AutismKB 2.0

Annotation Detail for PSAT1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PSAT1 ( EPIP,MGC1460,PSA,PSAT )
Gene Full Name: phosphoserine aminotransferase 1
Band: 9q21.2
Quick LinksEntrez ID:29968; OMIM: 610936; Uniprot ID:SERC_HUMAN; ENSEMBL ID: ENSG00000135069; HGNC ID: 19129
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
SERSYN-PWYserine biosynthesis
SER-GLYSYN-PWYsuperpathway of serine and glycine biosynthesis I
Pathway IDPathway Name
hsa00750Vitamin B6 metabolism
hsa01100Metabolic pathways
hsa00260Glycine, serine and threonine metabolism
No data
No data
Pathway IDPathway Name
P02776Serine glycine biosynthesis
P02759Pyridoxal-5-phosphate biosynthesis
P02787Vitamin B6 metabolism
No data
Related Diseases/Disorders Top
No data
No data
No data
No data
Desease Name
Phosphoserine aminotransferase deficiency
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of PSAT1 mRNAaffects expression 17562736
D000082 Acetaminophen Acetaminophen results in decreased expression of PSAT1 mRNAdecreases expression 18246545
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of PSAT1 proteinaffects expression 20106945
C040534 alpha-hexachlorocyclohexane alpha-hexachlorocyclohexane results in increased expression of PSAT1 mRNAincreases expression 17785943
D000643 Ammonium Chloride Ammonium Chloride affects the expression of PSAT1 mRNAaffects expression 16483693
C432165 anthra(1,9-cd)pyrazol-6(2H)-one anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of PSAT1 mRNA]decreases reaction|increases expression 17460151
D016718 Arachidonic Acid Arachidonic Acid results in increased expression of PSAT1 mRNAincreases expression 16704987
C006632 arsenic trioxide arsenic trioxide results in decreased expression of PSAT1 mRNAdecreases expression 19128835
D019324 beta-Naphthoflavone [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PSAT1 mRNAaffects cotreatment|increases expression 18164116
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PSAT1 mRNAincreases expression 20106945
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of PSAT1 mRNAincreases expression 20713471
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PSAT1 mRNAdecreases expression 20018196
C006780 bisphenol A bisphenol A results in decreased expression of PSAT1 mRNAdecreases expression 20678512
D002995 Clofibric Acid [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PSAT1 mRNAaffects cotreatment|affects expression 17602206
D016572 Cyclosporine Cyclosporine results in increased expression of PSAT1 mRNAincreases expression 20106945
D019259 Lamivudine [Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNAaffects cotreatment|increases expression 15784690
D004041 Dietary Fats Dietary Fats results in decreased expression of PSAT1 mRNAdecreases expression 18042831
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PSAT1 mRNAaffects cotreatment|increases expression 18164116
D004052 Diethylnitrosamine [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PSAT1 mRNAaffects cotreatment|affects expression 17602206
D004052 Diethylnitrosamine Diethylnitrosamine results in increased expression of PSAT1 mRNAincreases expression 19638242
D004958 Estradiol Estradiol results in increased expression of PSAT1 mRNAincreases expression 20106945
15757668
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of PSAT1 mRNAaffects expression 17555576
C056507 gemcitabine gemcitabine results in increased expression of PSAT1 mRNAincreases expression 17039268
D019833 Genistein Genistein results in increased expression of PSAT1 mRNAincreases expression 15757668
C029424 hydrazine hydrazine results in increased expression of PSAT1 mRNAincreases expression 15282401
C051890 irinotecan PSAT1 protein results in increased susceptibility to irinotecanincreases response to substance 16734730
D010126 Ozone anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [Ozone results in increased expression of PSAT1 mRNA]decreases reaction|increases expression 17460151
D010126 Ozone Ozone results in increased expression of PSAT1 mRNAincreases expression 17095637
C041786 palm oil palm oil results in decreased expression of PSAT1 mRNAdecreases expression 18042831
C006253 pirinixic acid [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PSAT1 mRNAaffects binding|increases activity|increases expression 19710929
C006253 pirinixic acid pirinixic acid results in increased expression of PSAT1 mRNAincreases expression 18301758
C006253 pirinixic acid pirinixic acid results in increased expression of PSAT1 mRNAincreases expression 17164430
