AutismKB 2.0

Annotation Detail for GLTSCR2


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Basic Information Top
Gene Symbol:GLTSCR2 ( PICT-1,PICT1 )
Gene Full Name: glioma tumor suppressor candidate region gene 2
Band: 19q13.3
Quick LinksEntrez ID:29997; OMIM: 605691; Uniprot ID:GSCR2_HUMAN; ENSEMBL ID: ENSG00000105373; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of GLTSCR2 mRNAincreases expression 18648102
D000082 Acetaminophen Acetaminophen affects the expression of GLTSCR2 mRNAaffects expression 17562736
D003024 Clozapine Clozapine affects the expression of GLTSCR2 mRNAaffects expression 14647396
D016572 Cyclosporine Cyclosporine results in increased expression of GLTSCR2 mRNAincreases expression 20106945
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GLTSCR2 mRNAaffects cotreatment|increases expression 17942748
D006220 Haloperidol Haloperidol results in increased expression of GLTSCR2 mRNAincreases expression 14647396
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in decreased expression of GLTSCR2 mRNAdecreases expression 17616710
C058305 phenethyl isothiocyanate phenethyl isothiocyanate results in decreased expression of GLTSCR2 mRNAdecreases expression 17616710
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GLTSCR2 mRNAaffects cotreatment|increases expression 17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 3.1311752688 15322242 14514962
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 4.2617505938
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 1.8514692618
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 2.863712494
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 3.6616835633
MESH:D000380 Agranulocytosis Clozapine 5.3116160616 14617031 12649775
MESH:D000740 Anemia Tetrachlorodibenzodioxin 3.1411748828
MESH:D000799 Angioedema Acetaminophen 4.1610982225
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.7211256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.7815885639
MESH:D001321 Autistic Disorder Acetaminophen 2.1318445737
MESH:D001321 Autistic Disorder Haloperidol 2.1318080171 19368416
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 5.3411289319 1440618
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 3.2512125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 4.1115340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.8915746008
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 1.6920435547
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.9616835633
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 2.897296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 2.893084413
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.767296757
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.4716120746 18670907 18850075
MESH:D002375 Catalepsy Haloperidol 5.1915215559 1977408
MESH:D002386 Cataract Acetaminophen 2.6910977129
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 7.037505956
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 7.0312371664
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 3.3416835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 14.279022650 19486331
MESH:D002779 Cholestasis Cyclosporine 14.2719486331
MESH:D002779 Cholestasis Ethinyl Estradiol 14.2717681005 16919318 16105132 11677210 17110522 17333356 15861022
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.1815340226 15668235 8697196 12621046 16354765
MESH:D003072 Cognition Disorders Clozapine 5.2217123785
MESH:D003093 Colitis, Ulcerative phenethyl isothiocyanate 3.7020423518
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 3.2417141729 14669216
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2615322242 10048152 20055451
MESH:D016757 Death, Sudden, Cardiac Haloperidol 5.0620210726
MESH:D003704 Dementia Haloperidol 4.7811575062
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 3.0618759878 2524372 12868966 11298694 8156756 8970840 11906362 14531868
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.712952479 3621924
MESH:D003924 Diabetes Mellitus, Type 2 Clozapine 4.6516402076
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.6517107852
MESH:D006970 Disorders of Excessive Somnolence Clozapine 5.8715331141
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 6.429328219 9653073 1440618 18692083 18648102 18289764 8291058 6679447 11289319 9022650 7440962 16192314 6482804
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 6.422444490 14986274 15619225 18071297 12594235 16227642 16177239 16781746 10774834 11461765 14550746 14725611 17562736 11834606 11529661 19416960 19923254 19739265 11743745 11421492 15968718 17522070 16393943 16109766 19085960 16081117 12540782 12958197 12392966 12705907 16485898 11287661 11739529 17906064 19164858 10663392 19420014 10915739 19370779 12153990 18713872
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 6.4220420201
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4219426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.9111462148
MESH:D050171 Dyslipidemias Clozapine 4.3316402076
MESH:D004487 Edema Tetrachlorodibenzodioxin 2.5812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 4.2215322242 16714409 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 3.4212538720
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 3.219294722 10568697
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 4.793581430
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 4.7915547721 15547733 15623463 16510608 15150132 15264214 16805852 15878914 16704527
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 3.1611564622
MESH:D005234 Fatty Liver Cyclosporine 8.2719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 8.2715345470
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.7111858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 5.346705139
MESH:D005355 Fibrosis Cyclosporine 9.3612639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 9.3620067830
