AutismKB 2.0

Annotation Detail for CPSF1


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Basic Information Top
Gene Symbol:CPSF1 ( CPSF160,HSU37012,P/cl.18 )
Gene Full Name: cleavage and polyadenylation specific factor 1, 160kDa
Band: 8q24.3
Quick LinksEntrez ID:29894; OMIM: 606027; Uniprot ID:CPSF1_HUMAN; ENSEMBL ID: ENSG00000071894; HGNC ID: 2324
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Post-Elongation Processing of the Transcript
Transcription
mRNA Processing
Gene Expression
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of CPSF1 mRNAaffects expression 21346803
D008727 Methotrexate CPSF1 protein affects the susceptibility to Methotrexateaffects response to substance 16217747
C006253 pirinixic acid pirinixic acid results in decreased expression of CPSF1 mRNAdecreases expression 17426115
D012643 Selenium Selenium results in increased expression of CPSF1 mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of CPSF1 mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 4.7812039119
MESH:D055371 Acute Lung Injury pirinixic acid 3.5218653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 4.0216434500
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.1617286800
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.5219483382
MESH:D001943 Breast Neoplasms Methotrexate 3.0716978400
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 1.7916705839
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 3.006135515
MESH:D002779 Cholestasis pirinixic acid 3.0819176532
MESH:D003092 Colitis Selenium 4.2617936198
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.089562676 12039119
MESH:D019465 Craniofacial Abnormalities Vitamin E 3.0819769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.5018551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.5819747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.5618249437
MESH:D003882 Dermatomyositis Methotrexate 5.5720191521
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 4.2118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Selenium 4.2115131321
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004487 Edema pirinixic acid 2.8512083418
MESH:D005234 Fatty Liver pirinixic acid 3.1419236843 20131406
MESH:D006086 Graft vs Host Disease Methotrexate 5.6316518429
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1516080930
MESH:D006333 Heart Failure pirinixic acid 7.6220558911
MESH:D006333 Heart Failure Selenium 7.6217162251
MESH:D006529 Hepatomegaly pirinixic acid 3.4816221962 19772884 19176532 18467677
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016490937 16863852
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006943 Hyperglycemia pirinixic acid 3.5320558911
MESH:D007251 Influenza, Human Selenium 13.0916624496
MESH:D007251 Influenza, Human Vitamin E 13.0916624496
MESH:D007333 Insulin Resistance pirinixic acid 2.8516306350
MESH:D007674 Kidney Diseases Vitamin E 2.9812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 3.2816705839
MESH:D007805 Language Development Disorders Methotrexate 5.519562676
MESH:D008103 Liver Cirrhosis Methotrexate 3.8714986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.4615474484
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.4616169303
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.777678174
MESH:D008113 Liver Neoplasms pirinixic acid 4.7715890375 20007298 16377806
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.746135515 2876784 2876786
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D017563 Lung Diseases, Interstitial Methotrexate 5.6318516814
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008223 Lymphoma Methotrexate 4.1917352296
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D052016 Mucositis Methotrexate 5.8217488658
MESH:D009135 Muscular Diseases pirinixic acid 3.9916239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2619151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.2216411023
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.4018551238 7678174
MESH:D009369 Neoplasms pirinixic acid 2.0917405874
MESH:D009765 Obesity pirinixic acid 1.8820558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7816049721
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2515084515
MESH:D011565 Psoriasis Methotrexate 3.5317410198
MESH:D051437 Renal Insufficiency Methotrexate 5.2017352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.5319058328
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7618551238
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D013576 Syndactyly Methotrexate 5.479562676
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 2.4016049721
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.8610091137
Pathway ID Pathway Name
REACT:71 Gene Expression
REACT:1675 mRNA Processing
KEGG:03015 mRNA surveillance pathway
REACT:78 Post-Elongation Processing of the Transcript
REACT:1788 Transcription
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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