AutismKB 2.0

Annotation Detail for GYPA


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Basic Information Top
Gene Symbol:GYPA ( CD235a,GPA,GPErik,GPSAT,GpMiIII,HGpMiIII,HGpMiV,HGpMiX,HGpMiXI,HGpSta(C),MN,MNS,PAS-2 )
Gene Full Name: glycophorin A (MNS blood group)
Band: 4q31.21
Quick LinksEntrez ID:2993; OMIM: 111300; Uniprot ID:GLPA_HUMAN; ENSEMBL ID: ENSG00000170180; HGNC ID: 4702
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04640Hematopoietic cell lineage
hsa05144Malaria
No data
No data
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
PHARMACOGENOMIC
benzene toxicity
No data
Desease Name
Blood group, MN
Malaria, resistance to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C072876 A 771726 A 771726 results in increased expression of GYPA proteinincreases expression 12181422
C072876 A 771726 Cytidine inhibits the reaction [A 771726 results in increased expression of GYPA protein]decreases reaction|increases expression 12181422
C072876 A 771726 Uridine inhibits the reaction [A 771726 results in increased expression of GYPA protein]decreases reaction|increases expression 12181422
D000082 Acetaminophen Acetaminophen results in decreased expression of GYPA mRNAdecreases expression 17942131
D001151 Arsenic Arsenic results in increased mutagenesis of GYPA geneincreases mutagenesis 17029826
D001151 Arsenic Arsenic results in decreased expression of GYPA mRNAdecreases expression 19654921
D001564 Benzo(a)pyrene Benzo(a)pyrene results in decreased expression of GYPA mRNAdecreases expression 17942131
C005961 bis(tri-n-butyltin)oxide bis(tri-n-butyltin)oxide results in decreased expression of GYPA mRNAdecreases expression 17942131
D020148 Butyric Acid Butyric Acid results in increased expression of GYPA proteinincreases expression 14757314
D020148 Butyric Acid tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GYPA protein]decreases reaction|increases expression 14757314
D002211 Capsaicin Capsaicin results in increased expression of GYPA mRNAincreases expression 17603282
C103481 chebulinic acid chebulinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GYPA protein]decreases reaction|increases expression 14769215
D016572 Cyclosporine Cyclosporine results in decreased expression of GYPA mRNAdecreases expression 17942131
D003562 Cytidine Cytidine inhibits the reaction [A 771726 results in increased expression of GYPA protein]decreases reaction|increases expression 12181422
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA geneaffects cotreatment|increases mutagenesis 17358027
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GYPA mRNAaffects cotreatment|increases expression 17942748
D006160 Guanosine Triphosphate Guanosine Triphosphate results in increased expression of GYPA proteinincreases expression 17002868
C087926 tellimagrandin I tellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GYPA protein]decreases reaction|increases expression 14757314
C087926 tellimagrandin I tellimagrandin I results in decreased expression of GYPA proteindecreases expression 14757314
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GYPA mRNAaffects cotreatment|increases expression 17942748
D013755 Tetradecanoylphorbol Acetate chebulinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GYPA protein]decreases reaction|increases expression 14769215
D013755 Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate results in increased expression of GYPA proteinincreases expression 14769215
D014529 Uridine Uridine inhibits the reaction [A 771726 results in increased expression of GYPA protein]decreases reaction|increases expression 12181422
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA geneaffects cotreatment|increases mutagenesis 17358027
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Capsaicin 8.5818926900
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5811752688 14514962 15322242
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.9117505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.799612607
MESH:D058186 Acute Kidney Injury Capsaicin 4.5018460982
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 4.1420127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 4.1414692618
MESH:D000236 Adenoma Benzo(a)pyrene 2.636695378
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.3416835633
MESH:D018246 Adrenocortical Adenoma Arsenic 5.1817306315
MESH:D000505 Alopecia Capsaicin 4.6917569567
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.9111748828
MESH:D000799 Angioedema Acetaminophen 3.8110982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.0319183758
MESH:D020261 Arsenic Poisoning Arsenic 2.8516835338 12569548 18414634 16251483
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.4211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6415885639
MESH:D050197 Atherosclerosis Arsenic 3.2219371607 12928151
MESH:D001321 Autistic Disorder Acetaminophen 1.4218445737
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.0012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.7615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.7315746008
MESH:D001919 Bradycardia Capsaicin 5.0218207255
MESH:D002545 Brain Ischemia Capsaicin 4.9419211983
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9020146248 17474063
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9020435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.7616835633
