AutismKB 2.0

Annotation Detail for MDFIC


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Basic Information Top
Gene Symbol:MDFIC ( HIC )
Gene Full Name: MyoD family inhibitor domain containing
Band: 7q31.1-q31.2
Quick LinksEntrez ID:29969; OMIM: NA; Uniprot ID:MDFIC_HUMAN; ENSEMBL ID: ENSG00000135272; HGNC ID: 28870
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200106Regulation of Wnt-mediated beta catenin signaling and target gene transcription
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of MDFIC mRNAaffects expression 17562736
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of MDFIC proteinaffects expression 20106945
D003520 Cyclophosphamide Cyclophosphamide results in decreased expression of MDFIC mRNAdecreases expression 17403535
D002117 Calcitriol Calcitriol results in increased expression of MDFIC mRNAincreases expression 16002434
D004958 Estradiol Estradiol affects the expression of MDFIC mRNAaffects expression 14699072
D005047 Etoposide MDFIC protein affects the susceptibility to Etoposideaffects response to substance 16217747
D005472 Fluorouracil Fluorouracil affects the expression of MDFIC mRNAaffects expression 16584549
C006253 pirinixic acid pirinixic acid results in increased expression of MDFIC mRNAincreases expression 20059764
18301758
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of MDFIC mRNA]increases expression|increases reaction 20059764
D020849 Raloxifene Raloxifene affects the expression of MDFIC mRNAaffects expression 14699072
D020849 Raloxifene [Raloxifene co-treated with ESR2 protein] results in decreased expression of MDFIC mRNAaffects cotreatment|decreases expression 19059307
D013629 Tamoxifen Tamoxifen affects the expression of MDFIC mRNAaffects expression 14699072
D013629 Tamoxifen [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MDFIC mRNAaffects cotreatment|decreases expression 19059307
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.8114745880
MESH:D055371 Acute Lung Injury pirinixic acid 3.3018653653
MESH:D000230 Adenocarcinoma Estradiol 4.5711473722
MESH:D000230 Adenocarcinoma Fluorouracil 4.5717638652
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.7216434500
MESH:D000419 Albuminuria Raloxifene 4.7917451421 17308373
MESH:D000544 Alzheimer Disease Raloxifene 2.5715800139
MESH:D000740 Anemia Fluorouracil 3.8715504547 16511603 17963324
MESH:D000799 Angioedema Acetaminophen 4.1110982225
MESH:D001161 Arteriosclerosis Cyclophosphamide 4.8115014928
MESH:D001321 Autistic Disorder Acetaminophen 1.4118445737
MESH:D001778 Blood Coagulation Disorders pirinixic acid 3.3219483382
MESH:D019046 Bone Marrow Neoplasms Etoposide 5.4314601052
MESH:D001930 Brain Injuries Raloxifene 4.6916580743
MESH:D001943 Breast Neoplasms Calcitriol 3.8711237771
MESH:D001943 Breast Neoplasms Cyclophosphamide 3.8718323546 17388661 12006526 11325840 15093573 18234424 15136595 16978400 17020986
MESH:D001943 Breast Neoplasms Estradiol 3.8719861407 17018787 14630087 12948864 16675129 17289903 17261762 18497071
MESH:D001943 Breast Neoplasms Etoposide 3.8716322251
MESH:D001943 Breast Neoplasms Fluorouracil 3.8715136595 16557594 18357371 16595493 16110121 19217205 18608205
MESH:D001943 Breast Neoplasms Raloxifene 3.8717440819 17242785 15758505 16837676 17893378 17595753 16912660 17261762 15775269 17049068 15572757 17952589
MESH:D001943 Breast Neoplasms Tamoxifen 3.8719289846 19221464 18997820 11161223 18821012 18351453 19066611 19115204 19011961 20135344 17440819 16202921 19200415 15565566 20859285 17893378 16818667 18815881 19059307 19142967 19244106 19189212 16873071 18855134 16273361 20544844 17242785 19103187 17261762 18629630 20065188 19155303 20390343 19189210 18425577 15668708 17049068 19084267 21138602 20005174 19487384 21152245 19410462 18984771 19288272
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.7016111702
MESH:D002276 Carcinoid Tumor Fluorouracil 4.9316051944
MESH:D002277 Carcinoma Fluorouracil 3.7017121937
