AutismKB 2.0

Annotation Detail for GUCY2C


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Basic Information Top
Gene Symbol:GUCY2C ( GUC2C,STAR )
Gene Full Name: guanylate cyclase 2C (heat stable enterotoxin receptor)
Band: 12p12.3
Quick LinksEntrez ID:2984; OMIM: 601330; Uniprot ID:GUC2C_HUMAN; ENSEMBL ID: ENSG00000070019; HGNC ID: 4688
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GUCY2C mRNAaffects expression 17562736
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GUCY2C mRNAaffects expression 16483693
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GUCY2C mRNAaffects cotreatment|increases expression 18164116
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GUCY2C mRNAaffects expression 12734012
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GUCY2C mRNAaffects cotreatment|increases expression 18164116
D004768 Enterotoxins Enterotoxins binds to GUCY2C proteinaffects binding 15049831
D005419 Flavonoids Flavonoids results in increased expression of GUCY2C mRNAincreases expression 18035473
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000236 Adenoma beta-Naphthoflavone 7.3719389873
MESH:D000236 Adenoma Diethylnitrosamine 7.3710737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 4.3016434500 17620307 17162532 19061943 18056438 19052882
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.2017474063
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 4.1416097048 16011737 16050911 16124888 16192424 15721981 18705752 15673190 10355542 15700767 3786805 16227642
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.733084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 4.7318788625
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 4.7320514400 17978847 20214788 19171122 18788625 17173139 3084413 17761372 20727157 16288022 19919837 20935162 16878318 17138121 19052882 3581430 16328049 18971187 16935385 19208518 18506893 19335982 19539802 18494052 18393292 18691550 17055752 19519916 18210153 11831363 10672840 16698587 16502159 18056438 16569478 19383236 19701751 20524982 10737359 20007298 17162532 16779866 21159647 17428255 18785209 19418558 20512989 18978308 16807293 16540662 20101231 19394651 19107877 18665156 20432363 20084675 19822196 16830150 16681979
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 3.0417174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.9319052882
MESH:D015179 Colorectal Neoplasms marker/mechanism 17155897
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2420387270
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6010774834 11743745 12392966 10663392 19420014 19923254 11287661 16393943 19739265 14550746 10915739 12153990 16781746 16485898 19416960 12594235 11834606 15619225 17906064 19164858 11461765 17562736 16177239 19370779 11421492 18713872 16227642 12540782 16109766 2444490 11529661 11739529 14986274 17522070 16081117 14725611 12958197 15968718 19085960 18071297 12705907
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 6.6015998439 10915739 3732212 15968718 10092053 16177239 3786805 19085960 7179309 17522070 11566570 7440962 7120509 21278145 19336974 4309450 6623471 9327722 6884620 16227642 15027814 2869522
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.6019107877
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.5616302075
MESH:D005234 Fatty Liver Carbon Tetrachloride 8.7861145 15959796 16045604 12795759 16239168 12631006 19224547 17595544
MESH:D005234 Fatty Liver Diethylnitrosamine 8.7821071580 20387270
MESH:D005355 Fibrosis Carbon Tetrachloride 3.8118705752
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D006505 Hepatitis Carbon Tetrachloride 3.9219110552 19900420
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.9316899240
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.4515338365
MESH:D007249 Inflammation Diethylnitrosamine 5.6218785209
MESH:D007249 Inflammation Flavonoids 5.6217296493
MESH:D007674 Kidney Diseases Acetaminophen 2.3415629191 12587719
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 7.0711408273 17174718 16943688 17334410 16239168 16221502 17157831 11903743 21278145
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 7.0719638242 18407596 18665156 20032147 18522880
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 1.7515818738 12667390 14716496 16192424 16248980 16027843 18210741 12609069 17714472 18279442 15931870 15959796 12666154 16097048 17823541 14724832 18395914 18187930 17805973 18205269 15338365 12445421 18412020 17525996 18251166 15052691 18472332 10355542 18376398 15362042 17922224 17900296 16638106 15123356 14748882 15057751 17557913 17631135 17761835 18420326 16015684 18263696 18277467 16011737 12632514 18395095 12898905 17766677 15730626 12958196 12546737 15876570 15673190 18339082 17481882 16116963 17869086 12586293 18054572 18166357 15370692 17640975 17698563 17976157 14620537 17708605 14512876 18705752 12649538 17944888 18006644 16033810 12445418 12632512 18472094 15996030 12389079 18317297 20821823 18429990 11481614 15893842 16136751 15650968 15925388 18481824 17565644 14716833 18418968 17721639 12741479 13678700 18156304
MESH:D008107 Liver Diseases Acetaminophen 6.8312587719 19014921 11587558 12969438 16610002 19460945 16611625 19784758
MESH:D008107 Liver Diseases Carbon Tetrachloride 6.8316246199 15720792 16964402 17285989 15830285
MESH:D008107 Liver Diseases Diethylnitrosamine 6.8317034775
MESH:D017093 Liver Failure Carbon Tetrachloride 4.5215123358
MESH:D017114 Liver Failure, Acute Acetaminophen 10.3117185352 16871587
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 10.3114706259 16899240
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 8.0521295105 19389873
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 8.0519294768
MESH:D008113 Liver Neoplasms Diethylnitrosamine 8.0518977376 16942905 19254457 19996281 19638242 21071580 18754104 19833225 19294768 19090486 18644402 9163691 19690152 19642983 19426721 20118626 21278145 20583210 20101389 20405173 18648771 15175105 19499222 2862719 20452335 2422723 19812893 21167192 20137499 18978307 12771043 19850985 19256749 15885732 12112319 10737359 19255062 19427195 20492335 19073162 20434301 20501860 21047994 19551842
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 10.8818164116
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 10.8812014681 15583823
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 10.8816267830 18544905 19539802 18079962 19009564 18775883 18093689 21159647 19126423 19004024 17174075 16842330 18308698 3124819 18164116 17854601 18253720 2563599 18282651 9362446 19519916 17942915
MESH:D008175 Lung Neoplasms Diethylnitrosamine 1.7620970405 20512841 6695378 21163286
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.663581430 9029167
MESH:D019636 Neurodegenerative Diseases Acetaminophen 8.9718514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 8.9720387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.5620387270
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.5016540662
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.802563599
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.197505956
MESH:D014581 Urticaria Acetaminophen 3.2810982225
Pathway ID Pathway Name
KEGG:00230 Purine metabolism
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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