 Neural Tube Defects arsenic trioxide 7.9010525206
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.724026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.543988306
MESH:D010051 Ovarian Neoplasms arsenic trioxide 2.4816624393 19769630 12452020
MESH:D010146 Pain Phenol 4.4517610455
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 2.6115580305
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.907296757
MESH:D010235 Paraganglioma arsenic trioxide 4.5119927285
MESH:D010392 Pemphigus Phenol 6.9616522979 17163923
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.996228378
MESH:D010864 Pilonidal Sinus Phenol 6.9615622588 19655223
MESH:D011041 Poisoning Phenol 5.068825745
MESH:D011471 Prostatic Neoplasms arsenic trioxide 3.2219131511
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9512832656 11597910 12490602
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.613692021
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 4.3416646077
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.5518724381
MESH:D013088 Spermatocele Phenol 6.1618646496
MESH:D013274 Stomach Neoplasms arsenic trioxide 1.8617007042
MESH:D013276 Stomach Ulcer Amiodarone 3.6418087811
MESH:D013610 Tachycardia Amiodarone 4.6711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.5719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.2819731979
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 7.977505956 1399818 3712494 6582329 6587162
MESH:D013964 Thyroid Neoplasms arsenic trioxide 7.9719014326
MESH:D013971 Thyrotoxicosis Amiodarone 5.2818020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 11.8517467628 11989578
MESH:D016171 Torsades de Pointes arsenic trioxide 11.8515213294
MESH:D014277 Trigeminal Neuralgia Phenol 6.9610223447 16527771
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.428074119
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 5.4211780464 20435036 12845720 12973940
MESH:D014860 Warts Phenol 6.6219122958
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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