D011374 Progesterone Progesterone results in increased expression of PSAT1 mRNAincreases expression 18037150
C031280 pyrazole pyrazole results in increased expression of PSAT1 mRNAincreases expression 17945193
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of PSAT1 mRNAdecreases expression 20106945
D014212 Tretinoin Tretinoin results in decreased expression of PSAT1 mRNAdecreases expression 16249480
C034613 triacsin C triacsin C results in increased expression of PSAT1 mRNAincreases expression 16704987
D015215 Zidovudine [Zidovudine co-treated with Lamivudine] results in increased expression of PSAT1 mRNAaffects cotreatment|increases expression 15784690
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.5615322242 14514962 11752688
MESH:D000138 Acidosis Ammonium Chloride 3.2618287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.6417505938
MESH:D000163 Acquired Immunodeficiency Syndrome Zidovudine 4.549612607
MESH:D055371 Acute Lung Injury pirinixic acid 2.8518653653
MESH:D000230 Adenocarcinoma arsenic trioxide 12.6811798837 19825857
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 12.6820127859 20464547
MESH:D000230 Adenocarcinoma Estradiol 12.6811473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.6814692618
MESH:D000230 Adenocarcinoma Genistein 12.6811473722
MESH:D000236 Adenoma Benzo(a)pyrene 10.216695378
MESH:D000236 Adenoma beta-Naphthoflavone 10.2119389873
MESH:D000236 Adenoma Diethylnitrosamine 10.2110737359 6695378
MESH:D018248 Adenoma, Liver Cell Diethylnitrosamine 15.5618056438 19061943 17162532 19052882 16434500 17620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 15.5616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 15.5616835633
MESH:D000505 Alopecia Tretinoin 3.3815955085
MESH:D000544 Alzheimer Disease Ozone 2.3715513908
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.6911748828
MESH:D000799 Angioedema Acetaminophen 3.5410982225
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.7819183758
MESH:D001161 Arteriosclerosis Dietary Fats 8.9515238619
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 8.9511256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.6015885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.6016412693
MESH:D001172 Arthritis, Rheumatoid Ozone 4.4215570426
MESH:D001172 Arthritis, Rheumatoid Tretinoin 4.4216292516
MESH:D001249 Asthma Ozone 4.6416373670 17854713
MESH:D001249 Asthma Tretinoin 4.6416456186
MESH:D001321 Autistic Disorder Acetaminophen 2.2318445737
MESH:D001321 Autistic Disorder Arachidonic Acid 2.2318582451
MESH:D001471 Barrett Esophagus Tretinoin 4.1216935849
MESH:D001778 Blood Coagulation Disorders arsenic trioxide 19.7816206674
MESH:D001778 Blood Coagulation Disorders pirinixic acid 19.7819483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 19.7812125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 19.7816206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.4915340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.5815746008
MESH:D001862 Bone Resorption bisphenol A 3.6011985600
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.0417868700
MESH:D001930 Brain Injuries Progesterone 3.9715665606 15845082 15380490
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 6.6717474063 20146248
MESH:D001943 Breast Neoplasms bisphenol A 6.6717123778
MESH:D001943 Breast Neoplasms Dietary Fats 6.6720435547
MESH:D001943 Breast Neoplasms Diethylnitrosamine 6.6717474063
MESH:D001943 Breast Neoplasms Estradiol 6.6717018787 19861407 14630087 17261762 18497071 16675129 17289903 12948864
MESH:D001943 Breast Neoplasms gemcitabine 6.6718382427 17039268
MESH:D001943 Breast Neoplasms Genistein 6.6717200150 16541309 16873071
MESH:D001943 Breast Neoplasms Progesterone 6.6715562024 16175315 17614352
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.6720435547
MESH:D001943 Breast Neoplasms Tretinoin 6.6716166294 16443354 16873071
MESH:D016535 Bronchial Hyperreactivity Ozone 3.4517626835 18417511 19059883 18315731 14754758 15516495 16777450
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.2916813970
MESH:D002051 Burkitt Lymphoma arsenic trioxide 4.0611589617
MESH:D002100 Cachexia Ozone 4.4416183385
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.1716111702
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.5716835633
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.8616168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 16.013084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 16.0121507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular anthra(1,9-cd)pyrazol-6(2H)-one 16.0119418558
