AutismKB 2.0

Annotation Detail for ANAPC2


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Basic Information Top
Gene Symbol:ANAPC2 ( APC2,RP11-350O14.5 )
Gene Full Name: anaphase promoting complex subunit 2
Band: 9q34.3
Quick LinksEntrez ID:29882; OMIM: 606946; Uniprot ID:ANC2_HUMAN; ENSEMBL ID: ENSG00000176248; HGNC ID: 19989
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle Checkpoints
No data
Pathway IDPathway Name
P00013Cell cycle
Pathway IDPathway Name
500391Regulation of APC/C activators between G1/S and early anaphase
500395Phosphorylation of the APC/C
500390APC/C-mediated degradation of cell cycle proteins
500401Autodegradation of Cdh1 by Cdh1:APC/C
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ANAPC2 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ANAPC2 mRNAaffects expression 21346803
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of ANAPC2 mRNAdecreases expression 18648102
D012643 Selenium Selenium results in increased expression of ANAPC2 mRNAincreases expression 19244175
C017947 sodium arsenite sodium arsenite results in decreased expression of ANAPC2 mRNAdecreases expression 20308225
C017947 sodium arsenite sodium arsenite results in decreased expression of ANAPC2 mRNAdecreases expression 16014739
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.933712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.3115276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.5116712894 17306315
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.631440618 11289319
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.9416705839
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.947296757 3581430
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.9415276417 17306315 16507464
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.817296757
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4618572023
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 12.606135515
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 12.607505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 12.6019524636 20056578
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.4119486331 9022650
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.5618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.5618551238
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.2811298694 14531868 8970840 2524372 8156756 11906362 18759878 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.892952479 3621924
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 9.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 9.7121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 9.719653073 18289764 6679447 16192314 6482804 1440618 11289319 7440962 9022650 18648102 9328219 8291058 18692083
MESH:D056486 Drug-Induced Liver Injury Selenium 9.7115131321
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.173581430
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.636705139
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.2216452187
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.447505956
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.956705139
MESH:D006689 Hodgkin Disease sodium arsenite 3.4712676792
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.4215034207
MESH:D007248 Infertility, Male sodium arsenite 3.2115346721 12646999
MESH:D007251 Influenza, Human Selenium 4.8116624496
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.639022650 8074119
MESH:D007674 Kidney Diseases sodium arsenite 2.9820008137
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 14.2316705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 14.2316705839
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 14.236582329
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.4015034207 9327722
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.987678174
MESH:D008113 Liver Neoplasms sodium arsenite 4.9816712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.582876786 6135515 2876784
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.583712494 598648 6587162 1399818
MESH:D008171 Lung Diseases sodium arsenite 3.4019095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9019931552 17306315 16712894 15276417 17077188
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009336 Necrosis 2,4-dinitrotoluene 12.2118551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 12.217678174 18551238
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.583581430
MESH:D009369 Neoplasms sodium arsenite 2.6411559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.1520056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 7.996679447
MESH:D009436 Neural Tube Defects sodium arsenite 7.9912854658
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 17.1716049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 17.1716049721
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 17.174026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.633988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5215276417 17306315
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.977296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.086228378
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2416039940
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.643692021
MESH:D012640 Seizures 2,4-dinitrotoluene 6.6518551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.6518551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.8419524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0712854658
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.157505956 1399818 3712494 6582329 6587162
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.8916049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.8916049721
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 12.898074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 12.8911723127 16712894 16452187 17306315
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.8610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.8610091137
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.1111813266
MESH:D014652 Vascular Diseases sodium arsenite 4.9617056641
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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