AutismKB 2.0

Annotation Detail for ANAPC4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ANAPC4 ( APC4 )
Gene Full Name: anaphase promoting complex subunit 4
Band: 4p15.2
Quick LinksEntrez ID:29945; OMIM: 606947; Uniprot ID:APC4_HUMAN; ENSEMBL ID: ENSG00000053900; HGNC ID: 19990
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa04914Progesterone-mediated oocyte maturation
hsa04120Ubiquitin mediated proteolysis
hsa04110Cell cycle
hsa04114Oocyte meiosis
Pathway IDPathway Name
APC-Cdc20 mediated degradation of Nek2A
Cell Cycle, Mitotic
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Cell Cycle Checkpoints
No data
No data
Pathway IDPathway Name
500391Regulation of APC/C activators between G1/S and early anaphase
500395Phosphorylation of the APC/C
500390APC/C-mediated degradation of cell cycle proteins
500401Autodegradation of Cdh1 by Cdh1:APC/C
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of ANAPC4 mRNAaffects expression 21346803
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ANAPC4 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of ANAPC4 mRNAaffects expression 17562736
D007657 Ketone Bodies Ketone Bodies results in increased expression of ANAPC4 mRNAincreases expression 16807920
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of ANAPC4 mRNAdecreases expression 17616710
C017947 sodium arsenite sodium arsenite results in decreased expression of ANAPC4 mRNAdecreases expression 16014739
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000310 Adrenal Gland Neoplasms sodium arsenite 5.2215276417
MESH:D018246 Adrenocortical Adenoma sodium arsenite 5.4217306315 16712894
MESH:D000799 Angioedema Acetaminophen 4.3610982225
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.8916705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.893084413
MESH:D006528 Carcinoma, Hepatocellular sodium arsenite 6.8915276417 16507464 17306315
MESH:D002294 Carcinoma, Squamous Cell sodium arsenite 2.4518572023
MESH:D002386 Cataract Acetaminophen 2.7510977129
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 7.446135515
MESH:D002471 Cell Transformation, Neoplastic sodium arsenite 7.4419524636 20056578
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7320423518
MESH:D003490 Cyanosis 2,4-dinitrotoluene 12.3218551238
MESH:D003490 Cyanosis 2,6-dinitrotoluene 12.3218551238
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 6.6221346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.6212540782 12705907 12153990 15968718 18713872 18071297 14550746 11461765 17906064 11421492 11743745 19416960 19739265 16227642 11529661 17522070 11287661 11834606 10915739 16781746 11739529 14725611 19164858 16081117 10663392 15619225 19420014 12958197 12594235 2444490 14986274 19923254 16177239 16485898 19085960 19370779 10774834 16109766 16393943 17562736 12392966
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.6219426721
MESH:D005756 Gastritis Acetaminophen 4.1916983495
MESH:D005833 Genital Neoplasms, Female sodium arsenite 5.1416452187
MESH:D006689 Hodgkin Disease sodium arsenite 3.4312676792
MESH:D006930 Hyperalgesia Acetaminophen 2.9516870215
MESH:D007248 Infertility, Male sodium arsenite 3.1912646999 15346721
MESH:D007674 Kidney Diseases Acetaminophen 6.5115629191 12587719
MESH:D007674 Kidney Diseases sodium arsenite 6.5120008137
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 8.2716705839
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 8.2716705839
MESH:D008107 Liver Diseases Acetaminophen 1.6912969438 12587719 19014921 16610002 19460945 11587558 16611625 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.5416871587 17185352
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 4.947678174
MESH:D008113 Liver Neoplasms sodium arsenite 4.9415276417 16712894
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 2.722876784 2876786 6135515
MESH:D008171 Lung Diseases sodium arsenite 3.3719095001
MESH:D008175 Lung Neoplasms sodium arsenite 1.9015276417 16712894 17077188 19931552 17306315
MESH:D008545 Melanoma sodium arsenite 2.0616487513 19082730
MESH:D008546 Melanoma, Experimental Acetaminophen 3.9819513568
MESH:D009336 Necrosis 2,4-dinitrotoluene 11.9418551238
MESH:D009336 Necrosis 2,6-dinitrotoluene 11.9418551238 7678174
MESH:D009369 Neoplasms sodium arsenite 2.6311559025
MESH:D009374 Neoplasms, Experimental sodium arsenite 4.0820056578
MESH:D009436 Neural Tube Defects sodium arsenite 3.3312854658
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.1418514411
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 9.9212819281 16049721
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 9.9216049721
MESH:D010051 Ovarian Neoplasms sodium arsenite 2.5117306315 15276417
MESH:D010146 Pain Acetaminophen 2.6516870215
MESH:D011471 Prostatic Neoplasms sodium arsenite 3.2516039940
MESH:D012640 Seizures 2,4-dinitrotoluene 6.5618551238
MESH:D012640 Seizures 2,6-dinitrotoluene 6.5618551238
MESH:D012878 Skin Neoplasms sodium arsenite 2.8218572023 19524636
MESH:D016135 Spinal Dysraphism sodium arsenite 4.0412854658
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.4115864552
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 8.9216049721
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 8.9216049721
MESH:D001749 Urinary Bladder Neoplasms sodium arsenite 8.9211723127 17306315 16712894 16452187
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 13.5810091137
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 13.5810091137
MESH:D014581 Urticaria Acetaminophen 3.3310982225
MESH:D002583 Uterine Cervical Neoplasms sodium arsenite 4.0711813266
MESH:D014652 Vascular Diseases sodium arsenite 4.8917056641
Pathway ID Pathway Name
REACT:8017 APC-Cdc20 mediated degradation of Nek2A
REACT:6850 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
KEGG:04110 Cell cycle
REACT:1538 Cell Cycle Checkpoints
REACT:152 Cell Cycle, Mitotic
KEGG:04114 Oocyte meiosis
KEGG:04914 Progesterone-mediated oocyte maturation
KEGG:04120 Ubiquitin mediated proteolysis
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA134894250
    • No data
    Releated disease ID Related disease Name
    PA443434Arthritis, Rheumatoid
    No data
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


    Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved