AutismKB 2.0

Annotation Detail for GMPPB


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Basic Information Top
Gene Symbol:GMPPB ( KIAA1851 )
Gene Full Name: GDP-mannose pyrophosphorylase B
Band: 3p21.31
Quick LinksEntrez ID:29925; OMIM: NA; Uniprot ID:GMPPB_HUMAN; ENSEMBL ID: ENSG00000173540; HGNC ID: 22932
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5659GDP-mannose biosynthesis
COLANSYN-PWYcolanic acid building blocks biosynthesis
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of proteins
No data
Pathway IDPathway Name
P02752Mannose metabolism
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of GMPPB mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GMPPB mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GMPPB mRNAaffects expression 17562736
D002251 Carbon Tetrachloride Carbon Tetrachloride affects the expression of GMPPB mRNAaffects expression 17484886
D016572 Cyclosporine Cyclosporine results in increased expression of GMPPB mRNAincreases expression 20106945
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of GMPPB mRNAdecreases expression 17557909
D008767 Methylmercury Compounds Methylmercury Compounds results in increased expression of GMPPB mRNAincreases expression 16966085
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GMPPB mRNAaffects binding|decreases expression|increases activity 19710929
D043343 Testosterone Propionate Testosterone Propionate results in decreased expression of GMPPB mRNAdecreases expression 15601916
D014303 Trinitrotoluene Trinitrotoluene affects the expression of GMPPB mRNAaffects expression 21346803
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 4.427525203
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2117505938
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.6811256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7615885639
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D002252 Carbon Tetrachloride Poisoning Carbon Tetrachloride 3.9918705752 16227642 16050911 15721981 16097048 15673190 16124888 15700767 16011737 10355542 16192424 3786805
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.7416705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.743084413
MESH:D006528 Carcinoma, Hepatocellular Carbon Tetrachloride 6.7418788625
MESH:D002386 Cataract Acetaminophen 7.8210977129
MESH:D002386 Cataract Trinitrotoluene 7.8215817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 6.966135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 6.9612371664
MESH:D002779 Cholestasis Cyclosporine 14.0919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.0917110522 11677210 15861022 16919318 17333356 17681005 16105132
MESH:D002779 Cholestasis pirinixic acid 14.0919176532
MESH:D000013 Congenital Abnormalities Trinitrotoluene 4.5515095906
MESH:D003490 Cyanosis 2,4-dinitrotoluene 20.1218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 20.1218551238
MESH:D003490 Cyanosis Trinitrotoluene 20.1218551238
MESH:D003704 Dementia Methylmercury Compounds 5.1716140633
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 12.5218551238 21346803
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 12.5221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 12.5210663392 14986274 17906064 14725611 11287661 16081117 10915739 16227642 12705907 11834606 19370779 16781746 19923254 18071297 16177239 11461765 19164858 19416960 14550746 16109766 19420014 19739265 11739529 17522070 12594235 11421492 19085960 12958197 10774834 12153990 12392966 16393943 12540782 16485898 15968718 2444490 11529661 11743745 17562736 18713872 15619225
MESH:D056486 Drug-Induced Liver Injury Carbon Tetrachloride 12.529327722 7179309 21278145 6884620 17522070 3786805 2869522 6623471 10915739 11566570 4309450 19336974 7440962 7120509 15968718 15027814 16177239 15998439 3732212 10092053 19085960 16227642
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 12.5218551238 21346803
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 2.6512083418
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.3812538720
MESH:D005234 Fatty Liver Carbon Tetrachloride 20.2212631006 16045604 15959796 61145 12795759 17595544 16239168 19224547
MESH:D005234 Fatty Liver Cyclosporine 20.2219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 20.2215345470
MESH:D005234 Fatty Liver pirinixic acid 20.2220131406 19236843
MESH:D005355 Fibrosis Carbon Tetrachloride 9.4018705752
MESH:D005355 Fibrosis Cyclosporine 9.4012639820 12168785
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.468708960
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.6615720958
MESH:D006505 Hepatitis Carbon Tetrachloride 3.7919110552 19900420
MESH:D006529 Hepatomegaly pirinixic acid 9.4818467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Trinitrotoluene 9.4815817613
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006932 Hyperbilirubinemia Carbon Tetrachloride 4.7716899240
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Cyclosporine 2.1510903974
