AutismKB 2.0

Annotation Detail for TBX21


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Basic Information Top
Gene Symbol:TBX21 ( T-PET,T-bet,TBET,TBLYM )
Gene Full Name: T-box 21
Band: 17q21.32
Quick LinksEntrez ID:30009; OMIM: 604895; Uniprot ID:TBX21_HUMAN; ENSEMBL ID: ENSG00000073861; HGNC ID: 11599
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Pathway IDPathway Name
200034IL12-mediated signaling events
200039Calcineurin-regulated NFAT-dependent transcription in lymphocytes
200077Glucocorticoid receptor regulatory network
200023IL27-mediated signaling events
200197IL12 signaling mediated by STAT4
No data
No data
Related Diseases/Disorders Top
No data
No data
Desease Name
Asthma
IMMUNE
hepatitis B
INFECTION
No data
Desease Name
Asthma, aspirin-induced, susceptibility to
Asthma and nasal polyps
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C026137 3-hydroxyacetanilide 3-hydroxyacetanilide results in decreased expression of TBX21 mRNAdecreases expression 18544908
D000082 Acetaminophen Acetaminophen results in decreased expression of TBX21 mRNAdecreases expression 18544908
C004712 cytisine cytisine analog results in decreased expression of TBX21 mRNAdecreases expression 17630191
D004958 Estradiol TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]]affects binding|decreases reaction|increases reaction 20068169
D004958 Estradiol TBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]]affects binding|decreases reaction|increases reaction 20068169
D004958 Estradiol TBX21 protein inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]decreases reaction|increases expression 20068169
D004958 Estradiol TBX21 protein inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA]decreases reaction|increases expression 20068169
D007052 Ibuprofen Ibuprofen analog results in decreased expression of TBX21 mRNAdecreases expression 17630191
D007052 Ibuprofen Ibuprofen results in decreased expression of TBX21 mRNAdecreases expression 17630191
D008070 Lipopolysaccharides Lipopolysaccharides results in increased expression of TBX21 mRNAincreases expression 18657572
D013629 Tamoxifen TBX21 protein results in decreased susceptibility to Tamoxifendecreases response to substance 20068169
D014212 Tretinoin Tretinoin results in decreased expression of TBX21 mRNAdecreases expression 17118196
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.9214745880
MESH:D058186 Acute Kidney Injury Ibuprofen 4.696375363
MESH:D055371 Acute Lung Injury Lipopolysaccharides 4.2911850527 18653653
MESH:D000230 Adenocarcinoma Estradiol 4.9211473722
MESH:D000230 Adenocarcinoma Ibuprofen 4.9210697514
MESH:D000505 Alopecia Tretinoin 3.8115955085
MESH:D000544 Alzheimer Disease Ibuprofen 3.2118351690
MESH:D000707 Anaphylaxis Ibuprofen 5.559532969
MESH:D000799 Angioedema Acetaminophen 4.2210982225
MESH:D001169 Arthritis, Experimental Tretinoin 3.2116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.3116292516
MESH:D001249 Asthma Tretinoin 2.4016456186
OMIM:208550 ASTHMA, NASAL POLYPS, AND ASPIRIN INTOLERANCE marker/mechanism
MESH:D001321 Autistic Disorder Acetaminophen 1.4018445737
MESH:D001471 Barrett Esophagus Tretinoin 4.6816935849
MESH:D001778 Blood Coagulation Disorders Tretinoin 3.8516197459 16206674
MESH:D002545 Brain Ischemia Ibuprofen 5.2215837124
MESH:D001943 Breast Neoplasms Estradiol 1.8918497071 16675129 14630087 17261762 17289903 12948864 17018787 19861407
MESH:D001943 Breast Neoplasms Tamoxifen 1.8918855134 20390343 19155303 20544844 18984771 17440819 19142967 19200415 18629630 19189212 17242785 19066611 20135344 19189210 11161223 19487384 18351453 17049068 20005174 19103187 16202921 17261762 18425577 19115204 19289846 18821012 18997820 16273361 15668708 19084267 21138602 17893378 18815881 20065188 19410462 19288272 19011961 19221464 19059307 20859285 15565566 16873071 21152245 16818667 19244106
MESH:D001943 Breast Neoplasms Tretinoin 1.8916443354 16166294 16873071
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.9316813970
MESH:D002100 Cachexia Ibuprofen 5.8115141370
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.8016111702
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.8119066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.5416168501
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 6.823084413
MESH:D006528 Carcinoma, Hepatocellular Estradiol 6.8216924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.8216924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.821917145
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.3416096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.8417572228
MESH:D002386 Cataract Acetaminophen 7.6610977129
