AutismKB 2.0

Annotation Detail for NME7


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Basic Information Top
Gene Symbol:NME7 ( FLJ37194,MN23H7,nm23-H7 )
Gene Full Name: non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase)
Band: 1q24.2
Quick LinksEntrez ID:29922; OMIM: 613465; Uniprot ID:NDK7_HUMAN; ENSEMBL ID: ENSG00000143156; HGNC ID: 20461
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5687pyrimidine ribonucleotides interconversion
PWY0-163salvage pathways of pyrimidine ribonucleotides
PWY0-162pyrimidine ribonucleotides de novo biosynthesis
PWY0-166pyrimidine deoxyribonucleotides de novo biosynthesis
Pathway IDPathway Name
hsa00240Pyrimidine metabolism
hsa00230Purine metabolism
hsa01100Metabolic pathways
No data
No data
Pathway IDPathway Name
P02738De novo purine biosynthesis
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of NME7 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of NME7 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of NME7 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of NME7 proteinaffects expression 20106945
D000643 Ammonium Chloride Ammonium Chloride affects the expression of NME7 mRNAaffects expression 16483693
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of NME7 mRNAdecreases expression 20106945
20064835
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of NME7 mRNAincreases expression 20127859
C006780 bisphenol A bisphenol A results in increased expression of NME7 mRNAincreases expression 17010207
D016572 Cyclosporine Cyclosporine results in increased expression of NME7 mRNAincreases expression 20106945
C025034 doxifluridine NME7 protein results in decreased susceptibility to doxifluridinedecreases response to substance 16734730
D005419 Flavonoids Flavonoids results in decreased expression of NME7 mRNAdecreases expression 18035473
D019833 Genistein Genistein results in increased expression of NME7 mRNAincreases expression 17010207
C025256 nonylphenol nonylphenol results in increased expression of NME7 mRNAincreases expression 17010207
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7118287403
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.5120464547 20127859
MESH:D000230 Adenocarcinoma Genistein 4.5111473722
MESH:D000236 Adenoma Benzo(a)pyrene 2.716695378
MESH:D000799 Angioedema Acetaminophen 4.0210982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.2119183758
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001862 Bone Resorption bisphenol A 3.9711985600
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 1.9417123778
MESH:D001943 Breast Neoplasms Genistein 1.9417200150 16541309 16873071
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 9.0416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 9.0416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 9.043084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 9.0421507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Genistein 9.0416924424
MESH:D002278 Carcinoma in Situ bisphenol A 5.1417123778
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 2.0820419170
MESH:D002318 Cardiovascular Diseases Genistein 3.3816332659
MESH:D002386 Cataract Acetaminophen 2.6410977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.826135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.8212371664
MESH:D002779 Cholestasis Cyclosporine 3.0019486331
MESH:D003110 Colonic Neoplasms Genistein 2.3017182828
MESH:D003490 Cyanosis 2,4-dinitrotoluene 11.3618551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 11.3618551238
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 2.5116647724
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.3521346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.3512540782 16177239 16393943 19923254 11743745 15619225 19164858 12958197 19370779 11287661 17562736 19739265 16485898 16081117 12153990 17522070 11739529 11461765 18713872 16109766 12594235 16227642 10663392 11421492 12705907 16781746 17906064 14725611 11529661 10915739 19420014 19416960 12392966 19085960 14550746 11834606 18071297 15968718 10774834 2444490 14986274
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.2719426721
MESH:D004714 Endometrial Hyperplasia Genistein 4.7416402032
MESH:D016889 Endometrial Neoplasms Genistein 3.4311473722
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0316530937
MESH:D005234 Fatty Liver Cyclosporine 2.9619224547
MESH:D005355 Fibrosis Cyclosporine 3.2812639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.8516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.378708960
MESH:D005909 Glioblastoma Genistein 3.3316598420
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 2.7120471113
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.5815720958
MESH:D006930 Hyperalgesia Acetaminophen 2.7916870215
MESH:D006973 Hypertension Cyclosporine 2.1310903974
MESH:D007249 Inflammation Flavonoids 2.7017296493
MESH:D007333 Insulin Resistance bisphenol A 3.3616393666
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.6215604871
MESH:D007674 Kidney Diseases Acetaminophen 5.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 5.9918776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 12.9116705839
MESH:D007680 Kidney Neoplasms Cyclosporine 12.9112371664
MESH:D007938 Leukemia Genistein 3.0718980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Genistein 2.0617823541
MESH:D008107 Liver Diseases Acetaminophen 1.6519014921 19784758 19460945 11587558 12969438 16610002 16611625 12587719
MESH:D017114 Liver Failure, Acute Acetaminophen 3.3417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.667678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 7.662125692 18177683 9163691 15890375
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.6621137059 20195826
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.192876784 6135515 2876786
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 6.198603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 2.4414755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 2.446695378 18816296 20869020 17053015 18520028 20464547 20064080 18569708 20135361
MESH:D008325 Mammary Neoplasms, Experimental Genistein 3.0112929590 14578162
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7119513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.9616801185
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.2716381670
MESH:D009203 Myocardial Infarction Genistein 2.9017141266
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.7417141266
MESH:D009336 Necrosis 2,4-dinitrotoluene 10.8718551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 10.877678174 18551238
MESH:D009369 Neoplasms Benzo(a)pyrene 2.2211141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.6217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3819348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 10.3116427766 11399458
MESH:D009421 Nervous System Malformations Genistein 10.3116427766
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9618514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.2316049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.2316049721
MESH:D010024 Osteoporosis Genistein 3.3219401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.2016169203
MESH:D010049 Ovarian Diseases bisphenol A 5.1411985600
MESH:D010051 Ovarian Neoplasms Genistein 2.6319005980
MESH:D010146 Pain Acetaminophen 2.4816870215
MESH:D011230 Precancerous Conditions Cyclosporine 3.3212371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 4.1010548101
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 4.3220887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 2.5717292933
MESH:D011471 Prostatic Neoplasms bisphenol A 2.5716740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5716925846 15378649 15256057
MESH:D011565 Psoriasis Cyclosporine 2.2616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.9410548101
MESH:D012640 Seizures 2,4-dinitrotoluene 6.1118551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.1118551238
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 2.4110029692 19755658
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 1.562093021 20155912
MESH:D019966 Substance-Related Disorders bisphenol A 4.1416684133 16045194
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.5016049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 8.5017053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.5110091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.5110091137
MESH:D014581 Urticaria Acetaminophen 3.0910982225
MESH:D014591 Uterine Diseases bisphenol A 5.1814652134
MESH:D014605 Uveitis Cyclosporine 4.161336536
MESH:D014985 Xerophthalmia Cyclosporine 4.6217120751
Pathway ID Pathway Name
KEGG:01100 Metabolic pathways
KEGG:00230 Purine metabolism
KEGG:00240 Pyrimidine metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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