Annotation Detail for GUCY2D
Basic Information
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| Gene Symbol: | GUCY2D ( CORD5,CORD6,CYGD,GUC1A4,GUC2D,LCA,LCA1,RCD2,RETGC-1,ROS-GC1,ROSGC,retGC ) |
|---|
| Gene Full Name: | guanylate cyclase 2D, membrane (retina-specific) |
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| Band: | 17p13.1 |
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| Quick Links | Entrez ID:3000; OMIM: 600179; Uniprot ID:GUC2D_HUMAN; ENSEMBL ID: ENSG00000132518; HGNC ID: 4689 |
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| Relate to Another Database: |
SFARIGene;
denovo-db |
| Pathway ID | Pathway Name |
|---|
| 200139 | Visual signal transduction: Rods |
| 200078 | Visual signal transduction: Cones |
| Desease Name |
|---|
| Cone-rod dystrophy 6 |
| Leber congenital amaurosis 1 |
| Chemical ID |
Chemical Name |
Interaction |
Interaction Action |
Publication |
|---|
| D000643 |
Ammonium Chloride |
Ammonium Chloride affects the expression of GUCY2D mRNA | affects expression | 16483693
|
| D002713 |
Chlorine |
[Ozone co-treated with Chlorine] affects the expression of GUCY2D mRNA | affects cotreatment|affects expression | 18636392
|
| D005419 |
Flavonoids |
Flavonoids results in decreased expression of GUCY2D mRNA | decreases expression | 18035473
|
| C419708 |
gefitinib |
gefitinib results in decreased expression of GUCY2D mRNA | decreases expression | 16685379
|
| D010126 |
Ozone |
[Ozone co-treated with Chlorine] affects the expression of GUCY2D mRNA | affects cotreatment|affects expression | 18636392
|
| C006253 |
pirinixic acid |
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GUCY2D mRNA | affects binding|increases activity|increases expression | 19710929
|
| Disease ID |
Disease Name |
Direct Evidence |
Inference Chemical Name |
Inference Score |
Publication |
|---|
| MESH:D000138 |
Acidosis |
|
Ammonium Chloride |
4.02 | 18287403 |
| MESH:D055371 |
Acute Lung Injury |
|
Chlorine |
10.34 | 20601635 |
| MESH:D055371 |
Acute Lung Injury |
|
pirinixic acid |
10.34 | 18653653 |
| MESH:D018248 |
Adenoma, Liver Cell |
|
pirinixic acid |
3.94 | 16434500 |
| MESH:D000544 |
Alzheimer Disease |
|
Ozone |
2.49 | 15513908 |
| MESH:D001172 |
Arthritis, Rheumatoid |
|
Ozone |
2.61 | 15570426 |
| MESH:D001249 |
Asthma |
|
Ozone |
2.71 | 17854713 16373670 |
| MESH:D001778 |
Blood Coagulation Disorders |
|
pirinixic acid |
3.47 | 19483382 |
| MESH:D016535 |
Bronchial Hyperreactivity |
|
Ozone |
3.93 | 18315731 17626835 18417511 14754758 15516495 16777450 19059883 |
| MESH:D002100 |
Cachexia |
|
Ozone |
5.20 | 16183385 |
| MESH:D002289 |
Carcinoma, Non-Small-Cell Lung |
|
gefitinib |
4.03 | 19233551 18347146 16230376 20005069 17290066 15496427 |
| MESH:D002779 |
Cholestasis |
|
pirinixic acid |
3.05 | 19176532 |
| MESH:D015179 |
Colorectal Neoplasms |
|
gefitinib |
3.24 | 17594712 |
| OMIM:600977 |
CONE-ROD DYSTROPHY 5 |
marker/mechanism |
|
| |
| OMIM:601777 |
CONE-ROD DYSTROPHY 6 |
marker/mechanism |
|
| |
| MESH:D003876 |
Dermatitis, Atopic |
|
pirinixic acid |
2.55 | 18249437 |
| MESH:D004417 |
Dyspnea |
|
Chlorine |
5.14 | 20016425 |
| MESH:D004487 |
Edema |
|
pirinixic acid |
2.80 | 12083418 |
| MESH:D005234 |
Fatty Liver |
|
pirinixic acid |
3.09 | 20131406 19236843 |
| MESH:D005739 |
Gas Poisoning |
|
Chlorine |
5.53 | 20016425 |
| MESH:D006333 |
Heart Failure |
|
pirinixic acid |
2.71 | 20558911 |
| MESH:D006529 |
Hepatomegaly |
|
pirinixic acid |
3.41 | 16221962 19772884 18467677 19176532 |
| MESH:D006943 |
Hyperglycemia |
|
pirinixic acid |
3.49 | 20558911 |
| MESH:D006976 |
Hypertension, Pulmonary |
|
gefitinib |
4.91 | 18424623 |
| MESH:D017380 |
Hypertrophy, Right Ventricular |
|
gefitinib |
6.70 | 18424623 |
| MESH:D007249 |
Inflammation |
|
Flavonoids |
2.79 | 17296493 |
| MESH:D007333 |
Insulin Resistance |
|
pirinixic acid |
2.82 | 16306350 |
| MESH:D007680 |
Kidney Neoplasms |
|
gefitinib |
4.81 | 18625569 |
| MESH:D057130 |
Leber Congenital Amaurosis |
marker/mechanism |
|
| |
| MESH:D008106 |
Liver Cirrhosis, Experimental |
|
pirinixic acid |
1.35 | 15474484 |
| MESH:D008113 |
Liver Neoplasms |
|
pirinixic acid |
1.91 | 20007298 16377806 15890375 |
| MESH:D008171 |
Lung Diseases |
|
Ozone |
3.57 | 19066396 8266340 |
| MESH:D055370 |
Lung Injury |
|
Ozone |
4.26 | 20417186 |
| MESH:D008175 |
Lung Neoplasms |
|
Ozone |
2.10 | 7614698 8597069 |
| MESH:D008325 |
Mammary Neoplasms, Experimental |
|
gefitinib |
4.31 | 18375820 |
| MESH:D008679 |
Metaplasia |
|
Ozone |
5.63 | 10496685 |
| MESH:D009135 |
Muscular Diseases |
|
pirinixic acid |
3.92 | 16239165 |
| MESH:D009203 |
Myocardial Infarction |
|
pirinixic acid |
2.25 | 19151258 |
| MESH:D015428 |
Myocardial Reperfusion Injury |
|
pirinixic acid |
3.19 | 16411023 |
| MESH:D009369 |
Neoplasms |
|
pirinixic acid |
2.08 | 17405874 |
| MESH:D009765 |
Obesity |
|
pirinixic acid |
1.87 | 20558911 |
| MESH:D010538 |
Peritonitis |
|
Ozone |
4.55 | 16369182 |
| MESH:D011014 |
Pneumonia |
|
Ozone |
4.86 | 18007984 18929643 18381685 |
| MESH:D011471 |
Prostatic Neoplasms |
|
gefitinib |
4.60 | 16685379 17914592 15651060 |
| MESH:D011658 |
Pulmonary Fibrosis |
|
gefitinib |
4.10 | 18424623 |
| MESH:D015427 |
Reperfusion Injury |
|
pirinixic acid |
2.52 | 19058328 |
| MESH:D012120 |
Respiration Disorders |
|
Chlorine |
5.73 | 18579056 |
| MESH:D012174 |
Retinitis Pigmentosa |
marker/mechanism |
|
| 16272259 |
| MESH:D013964 |
Thyroid Neoplasms |
|
gefitinib |
4.71 | 16940797 |
Drug Bank