MESH:D005756 Gastritis Acetaminophen 3.9916983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.508708960
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 4.267505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.9110696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.4311294989 10048152
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.7115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.5411000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.756705139
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 3.1515340226 12621046 16120746
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 4.3615340226 16959395 8697196 18606429 16354765
MESH:D006930 Hyperalgesia Acetaminophen 2.8616870215
MESH:D006948 Hyperkinesis Clozapine 5.1916046005
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 4.2015034207
MESH:D006973 Hypertension Cyclosporine 5.1710903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 5.1718670907 18850075
MESH:D007021 Hypospadias Ethinyl Estradiol 4.0716945680 16569931
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.6812013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 2.6217937319
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 1.9512200463 12878042
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 5.348074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.5416580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.7615604871
MESH:D007674 Kidney Diseases Acetaminophen 6.1612587719 15629191
MESH:D007674 Kidney Diseases Cyclosporine 6.1618776723 10903974 8314463
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 7.856582329
MESH:D007680 Kidney Neoplasms Cyclosporine 7.8512371664
MESH:D008064 Lipidoses Clozapine 4.1017567588
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.3115034207 9327722
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 1.2412878042
MESH:D008107 Liver Diseases Acetaminophen 1.6712969438 16610002 19014921 11587558 19460945 12587719 19784758 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4317185352 16871587
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 1.7816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 6.13598648 6587162 3712494 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 6.1312151625
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 1.2419555203 11884234
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8319513568
MESH:D001523 Mental Disorders Clozapine 9.3316856516
MESH:D001523 Mental Disorders Haloperidol 9.3316856516
MESH:D024821 Metabolic Syndrome X Clozapine 4.5819142101
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 5.1116801185
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 3.1812213967
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 2.543581430
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.7617954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.4719348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.4514600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 3.046679447
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0418514411
MESH:D009765 Obesity Clozapine 3.0618515891 19142110
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.616482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 5.343988306
MESH:D010146 Pain Acetaminophen 2.5616870215
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.9111578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.747296757
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.5712520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.796228378
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.8018163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.4012371664
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 3.4811896295 11399792 11118676 11222880
MESH:D011537 Pruritus Ethinyl Estradiol 3.6015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.2916882103
MESH:D011595 Psychomotor Agitation Haloperidol 5.2111575062
MESH:D011618 Psychotic Disorders Clozapine 9.6415331141
MESH:D011618 Psychotic Disorders Haloperidol 9.6411575062
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 4.0818990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 3.523692021
MESH:D012559 Schizophrenia Clozapine 4.1820107430 18806925 20521326 20168265 11763009 16141801 20580759 17667964 18855531 20521320 17726453 11151749 19369910 17123785 20452607
MESH:D012559 Schizophrenia Haloperidol 4.181830565 19369910 20107430 18513383
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 2.1316192470
MESH:D013088 Spermatocele Ethinyl Estradiol 4.2616709447
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.3317575124 12958204
MESH:D017180 Tachycardia, Ventricular Haloperidol 4.9420210726
MESH:D013733 Testicular Diseases phenethyl isothiocyanate 5.2315864552
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.8411994571
MESH:D013927 Thrombosis Ethinyl Estradiol 3.3315669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 4.2212697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 3.047505956 6582329 6587162 1399818 3712494
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 2.348074119
MESH:D014581 Urticaria Acetaminophen 3.2010982225
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 3.5414692618
MESH:D014605 Uveitis Cyclosporine 4.301336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.9112125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.7514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.5715886252
MESH:D015430 Weight Gain Clozapine 4.6516402076 20107430 20521320 17502770 16141801 20564506
MESH:D015431 Weight Loss Clozapine 5.3617933447
MESH:D014985 Xerophthalmia Cyclosporine 4.7617120751
No data
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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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