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.5715504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.993084413
MESH:D006528 Carcinoma, Hepatocellular Arsenic 2.9917306315 16507464
MESH:D002294 Carcinoma, Squamous Cell Arsenic 7.5715504454 17687452 18922899
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 7.5720419170
MESH:D002294 Carcinoma, Squamous Cell Tetradecanoylphorbol Acetate 7.5718922899
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.0418640142
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3418670907 16120746 18850075
MESH:D002318 Cardiovascular Diseases Arsenic 3.4215738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.2716973168 18022660
MESH:D002386 Cataract Acetaminophen 2.5510977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.5012371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.1216835633
MESH:D002779 Cholestasis Cyclosporine 7.6619486331
MESH:D002779 Cholestasis Ethinyl Estradiol 7.6616919318 17110522 16105132 17333356 17681005 11677210 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.088697196 15668235 15340226 12621046 16354765
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.0217141729 14669216
MESH:D003371 Cough Capsaicin 5.1510350223
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2520055451 10048152 15322242
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6617107852
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 3.5114986274 12594235 10915739 19370779 17522070 17562736 19739265 19923254 19164858 14550746 11834606 10774834 12958197 12540782 16227642 19420014 16109766 2444490 16081117 12153990 18071297 11529661 15968718 16393943 16781746 15619225 19416960 11743745 16177239 12392966 11461765 11739529 14725611 16485898 17906064 10663392 11287661 18713872 11421492 19085960 12705907
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 3.5120420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.0719426721
MESH:D004362 Drug Toxicity Lamivudine 13.6915040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 13.6911462148
MESH:D004362 Drug Toxicity Zidovudine 13.6915040536
MESH:D004381 Duodenal Ulcer Capsaicin 4.6510671773 11535926
MESH:D004487 Edema Tetrachlorodibenzodioxin 6.8212711302 11000095
MESH:D004487 Edema Tetradecanoylphorbol Acetate 6.8216716910 9599246 15177302 7812673 11698051 8273558 8113982
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.8715322242 18230668 16714409
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.1512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.9810568697 9294722
MESH:D004935 Esophageal Diseases Capsaicin 5.6719566590
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 2.0016530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.9811564622
MESH:D005234 Fatty Liver Cyclosporine 12.9219224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 12.9215345470
MESH:D005234 Fatty Liver Zidovudine 12.9218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.4211858732
MESH:D005355 Fibrosis Cyclosporine 8.3512168785 12639820
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.3520067830
MESH:D005534 Foot Diseases Arsenic 5.536392382
MESH:D005756 Gastritis Acetaminophen 3.6516983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.188708960
MESH:D005909 Glioblastoma Capsaicin 4.0918405923
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.5710696789
MESH:D006356 Heartburn Capsaicin 5.6719566590
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.3720471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.3710048152 11294989
MESH:D006402 Hematologic Diseases Zidovudine 4.6712579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.3915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.2911000095
MESH:D006509 Hepatitis B Lamivudine 5.0617703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 5.0615309715 15631357 12044531 16476009 15274664
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 2.8516120746 15340226 12621046
MESH:D015658 HIV Infections Lamivudine 6.9811141242 20032539 17530837 9296927
MESH:D015658 HIV Infections Zidovudine 6.9820032539 11363243 11698656 11141242 17358032
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.0215340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 7.9116870215
MESH:D006930 Hyperalgesia Capsaicin 7.9117434803 17043245
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.4217050553
MESH:D006973 Hypertension Arsenic 8.499931084 11953799 16076760
MESH:D006973 Hypertension Cyclosporine 8.4910903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.4918850075 18670907
MESH:D006987 Hypesthesia Arsenic 5.5316093927
MESH:D007021 Hypospadias Ethinyl Estradiol 3.7716569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.4212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.4617937319
MESH:D007249 Inflammation Capsaicin 8.3916956363
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.3912878042 12200463
MESH:D007249 Inflammation Tetradecanoylphorbol Acetate 8.3915177302 7562506 11698051 7812673 8273558
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.2916580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.4115604871
MESH:D007642 Keratosis Arsenic 4.9516930632 12749816
MESH:D007674 Kidney Diseases Acetaminophen 5.7115629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 5.7118776723 10903974 8314463
MESH:D007680 Kidney Neoplasms Cyclosporine 7.4512371664