MESH:D006528 Carcinoma, Hepatocellular arsenic trioxide 16.0111135700 16217749 15073043 15553829 14691202
MESH:D006528 Carcinoma, Hepatocellular Diethylnitrosamine 16.0118210153 10737359 17138121 19822196 19171122 20432363 18393292 17428255 18978308 20101231 17055752 18506893 19701751 16807293 17978847 20007298 19052882 19418558 19539802 19394651 16569478 19335982 16328049 11831363 16935385 16681979 16288022 18056438 16830150 17761372 20514400 19107877 16540662 3581430 10672840 21159647 16502159 18971187 17173139 20935162 20214788 18785209 3084413 17162532 18788625 19519916 19919837 16779866 16878318 20512989 19208518 19383236 20727157 18691550 16698587 18494052 18665156 20524982 20084675
MESH:D006528 Carcinoma, Hepatocellular Estradiol 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Genistein 16.0116924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 16.011917145
MESH:D002278 Carcinoma in Situ bisphenol A 4.6917123778
MESH:D002291 Carcinoma, Papillary arsenic trioxide 4.5719014326
MESH:D018288 Carcinoma, Small Cell arsenic trioxide 3.8612490120
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 4.2720419170
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 4.2716051514 16096774
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2116120746 18670907 18850075
MESH:D002318 Cardiovascular Diseases Genistein 3.1016332659
MESH:D002386 Cataract Acetaminophen 6.6510977129
MESH:D002386 Cataract Tretinoin 6.6517460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.3520889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.3512371664
MESH:D002471 Cell Transformation, Neoplastic Diethylnitrosamine 14.3517174075 7505956 21159647 2727394
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.3518566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.2916129372
MESH:D018281 Cholangiocarcinoma Diethylnitrosamine 8.5019052882
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 8.5016835633
MESH:D002779 Cholestasis Cyclosporine 12.0919486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.0915861022 16105132 17110522 11677210 17681005 16919318 17333356
MESH:D002779 Cholestasis pirinixic acid 12.0919176532
MESH:D002822 Choriocarcinoma Tretinoin 4.8616461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.3512621046 8697196 15340226 15668235 16354765
MESH:D002972 Cleft Palate Tretinoin 5.359407595
MESH:D003092 Colitis Tretinoin 3.4217035595
MESH:D003110 Colonic Neoplasms Genistein 3.7917182828
MESH:D003110 Colonic Neoplasms irinotecan 3.7917287894 17725105
MESH:D015179 Colorectal Neoplasms arsenic trioxide 2.6020501625
MESH:D015179 Colorectal Neoplasms irinotecan 2.6017159606 15273666 16391804 18259882 16303861 17454858 18509181
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8117141729 14669216
MESH:D023903 Coronary Restenosis arsenic trioxide 3.9012609071
MESH:D019465 Craniofacial Abnormalities arsenic trioxide 3.5610525206
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.5610048152 20055451 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.5614991402 8800419 9211117 10589399 9125849 17551590 9224671 16925845 9664655 9142499
MESH:D016757 Death, Sudden, Cardiac arsenic trioxide 3.8215213294
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.2918249437
MESH:D003924 Diabetes Mellitus, Type 2 Diethylnitrosamine 6.6520387270
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 6.6516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 6.6517107852
MESH:D003928 Diabetic Nephropathies Estradiol 3.1719279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2017187935
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 8.2214725611 12594235 12958197 12540782 19085960 16485898 18071297 12153990 11834606 2444490 16109766 19164858 10774834 19370779 10915739 14550746 12392966 18713872 12705907 10663392 15619225 17906064 19416960 19420014 16081117 19739265 15968718 19923254 16177239 17562736 14986274 16393943 11421492 11743745 16227642 11287661 11461765 11529661 16781746 11739529 17522070
MESH:D056486 Drug-Induced Liver Injury Diethylnitrosamine 8.2219107877
MESH:D056486 Drug-Induced Liver Injury pyrazole 8.2212499123
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 8.2220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8019426721
MESH:D004362 Drug Toxicity Lamivudine 12.6215040536
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 12.6211462148
MESH:D004362 Drug Toxicity Zidovudine 12.6215040536
MESH:D050171 Dyslipidemias Dietary Fats 3.2418367378
MESH:D004487 Edema Arachidonic Acid 10.0116716910 7990266 9599246 11698051 9831321 15177302
