AutismKB 2.0

Annotation Detail for SERTAD1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SERTAD1 ( SEI1,TRIP-Br1 )
Gene Full Name: SERTA domain containing 1
Band: 19q13.1-q13.2
Quick LinksEntrez ID:29950; OMIM: NA; Uniprot ID:SRTD1_HUMAN; ENSEMBL ID: ENSG00000197019; HGNC ID: 17932
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
No data
Desease IDDesease Name
1976Squamous cell cancer
No data
No data
No data
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C016403 2,4-dinitrotoluene 2,4-dinitrotoluene affects the expression of SERTAD1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen affects the expression of SERTAD1 mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of SERTAD1 proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of SERTAD1 mRNAincreases expression 18687144
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of SERTAD1 mRNAincreases expression 20064835
20106945
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SERTAD1 mRNAincreases expression 20382639
19150397
D004041 Dietary Fats Dietary Fats results in increased expression of SERTAD1 mRNAincreases expression 18042831
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERTAD1 mRNAaffects cotreatment|increases expression 17942748
D005472 Fluorouracil Fluorouracil results in increased expression of SERTAD1 mRNAincreases expression 16584549
16557594
D005472 Fluorouracil TP53 protein affects the reaction [Fluorouracil results in increased expression of SERTAD1 mRNA]affects reaction|increases expression 15016801
D009151 Mustard Gas Mustard Gas affects the expression of SERTAD1 mRNAaffects expression 15651846
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of SERTAD1 mRNAincreases expression 17616710
C041786 palm oil palm oil results in increased expression of SERTAD1 mRNAincreases expression 18042831
D010634 Phenobarbital Phenobarbital results in decreased expression of SERTAD1 mRNAdecreases expression 19270015
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SERTAD1 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 8.576195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 8.5715322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.0417505938
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 7.1220127859 20464547
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 7.1214692618
MESH:D000230 Adenocarcinoma Fluorouracil 7.1217638652
MESH:D000236 Adenoma Benzo(a)pyrene 2.686695378
MESH:D018248 Adenoma, Liver Cell Phenobarbital 10.3617620307
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 10.3616835633
MESH:D000740 Anemia Fluorouracil 8.8515504547 16511603 17963324
MESH:D000740 Anemia Tetrachlorodibenzodioxin 8.8511748828
MESH:D000799 Angioedema Acetaminophen 3.9410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 4.1519183758
MESH:D001161 Arteriosclerosis Dietary Fats 10.1515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 10.1511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.6915885639
MESH:D001249 Asthma Mustard Gas 2.7210378619
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001768 Blister Mustard Gas 5.2419167455
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.1012125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.8915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8015746008
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 1.9417474063 20146248
MESH:D001943 Breast Neoplasms Dietary Fats 1.9420435547
MESH:D001943 Breast Neoplasms Fluorouracil 1.9416110121 18608205 15136595 19217205 16557594 16595493 18357371
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.9420435547
MESH:D001989 Bronchiolitis Obliterans Mustard Gas 5.2415286001
MESH:D029481 Bronchitis, Chronic Mustard Gas 5.0717687719 10378619
MESH:D002276 Carcinoid Tumor Fluorouracil 4.7616051944
MESH:D002277 Carcinoma Fluorouracil 8.3317121937
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 8.3316835633
MESH:D006528 Carcinoma, Hepatocellular 2,4-dinitrotoluene 8.9616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 8.963084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 8.9621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 8.9617045692 17971768 17088986 16332177 18930000 16799960
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 8.966705139 17173139 20007298 1701930 20935162
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 3.0418695887
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.6920419170
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 4.6918986760 16757204 16280240 17066447
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.3918850075 18670907 16120746
MESH:D002386 Cataract Acetaminophen 2.6110977129
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 2.7620889678
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.324080065
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.2116835633
MESH:D002779 Cholestasis Ethinyl Estradiol 2.9111677210 15861022 17110522 17681005 17333356 16919318 16105132
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1216354765 15668235 12621046 8697196 15340226
MESH:D003110 Colonic Neoplasms marker/mechanism 18097604
