AutismKB 2.0

Annotation Detail for DPP7


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Basic Information Top
Gene Symbol:DPP7 ( DPP2,DPPII,QPP )
Gene Full Name: dipeptidyl-peptidase 7
Band: 9q34.3
Quick LinksEntrez ID:29952; OMIM: 610537; Uniprot ID:DPP2_HUMAN; ENSEMBL ID: ENSG00000176978; HGNC ID: 14892
Relate to Another Database: SFARIGene; denovo-db
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C013112 4-methoxy-2-naphthylamine DPP7 protein results in increased metabolism of 4-methoxy-2-naphthylamine analogincreases metabolic processing 3924993
D000643 Ammonium Chloride Ammonium Chloride affects the expression of DPP7 mRNAaffects expression 16483693
D001104 Arbutin Arbutin results in decreased expression of DPP7 mRNAdecreases expression 17103032
D001151 Arsenic Arsenic results in increased expression of DPP7 mRNAincreases expression 18315880
C015001 arsenite arsenite results in increased expression of DPP7 mRNAincreases expression 18929588
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DPP7 mRNAaffects cotreatment|increases expression 18164116
D004041 Dietary Fats Dietary Fats results in decreased expression of DPP7 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DPP7 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of DPP7 mRNAincreases expression 19638242
D007657 Ketone Bodies Ketone Bodies results in decreased expression of DPP7 mRNAdecreases expression 16807920
C041786 palm oil palm oil results in decreased expression of DPP7 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DPP7 mRNAaffects binding|decreases expression|increases activity 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of DPP7 mRNAincreases expression 18301758
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 3.7518287403
MESH:D055371 Acute Lung Injury pirinixic acid 3.2718653653
MESH:D000236 Adenoma beta-Naphthoflavone 7.1419389873
MESH:D000236 Adenoma Diethylnitrosamine 7.1410737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 10.7519052882 19061943 18056438 17620307 17162532 16434500
MESH:D018248 Adenoma, Liver Cell pirinixic acid 10.7516434500
MESH:D018246 Adrenocortical Adenoma Arsenic 5.4317306315
MESH:D020261 Arsenic Poisoning Arsenic 2.9016835338 12569548 16251483 18414634
MESH:D001161 Arteriosclerosis Dietary Fats 4.0615238619
MESH:D050197 Atherosclerosis Arsenic 3.3319371607 12928151
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.2919483382
MESH:D001943 Breast Neoplasms Dietary Fats 2.1720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 2.1717474063
MESH:D002280 Carcinoma, Basal Cell Arsenic 3.6615504454 17687452
MESH:D006528 Carcinoma, Hepatocellular Arsenic 3.2417306315 16507464
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 3.2416830150 17138121 20101231 17761372 16698587 17173139 17428255 17978847 20432363 18506893 19418558 16288022 17055752 20524982 18056438 20007298 16540662 19171122 18978308 19919837 18494052 16502159 19519916 19052882 10737359 16569478 16807293 20727157 17162532 19539802 19107877 18788625 19822196 20214788 16779866 16935385 11831363 3084413 10672840 19701751 18665156 16878318 16681979 18393292 20512989 19208518 19335982 18210153 3581430 16328049 19383236 20084675 18971187 21159647 18691550 18785209 19394651 20514400 20935162
MESH:D002294 Carcinoma, Squamous Cell Arsenic 2.7217687452 18922899 15504454
MESH:D002295 Carcinoma, Transitional Cell Arsenic 4.2118640142
MESH:D002318 Cardiovascular Diseases Arsenic 3.5415738583 19152805 17938729
MESH:D002340 Carotid Artery Diseases Arsenic 4.4316973168 18022660
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 2.9517174075 7505956 21159647 2727394
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 3.8119052882
MESH:D002779 Cholestasis pirinixic acid 2.9319176532
MESH:D003110 Colonic Neoplasms arsenite 2.6015037631
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4818249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 2.2220387270
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 2.0919107877
MESH:D050171 Dyslipidemias Dietary Fats 3.5518367378
MESH:D004487 Edema pirinixic acid 2.6212083418
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 5.3316302075
MESH:D005234 Fatty Liver arsenite 20.0118296743
MESH:D005234 Fatty Liver Dietary Fats 20.0118296743 17967931 19004024 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 20.0121071580 20387270
MESH:D005234 Fatty Liver pirinixic acid 20.0119236843 20131406
MESH:D005355 Fibrosis arsenite 9.6318296743