MESH:D004487 Edema pirinixic acid 10.0112083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.0111000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 10.9416714409 15322242 18230668
MESH:D004489 Edema, Cardiac Tretinoin 10.9418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.1012538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.1017692515
MESH:D004714 Endometrial Hyperplasia Genistein 4.2916402032
MESH:D016889 Endometrial Neoplasms Estradiol 11.3611473722 18566989 19148513
MESH:D016889 Endometrial Neoplasms Genistein 11.3611473722
MESH:D016889 Endometrial Neoplasms Tretinoin 11.3616569247
MESH:D004715 Endometriosis Progesterone 8.0816134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.089294722 10568697
MESH:D004931 Esophageal Achalasia Diethylnitrosamine 4.8216302075
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 6.7320426865
MESH:D004938 Esophageal Neoplasms arsenic trioxide 6.7312903497
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 6.7316530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.1111564622
MESH:D005124 Eye Abnormalities Tretinoin 8.1116938888 9664655
MESH:D005234 Fatty Liver arsenic trioxide 32.9215073043
MESH:D005234 Fatty Liver Cyclosporine 32.9219224547
MESH:D005234 Fatty Liver Dietary Fats 32.9218296743 19004024 17967931 19551842
MESH:D005234 Fatty Liver Diethylnitrosamine 32.9220387270 21071580
MESH:D005234 Fatty Liver Ethinyl Estradiol 32.9215345470
MESH:D005234 Fatty Liver pirinixic acid 32.9219236843 20131406
MESH:D005234 Fatty Liver Zidovudine 32.9218299183
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.1711858732
MESH:D005334 Fever Arachidonic Acid 4.4011852909
MESH:D005355 Fibrosis Cyclosporine 18.7512639820 12168785
MESH:D005355 Fibrosis Dietary Fats 18.7518296743
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 18.7520067830
MESH:D005355 Fibrosis Tretinoin 18.7517994277
MESH:D005706 Gallbladder Neoplasms arsenic trioxide 3.9816904648
MESH:D005756 Gastritis Acetaminophen 3.3816983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.928708960
MESH:D005909 Glioblastoma Genistein 6.5716598420
MESH:D005909 Glioblastoma Tretinoin 6.5717312396
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.2910696789
MESH:D006258 Head and Neck Neoplasms Tretinoin 2.9916096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.8616084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.1820471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.1810048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.1814991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.3620558911
MESH:D006402 Hematologic Diseases Zidovudine 4.4412579204
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1315720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.0711000095
MESH:D006509 Hepatitis B Lamivudine 4.8417703166
MESH:D019694 Hepatitis B, Chronic Lamivudine 4.8415309715 15631357 12044531 16476009 15274664
MESH:D006529 Hepatomegaly pirinixic acid 7.3018467677 19772884 19176532 16221962
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.3015340226 16120746 12621046
MESH:D006558 Herpes Genitalis Estradiol 4.7315709030
MESH:D015658 HIV Infections Lamivudine 6.5411141242 17530837 9296927 20032539
MESH:D015658 HIV Infections Zidovudine 6.5411141242 11698656 17358032 11363243 20032539
MESH:D019584 Hot Flashes Estradiol 3.4517088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.758697196 16959395 16354765 15340226 18606429
MESH:D006930 Hyperalgesia Acetaminophen 6.8616870215
MESH:D006930 Hyperalgesia Tretinoin 6.8616870215
MESH:D006937 Hypercholesterolemia Dietary Fats 3.3321332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.2816778211
MESH:D006943 Hyperglycemia pirinixic acid 2.9320558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.3421332399
MESH:D006973 Hypertension Cyclosporine 4.5610903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.5618850075 18670907
MESH:D007021 Hypospadias Ethinyl Estradiol 3.5216569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1115869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.1912013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.2917937319
MESH:D007249 Inflammation Arachidonic Acid 14.2215177302 17371808 9831321
MESH:D007249 Inflammation Dietary Fats 14.2220412841
MESH:D007249 Inflammation Diethylnitrosamine 14.2218785209
MESH:D007249 Inflammation Progesterone 14.2215869954
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 14.2212200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 16.0616393666
MESH:D007333 Insulin Resistance Dietary Fats 16.0618457598 11836018
MESH:D007333 Insulin Resistance Estradiol 16.0616393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 16.0616306350
