AutismKB 2.0

Annotation Detail for SAC3D1


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Basic Information Top
Gene Symbol:SAC3D1 ( HSU79266,SHD1 )
Gene Full Name: SAC3 domain containing 1
Band: 11q13.1
Quick LinksEntrez ID:29901; OMIM: NA; Uniprot ID:F8WC89_HUMAN; ENSEMBL ID: ENSG00000168061; HGNC ID: 30179
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of SAC3D1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SAC3D1 proteinaffects expression 20106945
C006780 bisphenol A bisphenol A results in increased expression of SAC3D1 mRNAincreases expression 16474171
D004958 Estradiol Estradiol results in increased expression of SAC3D1 mRNAincreases expression 16474171
D019833 Genistein Genistein results in increased expression of SAC3D1 mRNAincreases expression 16474171
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of SAC3D1 mRNAincreases expression 16474171
D018038 Sodium Selenite Sodium Selenite results in increased expression of SAC3D1 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Estradiol 4.6611473722
MESH:D000230 Adenocarcinoma Genistein 4.6611473722
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001862 Bone Resorption bisphenol A 4.1411985600
MESH:D001943 Breast Neoplasms bisphenol A 1.9617123778
MESH:D001943 Breast Neoplasms Estradiol 1.9617261762 12948864 17018787 19861407 18497071 14630087 17289903 16675129
MESH:D001943 Breast Neoplasms Genistein 1.9617200150 16541309 16873071
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.873084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.8712619106 12907637 21507988
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8716924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.8716924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.3817123778
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D019457 Chromosome Breakage Sodium Selenite 5.1115894690
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 2.7315531428
MESH:D003704 Dementia Polychlorinated Biphenyls 4.9816140633
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.0316285004
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5416647724
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 4.0519164858 16227642 19370779 11834606 12153990 11461765 10774834 11287661 10663392 17906064 15619225 10915739 16177239 14725611 12392966 11739529 19923254 19739265 2444490 12540782 15968718 18071297 18713872 11743745 11421492 11529661 19420014 16781746 16081117 19416960 19085960 14986274 16393943 14550746 12594235 12705907 17522070 12958197 16485898 16109766 17562736
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.0515131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004714 Endometrial Hyperplasia Genistein 4.9916402032
MESH:D016889 Endometrial Neoplasms Estradiol 8.0811473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Genistein 8.0811473722
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D007333 Insulin Resistance bisphenol A 13.4116393666
MESH:D007333 Insulin Resistance Estradiol 13.4116393666 16627594
MESH:D007333 Insulin Resistance Sodium Selenite 13.4114714311
MESH:D007674 Kidney Diseases Acetaminophen 6.3712587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3715618244
MESH:D007680 Kidney Neoplasms Estradiol 3.2115610895
MESH:D007938 Leukemia Genistein 3.1417468513 18980019
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 2.6314716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.6317823541
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 11587558 12969438 16611625 19784758 16610002 19014921 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5016871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 2.432125692 15890375 9163691 18177683
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.898603461
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 6.891423854
MESH:D008175 Lung Neoplasms Aflatoxin B1 1.8714755239
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.3614737004
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6511408345 11807958 17203775 16891317
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6512929590 14578162
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2317141266
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations bisphenol A 18.4811399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 18.4811399458 16427766
MESH:D009421 Nervous System Malformations Genistein 18.4816427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010049 Ovarian Diseases bisphenol A 5.3811985600
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1419005980
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.4716702228
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.3510548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 11.5120887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 11.5120887781
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8716740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8716740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8715256057 16925846 15378649
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 1.8715721890
MESH:D011471 Prostatic Neoplasms Sodium Selenite 1.8718760546
MESH:D011629 Puberty, Precocious bisphenol A 5.1810548101
MESH:D019966 Substance-Related Disorders bisphenol A 4.3816045194 16684133
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D014591 Uterine Diseases bisphenol A 5.4514652134
No data
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Syndromic Genes

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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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