AutismKB 2.0

Annotation Detail for GPR132


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Basic Information Top
Gene Symbol:GPR132 ( G2A,MGC99642 )
Gene Full Name: G protein-coupled receptor 132
Band: 14q32.33
Quick LinksEntrez ID:29933; OMIM: 606167; Uniprot ID:GP132_HUMAN; ENSEMBL ID: ENSG00000183484; HGNC ID: 17482
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
Signaling by GPCR
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Related Diseases/Disorders Top
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Desease IDDesease Name
1997Dental plaque
No data
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GPR132 mRNAincreases expression 18648102
D005472 Fluorouracil Fluorouracil results in increased expression of GPR132 mRNAincreases expression 16584549
C017947 sodium arsenite sodium arsenite results in increased expression of GPR132 mRNAincreases expression 17879257
D018038 Sodium Selenite Sodium Selenite results in increased expression of GPR132 mRNAincreases expression 18175754
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000230 Adenocarcinoma Fluorouracil 2.5017638652
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.963712494
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.4215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.6316712894 17306315
MESH:D000740 Anemia Fluorouracil 4.1116511603 17963324 15504547
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.7411289319 1440618
MESH:D001943 Breast Neoplasms Fluorouracil 2.4315136595 16595493 19217205 18608205 18357371 16557594 16110121
MESH:D002276 Carcinoid Tumor Fluorouracil 5.3916051944
MESH:D002277 Carcinoma Fluorouracil 3.8917121937
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 4.903581430 7296757
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 4.9018930000 17045692 16799960 16332177 17088986 17971768
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 4.9017306315 16507464 15276417
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 7.027296757
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 7.0218695887
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0718986760 16757204 17066447 16280240
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 5.0718572023
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.627505956
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.6220056578 19524636
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 3.449022650 19486331
MESH:D019457 Chromosome Breakage Sodium Selenite 5.3115894690
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2818772588 15001691 17172411 17725105 17169374 16510598 17018589 17016597 16340194 17287894
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017594712 18509181 15289873 20501625 17094418 14970324 17016601 18802399 18448328 17401013 18949393 16331619 18288408 16524972 16282729 16303861 16391804 17255274 17695437 17454858 18383874 15148649
MESH:D007644 Darier Disease Fluorouracil 5.4216733453
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.3511298694 14531868 8970840 11906362 8156756 2524372 12868966 18759878
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.953621924 2952479
MESH:D003920 Diabetes Mellitus Sodium Selenite 4.1516285004
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 4.276482804 18692083 8291058 9022650 6679447 18289764 9653073 16192314 9328219 7440962 1440618 11289319 18648102
MESH:D056486 Drug-Induced Liver Injury Sodium Selenite 4.2715131321
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.793581430
MESH:D004938 Esophageal Neoplasms Fluorouracil 4.7917638652 16337965 16785472 15173087 16481741
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.746705139
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.3116452187
MESH:D005910 Glioma Fluorouracil 2.9916145905
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.507505956
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.6415102660 15162350 18337622
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 4.026705139
MESH:D006689 Hodgkin Disease sodium arsenite 3.5212676792
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.5015034207
MESH:D007248 Infertility, Male sodium arsenite 3.2415346721 12646999
MESH:D007333 Insulin Resistance Sodium Selenite 3.5214714311
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.749022650 8074119
MESH:D007674 Kidney Diseases sodium arsenite 3.0020008137
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 8.646582329
MESH:D007680 Kidney Neoplasms Fluorouracil 8.6416985049
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.429327722 15034207
MESH:D008113 Liver Neoplasms Fluorouracil 5.1417045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms sodium arsenite 5.1416712894 15276417
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 2.753712494 598648 1399818 6587162
MESH:D008171 Lung Diseases sodium arsenite 3.4219095001
MESH:D008175 Lung Neoplasms Fluorouracil 2.6715246190
MESH:D008175 Lung Neoplasms sodium arsenite 2.6716712894 15276417 17306315 17077188 19931552
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.4215086387
MESH:D016393 Lymphoma, B-Cell Sodium Selenite 4.5214737004
MESH:D008545 Melanoma sodium arsenite 2.0716487513 19082730
MESH:D009062 Mouth Neoplasms Fluorouracil 3.9416757204 18986760
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.593581430
MESH:D009369 Neoplasms Fluorouracil 5.7518600527 16928823 18239605
MESH:D009369 Neoplasms sodium arsenite 5.7511559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.2220056578
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 8.076679447
MESH:D009436 Neural Tube Defects sodium arsenite 8.0712854658
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.6916436463
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.814026338 6482804
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.743988306
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5315276417 17306315
MESH:D010190 Pancreatic Neoplasms Fluorouracil 2.7719003803 16929163 16500647 15113037
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 4.047296757
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 5.196228378
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.5618626508 19082440
MESH:D011471 Prostatic Neoplasms sodium arsenite 2.5616039940
MESH:D011471 Prostatic Neoplasms Sodium Selenite 2.5618760546
MESH:D012004 Rectal Neoplasms Fluorouracil 4.3818722050 18286688 16160472 15538739
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.673692021
MESH:D012878 Skin Neoplasms sodium arsenite 2.8519524636 18572023
MESH:D016135 Spinal Dysraphism sodium arsenite 4.1012854658
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0017522103 16951190 16424979 15786421 18567086 19084572 18396642 19015929 17498489 17172411
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.191399818 6587162 6582329 3712494 7505956
MESH:D014062 Tongue Neoplasms Fluorouracil 4.3816280240
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 5.518074119
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 5.5111723127 17306315 16452187 16712894
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 10.8316803524
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 10.8311813266
MESH:D014652 Vascular Diseases sodium arsenite 5.0617056641
Pathway ID Pathway Name
REACT:14797 Signaling by GPCR
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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