AutismKB 2.0

Annotation Detail for GYPC


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Basic Information Top
Gene Symbol:GYPC ( CD236,CD236R,GE,GPC,GYPD,MGC117309,MGC126191,MGC126192 )
Gene Full Name: glycophorin C (Gerbich blood group)
Band: 2q14.3
Quick LinksEntrez ID:2995; OMIM: 110750; Uniprot ID:GLPC_HUMAN; ENSEMBL ID: ENSG00000136732; HGNC ID: 4704
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
No data
Desease Name
ovalocytosis and malaria susceptibility
INFECTION
No data
Desease Name
Blood group, Gerbich
Malaria, resistance to
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GYPC mRNA]affects expression|affects reaction 19414516
C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of GYPC mRNA]affects expression|affects reaction 19414516
D000082 Acetaminophen Acetaminophen affects the expression of GYPC mRNAaffects expression 17562736
D000242 Cyclic AMP 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of GYPC mRNA]affects expression|affects reaction 19414516
D016572 Cyclosporine Cyclosporine results in increased expression of GYPC mRNAincreases expression 20106945
C014347 decitabine decitabine results in decreased expression of GYPC mRNAdecreases expression 19194470
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in decreased expression of GYPC mRNA]affects reaction|decreases expression 19482888
D010634 Phenobarbital Phenobarbital results in decreased expression of GYPC mRNAdecreases expression 19482888
D011794 Quercetin Quercetin results in increased expression of GYPC mRNAincreases expression 17103110
C025643 vinclozolin vinclozolin affects the expression of GYPC mRNAaffects expression 19015723
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 3.786195326
MESH:D018248 Adenoma, Liver Cell Phenobarbital 4.3117620307
MESH:D000743 Anemia, Hemolytic Quercetin 4.4817084956
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001008 Anxiety Disorders vinclozolin 3.8319015723
MESH:D001260 Ataxia Telangiectasia Quercetin 5.3115336622
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001327 Autoimmune Diseases Quercetin 4.7119761891
MESH:D001943 Breast Neoplasms decitabine 2.4219208741 18320071
MESH:D001943 Breast Neoplasms Quercetin 2.4218628248
MESH:D002105 Cadmium Poisoning Quercetin 5.9216962696
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 4.783084413
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 4.7820935162 17173139 20007298 1701930 6705139
MESH:D006528 Carcinoma, Hepatocellular Quercetin 4.7819519916 12508355
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 5.2617234771
MESH:D002294 Carcinoma, Squamous Cell decitabine 2.6519215824
MESH:D006332 Cardiomegaly Quercetin 3.4419794523
MESH:D002386 Cataract Acetaminophen 2.7110977129
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 2.6812371664
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.564080065
MESH:D002779 Cholestasis Cyclosporine 3.0919486331
MESH:D003110 Colonic Neoplasms decitabine 4.0617616700
MESH:D003110 Colonic Neoplasms Quercetin 4.0617148506 19440933 11134977 16640504 19056647 17191121 15741050
MESH:D015179 Colorectal Neoplasms decitabine 2.7518981723
MESH:D015179 Colorectal Neoplasms Quercetin 2.7518095365 18852136
MESH:D003456 Cryptorchidism vinclozolin 4.6214966744
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.9319496084
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6415968718 19416960 12958197 11461765 11287661 19739265 12705907 10663392 18071297 11739529 17522070 19923254 11421492 19164858 16109766 18713872 16177239 12153990 14725611 19420014 16781746 14550746 19085960 12540782 11834606 11529661 16227642 12392966 17906064 16485898 14986274 2444490 10915739 19370779 12594235 17562736 16393943 11743745 15619225 16081117 10774834
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004421 Dystonia Phenobarbital 4.261851702
MESH:D004701 Endocrine Gland Neoplasms decitabine 5.4919294695
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.413659116
MESH:D004828 Epilepsies, Partial Phenobarbital 4.253922381 11558140
MESH:D004827 Epilepsy Phenobarbital 3.0020417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.766401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.567750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.363659116
MESH:D005234 Fatty Liver Cyclosporine 3.1019224547
MESH:D005355 Fibrosis Cyclosporine 9.8712639820 12168785
MESH:D005355 Fibrosis Quercetin 9.8719474275
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D030342 Genetic Diseases, Inborn vinclozolin 5.2716973722
MESH:D005832 Genital Diseases, Male vinclozolin 5.6816417039
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.568708960
MESH:D005909 Glioblastoma Quercetin 3.5419804834
MESH:D005910 Glioma Quercetin 3.1317643826
MESH:D006258 Head and Neck Neoplasms decitabine 3.6419215824
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7615720958
