AutismKB 2.0

Annotation Detail for SEC61A1


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Basic Information Top
Gene Symbol:SEC61A1 ( HSEC61,SEC61,SEC61A )
Gene Full Name: Sec61 alpha 1 subunit (S. cerevisiae)
Band: 3q21.3
Quick LinksEntrez ID:29927; OMIM: 609213; Uniprot ID:S61A1_HUMAN; ENSEMBL ID: ENSG00000058262; HGNC ID: 18276
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa03060Protein export
hsa04141Protein processing in endoplasmic reticulum
hsa04145Phagosome
hsa05110Vibrio cholerae infection
Pathway IDPathway Name
Diabetes pathways
No data
No data
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of SEC61A1 mRNAincreases expression 18648102
D000643 Ammonium Chloride Ammonium Chloride affects the expression of SEC61A1 mRNAaffects expression 16483693
D001280 Atrazine [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of SEC61A1 mRNAaffects cotreatment|decreases expression 15654877
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SEC61A1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of SEC61A1 mRNAincreases expression 20106945
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of SEC61A1 mRNAaffects cotreatment|affects expression 17602206
D004237 Diuron [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of SEC61A1 mRNAaffects cotreatment|decreases expression 15654877
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of SEC61A1 mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of SEC61A1 mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SEC61A1 mRNAaffects cotreatment|increases expression 17942748
D019833 Genistein Genistein results in decreased expression of SEC61A1 mRNAdecreases expression 16705744
C028904 isoproturon [Atrazine co-treated with Diuron co-treated with isoproturon] results in decreased expression of SEC61A1 mRNAaffects cotreatment|decreases expression 15654877
D007657 Ketone Bodies Ketone Bodies results in decreased expression of SEC61A1 mRNAdecreases expression 16807920
D013629 Tamoxifen Tamoxifen affects the expression of SEC61A1 mRNAaffects expression 17555576
C004648 testosterone enanthate testosterone enanthate affects the expression of SEC61A1 mRNAaffects expression 17440010
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SEC61A1 mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of SEC61A1 mRNAincreases expression 17942748
C032910 triadimefon triadimefon results in decreased expression of SEC61A1 mRNAdecreases expression 16730040
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.6114745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.9015322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.6118287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0017505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.3814692618
MESH:D000230 Adenocarcinoma Genistein 4.3811473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 6.723712494
MESH:D000236 Adenoma Diethylnitrosamine 6.7210737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.2316434500 17620307 18056438 19061943 17162532 19052882
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.2316835633
MESH:D000382 Agricultural Workers' Diseases Atrazine 4.2711874814
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9711748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.5111256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6815885639
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.081440618 11289319
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0712125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8515340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7815746008
MESH:D001943 Breast Neoplasms Diethylnitrosamine 1.9517474063
MESH:D001943 Breast Neoplasms Genistein 1.9516541309 17200150 16873071
MESH:D001943 Breast Neoplasms Tamoxifen 1.9519200415 16818667 19410462 19142967 19487384 19011961 17261762 18855134 16873071 20135344 15668708 19289846 17440819 18815881 19103187 15565566 21138602 18351453 19288272 17893378 18425577 18629630 20005174 19155303 18984771 19059307 17049068 17242785 21152245 19066611 19084267 19189210 20859285 16202921 20390343 18821012 16273361 19244106 19189212 20065188 18997820 19115204 11161223 20544844 19221464
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9520435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.8216835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.5519066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 6.623581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 6.6216569478 16807293 18665156 18506893 20214788 17162532 20727157 17173139 17055752 17428255 19919837 16288022 19208518 19539802 16878318 16830150 10737359 20512989 18056438 20935162 20432363 19822196 19418558 21159647 18393292 20007298 16681979 19383236 18788625 17138121 18971187 20524982 20514400 19701751 16935385 16779866 17761372 16698587 3084413 18978308 16328049 19171122 10672840 19107877 16502159 20101231 18691550 19519916 3581430 19394651 19052882 19335982 11831363 20084675 18785209 16540662 18494052 17978847 18210153
MESH:D006528 Carcinoma, Hepatocellular Genistein 6.6216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.6216924424
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.697296757
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.6417572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3818670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.3216332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 11.277505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 11.2712371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 11.2717174075 2727394 21159647 7505956
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 9.4119052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 9.4116835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 13.5119486331 9022650
MESH:D002779 Cholestasis Cyclosporine 13.5119486331
MESH:D002779 Cholestasis Ethinyl Estradiol 13.5116105132 17333356 16919318 11677210 17110522 17681005 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 6.1912621046 15340226 16354765 15668235 8697196
MESH:D002972 Cleft Palate triadimefon 6.1916781842
MESH:D003110 Colonic Neoplasms Genistein 2.2917182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0814669216 17141729
MESH:D019465 Craniofacial Abnormalities marker/mechanism 16759393
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 2.8415322242 20055451 10048152
MESH:D019465 Craniofacial Abnormalities triadimefon 2.8415834900 16875885
MESH:D003711 Demyelinating Diseases Tamoxifen 4.4019031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.8418759878 11906362 8156756 11298694 2524372 8970840 14531868 12868966
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.523621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 7.1520387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 7.1516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 7.1517107852
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.5019279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.227440962 8291058 16192314 9653073 9022650 6679447 18692083 1440618 9328219 18289764 18648102 11289319 6482804
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 6.2219107877
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2220420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.7811462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.4111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.9616714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 9.0712538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 9.0719031437
MESH:D004714 Endometrial Hyperplasia Genistein 4.6416402032
MESH:D016889 Endometrial Neoplasms Genistein 7.5911473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.5919155303 20544844 16202921 17893378
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.059294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.1816302075
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 2.113581430
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0311564622
MESH:D005234 Fatty Liver Cyclosporine 19.0119224547
MESH:D005234 Fatty Liver Diethylnitrosamine 19.0120387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 19.0115345470
MESH:D005234 Fatty Liver Tamoxifen 19.0119224547 14986274