MESH:D007680 Kidney Neoplasms Zidovudine 7.4512579204
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 4.3720370541
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.5217339181
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 6.6319784758 16611625 19460945 11587558 12969438 12587719 19014921 16610002
MESH:D008107 Liver Diseases Arsenic 6.6311134558
MESH:D008107 Liver Diseases Capsaicin 6.6316956363
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2017185352 16871587
MESH:D008113 Liver Neoplasms Arsenic 7.3316368122
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 7.3321137059 20195826
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 7.3316984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.0812151625
MESH:D008175 Lung Neoplasms Arsenic 6.5517976673 17306315 19168569
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.5520464547 20064080 18816296 20869020 18569708 17053015 6695378 18520028 20135361
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.5511884234 19555203
MESH:D008175 Lung Neoplasms Tetradecanoylphorbol Acetate 6.5511807781
MESH:D008175 Lung Neoplasms Zidovudine 6.5518800350
MESH:D008288 Malaria marker/mechanism
MESH:D008325 Mammary Neoplasms, Experimental Tetradecanoylphorbol Acetate 3.338985016
MESH:D008546 Melanoma, Experimental Acetaminophen 3.5319513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.7616801185
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.8117358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.1516381670
MESH:D009101 Multiple Myeloma Capsaicin 4.1217505005
MESH:D017202 Myocardial Ischemia Arsenic 8.8815371236
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 8.8812213967
MESH:D009369 Neoplasms Benzo(a)pyrene 2.1511141357
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.4117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.2418481113 19348381
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.1714600291
MESH:D009436 Neural Tube Defects Arsenic 3.4216620997
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.8318514411
MESH:D020078 Neurogenic Inflammation Arsenic 10.8217056641
MESH:D020078 Neurogenic Inflammation Capsaicin 10.8217961222
MESH:D009765 Obesity Capsaicin 3.3819056576
MESH:D010051 Ovarian Neoplasms Arsenic 2.7317306315
MESH:D010146 Pain Acetaminophen 6.8716870215
MESH:D010146 Pain Capsaicin 6.8717043245 16996476 17084039 17434803 18987195 19081190
MESH:D010190 Pancreatic Neoplasms Tetradecanoylphorbol Acetate 3.1215976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.6511578682
MESH:D010212 Papilloma Tetradecanoylphorbol Acetate 4.258330346 12065085 18922899 18404319
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.2212520081
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.1416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 4.9515371236 6392382 16905509
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.5218163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.1812371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.1611896295 11222880 11118676 11399792
MESH:D011471 Prostatic Neoplasms Arsenic 3.3216140617
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.3217292933
MESH:D011507 Proteinuria Arsenic 3.9621343184
MESH:D011537 Pruritus Ethinyl Estradiol 3.2815861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2116882103
MESH:D015427 Reperfusion Injury Capsaicin 3.9418460982 19211983
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.8018990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.509296927
MESH:D012871 Skin Diseases Arsenic 2.7419834688 15952646 6392382 18709164 16759981 16353154 17453740 17938729 16702368 17548696 17050553
MESH:D012878 Skin Neoplasms marker/mechanism 17029826
MESH:D012878 Skin Neoplasms Arsenic 13.4316251483 17976673 19538983 17029826 15504454 17050553
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 13.4319755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 13.4316192470
MESH:D012878 Skin Neoplasms Tetradecanoylphorbol Acetate 13.4318404319 11807781 8985016 8330346 12065085
MESH:D013088 Spermatocele Ethinyl Estradiol 3.9116709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 2.592093021 20155912
MESH:D013274 Stomach Neoplasms Zidovudine 2.5917696246
MESH:D013705 Temporomandibular Joint Disorders Capsaicin 5.7017997062
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.5811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.1115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.8712697716
MESH:D001749 Urinary Bladder Neoplasms Arsenic 5.1119429237 19322015 15987713 17976673 17306315 11144890 18640142
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.1117053015
MESH:D014581 Urticaria Acetaminophen 2.9410982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.2614692618
MESH:D014605 Uveitis Cyclosporine 3.961336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.7212579204
MESH:D014652 Vascular Diseases Arsenic 4.7017056641
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.5712125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5014671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.2215886252
MESH:D014985 Xerophthalmia Cyclosporine 4.4117120751
Pathway ID Pathway Name
KEGG:04640 Hematopoietic cell lineage
KEGG:05144 Malaria
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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