AutismKB 2.0

Annotation Detail for STRN4


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Basic Information Top
Gene Symbol:STRN4 ( FLJ35594,ZIN,zinedin )
Gene Full Name: striatin, calmodulin binding protein 4
Band: 19q13.32
Quick LinksEntrez ID:29888; OMIM: NA; Uniprot ID:STRN4_HUMAN; ENSEMBL ID: ENSG00000090372; HGNC ID: 15721
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
CANCER
Chronic lymphocytic leukemia
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of STRN4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of STRN4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of STRN4 mRNAaffects expression 17562736
D001241 Aspirin Aspirin results in increased expression of STRN4 mRNAincreases expression 11906190
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of STRN4 mRNAdecreases expression 20106945
D003024 Clozapine Clozapine results in increased expression of STRN4 mRNAincreases expression 14647396
D006220 Haloperidol Haloperidol results in increased expression of STRN4 mRNAincreases expression 14647396
C006253 pirinixic acid pirinixic acid results in increased expression of STRN4 mRNAincreases expression 12832660
D011794 Quercetin Quercetin affects the expression of STRN4 mRNAaffects expression 18178720
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D055371 Acute Lung Injury pirinixic acid 3.3418653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 2.0220127859 20464547
MESH:D000236 Adenoma Benzo(a)pyrene 2.766695378
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7616434500
MESH:D000380 Agranulocytosis Clozapine 5.3112649775 14617031 16160616
MESH:D000743 Anemia, Hemolytic Quercetin 4.4517084956
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.3319183758
MESH:D055963 Asthma, Aspirin-Induced Aspirin 4.8720485159 12372130
MESH:D001260 Ataxia Telangiectasia Quercetin 5.2615336622
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001327 Autoimmune Diseases Quercetin 4.6719761891
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3519483382
MESH:D001932 Brain Neoplasms Aspirin 4.6115481559
MESH:D001943 Breast Neoplasms Aspirin 2.0615161893
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 2.0617474063 20146248
MESH:D001943 Breast Neoplasms Quercetin 2.0618628248
MESH:D002105 Cadmium Poisoning Quercetin 5.8616962696
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.803084413
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.8012508355 19519916
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2117234771
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.1020419170
MESH:D006332 Cardiomegaly Quercetin 3.4219794523
MESH:D002375 Catalepsy Haloperidol 5.1915215559 1977408
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 2.906135515
MESH:D002779 Cholestasis pirinixic acid 2.9719176532
MESH:D003072 Cognition Disorders Clozapine 5.2217123785
MESH:D003110 Colonic Neoplasms Aspirin 4.2812411196
MESH:D003110 Colonic Neoplasms Quercetin 4.2817148506 11134977 17191121 15741050 19056647 16640504 19440933
MESH:D015179 Colorectal Neoplasms Aspirin 2.9817047198
MESH:D015179 Colorectal Neoplasms Quercetin 2.9818095365 18852136
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.7718551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.7718551238
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0620210726
MESH:D003704 Dementia Haloperidol 4.7811575062
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5118249437
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9019496084
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 3.0116402076
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8715331141
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.4818551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.4821346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.4819420014 17906064 16485898 18071297 19085960 11743745 16227642 16081117 17522070 19739265 12594235 11739529 16177239 19416960 19923254 11461765 10774834 11287661 2444490 16109766 12540782 16781746 12958197 10915739 14986274 12705907 11834606 11529661 12392966 14725611 10663392 15968718 16393943 19164858 18713872 12153990 19370779 11421492 14550746 15619225 17562736
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D050171 Dyslipidemias Clozapine 4.3316402076
MESH:D004487 Edema Aspirin 7.7817259670
MESH:D004487 Edema pirinixic acid 7.7812083418
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0516530937
MESH:D005234 Fatty Liver pirinixic acid 2.9720131406 19236843
MESH:D005355 Fibrosis Quercetin 4.1619474275
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005909 Glioblastoma Aspirin 8.0312870263
MESH:D005909 Glioblastoma Quercetin 8.0319804834
MESH:D005910 Glioma Quercetin 3.1217643826
MESH:D006261 Headache Aspirin 5.2815240983
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7520471113
MESH:D006333 Heart Failure pirinixic acid 2.6520558911
MESH:D006529 Hepatomegaly pirinixic acid 3.2519772884 18467677 16221962 19176532
MESH:D012001 Hyperacusis Aspirin 6.0815240983
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006943 Hyperglycemia pirinixic acid 9.8920558911