MESH:D007410 Intestinal Diseases Tretinoin 3.4817994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.0516580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.0515992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.1415604871
MESH:D007674 Kidney Diseases Acetaminophen 8.9912587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 8.9918776723 10903974 8314463
MESH:D007674 Kidney Diseases Estradiol 8.9915618244
MESH:D007680 Kidney Neoplasms Cyclosporine 11.1012371664
MESH:D007680 Kidney Neoplasms Estradiol 11.1015610895
MESH:D007680 Kidney Neoplasms Zidovudine 11.1012579204
MESH:D007938 Leukemia arsenic trioxide 9.6315070760
MESH:D007938 Leukemia Genistein 9.6318980019 17468513
MESH:D007938 Leukemia Tretinoin 9.6317143497
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell arsenic trioxide 8.9617077332 12560223
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell Zidovudine 8.9620370541
MESH:D007948 Leukemia, Monocytic, Acute anthra(1,9-cd)pyrazol-6(2H)-one 10.7916972261
MESH:D007948 Leukemia, Monocytic, Acute arsenic trioxide 10.7916972261
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive arsenic trioxide 3.2114633726
MESH:D007951 Leukemia, Myeloid arsenic trioxide 8.6019077051
MESH:D007951 Leukemia, Myeloid Tretinoin 8.6016932348 19285840 16482212
MESH:D015470 Leukemia, Myeloid, Acute arsenic trioxide 3.6917050201 16467208 16968895 20471514 19850784
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 3.6919850784 17596541 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute arsenic trioxide 7.0016112521 19225113 17712046 16966277 19075265 16331271 12712474 12679006 17107899 15748426 9834237 11161223 16330433 15213294 19035177 12018890 19642359 16891316 11468182 15336539 17869043 15622746 16823087 17217047 17649720
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 7.0016891316 17506722 17361223 15748426 17712046 19225113 17107899 16331271 19035177 17217047 17294898 16788101 17649720 19029980 16823087 17301526 9834237 17368321 16140955 16766008 19642359 16935935 17339181 19075265 12679006
MESH:D015458 Leukemia, T-Cell arsenic trioxide 4.0716882451
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.109224671
MESH:D008103 Liver Cirrhosis Dietary Fats 6.0918296743
MESH:D008103 Liver Cirrhosis Diethylnitrosamine 6.0919638242 20032147 18522880 18665156 18407596
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 6.3014716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Genistein 6.3017823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.3015474484
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 6.3012878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.3016248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 3.6419784758 19460945 16610002 19014921 16611625 12969438 12587719 11587558
MESH:D008107 Liver Diseases Diethylnitrosamine 3.6417034775
MESH:D017114 Liver Failure, Acute Acetaminophen 2.9816871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 23.932125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms arsenic trioxide 23.9314682389
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 23.9321137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 23.9321295105 19389873
MESH:D008113 Liver Neoplasms Clofibric Acid 23.9317602206
MESH:D008113 Liver Neoplasms Diethylnitrosamine 23.9321167192 20492335 19690152 19638242 12112319 20405173 15175105 19499222 20583210 9163691 21071580 15885732 19294768 18978307 18754104 19256749 19254457 20501860 19642983 19090486 20137499 16942905 12771043 20118626 20101389 19073162 19255062 19812893 18648771 19427195 18977376 19850985 19996281 19551842 18644402 19833225 19426721 21278145 2862719 20434301 2422723 10737359 20452335 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 23.9315890375 16377806 20007298
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 23.9316984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 16.708603461
MESH:D008114 Liver Neoplasms, Experimental arsenic trioxide 16.7020377131
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 16.7018164116
MESH:D008114 Liver Neoplasms, Experimental Diethylnitrosamine 16.7018164116 19519916 3124819 19009564 19126423 18308698 17174075 16267830 18544905 9362446 16842330 19539802 19004024 18282651 18093689 18253720 17854601 2563599 17942915 21159647 18775883 18079962
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 16.7012151625
MESH:D008133 Long QT Syndrome arsenic trioxide 3.1315213294
MESH:D008171 Lung Diseases Ozone 3.1819066396 8266340
MESH:D055370 Lung Injury Ozone 3.5620417186