MESH:D005355 Fibrosis Dietary Fats 9.6318296743
MESH:D005534 Foot Diseases Arsenic 5.786392382
MESH:D006333 Heart Failure pirinixic acid 2.6220558911
MESH:D006529 Hepatomegaly pirinixic acid 3.1719772884 18467677 19176532 16221962
MESH:D006937 Hypercholesterolemia Dietary Fats 3.7321332399
MESH:D006943 Hyperglycemia pirinixic acid 3.3120558911
MESH:D017488 Hyperkeratosis, Epidermolytic Arsenic 4.5917050553
MESH:D006949 Hyperlipidemias Dietary Fats 3.7621332399
MESH:D006973 Hypertension Arsenic 2.919931084 11953799 16076760
MESH:D006987 Hypesthesia Arsenic 5.7816093927
MESH:D007249 Inflammation Dietary Fats 5.3320412841
MESH:D007249 Inflammation Diethylnitrosamine 5.3318785209
MESH:D007333 Insulin Resistance Dietary Fats 7.5418457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.5416306350
MESH:D007642 Keratosis Arsenic 5.1812749816 16930632
MESH:D015473 Leukemia, Promyelocytic, Acute Arsenic 3.6417339181
MESH:D008103 Liver Cirrhosis arsenite 11.5218296743
MESH:D008103 Liver Cirrhosis Dietary Fats 11.5218296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 11.5218665156 20032147 19638242 18522880 18407596
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 1.3415474484
MESH:D008107 Liver Diseases Arsenic 4.3511134558
MESH:D008107 Liver Diseases Diethylnitrosamine 4.3517034775
MESH:D008113 Liver Neoplasms Arsenic 11.1516368122
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 11.1519389873 21295105
MESH:D008113 Liver Neoplasms Diethylnitrosamine 11.1519690152 21071580 18977376 20501860 18754104 19256749 19426721 19850985 19294768 20583210 18644402 19833225 19254457 21167192 15175105 19073162 18648771 19996281 20101389 2422723 19812893 21047994 19499222 19642983 19427195 10737359 21278145 2862719 20137499 9163691 19638242 20492335 12771043 20118626 12112319 19255062 16942905 20405173 20452335 20434301 18978307 19551842 15885732 19090486
MESH:D008113 Liver Neoplasms pirinixic acid 11.1520007298 15890375 16377806
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 6.4118164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 6.4117942915 19539802 19519916 18775883 17854601 16267830 19004024 19009564 3124819 18079962 18308698 18253720 9362446 18544905 2563599 19126423 18093689 18164116 17174075 21159647 18282651 16842330
MESH:D008175 Lung Neoplasms Arsenic 3.6619168569 17976673 17306315
MESH:D008175 Lung Neoplasms arsenite 3.6616809336
MESH:D008175 Lung Neoplasms Diethylnitrosamine 3.6620970405 21163286 6695378 20512841
MESH:D009135 Muscular Diseases pirinixic acid 3.6816239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.1919151258
MESH:D017202 Myocardial Ischemia Arsenic 4.0915371236
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 3.0516411023
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 2.613581430 9029167
MESH:D009369 Neoplasms pirinixic acid 2.0117405874
MESH:D009389 Neovascularization, Pathologic arsenite 4.6115738583
MESH:D009436 Neural Tube Defects Arsenic 3.5416620997
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 3.4620387270
MESH:D020078 Neurogenic Inflammation Arsenic 4.5217056641
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 5.3320387270
MESH:D009765 Obesity Dietary Fats 4.5417217161 21332399 20518802 11836018 18674790 20132043 18457598 16723640 19632207
MESH:D009765 Obesity pirinixic acid 4.5420558911
MESH:D010051 Ovarian Neoplasms Arsenic 2.7817306315
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 2.4616540662
MESH:D010523 Peripheral Nervous System Diseases Arsenic 4.3416093927
MESH:D016491 Peripheral Vascular Diseases Arsenic 5.1816905509 15371236 6392382
MESH:D011230 Precancerous Conditions Diethylnitrosamine 3.682563599
MESH:D011471 Prostatic Neoplasms Arsenic 3.5916140617
MESH:D011507 Proteinuria Arsenic 4.1521343184
MESH:D015427 Reperfusion Injury pirinixic acid 2.4519058328
MESH:D012871 Skin Diseases Arsenic 2.7816353154 19834688 6392382 17548696 18709164 15952646 16759981 17050553 17938729 16702368 17453740
MESH:D012878 Skin Neoplasms Arsenic 3.0717029826 16251483 17976673 15504454 19538983 17050553
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 1.7618456281
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 3.097505956
MESH:D001749 Urinary Bladder Neoplasms Arsenic 2.8617306315 11144890 19429237 19322015 18640142 15987713 17976673
MESH:D014652 Vascular Diseases Arsenic 4.9317056641
MESH:D015430 Weight Gain Dietary Fats 3.8616723640
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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