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2417018589 16510598 17287894 17725105 16340194 15001691 17172411 18772588 17016597 17169374
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0017454858 16524972 17594712 18383874 16303861 20501625 17401013 16282729 18509181 18802399 18288408 17695437 17094418 18949393 18448328 17255274 16391804 16331619 15148649 15289873 17016601 14970324
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.1117141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 20055451 10048152
MESH:D003490 Cyanosis 2,4-dinitrotoluene 4.0918551238
MESH:D007644 Darier Disease Fluorouracil 4.8716733453
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6817107852
MESH:D056486 Drug-Induced Liver Injury 2,4-dinitrotoluene 6.2021346803 18551238
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.2012392966 11739529 19923254 12705907 19420014 18071297 16109766 11529661 2444490 18713872 12958197 14550746 16781746 10663392 16227642 17906064 10915739 12153990 11421492 12540782 16485898 16393943 19739265 11743745 17522070 10774834 11287661 16081117 14986274 15619225 19370779 19085960 15968718 11834606 14725611 16177239 12594235 19164858 19416960 11461765 17562736
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.2020420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.1919426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.8011462148
MESH:D050171 Dyslipidemias Dietary Fats 3.4918367378
MESH:D004421 Dystonia Phenobarbital 4.061851702
MESH:D004487 Edema Mustard Gas 7.0211428647 11428631 9260866 11402378
MESH:D004487 Edema Tetrachlorodibenzodioxin 7.0211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.0018230668 16714409 15322242
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.2512538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.079294722 10568697
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 4.183659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.9711558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.9120417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.596401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.327750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 4.103659116
MESH:D004890 Erythema Mustard Gas 5.249357497
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.5320426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 10.5316530937
MESH:D004938 Esophageal Neoplasms Fluorouracil 10.5317638652 16481741 16337965 16785472 15173087
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 10.5315878914 16704527 15547721 15623463 16510608 15547733 15264214 16805852 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.0511564622
MESH:D005234 Fatty Liver Dietary Fats 7.9019551842 17967931 19004024 18296743
MESH:D005234 Fatty Liver Ethinyl Estradiol 7.9015345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.5311858732
MESH:D005355 Fibrosis Dietary Fats 8.8718296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 8.8720067830
MESH:D005756 Gastritis Acetaminophen 3.7716983495
MESH:D005910 Glioma Fluorouracil 2.8916145905
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.6910696789
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.4218337622 15162350 15102660
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 6.5420471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 6.5410048152 11294989
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.3911000095
MESH:D006529 Hepatomegaly Phenobarbital 8.6816109766
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 8.6816120746 15340226 12621046
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.1416354765 16959395 8697196 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 2.7416870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.6521332399
MESH:D006949 Hyperlipidemias Dietary Fats 3.6721332399
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 1.9218670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 3.8816569931 16945680
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.5212013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.5217937319
MESH:D007249 Inflammation Dietary Fats 8.4920412841
MESH:D007249 Inflammation Mustard Gas 8.4917524151 9357497 8975870 11428647 16001271 11428631 9260866 11402378 11428620
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 8.4912200463 12878042
MESH:D007333 Insulin Resistance Dietary Fats 3.1411836018 18457598
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.3916580747
MESH:D007674 Kidney Diseases Acetaminophen 2.2315629191 12587719
MESH:D007680 Kidney Neoplasms 2,4-dinitrotoluene 7.6316705839
MESH:D007680 Kidney Neoplasms Fluorouracil 7.6316985049
MESH:D008103 Liver Cirrhosis Dietary Fats 6.7618296743
MESH:D008103 Liver Cirrhosis Phenobarbital 6.7621047994
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 3.9719784758 12969438 16610002 19460945 11587558 19014921 12587719 16611625
MESH:D008107 Liver Diseases Phenobarbital 3.9719363144
MESH:D017114 Liver Failure, Acute Acetaminophen 3.2917185352 16871587
MESH:D008113 Liver Neoplasms Aflatoxin B1 14.4518177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 14.4520195826 21137059