MESH:D006943 Hyperglycemia Quercetin 9.8918262572 11834736
MESH:D006948 Hyperkinesis Clozapine 5.1916046005
MESH:D006973 Hypertension Quercetin 2.9218356687
MESH:D007251 Influenza, Human Quercetin 4.8216624496
MESH:D007333 Insulin Resistance pirinixic acid 2.7616306350
MESH:D007627 Keloid Quercetin 5.2117086741
MESH:D007674 Kidney Diseases Acetaminophen 6.4412587719 15629191
MESH:D007674 Kidney Diseases Quercetin 6.4416962696
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.9416705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 7.9416705839
MESH:D007938 Leukemia Quercetin 3.2517468513
MESH:D008064 Lipidoses Clozapine 4.1017567588
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.5412741479
MESH:D008107 Liver Diseases Acetaminophen 1.6716611625 19784758 12969438 19014921 12587719 19460945 11587558 16610002
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 11.287678174
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 11.2820195826 21137059
MESH:D008113 Liver Neoplasms pirinixic acid 11.2820007298 16377806 15890375
MESH:D008113 Liver Neoplasms Quercetin 11.2818980244
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.492876786 2876784 6135515
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.4919519916
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.5818520028 18816296 6695378 18569708 20464547 20869020 17053015 20135361 20064080
MESH:D008175 Lung Neoplasms Quercetin 2.5816280456
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D001523 Mental Disorders Clozapine 9.3316856516
MESH:D001523 Mental Disorders Haloperidol 9.3316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5819142101
MESH:D008881 Migraine Disorders Aspirin 4.2115240983
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.3516381670
MESH:D009135 Muscular Diseases pirinixic acid 3.7616239165
MESH:D009203 Myocardial Infarction Aspirin 10.0212692751
MESH:D009203 Myocardial Infarction pirinixic acid 10.0219151258
MESH:D009203 Myocardial Infarction Quercetin 10.0219595682
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.9716411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 8.9719207477
MESH:D009325 Nausea Aspirin 5.5315240983
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.3218551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.327678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 8.7911141357
MESH:D009369 Neoplasms pirinixic acid 8.7917405874
MESH:D009369 Neoplasms Quercetin 8.7915185748
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.5817929310
MESH:D009765 Obesity Clozapine 4.8519142110 18515891
MESH:D009765 Obesity pirinixic acid 4.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.5412819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.5416049721
MESH:D010003 Osteoarthritis Aspirin 4.177009135
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4419495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.7819005980
MESH:D010146 Pain Acetaminophen 7.5116870215
MESH:D010146 Pain Aspirin 7.516363464 6995502
MESH:D010190 Pancreatic Neoplasms Quercetin 2.9116965848
MESH:D010438 Peptic Ulcer Hemorrhage Aspirin 5.8211156591
MESH:D020795 Photophobia Aspirin 6.0815240983
MESH:D011230 Precancerous Conditions Quercetin 4.1619056647
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2517292933
MESH:D011471 Prostatic Neoplasms Quercetin 3.2514715546 17292933
MESH:D011595 Psychomotor Agitation Haloperidol 5.2111575062
MESH:D011618 Psychotic Disorders Clozapine 9.6415331141
MESH:D011618 Psychotic Disorders Haloperidol 9.6411575062
MESH:D015427 Reperfusion Injury pirinixic acid 2.4719058328
MESH:D012220 Rhinitis Aspirin 4.5712372130
MESH:D012554 Schistosomiasis japonica Quercetin 5.8616862918
MESH:D012559 Schizophrenia Clozapine 4.1820107430 20521320 17726453 17667964 20580759 11763009 18855531 17123785 20521326 20168265 11151749 18806925 20452607 19369910 16141801
MESH:D012559 Schizophrenia Haloperidol 4.181830565 20107430 18513383 19369910
MESH:D012640 Seizures 2,4-dinitrotoluene 6.3218551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.3218551238
MESH:D012851 Sinus Thrombosis, Intracranial Aspirin 5.5212269725
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4510029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.5620155912 2093021
MESH:D020521 Stroke Aspirin 4.5416403987
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9420210726
MESH:D013927 Thrombosis Aspirin 4.7017672075
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 12.5216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 12.5216049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 12.5217053015
MESH:D001749 Urinary Bladder Neoplasms Quercetin 12.5216720314
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.9610091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.9610091137
MESH:D014581 Urticaria Acetaminophen 9.6510982225
MESH:D014581 Urticaria Aspirin 9.6520485159 10982225
MESH:D015430 Weight Gain Clozapine 4.6517502770 20521320 20107430 20564506 16141801 16402076
MESH:D015431 Weight Loss Clozapine 5.3617933447
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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