AutismKB 2.0

Annotation Detail for TNPO2


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Basic Information Top
Gene Symbol:TNPO2 ( FLJ12155,IPO3,KPNB2B,TRN2 )
Gene Full Name: transportin 2
Band: 19p13.13
Quick LinksEntrez ID:30000; OMIM: 603002; Uniprot ID:TNPO2_HUMAN; ENSEMBL ID: ENSG00000105576; HGNC ID: 19998
Relate to Another Database: SFARIGene; denovo-db
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Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D020122 tert-Butylhydroperoxide tert-Butylhydroperoxide results in decreased expression of TNPO2 mRNAdecreases expression 15336504
D002117 Calcitriol Calcitriol results in decreased expression of TNPO2 mRNAdecreases expression 18614847
16847355
D012643 Selenium Selenium results in decreased expression of TNPO2 mRNAdecreases expression 19244175
D014212 Tretinoin Tretinoin results in decreased expression of TNPO2 mRNAdecreases expression 18614847
D014810 Vitamin E Vitamin E results in decreased expression of TNPO2 mRNAdecreases expression 19244175
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000505 Alopecia Tretinoin 3.9015955085
MESH:D001169 Arthritis, Experimental Tretinoin 3.2816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3316292516
MESH:D001249 Asthma Tretinoin 2.4316456186
MESH:D001471 Barrett Esophagus Tretinoin 4.8416935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.9816206674 16197459
MESH:D001943 Breast Neoplasms Calcitriol 2.2811237771
MESH:D001943 Breast Neoplasms Tretinoin 2.2816443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 5.1316813970
MESH:D002252 Carbon Tetrachloride Poisoning Vitamin E 4.4116050911
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.7716168501
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 1.911917145
MESH:D002294 Carcinoma, Squamous Cell Calcitriol 5.0511237771
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 5.0516096774 16051514
MESH:D002386 Cataract Tretinoin 3.2817460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 5.1316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.7716461808
MESH:D002972 Cleft Palate Tretinoin 2.799407595
MESH:D003092 Colitis Selenium 11.1617936198
MESH:D003092 Colitis Tretinoin 11.1617035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.7717551590 9211117 10589399 16925845 14991402 9142499 8800419 9224671 9664655 9125849
MESH:D019465 Craniofacial Abnormalities Vitamin E 2.7719769572
MESH:D056486 Drug-Induced Liver Injury Selenium 2.2515131321
MESH:C538011 Eales disease Vitamin E 5.329068938
MESH:D004489 Edema, Cardiac Tretinoin 5.0818230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Calcitriol 4.3715138306
MESH:D016889 Endometrial Neoplasms Tretinoin 3.3216569247
MESH:D005124 Eye Abnormalities Tretinoin 3.8416938888 9664655
MESH:D005355 Fibrosis Tretinoin 3.9917994277
MESH:D005909 Glioblastoma Tretinoin 3.2217312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.4116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.7716084493
MESH:D006330 Heart Defects, Congenital Tretinoin 7.3214991402 9664655
MESH:D006330 Heart Defects, Congenital Vitamin E 7.3216080930
MESH:D006333 Heart Failure Selenium 3.2717162251
MESH:D006548 Hernia, Diaphragmatic Vitamin E 2.8016863852 16490937
MESH:D019584 Hot Flashes Vitamin E 4.5814716179
MESH:D006930 Hyperalgesia Tretinoin 3.5016870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 5.0516778211
MESH:D007251 Influenza, Human Selenium 13.0916624496
MESH:D007251 Influenza, Human Vitamin E 13.0916624496
MESH:D007410 Intestinal Diseases Tretinoin 4.2517994277
MESH:D007569 Jaw Abnormalities Tretinoin 4.2717551590 15992940
MESH:D007674 Kidney Diseases Vitamin E 2.9812488133
MESH:D007676 Kidney Failure, Chronic Selenium 4.2616518626
MESH:D007938 Leukemia Tretinoin 2.9217143497
MESH:D007951 Leukemia, Myeloid Tretinoin 4.0719285840 16932348 16482212
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1216294345 19850784 17596541
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.379834237 16891316 17339181 16788101 17107899 16935935 17712046 17294898 19642359 17361223 16140955 16823087 19035177 17368321 19075265 17649720 16331271 17506722 12679006 19029980 19225113 17217047 15748426 17301526 16766008
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.559224671
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 2.6316248980 18397230
MESH:D008106 Liver Cirrhosis, Experimental Vitamin E 2.6316169303
MESH:D008171 Lung Diseases Vitamin E 3.4016863852
MESH:D008175 Lung Neoplasms Vitamin E 1.9011062179
MESH:D008325 Mammary Neoplasms, Experimental Selenium 2.9715318939
MESH:D008527 Medulloblastoma Tretinoin 2.9017453147
MESH:D008545 Melanoma Tretinoin 1.9816752155
MESH:D008591 Meningomyelocele Tretinoin 4.9116940565
MESH:D008654 Mesothelioma Selenium 2.9015107826
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2617596541
MESH:D009369 Neoplasms Tretinoin 2.5516594593 16946489
MESH:D009421 Nervous System Malformations Tretinoin 4.229125849
MESH:D009436 Neural Tube Defects Tretinoin 3.279142499
MESH:D010051 Ovarian Neoplasms Tretinoin 2.4316936753
MESH:D010146 Pain Tretinoin 3.2016870215
MESH:D010190 Pancreatic Neoplasms Tretinoin 2.5615976015
MESH:D010954 Plasmacytoma Selenium 5.5015087411
MESH:D011470 Prostatic Hyperplasia Calcitriol 5.3215572423
MESH:D011471 Prostatic Neoplasms Calcitriol 3.3216289102 18247401 12479363 15754350 16644109
MESH:D011471 Prostatic Neoplasms Vitamin E 3.3215084515
MESH:D011507 Proteinuria Tretinoin 4.0116636307
MESH:D011625 Pterygium Tretinoin 5.3316723453
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.5016283617 16116481
MESH:D012871 Skin Diseases Vitamin E 2.5118709164
MESH:D012878 Skin Neoplasms tert-Butylhydroperoxide 6.288532709
MESH:D012878 Skin Neoplasms Tretinoin 6.2816467112
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D020521 Stroke Vitamin E 3.8116517955
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2916026305 17045167
MESH:D014062 Tongue Neoplasms Tretinoin 4.1416051514
MESH:D014376 Tuberculosis Tretinoin 3.4316040207
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 4.0216129372
MESH:D014604 Uveal Neoplasms Tretinoin 5.2216752155
MESH:D014820 Vitiligo Tretinoin 4.5016761959
MESH:D009396 Wilms Tumor Tretinoin 4.2916287080
No data
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AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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