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.7219066611
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 11.723084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 11.7221507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 11.7219701751
MESH:D006528 Carcinoma, Hepatocellular Estradiol 11.7216924424
MESH:D006528 Carcinoma, Hepatocellular Fluorouracil 11.7217045692 17971768 16332177 16799960 17088986 18930000
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 11.7216924424
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 5.1316152834
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 7.0516201981
MESH:D002292 Carcinoma, Renal Cell Fluorouracil 7.0518695887
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0011237771
MESH:D002294 Carcinoma, Squamous Cell Fluorouracil 5.0016757204 18986760 16280240 17066447
MESH:D002295 Carcinoma, Transitional Cell Raloxifene 10.0417572228
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 10.0417572228
MESH:D002318 Cardiovascular Diseases Raloxifene 3.5615775269
MESH:D002386 Cataract Acetaminophen 2.6710977129
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.8818566989
MESH:D002779 Cholestasis pirinixic acid 2.9519176532
MESH:D003072 Cognition Disorders Raloxifene 4.8315800139
MESH:D003110 Colonic Neoplasms Fluorouracil 2.2616510598 17172411 15001691 17169374 17725105 17016597 18772588 16340194 17287894 17018589
MESH:D015179 Colorectal Neoplasms Fluorouracil 2.0018448328 18802399 15289873 16282729 18949393 17695437 17594712 16524972 17094418 17401013 16303861 16331619 17255274 15148649 14970324 20501625 18288408 18383874 17016601 16391804 18509181 17454858
MESH:D003556 Cystitis Cyclophosphamide 5.2511948286 16413132 10498854 18093676 16614059 15643279 17979934 12913760 16651033 10700343 15276878 18372110 12161096 18433785 18710439 12388444 18483878 16989017 17010015 18295254
MESH:D007644 Darier Disease Fluorouracil 5.0316733453
MESH:D003711 Demyelinating Diseases Tamoxifen 4.5819031437
MESH:D003865 Depressive Disorder, Major Raloxifene 4.3117474826
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.4918249437
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 4.2111751995 15331540 10990075
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.2618772604
MESH:D003928 Diabetic Nephropathies Estradiol 15.9319279558
MESH:D003928 Diabetic Nephropathies Raloxifene 15.9315920148 17451421 17308373
MESH:D003928 Diabetic Nephropathies Tamoxifen 15.9319279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6318713872 16109766 11739529 15968718 12540782 12958197 11529661 17562736 2444490 11287661 19739265 19085960 12594235 12705907 15619225 17522070 11743745 19370779 19923254 11421492 10663392 16081117 19420014 16177239 19164858 16485898 14550746 14725611 12392966 16781746 16393943 17906064 10774834 11834606 12153990 16227642 19416960 14986274 11461765 18071297 10915739
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.3619426721
MESH:D004487 Edema pirinixic acid 7.4612083418
MESH:D004487 Edema Raloxifene 7.4615860553
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 16.6515138306
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Raloxifene 16.6515845917
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 16.6519031437
MESH:D016889 Endometrial Neoplasms Estradiol 7.7518566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.7520544844 16202921 19155303 17893378
MESH:D004802 Eosinophilia Cyclophosphamide 4.4311006010
MESH:D004938 Esophageal Neoplasms Fluorouracil 2.4816337965 16785472 15173087 16481741 17638652
MESH:D005234 Fatty Liver pirinixic acid 14.1820131406 19236843
MESH:D005234 Fatty Liver Raloxifene 14.1817473493
MESH:D005234 Fatty Liver Tamoxifen 14.1814986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3316709447
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.7614745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.4219069698
MESH:D005756 Gastritis Acetaminophen 3.9416983495
MESH:D005910 Glioma Fluorouracil 2.9316145905