MESH:D008113 Liver Neoplasms Fluorouracil 14.4517045692 18383874 16603448 15113037
MESH:D008113 Liver Neoplasms Phenobarbital 14.458742319 19482888 21047994 19073162 15975961 19812893
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 14.4516984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 10.018603461
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 10.012563599 1399818 17172636 6150874 18308698
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 10.0112151625
MESH:D008171 Lung Diseases Mustard Gas 3.4818702808 18161513
MESH:D055370 Lung Injury Asbestos, Crocidolite 4.0917365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 6.6514755239
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 6.6520869020 20464547 18569708 17053015 20135361 18520028 20064080 18816296 6695378
MESH:D008175 Lung Neoplasms Fluorouracil 6.6515246190
MESH:D008175 Lung Neoplasms Mustard Gas 6.653148597 8781369
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 6.6519555203 11884234
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 4.8715086387
MESH:D008546 Melanoma, Experimental Acetaminophen 3.6419513568
MESH:D008654 Mesothelioma Asbestos, Crocidolite 3.2016966607 16166281 18303189
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 8.6716381670
MESH:D009062 Mouth Neoplasms Fluorouracil 8.6716757204 18986760
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.0612213967
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.5617484760
MESH:D009336 Necrosis 2,4-dinitrotoluene 3.9418551238
MESH:D009369 Neoplasms Benzo(a)pyrene 5.1511141357
MESH:D009369 Neoplasms Fluorouracil 5.1516928823 18239605 18600527
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.2814600291
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.9118514411
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.4716436463
MESH:D009503 Neutropenia Mustard Gas 4.037688884 16761898
MESH:D009765 Obesity Dietary Fats 2.3017217161 16723640 21332399 18457598 20132043 19632207 11836018 20518802 18674790
MESH:D009784 Occupational Diseases 2,4-dinitrotoluene 3.4812819281 16049721
MESH:D010018 Osteomalacia Phenobarbital 4.4517016548
MESH:D010146 Pain Acetaminophen 2.4316870215
MESH:D010190 Pancreatic Neoplasms Fluorouracil 5.4115113037 16929163 19003803 16500647
MESH:D010190 Pancreatic Neoplasms Phenobarbital 5.4116965848
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.7511578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.3512520081
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.9610923243
MESH:D011041 Poisoning Mustard Gas 3.8515727166
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.6218163543
MESH:D011230 Precancerous Conditions Phenobarbital 3.672563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.2711222880 11118676 11399792 11896295
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 3.2217292933
MESH:D011471 Prostatic Neoplasms Fluorouracil 3.2218626508 19082440
MESH:D011537 Pruritus Ethinyl Estradiol 9.8016919318 15861022
MESH:D011537 Pruritus Mustard Gas 9.8018058305
MESH:D019310 Pseudolymphoma Phenobarbital 4.5912752131
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 5.9817365031 17322281 17975199 15814490
MESH:D011658 Pulmonary Fibrosis Mustard Gas 5.9817894541 17266442 10334151 17720292 17620002
MESH:D012004 Rectal Neoplasms Fluorouracil 4.0618722050 16160472 18286688 15538739
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.9018990726
MESH:D012640 Seizures 2,4-dinitrotoluene 6.0518551238
MESH:D012640 Seizures Phenobarbital 6.054039156 3137016 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.906407741
MESH:D012871 Skin Diseases Mustard Gas 2.7315451306 12880345 16961503
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 5.5510029692 19755658
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5516192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.0416709447
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 3.462093021 20155912
MESH:D013274 Stomach Neoplasms Fluorouracil 3.4618396642 15786421 16951190 17172411 17498489 18567086 16424979 19015929 17522103 19084572
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 3.4617575124 12958204
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.6811994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.2015669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.0012697716
MESH:D013964 Thyroid Neoplasms Phenobarbital 3.091399818
MESH:D014062 Tongue Neoplasms Fluorouracil 4.0416280240
MESH:D001749 Urinary Bladder Neoplasms 2,4-dinitrotoluene 5.0416049721
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 5.0417053015
MESH:D014571 Urologic Neoplasms 2,4-dinitrotoluene 4.4010091137
MESH:D014581 Urticaria Acetaminophen 3.0310982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 3.9316803524
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.3614692618
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.6912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.5914671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.3515886252
MESH:D015430 Weight Gain Dietary Fats 3.7916723640
No data
Pharmacogenomics Knowledge Base Top
Drug Bank Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved