AutismKB 2.0

Annotation Detail for ACAA1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:ACAA1 ( ACAA,PTHIO,THIO )
Gene Full Name: acetyl-CoA acyltransferase 1
Band: 3p22.2
Quick LinksEntrez ID:30; OMIM: 604054; Uniprot ID:THIK_HUMAN; ENSEMBL ID: ENSG00000060971; HGNC ID: 82
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Pathway IDPathway Name
ILEUDEG-PWYisoleucine degradation I
FAO-PWYfatty acid beta-oxidation I
Pathway IDPathway Name
hsa03320PPAR signaling pathway
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
hsa04146Peroxisome
hsa01040Biosynthesis of unsaturated fatty acids
hsa00071Fatty acid metabolism
Pathway IDPathway Name
Metabolism of lipids and lipoproteins
No data
No data
Pathway IDPathway Name
500821Beta-oxidation of very long chain fatty acids
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACAA1 mRNAdecreases expression 18281256
C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACAA1 mRNA]decreases expression|increases reaction 18281256
C031903 1-UFT protocol ACAA1 protein results in increased susceptibility to 1-UFT protocolincreases response to substance 16734730
C023514 2,6-dinitrotoluene 2,6-dinitrotoluene affects the expression of ACAA1 mRNAaffects expression 21346803
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of ACAA1 mRNAaffects expression 21346803
D000082 Acetaminophen Acetaminophen results in decreased expression of ACAA1 mRNAdecreases expression 15084756
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of ACAA1 proteinaffects expression 20106945
D000638 Amiodarone Amiodarone results in increased expression of ACAA1 mRNAincreases expression 15265979
D002104 Cadmium Cadmium results in increased expression of ACAA1 mRNAincreases expression 17327699
D019256 Cadmium Chloride Cadmium Chloride results in increased expression of ACAA1 mRNAincreases expression 17327699
C110904 capecitabine ACAA1 protein results in increased susceptibility to capecitabineincreases response to substance 16734730
C030123 coumarin coumarin results in increased expression of ACAA1 mRNAincreases expression 18480146
D016572 Cyclosporine Cyclosporine results in decreased expression of ACAA1 mRNAdecreases expression 20106945
D004041 Dietary Fats Dietary Fats results in increased expression of ACAA1 mRNAincreases expression 18457598
16357043
C025034 doxifluridine ACAA1 protein results in increased susceptibility to doxifluridineincreases response to substance 16734730
C039281 furan furan results in decreased expression of ACAA1 mRNAdecreases expression 15120968
D006830 Hydralazine [Hydralazine co-treated with Valproic Acid] results in increased expression of ACAA1 mRNAaffects cotreatment|increases expression 17183730
D008701 Methapyrilene Methapyrilene results in decreased expression of ACAA1 mRNAdecreases expression 15120968
D008727 Methotrexate Methotrexate results in decreased expression of ACAA1 mRNAdecreases expression 15120968
C076994 perfluorooctane sulfonic acid perfluorooctane sulfonic acid results in increased expression of ACAA1 mRNAincreases expression 16221955
C023036 perfluorooctanoic acid perfluorooctanoic acid affects the expression of ACAA1 mRNAaffects expression 18281256
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACAA1 mRNAincreases expression 18467677
C023036 perfluorooctanoic acid PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACAA1 mRNA]increases expression|increases reaction 18467677
C023036 perfluorooctanoic acid perfluorooctanoic acid results in increased expression of ACAA1 mRNAincreases expression 16221955
D010795 Phthalic Acids Phthalic Acids results in decreased expression of ACAA1 mRNAdecreases expression 15728792
C006253 pirinixic acid pirinixic acid results in increased expression of ACAA1 mRNAincreases expression 16357043
15375163
18467677
C006253 pirinixic acid pirinixic acid results in increased expression of ACAA1 proteinincreases expression 15226431
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of ACAA1 mRNA]increases expression|increases reaction 18467677
C006253 pirinixic acid pirinixic acid results in increased expression of ACAA1 mRNAincreases expression 16940010
D011794 Quercetin Quercetin results in decreased expression of ACAA1 mRNAdecreases expression 16455785
C079198 S 1 (combination) ACAA1 protein results in increased susceptibility to S 1 (combination)increases response to substance 16734730
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of ACAA1 mRNAincreases expression 16054898
16960034
D014303 Trinitrotoluene Trinitrotoluene affects the expression of ACAA1 mRNAaffects expression 21346803
D014635 Valproic Acid [Hydralazine co-treated with Valproic Acid] results in increased expression of ACAA1 mRNAaffects cotreatment|increases expression 17183730
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 24.257525203
MESH:D000014 Abnormalities, Drug-Induced Methotrexate 24.2512039119
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 24.2515322242 11752688 14514962
MESH:D000014 Abnormalities, Drug-Induced Trinitrotoluene 24.257525203
MESH:D000014 Abnormalities, Drug-Induced Valproic Acid 24.258875741
MESH:D000015 Abnormalities, Multiple Valproic Acid 3.7219490988
MESH:D055371 Acute Lung Injury pirinixic acid 2.9118653653
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.1416434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.1416835633
MESH:D000550 Amblyopia Valproic Acid 5.0017688650
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7511748828
MESH:D000743 Anemia, Hemolytic Quercetin 4.0317084956
MESH:D000799 Angioedema Acetaminophen 3.6110982225
MESH:D001008 Anxiety Disorders Valproic Acid 3.3917497229
MESH:D001145 Arrhythmias, Cardiac Amiodarone 3.6020041841 18218290 18057881
MESH:D001161 Arteriosclerosis Dietary Fats 3.6615238619
MESH:D001172 Arthritis, Rheumatoid Methotrexate 3.0517286800
MESH:D001260 Ataxia Telangiectasia Quercetin 4.7515336622
MESH:D050197 Atherosclerosis Cadmium 3.5115687053
MESH:D001281 Atrial Fibrillation Amiodarone 3.7319698954 18651412
MESH:D001289 Attention Deficit Disorder with Hyperactivity Phthalic Acids 4.2120106747
MESH:D001321 Autistic Disorder Acetaminophen 1.8518445737
MESH:D001321 Autistic Disorder Valproic Acid 1.8518316065 16609825 17157402 18775368 17507914 18396377 20603192 18558336 15238991 19460635 18940202 17688650 18985861 18177632 19232924
MESH:D001327 Autoimmune Diseases Quercetin 4.1819761891
MESH:D001714 Bipolar Disorder Valproic Acid 2.9617594078 20046352
MESH:D001778 Blood Coagulation Disorders Amiodarone 14.1219483382
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1219483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1212125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5615340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 7.5415746008
MESH:D001848 Bone Diseases, Developmental Valproic Acid 7.548888407
MESH:D001943 Breast Neoplasms capecitabine 2.3012972520 18473752
MESH:D001943 Breast Neoplasms Dietary Fats 2.3020435547
MESH:D001943 Breast Neoplasms Methotrexate 2.3016978400
MESH:D001943 Breast Neoplasms Quercetin 2.3018628248
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 2.3020435547
MESH:D002105 Cadmium Poisoning Quercetin 5.3116962696
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6216835633
MESH:D006528 Carcinoma, Hepatocellular 2,6-dinitrotoluene 6.2616705839
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.263084413
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 6.2621507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Quercetin 6.2619519916 12508355
MESH:D002289 Carcinoma, Non-Small-Cell Lung S 1 (combination) 3.9918212800 18347146
MESH:D021441 Carcinoma, Pancreatic Ductal Quercetin 4.7317234771
MESH:D002294 Carcinoma, Squamous Cell S 1 (combination) 3.7915984520
MESH:D006332 Cardiomegaly Quercetin 6.3919794523
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 6.3918670907 18850075 16120746
MESH:D002311 Cardiomyopathy, Dilated Amiodarone 2.8215710769 19225199
MESH:D002341 Carotid Artery Thrombosis Amiodarone 4.8518974383
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 11.7114694615
MESH:D002386 Cataract Acetaminophen 11.7110977129
MESH:D002386 Cataract Trinitrotoluene 11.7115817613 14694615
MESH:D002471 Cell Transformation, Neoplastic 2,6-dinitrotoluene 10.376135515
MESH:D002471 Cell Transformation, Neoplastic Cadmium 10.3717332340
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3712371664
MESH:D002659 Child Development Disorders, Pervasive Valproic Acid 2.6320734317
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9716835633
MESH:D002779 Cholestasis Cyclosporine 7.2019486331
MESH:D002779 Cholestasis pirinixic acid 7.2019176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0116354765 15668235 15340226 12621046 8697196
MESH:D003110 Colonic Neoplasms Quercetin 2.3817191121 11134977 19056647 17148506 16640504 19440933 15741050
MESH:D015179 Colorectal Neoplasms capecitabine 3.0918448328 18473752
MESH:D015179 Colorectal Neoplasms Quercetin 3.0918852136 18095365
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 14.5015095906
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 14.5014669216 17141729
MESH:D000013 Congenital Abnormalities Trinitrotoluene 14.5015095906
MESH:D003329 Coronary Vasospasm capecitabine 5.5917465463
MESH:D019465 Craniofacial Abnormalities Methotrexate 3.739562676 12039119
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7320055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Valproic Acid 3.7317688650 16575769 8888407
MESH:D003490 Cyanosis 2,6-dinitrotoluene 10.4818551238
MESH:D003490 Cyanosis Trinitrotoluene 10.4818551238
MESH:D003550 Cystic Fibrosis Methotrexate 4.0419747007
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3218249437
MESH:D003882 Dermatomyositis Methotrexate 4.9120191521
MESH:D003921 Diabetes Mellitus, Experimental Quercetin 3.5519496084
MESH:D003924 Diabetes Mellitus, Type 2 coumarin 4.4019647726
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.4017107852
MESH:D056486 Drug-Induced Liver Injury 2,6-dinitrotoluene 17.6121346803 18551238
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 17.6121346803
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 17.6114550746 16109766 18713872 16227642 16393943 17906064 19416960 16081117 16781746 11287661 17562736 19739265 10663392 16177239 12705907 14986274 11461765 10915739 11739529 19085960 14725611 11834606 12153990 12958197 11529661 10774834 18071297 19923254 16485898 19164858 19370779 11421492 11743745 15968718 12540782 12594235 19420014 17522070 12392966 15619225 2444490
MESH:D056486 Drug-Induced Liver Injury Amiodarone 17.6118218290 15265979
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 17.6120420201
MESH:D056486 Drug-Induced Liver Injury Trinitrotoluene 17.6118551238 21346803
MESH:D056486 Drug-Induced Liver Injury Valproic Acid 17.611733752 19641884
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 3.8719426721
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.5911462148
MESH:D050171 Dyslipidemias Dietary Fats 3.2918367378
MESH:D004421 Dystonia Valproic Acid 3.841851702
MESH:D004487 Edema perfluorooctanoic acid 10.2812083418 17259670
MESH:D004487 Edema pirinixic acid 10.2812083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 10.2812711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6718230668 16714409 15322242
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.829294722 10568697
MESH:D004831 Epilepsies, Myoclonic Valproic Acid 3.9317275665 3659116
MESH:D004828 Epilepsies, Partial Valproic Acid 3.693922381 16628512
MESH:D004827 Epilepsy Valproic Acid 2.8220417680 18234410
MESH:D004832 Epilepsy, Absence Valproic Acid 3.406426943 7562514 6254150
MESH:D017029 Epilepsy, Complex Partial Valproic Acid 4.077750514
MESH:D004830 Epilepsy, Tonic-Clonic Valproic Acid 3.843659116
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8411564622
MESH:D005234 Fatty Liver Amiodarone 22.4714986274
MESH:D005234 Fatty Liver Cyclosporine 22.4719224547
MESH:D005234 Fatty Liver Dietary Fats 22.4717967931 19551842 18296743 19004024
MESH:D005234 Fatty Liver pirinixic acid 22.4720131406 19236843
MESH:D005234 Fatty Liver Valproic Acid 22.4714986274 19224547
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2311858732
MESH:D005315 Fetal Diseases Valproic Acid 4.6616575769
MESH:D005317 Fetal Growth Retardation Valproic Acid 3.918888407 18558336
MESH:D005355 Fibrosis Cyclosporine 19.3012168785 12639820
MESH:D005355 Fibrosis Dietary Fats 19.3018296743
MESH:D005355 Fibrosis Quercetin 19.3019474275
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 19.3020067830
MESH:D005706 Gallbladder Neoplasms S 1 (combination) 5.5419093184
MESH:D005756 Gastritis Acetaminophen 3.4416983495
MESH:D005885 Gingival Hyperplasia Cyclosporine 3.998708960
MESH:D005909 Glioblastoma perfluorooctane sulfonic acid 7.2317162496
MESH:D005909 Glioblastoma Quercetin 7.2319804834
MESH:D005910 Glioma Quercetin 2.9717643826
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3610696789
MESH:D006086 Graft vs Host Disease Methotrexate 4.9216518429
MESH:D006258 Head and Neck Neoplasms S 1 (combination) 4.6015984520 18607998
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2110048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4020558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.1915720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1311000095
MESH:D006529 Hepatomegaly 1,4-bis(2-(3,5-dichloropyridyloxy))benzene 30.8516109766
MESH:D006529 Hepatomegaly Amiodarone 30.8515265979
MESH:D006529 Hepatomegaly perfluorooctanoic acid 30.853609246
MESH:D006529 Hepatomegaly pirinixic acid 30.8516221962 18467677 19772884 19176532
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 30.8515340226 12621046 16120746
MESH:D006529 Hepatomegaly Trinitrotoluene 30.8515817613
MESH:D006849 Hydrocephalus Valproic Acid 4.6417688650
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8118606429 16354765 8697196 16959395 15340226
MESH:D006930 Hyperalgesia Acetaminophen 7.2716870215
MESH:D006930 Hyperalgesia perfluorooctanoic acid 7.2712083418
MESH:D006937 Hypercholesterolemia Amiodarone 8.489751232 8137927
MESH:D006937 Hypercholesterolemia Dietary Fats 8.4821332399
MESH:D006943 Hyperglycemia pirinixic acid 8.5820558911
MESH:D006943 Hyperglycemia Quercetin 8.5811834736 18262572
MESH:D006949 Hyperlipidemias Dietary Fats 3.4021332399
MESH:D006973 Hypertension Cyclosporine 8.0710903974
MESH:D006973 Hypertension Quercetin 8.0718356687
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.0718850075 18670907
MESH:D046110 Hypertension, Pregnancy-Induced Hydralazine 4.4016612254
MESH:D007037 Hypothyroidism Amiodarone 4.2917991464 18020914
MESH:D007248 Infertility, Male Trinitrotoluene 3.5312150543
MESH:D007249 Inflammation Dietary Fats 7.6820412841
MESH:D007249 Inflammation perfluorooctanoic acid 7.6812083418
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6812878042 12200463
MESH:D007251 Influenza, Human Quercetin 4.2816624496
MESH:D007333 Insulin Resistance Dietary Fats 6.7611836018 18457598
MESH:D007333 Insulin Resistance pirinixic acid 6.7616306350
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1316580747
MESH:D007627 Keloid Quercetin 4.7317086741
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2115604871
MESH:D007674 Kidney Diseases Acetaminophen 17.6912587719 15629191
MESH:D007674 Kidney Diseases Cadmium 17.6916962696 16322080 16226777
MESH:D007674 Kidney Diseases Cadmium Chloride 17.6916962696
MESH:D007674 Kidney Diseases Cyclosporine 17.698314463 18776723 10903974
MESH:D007674 Kidney Diseases Quercetin 17.6916962696
MESH:D007680 Kidney Neoplasms 2,6-dinitrotoluene 6.6616705839
MESH:D007680 Kidney Neoplasms Cyclosporine 6.6612371664
MESH:D007805 Language Development Disorders Methotrexate 4.899562676
MESH:D007938 Leukemia Quercetin 3.0417468513
MESH:D015470 Leukemia, Myeloid, Acute Valproic Acid 2.1117596541 16294345
MESH:D007984 Leydig Cell Tumor perfluorooctanoic acid 5.008812269
MESH:D008064 Lipidoses Amiodarone 3.3517567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.5418296743
MESH:D008103 Liver Cirrhosis Methotrexate 6.5414986274
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 3.2915474484
MESH:D008106 Liver Cirrhosis, Experimental Quercetin 3.2912741479
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 3.2912878042
MESH:D008107 Liver Diseases Acetaminophen 1.5811587558 16611625 12587719 19784758 19460945 12969438 16610002 19014921
MESH:D017114 Liver Failure, Acute Acetaminophen 3.0417185352 16871587
MESH:D008113 Liver Neoplasms 2,6-dinitrotoluene 20.567678174
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.562125692 15890375 18177683 9163691
MESH:D008113 Liver Neoplasms Methapyrilene 20.5615890375
MESH:D008113 Liver Neoplasms perfluorooctanoic acid 20.5618709148 14757943
MESH:D008113 Liver Neoplasms pirinixic acid 20.5616377806 20007298 15890375
MESH:D008113 Liver Neoplasms Quercetin 20.5618980244
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.5616984957
MESH:D008114 Liver Neoplasms, Experimental 2,6-dinitrotoluene 12.972876784 2876786 6135515
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 12.978603461
MESH:D008114 Liver Neoplasms, Experimental Quercetin 12.9719519916
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 12.9712151625
MESH:D008133 Long QT Syndrome Amiodarone 3.4115350150 11989578 17391786
MESH:D008171 Lung Diseases Amiodarone 3.2212587719
MESH:D017563 Lung Diseases, Interstitial Amiodarone 17.8018516814
MESH:D017563 Lung Diseases, Interstitial Methotrexate 17.8018516814
MESH:D017563 Lung Diseases, Interstitial Valproic Acid 17.8017228818
MESH:D008175 Lung Neoplasms Aflatoxin B1 3.2914755239
MESH:D008175 Lung Neoplasms Quercetin 3.2916280456
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 3.2919555203 11884234
MESH:D008223 Lymphoma Methotrexate 3.7917352296
MESH:D008546 Melanoma, Experimental Acetaminophen 3.3419513568
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5616801185
MESH:D008881 Migraine Disorders Valproic Acid 3.0318765137 18803445
MESH:D052016 Mucositis Methotrexate 5.0517488658
MESH:D009135 Muscular Diseases pirinixic acid 3.2816239165
MESH:D009139 Musculoskeletal Abnormalities Valproic Acid 3.828888407
MESH:D009181 Mycoses Amiodarone 4.6712754197 17974566
MESH:D009190 Myelodysplastic Syndromes Valproic Acid 3.0317596541
MESH:D009203 Myocardial Infarction pirinixic acid 5.4119151258
MESH:D009203 Myocardial Infarction Quercetin 5.4119595682
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8412213967
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.8616411023
MESH:D015428 Myocardial Reperfusion Injury Quercetin 7.8619207477
MESH:D009336 Necrosis 2,6-dinitrotoluene 9.9218551238 7678174
MESH:D009336 Necrosis Trinitrotoluene 9.9218551238
MESH:D009362 Neoplasm Metastasis capecitabine 4.0412972520
MESH:D009369 Neoplasms capecitabine 7.8216374040
MESH:D009369 Neoplasms pirinixic acid 7.8217405874
MESH:D009369 Neoplasms Quercetin 7.8215185748
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2117954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.0919348381 18481113
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 3.0014600291
MESH:D009436 Neural Tube Defects Valproic Acid 2.9816359493 8888407
MESH:D019636 Neurodegenerative Diseases Acetaminophen 2.6918514411
MESH:D020078 Neurogenic Inflammation Quercetin 4.1517929310
MESH:D052556 Niemann-Pick Disease, Type C perfluorooctanoic acid 4.739802331
MESH:D009765 Obesity Dietary Fats 4.2419632207 21332399 20518802 20132043 18674790 11836018 16723640 17217161 18457598
MESH:D009765 Obesity pirinixic acid 4.2420558911
MESH:D009784 Occupational Diseases 2,6-dinitrotoluene 14.1316049721
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 14.1314694615
MESH:D009784 Occupational Diseases Trinitrotoluene 14.1314694615 12819281 17852074
MESH:D015663 Osteoporosis, Postmenopausal Quercetin 4.0119495926
MESH:D010051 Ovarian Neoplasms Quercetin 2.6619005980
MESH:D010146 Pain Acetaminophen 2.2116870215
MESH:D010190 Pancreatic Neoplasms Quercetin 2.7716965848
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0212520081
MESH:D016491 Peripheral Vascular Diseases Cadmium 5.1515687053
MESH:C536663 Peroxisomal bifunctional enzyme deficiency marker/mechanism
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3418163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.4612371664
MESH:D011230 Precancerous Conditions Quercetin 8.4619056647
MESH:D011297 Prenatal Exposure Delayed Effects perfluorooctanoic acid 14.9717132714
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 14.9711896295 11399792 11222880 11118676
MESH:D011297 Prenatal Exposure Delayed Effects Valproic Acid 14.9720603192
MESH:D011471 Prostatic Neoplasms Cadmium 3.7617075824
MESH:D011471 Prostatic Neoplasms Quercetin 3.7617292933 14715546
MESH:D019310 Pseudolymphoma Valproic Acid 4.3112752131 11422049
MESH:D011565 Psoriasis Cyclosporine 5.6416882103
MESH:D011565 Psoriasis Methotrexate 5.6417410198
MESH:D011658 Pulmonary Fibrosis Amiodarone 2.7712490602 11597910 12832656
MESH:D051437 Renal Insufficiency Methotrexate 4.4917352296
MESH:D015427 Reperfusion Injury pirinixic acid 2.2819058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6218990726
MESH:D012208 Rhabdomyosarcoma Valproic Acid 3.9619155313
MESH:D012554 Schistosomiasis japonica Quercetin 5.3116862918
MESH:D012559 Schizophrenia Valproic Acid 2.0419110320 15737665
MESH:D012640 Seizures 2,6-dinitrotoluene 9.0518551238
MESH:D012640 Seizures Trinitrotoluene 9.0518551238
MESH:D012640 Seizures Valproic Acid 9.0515475178 11738929 14763951 16876388 3137016 11044598 1511512 17978042
OMIM:609620 SHORT QT SYNDROME 1 Amiodarone 4.8518724381
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 1.9416192470
MESH:D016135 Spinal Dysraphism Valproic Acid 3.6119490988
MESH:D013163 Splenomegaly Trinitrotoluene 4.9815817613
MESH:D013226 Status Epilepticus Valproic Acid 4.3112833885
MESH:D013274 Stomach Neoplasms S 1 (combination) 3.3616557585 18506536 18553229
MESH:D013276 Stomach Ulcer Amiodarone 3.1218087811
MESH:D013576 Syndactyly Methotrexate 4.819562676
MESH:D013610 Tachycardia Amiodarone 4.0711238279
MESH:D017180 Tachycardia, Ventricular Amiodarone 3.9719225199
MESH:D013959 Thyroid Diseases Amiodarone 11.2819731979
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 11.2812697716
MESH:D013971 Thyrotoxicosis Amiodarone 4.6318020914 19584973
MESH:D016171 Torsades de Pointes Amiodarone 3.9611989578 17467628
MESH:D014178 Translocation, Genetic Valproic Acid 5.0017262798
MESH:D020194 Unverricht-Lundborg Syndrome Valproic Acid 4.293119515
MESH:D001749 Urinary Bladder Neoplasms 2,6-dinitrotoluene 4.9016049721
MESH:D001749 Urinary Bladder Neoplasms Quercetin 4.9016720314
MESH:D014564 Urogenital Abnormalities Valproic Acid 4.428888407
MESH:D014571 Urologic Neoplasms 2,6-dinitrotoluene 4.0910091137
MESH:D014581 Urticaria Acetaminophen 2.7710982225
MESH:D014605 Uveitis Cyclosporine 3.751336536
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3612125929
MESH:D014689 Venous Insufficiency coumarin 5.5512708602
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0215886252
MESH:D015430 Weight Gain Dietary Fats 3.5516723640
MESH:D014985 Xerophthalmia Cyclosporine 4.2117120751
Pathway ID Pathway Name
KEGG:01040 Biosynthesis of unsaturated fatty acids
KEGG:00071 Fatty acid metabolism
KEGG:01100 Metabolic pathways
REACT:22258 Metabolism of lipids and lipoproteins
KEGG:04146 Peroxisome
KEGG:03320 PPAR signaling pathway
KEGG:00280 Valine, leucine and isoleucine degradation
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA24419
    • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB03684 - 2-Methyl-2,4-Pentanediol
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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