AutismKB 2.0

Annotation Detail for PADI1


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Basic Information Top
Gene Symbol:PADI1 ( HPAD10,PAD1,PDI,PDI1 )
Gene Full Name: peptidyl arginine deiminase, type I
Band: 1p36.13
Quick LinksEntrez ID:29943; OMIM: 607934; Uniprot ID:PADI1_HUMAN; ENSEMBL ID: ENSG00000142623; HGNC ID: 18367
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
PWY-4921protein citrullination
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PADI1 mRNAaffects expression 16483693
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of PADI1 mRNAincreases expression 16636312
15289156
D004958 Estradiol Estradiol results in increased expression of PADI1 mRNAincreases expression 14664709
15289156
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of PADI1 mRNAincreases expression 17557909
D019833 Genistein Genistein results in increased expression of PADI1 mRNAincreases expression 15289156
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of PADI1 mRNAdecreases expression 17616710
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PADI1 mRNAdecreases expression 19490992
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.2414514962 11752688 15322242
MESH:D000138 Acidosis Ammonium Chloride 3.9518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.3817505938
MESH:D000230 Adenocarcinoma Estradiol 7.4111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.4114692618
MESH:D000230 Adenocarcinoma Genistein 7.4111473722
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.7716835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.8115469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.2111748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.8211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.8215885639
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.3312125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.2315340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.9315746008
MESH:D001943 Breast Neoplasms Diethylstilbestrol 1.9917129689 15324884
MESH:D001943 Breast Neoplasms Estradiol 1.9917289903 17261762 12948864 14630087 18497071 17018787 16675129 19861407
MESH:D001943 Breast Neoplasms Genistein 1.9916873071 17200150 16541309
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9920435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8616111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 3.0216835633
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 4.8815948411 16924424
MESH:D006528 Carcinoma, Hepatocellular Estradiol 4.8816924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 4.8816924424
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.5018670907 18850075 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.4816332659
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9518566989
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.4116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 3.0717110522 16105132 15861022 17681005 11677210 16919318 17333356
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.2015340226 12621046 8697196 15668235 16354765
MESH:D003110 Colonic Neoplasms Genistein 2.3217182828
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.3117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.8916002989 12952375
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.5116647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.5117107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.6619279558
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 1.5920420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9611462148
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.6511000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.3516714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.5212538720
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 13.2516402032
MESH:D004714 Endometrial Hyperplasia Genistein 13.2516402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 13.5216804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 13.5219148513 18566989 11473722
MESH:D016889 Endometrial Neoplasms Genistein 13.5211473722
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.299294722 10568697
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 2.8315878914 16805852 15547733 16704527 16510608 15623463 15264214 15150132 15547721
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.2111564622
MESH:D005234 Fatty Liver Ethinyl Estradiol 3.0915345470
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 3.8116513791 16611131 16002989 15751030 16534752
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.8111858732
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 3.3120067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 5.3416452187
MESH:D005909 Glioblastoma Genistein 3.4316598420
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 5.0410696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4611294989 10048152
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.6211000095
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.2515340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 5.4815709030
MESH:D019584 Hot Flashes Estradiol 4.1917088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.4915340226 18606429 8697196 16959395 16354765
MESH:D006965 Hyperplasia Diethylstilbestrol 4.7912960047 14722030
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9918850075 18670907
MESH:D007021 Hypospadias Diethylstilbestrol 12.4716002989
MESH:D007021 Hypospadias Ethinyl Estradiol 12.4716945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.6815036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.7712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6617937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9812878042 12200463
MESH:D007333 Insulin Resistance Estradiol 3.1316627594 16393666
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.6216580747
MESH:D007674 Kidney Diseases Estradiol 2.7215618244
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 8.3314681315 15003126 16762066
MESH:D007680 Kidney Neoplasms Estradiol 8.3315610895
MESH:D007859 Learning Disorders Diethylstilbestrol 4.4217184923
MESH:D007938 Leukemia Genistein 3.1418980019 17468513
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.6214716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 3.6217823541
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.6212878042
MESH:D008113 Liver Neoplasms Diethylstilbestrol 4.8415890375 16712894
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 4.8416984957
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 2.2612151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2411884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 5.5515166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.6615700306
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.9616002989
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.6517203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Genistein 6.6514578162 12929590
MESH:D020149 Manganese Poisoning Estradiol 4.9319453300
MESH:D009203 Myocardial Infarction Genistein 2.9517141266
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.2412213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 9.2316810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 9.2317141266
MESH:D009369 Neoplasms Diethylstilbestrol 2.8815313581
MESH:D009389 Neovascularization, Pathologic Estradiol 4.1317289903
MESH:D009421 Nervous System Malformations Diethylstilbestrol 26.4011399458
MESH:D009421 Nervous System Malformations Estradiol 26.4011399458 16427766
MESH:D009421 Nervous System Malformations Genistein 26.4016427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 26.4014600291
MESH:D010024 Osteoporosis Genistein 3.4119401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 4.3916169203
MESH:D010051 Ovarian Neoplasms Estradiol 5.1419401270
MESH:D010051 Ovarian Neoplasms Genistein 5.1419005980
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.6912520081
MESH:D010900 Pituitary Diseases Diethylstilbestrol 5.6114722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 5.0315687265 16977796
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8918163543
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 10.9217184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 10.9211222880 11118676 11399792 11896295
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1720887781
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.5817136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.5816740699
MESH:D011471 Prostatic Neoplasms Genistein 2.5816925846 15378649 15256057
MESH:D011537 Pruritus Ethinyl Estradiol 3.7115861022 16919318
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.1718990726
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1516192470
MESH:D013088 Spermatocele Diethylstilbestrol 13.2416709447 16002989
MESH:D013088 Spermatocele Ethinyl Estradiol 13.2416709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3312958204 17575124
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.9211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.4015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.3512697716
MESH:D013978 Tibial Fractures Estradiol 5.1319048282
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 2.8617306315 16712894 16452187
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 4.3016175088
MESH:D014591 Uterine Diseases Diethylstilbestrol 5.6114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 10.5915809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 10.5914692618
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.7916002989 16513791
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 5.0412125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.8215869587 14671159
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.6915886252
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00155 - L-Citrulline Dietary supplement;Micronutrient;Non-Essential Amino Acids
No data
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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