AutismKB 2.0

Annotation Detail for TRPM5


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Basic Information Top
Gene Symbol:TRPM5 ( LTRPC5,MTR1 )
Gene Full Name: transient receptor potential cation channel, subfamily M, member 5
Band: 11p15.5
Quick LinksEntrez ID:29850; OMIM: 604600; Uniprot ID:TRPM5_HUMAN; ENSEMBL ID: ENSG00000070985; HGNC ID: 14323
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of TRPM5 mRNAincreases expression 18648102
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of TRPM5 mRNAdecreases expression 20713471
D003300 Copper TRPM5 protein affects the susceptibility to Copperaffects response to substance 19244541
D019327 Copper Sulfate TRPM5 protein affects the susceptibility to Copper Sulfateaffects response to substance 19244541
C020748 ferrous sulfate TRPM5 protein affects the susceptibility to ferrous sulfateaffects response to substance 19244541
D008278 Magnesium Sulfate TRPM5 protein affects the susceptibility to Magnesium Sulfateaffects response to substance 19244541
D012492 Salts TRPM5 protein affects the susceptibility to Saltsaffects response to substance 19244541
D018038 Sodium Selenite Sodium Selenite results in decreased expression of TRPM5 mRNAdecreases expression 18175754
D019287 Zinc Sulfate TRPM5 protein affects the susceptibility to Zinc Sulfateaffects response to substance 19244541
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Zinc Sulfate 5.197265320
MESH:D000142 Acidosis, Respiratory Copper Sulfate 6.757265320
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220464547 20127859
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.963712494
MESH:D000236 Adenoma Benzo(a)pyrene 6.966695378
MESH:D000544 Alzheimer Disease Copper 3.2716325427 16886094 16962711 16410023 16866297 17119284
MESH:D000690 Amyotrophic Lateral Sclerosis Copper 4.4110694572
MESH:D018798 Anemia, Iron-Deficiency Copper 5.0716614410
MESH:D000860 Anoxia Copper Sulfate 12.817265320
MESH:D000860 Anoxia Zinc Sulfate 12.817265320
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders ferrous sulfate 5.506421970
MESH:D001932 Brain Neoplasms Copper 4.7517079463
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.4820146248 17474063
MESH:D001943 Breast Neoplasms Copper 2.4815986119 17079463
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 1.763581430 7296757
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Copper 4.1217327471
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 2.897505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.309022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.0115894690
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.068970840 8156756 2524372 11906362 11298694 12868966 18759878 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003920 Diabetes Mellitus Sodium Selenite 3.9616285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.149653073 9328219 8291058 1440618 11289319 18289764 9022650 6679447 6482804 18692083 18648102 7440962 16192314
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.1415131321
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.513581430
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.5116530937
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006521 Hepatitis, Chronic Copper 5.5917338147
MESH:D006527 Hepatolenticular Degeneration Copper 12.3717276780 17182432 17109627 19888908 16607473
MESH:D006527 Hepatolenticular Degeneration Zinc Sulfate 12.3717063115
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006976 Hypertension, Pulmonary Copper Sulfate 5.227265320
MESH:D007022 Hypotension Zinc Sulfate 4.697265320
MESH:D007333 Insulin Resistance Sodium Selenite 3.4014714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.349022650 8074119
MESH:D007676 Kidney Failure, Chronic Copper 5.1016518626
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.146582329
MESH:D007859 Learning Disorders Copper 5.0517134702
MESH:D016773 Leishmaniasis, Cutaneous Zinc Sulfate 4.4315237267
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.319327722 15034207
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 5.1621137059 20195826
MESH:D008113 Liver Neoplasms Copper 5.1620302851
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.653712494 598648 1399818 6587162
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 1.5617053015 18816296 20464547 6695378 18520028 20869020 18569708 20064080 20135361
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.2814737004
MESH:D007706 Menkes Kinky Hair Syndrome Copper 6.1717268249 17109627
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2511141357
MESH:D009389 Neovascularization, Pathologic Copper 5.2317308104
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.614026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.6617292933
MESH:D011471 Prostatic Neoplasms Copper 2.6617079463 17308104
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.6618760546
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012559 Schizophrenia Copper 3.1016842975
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4519755658 10029692
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.041399818 7505956 6582329 6587162 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.208074119
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.2017053015
Pathway ID Pathway Name
KEGG:04742 Taste transduction
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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