MESH:D006529 Hepatomegaly Phenobarbital 3.7916109766
MESH:D006930 Hyperalgesia Acetaminophen 2.8916870215
MESH:D006943 Hyperglycemia Quercetin 4.2618262572 11834736
MESH:D006973 Hypertension Cyclosporine 5.5610903974
MESH:D006973 Hypertension Quercetin 5.5618356687
MESH:D007248 Infertility, Male decitabine 7.4417581917
MESH:D007248 Infertility, Male vinclozolin 7.4416467254
MESH:D007251 Influenza, Human Quercetin 4.8816624496
MESH:D007627 Keloid Quercetin 5.2617086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.8215604871
MESH:D007674 Kidney Diseases Acetaminophen 10.7915629191 12587719
MESH:D007674 Kidney Diseases Cyclosporine 10.7918776723 10903974 8314463
MESH:D007674 Kidney Diseases Quercetin 10.7916962696
MESH:D007680 Kidney Neoplasms Cyclosporine 2.9312371664
MESH:D007938 Leukemia decitabine 6.9319235587 18980019
MESH:D007938 Leukemia Quercetin 6.9317468513
MESH:D007951 Leukemia, Myeloid decitabine 4.2418454857 19117987 17236224
MESH:D015470 Leukemia, Myeloid, Acute decitabine 2.4119387464 18460780 18704418 19010910 18206229 17679729
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.8418055864
MESH:D007984 Leydig Cell Tumor vinclozolin 5.0716417039
MESH:D008103 Liver Cirrhosis Phenobarbital 3.0121047994
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 2.1912741479
MESH:D008107 Liver Diseases Acetaminophen 4.1019460945 19014921 19784758 16610002 12969438 16611625 11587558 12587719
MESH:D008107 Liver Diseases Phenobarbital 4.1019363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Phenobarbital 5.0419482888 19812893 21047994 8742319 19073162 15975961
MESH:D008113 Liver Neoplasms Quercetin 5.0418980244
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 6.611399818 2563599 17172636 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Quercetin 6.6119519916
MESH:D008175 Lung Neoplasms Quercetin 2.1916280456
MESH:D008223 Lymphoma decitabine 3.5819470736
MESH:D008288 Malaria marker/mechanism
MESH:D008545 Melanoma decitabine 2.2716505122 17785578
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1616801185
MESH:D020326 Migraine without Aura Cyclic AMP 5.4411304026
MESH:D009101 Multiple Myeloma decitabine 3.5118172295
MESH:D009190 Myelodysplastic Syndromes decitabine 3.5119157545 16882708 19010910 18608210
MESH:D009203 Myocardial Infarction Quercetin 3.0719595682
MESH:D015428 Myocardial Reperfusion Injury Quercetin 3.9819207477
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.8117484760
MESH:D009369 Neoplasms decitabine 5.6919116145 17925555 19470736
MESH:D009369 Neoplasms Quercetin 5.6915185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.8217954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.5018481113 19348381
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.6217929310
MESH:D010018 Osteomalacia Phenobarbital 4.7017016548
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.4819495926
MESH:D010051 Ovarian Neoplasms decitabine 5.3219331143 19259094
MESH:D010051 Ovarian Neoplasms Quercetin 5.3219005980
MESH:D010146 Pain Acetaminophen 2.5916870215
MESH:D010190 Pancreatic Neoplasms decitabine 9.1419294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 9.1416965848
MESH:D010190 Pancreatic Neoplasms Quercetin 9.1416965848
MESH:D011230 Precancerous Conditions Cyclosporine 16.6212371664
MESH:D011230 Precancerous Conditions Phenobarbital 16.622563599
MESH:D011230 Precancerous Conditions Quercetin 16.6219056647
MESH:D011297 Prenatal Exposure Delayed Effects vinclozolin 4.2318220299 18042343 19015723
MESH:D055728 Primary Myelofibrosis decitabine 5.0317616702
MESH:D011469 Prostatic Diseases vinclozolin 5.2718220299
MESH:D011471 Prostatic Neoplasms Quercetin 3.5617292933 14715546
MESH:D011472 Prostatitis vinclozolin 5.2718629315
MESH:D019310 Pseudolymphoma Phenobarbital 4.8712752131
MESH:D011565 Psoriasis Cyclosporine 2.3016882103
MESH:D012208 Rhabdomyosarcoma decitabine 4.6619155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.9216862918
MESH:D012640 Seizures Phenobarbital 2.843137016 16876388 4039156 11442880
MESH:D003294 Seizures, Febrile Phenobarbital 5.166407741
MESH:D013274 Stomach Neoplasms decitabine 2.1019037991
MESH:D013964 Thyroid Neoplasms decitabine 7.9217967635
MESH:D013964 Thyroid Neoplasms Phenobarbital 7.921399818
MESH:D001749 Urinary Bladder Neoplasms decitabine 5.6317616700 19087683
MESH:D001749 Urinary Bladder Neoplasms Quercetin 5.6316720314
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D014604 Uveal Neoplasms decitabine 5.2917785578
MESH:D014605 Uveitis Cyclosporine 4.361336536
MESH:D014985 Xerophthalmia Cyclosporine 4.8217120751
Pathway ID Pathway Name
KEGG:05144 Malaria
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29082
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top

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    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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