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.0914755239
MESH:D008175 Lung Neoplasms arsenic trioxide 10.0911798837 19825857
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 10.0918816296 20869020 18569708 6695378 20464547 20135361 17053015 20064080 18520028
MESH:D008175 Lung Neoplasms Diethylnitrosamine 10.0920970405 6695378 20512841 21163286
MESH:D008175 Lung Neoplasms Ozone 10.097614698 8597069
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.0919555203 11884234
MESH:D008175 Lung Neoplasms Zidovudine 10.0918800350
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 8.9216891317 11408345 17203775 11807958
MESH:D008325 Mammary Neoplasms, Experimental Genistein 8.9214578162 12929590
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 8.9217203775 11408345
MESH:D020149 Manganese Poisoning Estradiol 4.1819453300
MESH:D008527 Medulloblastoma Tretinoin 2.6717453147
MESH:D008545 Melanoma Tretinoin 1.9016752155
MESH:D008546 Melanoma, Experimental Acetaminophen 3.2819513568
MESH:D008591 Meningomyelocele Tretinoin 4.1416940565
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.4916801185
MESH:D008679 Metaplasia Ozone 4.8110496685
MESH:D048629 Micronuclei, Chromosome-Defective Zidovudine 5.5417358032
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 2.9716381670
MESH:D052016 Mucositis irinotecan 4.7117159606
MESH:D009101 Multiple Myeloma arsenic trioxide 2.9019549372 15949261 19417148 11468182 14977855
MESH:D009135 Muscular Diseases pirinixic acid 3.2216239165
MESH:D009182 Mycosis Fungoides arsenic trioxide 4.3718349030
MESH:D009190 Myelodysplastic Syndromes arsenic trioxide 6.8316105982 16882451
MESH:D009190 Myelodysplastic Syndromes Tretinoin 6.8317596541
MESH:D009203 Myocardial Infarction Genistein 5.2617141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.2619151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.7912213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 12.8816810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 12.8817141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 12.8816411023
MESH:D009361 Neoplasm Invasiveness arsenic trioxide 3.6816624393
MESH:D009362 Neoplasm Metastasis Diethylnitrosamine 5.563581430 9029167
MESH:D009362 Neoplasm Metastasis irinotecan 5.5618259882
MESH:D009369 Neoplasms Benzo(a)pyrene 7.3311141357
MESH:D009369 Neoplasms pirinixic acid 7.3317405874
MESH:D009369 Neoplasms Tretinoin 7.3316594593 16946489
MESH:D009389 Neovascularization, Pathologic Estradiol 3.4417289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.1417954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0418481113 19348381
MESH:D009421 Nervous System Malformations bisphenol A 27.7411399458 16427766
MESH:D009421 Nervous System Malformations Estradiol 27.7416427766 11399458
MESH:D009421 Nervous System Malformations Genistein 27.7416427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 27.7414600291
MESH:D009421 Nervous System Malformations Tretinoin 27.749125849
MESH:D009436 Neural Tube Defects arsenic trioxide 6.6610525206
MESH:D009436 Neural Tube Defects Tretinoin 6.669142499
MESH:D009447 Neuroblastoma irinotecan 3.338761367
MESH:D019636 Neurodegenerative Diseases Acetaminophen 7.3918514411
MESH:D019636 Neurodegenerative Diseases Diethylnitrosamine 7.3920387270
MESH:D017599 Neuroectodermal Tumors irinotecan 4.438761367
MESH:D009461 Neurologic Manifestations Diethylnitrosamine 4.8220387270
MESH:D009765 Obesity Dietary Fats 4.1717217161 18674790 20132043 20518802 19632207 11836018 16723640 21332399 18457598
MESH:D009765 Obesity pirinixic acid 4.1720558911
MESH:D010024 Osteoporosis Genistein 3.0719401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8116169203
MESH:D010049 Ovarian Diseases bisphenol A 4.6911985600
MESH:D010051 Ovarian Neoplasms arsenic trioxide 13.9419769630 12452020 16624393
MESH:D010051 Ovarian Neoplasms Estradiol 13.9419401270
MESH:D010051 Ovarian Neoplasms Genistein 13.9419005980
MESH:D010051 Ovarian Neoplasms Progesterone 13.9417393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 13.9416936753
MESH:D010146 Pain Acetaminophen 5.8116870215
MESH:D010146 Pain Tretinoin 5.8116870215
MESH:D010190 Pancreatic Neoplasms arsenic trioxide 11.4715580305
MESH:D010190 Pancreatic Neoplasms Diethylnitrosamine 11.4716540662
MESH:D010190 Pancreatic Neoplasms gemcitabine 11.4711504793 17440100 16929163 18383843 18992248
MESH:D010190 Pancreatic Neoplasms Tretinoin 11.4715976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4111578682
MESH:D010235 Paraganglioma arsenic trioxide 3.8919927285
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 3.9512520081
