AutismKB 2.0

Annotation Detail for GMPPA


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Basic Information Top
Gene Symbol:GMPPA ( - )
Gene Full Name: GDP-mannose pyrophosphorylase A
Band: 2q35
Quick LinksEntrez ID:29926; OMIM: NA; Uniprot ID:GMPPA_HUMAN; ENSEMBL ID: ENSG00000144591; HGNC ID: 22923
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-5659GDP-mannose biosynthesis
COLANSYN-PWYcolanic acid building blocks biosynthesis
Pathway IDPathway Name
hsa00520Amino sugar and nucleotide sugar metabolism
hsa01100Metabolic pathways
hsa00051Fructose and mannose metabolism
Pathway IDPathway Name
Metabolism of proteins
No data
Pathway IDPathway Name
P02752Mannose metabolism
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of GMPPA mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of GMPPA mRNAaffects expression 17562736
D016572 Cyclosporine Cyclosporine results in increased expression of GMPPA mRNAincreases expression 20106945
D002945 Cisplatin GMPPA protein results in decreased susceptibility to Cisplatindecreases response to substance 16734730
D015735 Mifepristone Mifepristone results in decreased expression of GMPPA mRNAdecreases expression 17584828
D012643 Selenium Selenium results in increased expression of GMPPA mRNAincreases expression 19244175
D014810 Vitamin E Vitamin E results in increased expression of GMPPA mRNAincreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D058186 Acute Kidney Injury Cisplatin 4.2415814532 17670903 12690470
MESH:D000230 Adenocarcinoma Cisplatin 2.8111798837 17638652
MESH:D000799 Angioedema Acetaminophen 4.2910982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D019046 Bone Marrow Neoplasms Cisplatin 5.3314601052
MESH:D001943 Breast Neoplasms Cisplatin 2.7718382427 19526202
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.2916050911
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 4.8016705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.803084413
MESH:D006528 Carcinoma, Hepatocellular Cisplatin 4.8017982673
MESH:D002289 Carcinoma, Non-Small-Cell Lung Cisplatin 3.1116685392 12023789
MESH:D002294 Carcinoma, Squamous Cell Cisplatin 2.8818337622 17066447 6189445
MESH:D002386 Cataract Acetaminophen 2.7310977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.196135515
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.1912371664
MESH:D002779 Cholestasis Cyclosporine 3.1219486331
MESH:D003092 Colitis Selenium 4.1417936198
MESH:D015179 Colorectal Neoplasms Cisplatin 2.3315273666
MESH:D019465 Craniofacial Abnormalities Vitamin E 1.9219769572
MESH:D003490 Cyanosis 2,6-dinitrotoluene 4.3818551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6018551238 21346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6019164858 17522070 15619225 15968718 11739529 11421492 10774834 14725611 19923254 16781746 2444490 19085960 10663392 16081117 11743745 12958197 11529661 10915739 14550746 12705907 19370779 14986274 16485898 18071297 16109766 11287661 12392966 16177239 19420014 17906064 18713872 11834606 12594235 16227642 16393943 12153990 17562736 12540782 19416960 19739265 11461765
MESH:D056486 Drug-Induced Liver Injury Selenium 6.6015131321
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.5419426721
MESH:D004362 Drug Toxicity Cisplatin 4.0619839026 12649298 12231392 15033597
MESH:C538011 Eales disease Vitamin E 5.159068938
MESH:D004715 Endometriosis Mifepristone 4.6316134523
MESH:D004938 Esophageal Neoplasms Cisplatin 2.8317638652 15173087 16481741 15464296 16785472
MESH:D005234 Fatty Liver Cyclosporine 3.1419224547
MESH:D005355 Fibrosis Cyclosporine 3.5012639820 12168785
MESH:D005756 Gastritis Acetaminophen 4.1216983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.628708960
MESH:D006258 Head and Neck Neoplasms Cisplatin 3.8915102660 15464296
MESH:D034381 Hearing Loss Cisplatin 4.5519898482
MESH:D006319 Hearing Loss, Sensorineural Cisplatin 4.6515464296
MESH:D006330 Heart Defects, Congenital Vitamin E 3.1216080930
MESH:D006333 Heart Failure Selenium 3.2317162251
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.8215720958
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.7816490937 16863852
MESH:D006689 Hodgkin Disease Cisplatin 3.8416200630 16170182
MESH:D019584 Hot Flashes Vitamin E 4.4114716179