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.2516709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5011858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.086705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.5814745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.2319069698
MESH:D005355 Fibrosis Cyclosporine 8.6212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.6220067830
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.278708960
MESH:D005909 Glioblastoma Genistein 3.2816598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.077505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6610696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.3410048152 11294989
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.4715720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3611000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.556705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.9615340226 12621046 16120746
MESH:D006529 Hepatomegaly triadimefon 8.9617178688 17178689
MESH:D019247 HIV Wasting Syndrome testosterone enanthate 5.8117440010
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1118606429 8697196 16354765 15340226 16959395
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 3.9815034207
MESH:D006973 Hypertension Cyclosporine 4.9810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.9818850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8516569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4912013081
MESH:D007248 Infertility, Male Atrazine 6.9712948887
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.9717937319
MESH:D007249 Inflammation Diethylnitrosamine 8.3518785209
MESH:D007249 Inflammation Tamoxifen 8.3519457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3512878042 12200463
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.088074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 10.4216580747
MESH:D007569 Jaw Abnormalities triadimefon 10.4215992940 15834900
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.5015604871
MESH:D007674 Kidney Diseases Cyclosporine 2.358314463 10903974 18776723
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 12.516582329
MESH:D007680 Kidney Neoplasms Cyclosporine 12.5112371664
MESH:D007680 Kidney Neoplasms Tamoxifen 12.5118625569
MESH:D007938 Leukemia Genistein 3.0417468513 18980019
MESH:D008064 Lipidoses Tamoxifen 3.1715342952 17567588
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 2.8419638242 18407596 20032147 18522880 18665156
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.2115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.5017823541
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5018564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.5012878042
MESH:D008107 Liver Diseases Diethylnitrosamine 4.5017034775
MESH:D008107 Liver Diseases triadimefon 4.5019363144
MESH:D008113 Liver Neoplasms Clofibric Acid 14.3817602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 14.3819090486 15885732 19812893 19850985 18648771 19833225 15175105 19255062 19254457 9163691 2422723 19256749 21071580 19073162 19294768 20137499 2862719 19996281 18977376 12112319 20452335 18754104 18978307 16942905 20118626 19499222 18644402 10737359 20501860 20492335 20101389 21167192 19551842 19426721 19642983 19690152 20405173 21278145 19638242 12771043 19427195 20583210 21047994 20434301
MESH:D008113 Liver Neoplasms Tamoxifen 14.3816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.3816984957
MESH:D008113 Liver Neoplasms triadimefon 14.3819028983
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 14.301399818 3712494 6587162 598648
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 14.3017854601 19009564 19126423 17174075 19519916 16267830 18253720 2563599 18282651 18775883 21159647 9362446 16842330 18079962 18308698 19004024 18093689 19539802 17942915 18544905 18164116 3124819
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 14.3012151625
MESH:D008114 Liver Neoplasms, Experimental triadimefon 14.3017178689
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.3821163286 20970405 6695378 20512841
MESH:D008175 Lung Neoplasms Tamoxifen 3.3818625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.3811884234 19555203
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.8119428831
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.1714578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.1719196723 11731420 19196722 16827153 14580682
MESH:D020149 Manganese Poisoning Tamoxifen 4.6119453300
MESH:D008545 Melanoma Tamoxifen 1.8819393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.2315990972
MESH:D008654 Mesothelioma Atrazine 3.541916698
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.8516801185
MESH:D009203 Myocardial Infarction Genistein 2.8717141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0412213967
MESH:D015428 Myocardial Reperfusion Injury Genistein 3.6817141266
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 9.523581430
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 9.523581430 9029167
MESH:D009362 Neoplasm Metastasis Tamoxifen 9.5219393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5219410462
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.0619189210 19196722 19200415
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.5017954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.3119348381 18481113
MESH:D009421 Nervous System Malformations Genistein 9.7316427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 9.7314600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.936679447
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.3620387270
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.1820387270
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.454026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.083988306
MESH:D010024 Osteoporosis Genistein 3.2719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.1216169203
MESH:D010051 Ovarian Neoplasms Genistein 2.6119005980
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4316540662
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7211578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.527296757
MESH:D010300 Parkinson Disease Atrazine 3.2817218051
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3112520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.536228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5918163543
MESH:D011230 Precancerous Conditions Cyclosporine 9.0312371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 9.032563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2411896295 11399792 11222880 11118676
MESH:D011471 Prostatic Neoplasms Genistein 3.3115256057 15378649 16925846
MESH:D011471 Prostatic Neoplasms Tamoxifen 3.3115067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.3616919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.2416882103
MESH:D012135 Respiratory Sounds Atrazine 4.5611874814
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8718990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.393692021
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.0516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 11.7716709447
MESH:D013088 Spermatocele Tamoxifen 11.7716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.0919457130
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7518456281
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.9612697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 12.221399818 6587162 6582329 7505956 3712494
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 12.227505956
MESH:D013964 Thyroid Neoplasms triadimefon 12.2217178689
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.078074119
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.078653321 16712894 17572228
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3314692618
MESH:D014605 Uveitis Cyclosporine 4.051336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6612125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5714671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3115886252
MESH:D014985 Xerophthalmia Cyclosporine 4.5017120751
Pathway ID Pathway Name
REACT:30228 Diabetes pathways
REACT:15380 Diabetes pathways
KEGG:04145 Phagosome
KEGG:03060 Protein export
KEGG:04141 Protein processing in endoplasmic reticulum
KEGG:05110 Vibrio cholerae infection
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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