MESH:D018316 Gliosarcoma Cyclophosphamide 5.7511389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 5.2515172196 11014644 16376943
MESH:D006258 Head and Neck Neoplasms Fluorouracil 3.5015162350 18337622 15102660
MESH:D006331 Heart Diseases Raloxifene 3.6511110106
MESH:D006333 Heart Failure pirinixic acid 2.6320558911
MESH:D006467 Hemophilia A Cyclophosphamide 5.5111918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.8014986274
MESH:D006529 Hepatomegaly pirinixic acid 3.2116221962 18467677 19176532 19772884
MESH:D006558 Herpes Genitalis Estradiol 5.3015709030
MESH:D006561 Herpes Simplex Etoposide 4.8010809021
MESH:D006689 Hodgkin Disease Cyclophosphamide 8.3916135485 17606976
MESH:D006689 Hodgkin Disease Etoposide 8.3916200630 15147373 16135485 18180244 17606976
MESH:D019584 Hot Flashes Estradiol 4.0217088409
MESH:D006930 Hyperalgesia Acetaminophen 2.8416870215
MESH:D006943 Hyperglycemia pirinixic acid 3.3420558911
MESH:D006973 Hypertension Raloxifene 2.9215787275 17577099
MESH:D007154 Immune System Diseases Cyclophosphamide 5.6016076520
MESH:D007248 Infertility, Male Cyclophosphamide 3.7316517039 7193160
MESH:D007249 Inflammation Tamoxifen 2.4319457130
MESH:D007333 Insulin Resistance Estradiol 7.5516393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 7.5516306350
MESH:D007674 Kidney Diseases Acetaminophen 6.1915629191 12587719
MESH:D007674 Kidney Diseases Estradiol 6.1915618244
MESH:D007680 Kidney Neoplasms Estradiol 13.3115610895
MESH:D007680 Kidney Neoplasms Fluorouracil 13.3116985049
MESH:D007680 Kidney Neoplasms Tamoxifen 13.3118625569
MESH:D007889 Leiomyoma Raloxifene 4.6816973256
MESH:D007938 Leukemia Cyclophosphamide 3.5710602166
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.5617008537 17296974 17658394 18587576 18172266 17802794
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.2110373061
MESH:D007970 Leukopenia Cyclophosphamide 5.2010052129 11830472
MESH:D008064 Lipidoses Tamoxifen 3.2715342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 3.5414716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.5415474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 3.5418564211
MESH:D008107 Liver Diseases Acetaminophen 1.6616611625 19460945 16610002 19784758 11587558 12969438 12587719 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4016871587 17185352
MESH:D008113 Liver Neoplasms Aflatoxin B1 11.202125692 9163691 18177683 15890375
MESH:D008113 Liver Neoplasms Fluorouracil 11.2015113037 17045692 16603448 18383874
MESH:D008113 Liver Neoplasms pirinixic acid 11.2020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 11.2016684651
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 2.848603461
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.5814755239
MESH:D008175 Lung Neoplasms Fluorouracil 3.5815246190
MESH:D008175 Lung Neoplasms Tamoxifen 3.5818625569
MESH:D008178 Lupus Erythematosus, Cutaneous Fluorouracil 5.0315086387
MESH:D008223 Lymphoma Cyclophosphamide 8.4512854902
MESH:D008223 Lymphoma Etoposide 8.4512556972 12854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.7816675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.3111911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.0019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 6.3217203775 11807958 16891317 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 6.3214580682 16827153 11731420 19196723 19196722
MESH:D020149 Manganese Poisoning Estradiol 13.5519453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.5519453300
MESH:D008545 Melanoma Tamoxifen 1.9019393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.4215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 11.5619513568
MESH:D008546 Melanoma, Experimental Cyclophosphamide 11.5616388313
MESH:D018200 Mixed Tumor, Mullerian Raloxifene 5.8215863610
MESH:D009062 Mouth Neoplasms Fluorouracil 3.7618986760 16757204
MESH:D009101 Multiple Myeloma Raloxifene 3.5616497877
MESH:D009135 Muscular Diseases pirinixic acid 3.7216239165
