AutismKB 2.0

Annotation Detail for MYLPF


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Basic Information Top
Gene Symbol:MYLPF ( DKFZp779C0757,HUMMLC2B,MGC13450,MRLC2,MYL11 )
Gene Full Name: myosin light chain, phosphorylatable, fast skeletal muscle
Band: 16p11.2
Quick LinksEntrez ID:29895; OMIM: NA; Uniprot ID:MLRS_HUMAN; ENSEMBL ID: ENSG00000180209; HGNC ID: 29824
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04670Leukocyte transendothelial migration
hsa04530Tight junction
hsa04810Regulation of actin cytoskeleton
hsa04510Focal adhesion
No data
Pathway IDPathway Name
200113ErbB1 downstream signaling
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in decreased expression of MYLPF mRNAdecreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of MYLPF mRNAaffects expression 16483693
D000431 Ethanol Ethanol results in decreased expression of MYLPF mRNAdecreases expression 15513904
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Ethanol 4.6617676605 18926900
MESH:D000138 Acidosis Ammonium Chloride 13.0818287403
MESH:D000138 Acidosis Ethanol 13.0811192467
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.983712494
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 6.1915451039 15451040
MESH:D000853 Anophthalmos Ethanol 5.4715513904
MESH:D001008 Anxiety Disorders Ethanol 4.3711141031
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.8911289319 1440618
MESH:D002056 Burns Ethanol 5.3016374292
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 3.343581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Ethanol 3.3415289165 15763234 18788625
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.847296757
MESH:D006332 Cardiomegaly Ethanol 3.6519332462
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 3.057505956
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.479022650 19486331
MESH:D002971 Cleft Lip Ethanol 3.7815513904
MESH:D002972 Cleft Palate Ethanol 3.3215513904
MESH:D019465 Craniofacial Abnormalities Ethanol 2.3415451039 11198716 19302082 11873399 10194807 15451040 15513904
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.4414531868 8156756 12868966 18759878 11298694 8970840 2524372 11906362
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 4.023621924 2952479
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.4211289319 9653073 18289764 1440618 18692083 6679447 6482804 16192314 18648102 9328219 8291058 9022650 7440962
MESH:D056486 Drug-Induced Liver Injury Ethanol 4.4211566570
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.933581430
MESH:D004938 Esophageal Neoplasms Ethanol 4.9316704527
MESH:D005234 Fatty Liver Ethanol 4.2116409862 19236843 18620774
MESH:D005235 Fatty Liver, Alcoholic Ethanol 6.5317920746
MESH:D005310 Fetal Alcohol Syndrome Ethanol 6.0416946407 15451040 10194807 15513904
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.896705139
MESH:D005756 Gastritis Ethanol 5.5615046732
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.577505956
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.106705139
MESH:D006930 Hyperalgesia Ethanol 4.0818783367
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5915034207
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.899022650 8074119
MESH:D007569 Jaw Abnormalities Ethanol 4.8915513904
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 3.356582329
MESH:D007859 Learning Disorders Ethanol 4.8615451040
MESH:D017880 Limb Deformities, Congenital Ethanol 4.1217676605
MESH:D008103 Liver Cirrhosis Ethanol 3.5815289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 5.8418295389
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.449327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 2.3218166357
MESH:D008108 Liver Diseases, Alcoholic Ethanol 5.3017347304 17207112
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.781399818 598648 3712494 6587162
MESH:D008569 Memory Disorders Ethanol 4.7718411066 15451040
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.613581430
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.186679447
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.876482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.893988306
MESH:D010190 Pancreatic Neoplasms Ethanol 3.0912384795
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.137296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.346228378
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.703692021
MESH:D012640 Seizures Ethanol 3.459754883
MESH:D013274 Stomach Neoplasms Ethanol 2.3118456281
MESH:D013276 Stomach Ulcer Ethanol 4.019562338 11906479 9211565 17918041 17189318 16755016
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.709754883
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.223712494 1399818 6582329 7505956 6587162
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.418074119
Pathway ID Pathway Name
KEGG:04510 Focal adhesion
KEGG:04670 Leukocyte transendothelial migration
KEGG:04810 Regulation of actin cytoskeleton
KEGG:04530 Tight junction
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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