MESH:D010538 Peritonitis Ozone 3.8416369182
OMIM:610992 PHOSPHOSERINE AMINOTRANSFERASE DEFICIENCY marker/mechanism
MESH:D011014 Pneumonia Ozone 4.1018007984 18929643 18381685
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.2818163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.1212371664
MESH:D011230 Precancerous Conditions Diethylnitrosamine 8.122563599
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 8.5210548101
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 8.5211896295 11399792 11118676 11222880
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.6720887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.6720887781
MESH:D011471 Prostatic Neoplasms arsenic trioxide 1.8819131511
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8817292933
MESH:D011471 Prostatic Neoplasms bisphenol A 1.8816740699
MESH:D011471 Prostatic Neoplasms Estradiol 1.8816740699
MESH:D011471 Prostatic Neoplasms Genistein 1.8815256057 15378649 16925846
MESH:D011507 Proteinuria Tretinoin 3.3316636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.0216919318 15861022
MESH:D011565 Psoriasis Cyclosporine 2.1216882103
MESH:D011625 Pterygium Tretinoin 4.5016723453
MESH:D011629 Puberty, Precocious bisphenol A 4.4910548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2419058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.5618990726
MESH:D012206 Rhabdomyolysis Lamivudine 5.249296927
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.8316283617 16116481
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7518045962
MESH:D012512 Sarcoma, Ewing's arsenic trioxide 3.6816646077
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 8.5619755658 10029692
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 8.5616192470
MESH:D012878 Skin Neoplasms Tretinoin 8.5616467112
MESH:D013088 Spermatocele Ethinyl Estradiol 3.6416709447
MESH:D013119 Spinal Cord Injuries Progesterone 3.9816503802 15862959
MESH:D013274 Stomach Neoplasms arsenic trioxide 7.8717007042
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 7.8720155912 2093021
MESH:D013274 Stomach Neoplasms Diethylnitrosamine 7.8718456281
MESH:D013274 Stomach Neoplasms irinotecan 7.8715723263
MESH:D013274 Stomach Neoplasms Tretinoin 7.8717261132
MESH:D013274 Stomach Neoplasms Zidovudine 7.8717696246
MESH:D019966 Substance-Related Disorders bisphenol A 3.6916045194 16684133
MESH:D013733 Testicular Diseases pyrazole 4.526499806
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.3511994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9115669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6012697716
MESH:D013964 Thyroid Neoplasms arsenic trioxide 10.6919014326
MESH:D013964 Thyroid Neoplasms Diethylnitrosamine 10.697505956
MESH:D013964 Thyroid Neoplasms Tretinoin 10.6917045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.3919048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.5316051514
MESH:D016171 Torsades de Pointes arsenic trioxide 3.6715213294
MESH:D014376 Tuberculosis Tretinoin 3.0516040207
MESH:D001749 Urinary Bladder Neoplasms arsenic trioxide 4.6511780464 20435036 12973940 12845720
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 4.6517053015
MESH:D014581 Urticaria Acetaminophen 2.7110982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4216129372
MESH:D014591 Uterine Diseases bisphenol A 4.7114652134
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.0214692618
MESH:D014604 Uveal Neoplasms Tretinoin 4.3116752155
MESH:D014605 Uveitis Cyclosporine 3.681336536
MESH:D014625 Vaginal Neoplasms Zidovudine 4.4712579204
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.2912125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.2814671159 15869587
MESH:D014820 Vitiligo Tretinoin 3.7816761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 3.9515886252
MESH:D015430 Weight Gain Dietary Fats 3.4916723640
MESH:D009396 Wilms Tumor Tretinoin 3.7216287080
MESH:D014985 Xerophthalmia Cyclosporine 4.1417120751
Pathway ID Pathway Name
KEGG:00260 Glycine, serine and threonine metabolism
KEGG:01100 Metabolic pathways
KEGG:00750 Vitamin B6 metabolism
Pharmacogenomics Knowledge Base Top
Drug Bank Top
Drugbank ID Action Drug Name Description
DB00114 - Pyridoxal Phosphate Dietary supplement;Micronutrient;Vitamin B Complex
DB00142 - L-Glutamic Acid Dietary supplement;Micronutrient;Non-Essential Amino Acids
DB00165 - Pyridoxine Essential Vitamin;Vitamins (Vitamin B Complex);Anti-inflammatory Agents;Vitamin B Complex
No data
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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