AutismKB 2.0

Annotation Detail for CNOT7


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Basic Information Top
Gene Symbol:CNOT7 ( CAF1,hCAF-1 )
Gene Full Name: CCR4-NOT transcription complex, subunit 7
Band: 8p22
Quick LinksEntrez ID:29883; OMIM: 604913; Uniprot ID:CNOT7_HUMAN; ENSEMBL ID: ENSG00000198791; HGNC ID: 14101
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03018RNA degradation
Pathway IDPathway Name
Metabolism of RNA
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000638 Amiodarone Amiodarone results in increased expression of CNOT7 mRNAincreases expression 19774075
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CNOT7 mRNAdecreases expression 19150397
D012402 Rotenone Rotenone results in increased expression of CNOT7 mRNAincreases expression 18191903
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D001145 Arrhythmias, Cardiac Amiodarone 4.2518057881 18218290 20041841
MESH:D001281 Atrial Fibrillation Amiodarone 4.2318651412 19698954
MESH:D001778 Blood Coagulation Disorders Amiodarone 4.3819483382
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 3.0115710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 5.8318974383
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 3.0120889678
MESH:D056486 Drug-Induced Liver Injury Amiodarone 2.4818218290 15265979
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.1520426865
MESH:D005234 Fatty Liver Amiodarone 4.0014986274
MESH:D006529 Hepatomegaly Amiodarone 4.4015265979
MESH:D006937 Hypercholesterolemia Amiodarone 4.369751232 8137927
MESH:D007037 Hypothyroidism Amiodarone 5.1717991464 18020914
MESH:D008064 Lipidoses Amiodarone 3.8215342952 17567588
MESH:D008133 Long QT Syndrome Amiodarone 3.9215350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.6512587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 5.3418516814
MESH:D009181 Mycoses Amiodarone 5.7712754197 17974566
MESH:D009410 Nerve Degeneration Rotenone 4.2215790535 18619942 17356569
MESH:D010300 Parkinson Disease Rotenone 3.1015451049 19232380 18619942 11445065 16140633 11535288 16412576 19114014 18191903
MESH:D020734 Parkinsonian Disorders Rotenone 4.5215795934 15574749 18197244 15927086
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.9812832656 11597910 12490602
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 5.8318724381
MESH:D013276 Stomach Ulcer Amiodarone 3.7918087811
MESH:D013610 Tachycardia Amiodarone 4.8711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 4.7719225199
MESH:D013959 Thyroid Diseases Amiodarone 5.6219731979
MESH:D013971 Thyrotoxicosis Amiodarone 5.5118020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 4.9311989578 17467628
Pathway ID Pathway Name
REACT:21257 Metabolism of RNA
KEGG:03018 RNA degradation
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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