MESH:D006975 Hypertension, Portal Carbon Tetrachloride 4.3015338365
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0216945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6512013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 7.2617937319
MESH:D007248 Infertility, Male Trinitrotoluene 7.2612150543
MESH:D007333 Insulin Resistance pirinixic acid 2.7416306350
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7115604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1015629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 6.1018776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 13.2216705839
MESH:D007680 Kidney Neoplasms Cyclosporine 13.2212371664
MESH:D008103 Liver Cirrhosis Carbon Tetrachloride 2.8916221502 16943688 17174718 11408273 16239168 17157831 11903743 21278145 17334410
MESH:D008106 Liver Cirrhosis, Experimental Carbon Tetrachloride 2.3712586293 17708605 15362042 18006644 18339082 15893842 15996030 15370692 15123356 18251166 18205269 12389079 15818738 17714472 17721639 16638106 12741479 18472094 10355542 18472332 17761835 12666154 18279442 12898905 18429990 12649538 14716833 18277467 18263696 17805973 18156304 14748882 15959796 17557913 18166357 16015684 17976157 15730626 20821823 15925388 18187930 12632514 17525996 18210741 16011737 18376398 12667390 12445418 18418968 15338365 18420326 16136751 17565644 17922224 18395095 17698563 12609069 12546737 15057751 15673190 18317297 17481882 17944888 14620537 15876570 16248980 17631135 15650968 12445421 14724832 18705752 14512876 17640975 18395914 18481824 18412020 16192424 17823541 16097048 17869086 12632512 15931870 17900296 18054572 16033810 14716496 16116963 15052691 17766677 11481614 12958196 16027843 13678700
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 2.3715474484
MESH:D008107 Liver Diseases Acetaminophen 4.0312969438 16611625 19014921 11587558 19460945 12587719 19784758 16610002
MESH:D008107 Liver Diseases Carbon Tetrachloride 4.0316246199 15720792 15830285 16964402 17285989
MESH:D017093 Liver Failure Carbon Tetrachloride 4.3815123358
MESH:D017114 Liver Failure, Acute Acetaminophen 9.9516871587 17185352
MESH:D017114 Liver Failure, Acute Carbon Tetrachloride 9.9514706259 16899240
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 7.737678174
MESH:D008113 Liver Neoplasms Carbon Tetrachloride 7.7319294768
MESH:D008113 Liver Neoplasms pirinixic acid 7.7316377806 20007298 15890375
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 6.266135515 2876784 2876786
MESH:D008114 Liver Neoplasms, Experimental Carbon Tetrachloride 6.2612014681 15583823
MESH:D008546 Melanoma, Experimental Acetaminophen 3.7819513568
MESH:D008569 Memory Disorders Methylmercury Compounds 5.1018436314
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.0516801185
MESH:D009069 Movement Disorders Methylmercury Compounds 5.5118436314
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0816411023
MESH:D009336 Necrosis 2,4-dinitrotoluene 19.2418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 19.247678174 18551238
MESH:D009336 Necrosis Trinitrotoluene 19.2418551238
MESH:D009369 Neoplasms pirinixic acid 2.0217405874
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4419348381 18481113
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 16.1616049721 12819281
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 16.1616049721
MESH:D009784 Occupational Diseases Trinitrotoluene 16.1612819281 17852074 14694615
MESH:D010146 Pain Acetaminophen 2.5316870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.8711578682
MESH:D011230 Precancerous Conditions Cyclosporine 3.3712371664
MESH:D011297 Prenatal Exposure Delayed Effects Methylmercury Compounds 5.2218436314
MESH:D011537 Pruritus Ethinyl Estradiol 3.5515861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2816882103
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012640 Seizures 2,4-dinitrotoluene 10.5918551238
MESH:D012640 Seizures 2,6-dinitrotoluene 10.5918551238
MESH:D012640 Seizures Trinitrotoluene 10.5918551238
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2116709447
MESH:D013163 Splenomegaly Trinitrotoluene 5.4215817613
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8011994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3015669648
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.2116049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.2116049721
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 12.8010091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 12.8010091137
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5014692618
MESH:D014605 Uveitis Cyclosporine 4.251336536
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7115869587 14671159
MESH:D014985 Xerophthalmia Cyclosporine 4.7117120751
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
KEGG:00051 Fructose and mannose metabolism
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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