MESH:D006930 Hyperalgesia Acetaminophen 2.9216870215
MESH:D006973 Hypertension Cyclosporine 2.1810903974
MESH:D007251 Influenza, Human Selenium 12.4816624496
MESH:D007251 Influenza, Human Vitamin E 12.4816624496
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8815604871
MESH:D007673 Kidney Cortex Necrosis Cisplatin 5.5815464296
MESH:D007674 Kidney Diseases Acetaminophen 15.6712587719 15629191
MESH:D007674 Kidney Diseases Cisplatin 15.6712649298 15190930 12231392 18289764 19839026
MESH:D007674 Kidney Diseases Cyclosporine 15.6718776723 10903974 8314463
MESH:D007674 Kidney Diseases Vitamin E 15.6712488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.1716518626
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.0616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 8.0612371664
MESH:D007683 Kidney Tubular Necrosis, Acute Cisplatin 5.2411231351
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 1.9016169303
MESH:D008107 Liver Diseases Acetaminophen 1.6819460945 16611625 19784758 16610002 12969438 12587719 19014921 11587558
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5017185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 2.237678174
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.702876784 6135515 2876786
MESH:D008171 Lung Diseases Vitamin E 3.3516863852
MESH:D008175 Lung Neoplasms Cisplatin 2.7711798837 6189445 17225452
MESH:D008175 Lung Neoplasms Vitamin E 2.7711062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9215318939
MESH:D008545 Melanoma Cisplatin 2.5018176117 11135225 16432458 18332650 18505091 12883367 16248763 12393984 17023156 12374674 17761969 15577323 16809738
MESH:D018328 Melanoma, Amelanotic Cisplatin 5.1715990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9319513568
MESH:D008654 Mesothelioma Cisplatin 6.6717638057
MESH:D008654 Mesothelioma Selenium 6.6715107826
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.2316801185
MESH:D009336 Necrosis 2,6-dinitrotoluene 4.2618551238 7678174
MESH:D009369 Neoplasms Cisplatin 3.0516773208
MESH:D009395 Nephritis, Interstitial Cisplatin 4.9315464296
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8817954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5318481113 19348381
MESH:D009447 Neuroblastoma Cisplatin 3.578761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1018514411
MESH:D017599 Neuroectodermal Tumors Cisplatin 5.098761367
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 3.7016049721
MESH:D010051 Ovarian Neoplasms Cisplatin 5.576897625 19769630 15464296 17225452
MESH:D010051 Ovarian Neoplasms Mifepristone 5.5716525653
MESH:D010146 Pain Acetaminophen 2.6216870215
MESH:D010190 Pancreatic Neoplasms Cisplatin 3.0719003803
MESH:D010523 Peripheral Nervous System Diseases Cisplatin 4.6415464296
MESH:D010954 Plasmacytoma Selenium 5.3315087411
MESH:D010997 Pleural Neoplasms Cisplatin 5.7917638057
MESH:D011230 Precancerous Conditions Cyclosporine 3.4712371664
MESH:D011471 Prostatic Neoplasms Vitamin E 3.2615084515
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D051437 Renal Insufficiency Cisplatin 4.7715464296
MESH:D012512 Sarcoma, Ewing's Cisplatin 4.7614601052
MESH:D012640 Seizures 2,6-dinitrotoluene 2.7118551238
MESH:D012871 Skin Diseases Vitamin E 2.5018709164
MESH:D055752 Small Cell Lung Carcinoma Cisplatin 5.7915464296
MESH:D013274 Stomach Neoplasms Cisplatin 2.3318396642 17522103 15958060
MESH:D020521 Stroke Vitamin E 3.7416517955
MESH:D013736 Testicular Neoplasms Cisplatin 4.9315464296 17225452
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 5.5616049721
MESH:D001749 Urinary Bladder Neoplasms Cisplatin 5.5612973940 17225452 15464296
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.7110091137
MESH:D014581 Urticaria Acetaminophen 3.2810982225
MESH:D002583 Uterine Cervical Neoplasms Cisplatin 4.4716803524
MESH:D014605 Uveitis Cyclosporine 4.431336536
MESH:D014625 Vaginal Neoplasms Cisplatin 4.9715577323
MESH:D014839 Vomiting Cisplatin 5.1611897121
MESH:D014985 Xerophthalmia Cyclosporine 4.8817120751
Pathway ID Pathway Name
KEGG:00520 Amino sugar and nucleotide sugar metabolism
KEGG:00051 Fructose and mannose metabolism
KEGG:01100 Metabolic pathways
REACT:17015 Metabolism of proteins
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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