MESH:D009203 Myocardial Infarction pirinixic acid 2.2019151258
MESH:D015428 Myocardial Reperfusion Injury Estradiol 8.6916810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 8.6916411023
MESH:D009232 Myxoma Raloxifene 5.8216343187
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6019393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5619410462
MESH:D009369 Neoplasms Cyclophosphamide 8.8118854779
MESH:D009369 Neoplasms Fluorouracil 8.8116928823 18600527 18239605
MESH:D009369 Neoplasms pirinixic acid 8.8117405874
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.2619189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.9717289903
MESH:D009421 Nervous System Malformations Estradiol 3.8516427766 11399458
MESH:D009447 Neuroblastoma Cyclophosphamide 3.7216115947 8761367 15176712
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0118514411
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 5.138761367 12837982
MESH:D020258 Neurotoxicity Syndromes Fluorouracil 3.5516436463
MESH:D009503 Neutropenia Cyclophosphamide 4.518291058
MESH:D009765 Obesity pirinixic acid 1.8520558911
MESH:D009845 Oligospermia Cyclophosphamide 4.9516517039
MESH:D010024 Osteoporosis Raloxifene 3.4915775268 19059307 17882678
MESH:D015663 Osteoporosis, Postmenopausal Raloxifene 4.4115758505 17823083 17893378 15579764
MESH:D010051 Ovarian Neoplasms Estradiol 2.2619401270
MESH:D010146 Pain Acetaminophen 7.3316870215
MESH:D010146 Pain Cyclophosphamide 7.3318093676 12161096
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 9.1611332152
MESH:D010190 Pancreatic Neoplasms Etoposide 9.1619003803
MESH:D010190 Pancreatic Neoplasms Fluorouracil 9.1619003803 16929163 16500647 15113037
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.8921297632
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.0215572423
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.0620887781
MESH:D011471 Prostatic Neoplasms Calcitriol 2.1312479363 18247401 16289102 15754350 16644109
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 2.1317136230
MESH:D011471 Prostatic Neoplasms Estradiol 2.1316740699
MESH:D011471 Prostatic Neoplasms Etoposide 2.1317172428
MESH:D011471 Prostatic Neoplasms Fluorouracil 2.1319082440 18626508
MESH:D011471 Prostatic Neoplasms Raloxifene 2.1316536755 15731164 16220300
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.1315067354
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.3416636934
MESH:D011693 Purpura Raloxifene 5.8215770314
MESH:D012004 Rectal Neoplasms Fluorouracil 4.1618286688 18722050 16160472 15538739
MESH:D015427 Reperfusion Injury pirinixic acid 2.4619058328
MESH:D012512 Sarcoma, Ewing's Etoposide 4.9014601052
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 5.0116636934
MESH:D013088 Spermatocele Tamoxifen 4.5616709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.7516517039
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.2819457130
MESH:D013274 Stomach Neoplasms Fluorouracil 2.0019015929 16424979 16951190 18396642 17522103 17498489 19084572 18567086 15786421 17172411
MESH:D020521 Stroke Raloxifene 3.9616837676
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 5.2912837982
MESH:D013978 Tibial Fractures Estradiol 14.6219048282
MESH:D013978 Tibial Fractures Raloxifene 14.6219048282
MESH:D014062 Tongue Neoplasms Fluorouracil 4.1516280240
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 8.8314692829
MESH:D001749 Urinary Bladder Neoplasms Raloxifene 8.8317572228
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 8.8316712894 17572228 8653321
MESH:D014581 Urticaria Acetaminophen 3.1610982225
MESH:D002583 Uterine Cervical Neoplasms Fluorouracil 4.0416803524
MESH:D054556 Venous Thromboembolism Raloxifene 5.4716837676
MESH:D014846 Vulvar Neoplasms Raloxifene 5.8216343187
No data
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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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