MESH:D002386 Cataract Tretinoin 7.6617460283
MESH:D002471 Cell Transformation, Neoplastic Estradiol 2.9318566989
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.9316129372
MESH:D002822 Choriocarcinoma Tretinoin 5.5416461808
MESH:D002972 Cleft Palate Tretinoin 2.759407595
MESH:D003092 Colitis Tretinoin 4.0117035595
MESH:D019465 Craniofacial Abnormalities Tretinoin 1.838800419 9142499 9125849 9224671 16925845 9211117 9664655 10589399 17551590 14991402
MESH:D003711 Demyelinating Diseases Tamoxifen 4.6719031437
MESH:D003928 Diabetic Nephropathies Estradiol 9.5619279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 9.5619279558
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6411421492 16393943 15619225 12153990 11834606 11529661 15968718 11739529 17522070 16485898 14986274 14725611 12392966 11743745 10774834 19420014 16081117 18713872 16227642 16781746 12958197 19416960 16109766 11461765 16177239 14550746 19085960 18071297 12705907 19739265 11287661 12594235 10663392 17562736 19164858 19923254 2444490 17906064 10915739 12540782 19370779
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 4.4719426721
MESH:D004374 Ductus Arteriosus, Patent Ibuprofen 5.9516133044 18446180 18450898
MESH:D004489 Edema, Cardiac Tretinoin 4.8418230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 3.8219031437
MESH:D016889 Endometrial Neoplasms Estradiol 13.3011473722 19148513 18566989
MESH:D016889 Endometrial Neoplasms Tamoxifen 13.3016202921 20544844 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 13.3016569247
MESH:D004715 Endometriosis Ibuprofen 4.8415652904
MESH:D019446 Endotoxemia Ibuprofen 11.9711545620
MESH:D019446 Endotoxemia Lipopolysaccharides 11.9717637181 15821434 15328337
MESH:D005124 Eye Abnormalities Tretinoin 3.7516938888 9664655
MESH:D005234 Fatty Liver Tamoxifen 3.4014986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.3716709447
MESH:D005334 Fever Ibuprofen 10.2916997862
MESH:D005334 Fever Lipopolysaccharides 10.299205823 11852909
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.8714745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.5219069698
MESH:D005355 Fibrosis Tretinoin 3.8217994277
MESH:D005756 Gastritis Acetaminophen 4.0516983495
MESH:D005909 Glioblastoma Tretinoin 3.1517312396
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.3416096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.5416084493
MESH:D006330 Heart Defects, Congenital Tretinoin 3.0114991402 9664655
MESH:D006463 Hemolytic-Uremic Syndrome Lipopolysaccharides 4.6116366002
MESH:D006558 Herpes Genitalis Estradiol 5.4115709030
MESH:D019584 Hot Flashes Estradiol 4.1317088409
MESH:D006930 Hyperalgesia Acetaminophen 8.2716870215
MESH:D006930 Hyperalgesia Tretinoin 8.2716870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.8816778211
MESH:D006984 Hypertrophy Ibuprofen 5.2216672835
MESH:D007235 Infant, Premature, Diseases Ibuprofen 6.2116133044
MESH:D007249 Inflammation Ibuprofen 9.223291741
MESH:D007249 Inflammation Lipopolysaccharides 9.2217255318 9205823 17963957 12878042 17237260
MESH:D007249 Inflammation Tamoxifen 9.2219457130
MESH:D007333 Insulin Resistance Estradiol 3.1116627594 16393666
MESH:D007410 Intestinal Diseases Tretinoin 4.0717994277
MESH:D019189 Iron Metabolism Disorders Lipopolysaccharides 4.8917255318
MESH:D007569 Jaw Abnormalities Tretinoin 4.1415992940 17551590
MESH:D007674 Kidney Diseases Acetaminophen 6.3112587719 15629191
MESH:D007674 Kidney Diseases Estradiol 6.3115618244
MESH:D007680 Kidney Neoplasms Estradiol 8.0715610895
MESH:D007680 Kidney Neoplasms Tamoxifen 8.0718625569
MESH:D007938 Leukemia Tretinoin 2.8717143497
MESH:D007951 Leukemia, Myeloid Tretinoin 3.9416482212 16932348 19285840
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 2.1117596541 19850784 16294345
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.3017649720 16766008 17712046 15748426 19035177 17301526 19642359 19029980 17107899 16935935 16140955 16788101 9834237 16331271 17339181 17506722 12679006 19075265 16823087 17361223 17217047 19225113 16891316 17294898 17368321
MESH:D007970 Leukopenia Lipopolysaccharides 5.0315821434
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.479224671
MESH:D008064 Lipidoses Tamoxifen 3.3215342952 17567588
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 5.1814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental Lipopolysaccharides 5.1812878042
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 5.1818564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 5.1816248980 18397230
MESH:D008107 Liver Diseases Acetaminophen 1.6716610002 19460945 19014921 12969438 16611625 11587558 12587719 19784758
MESH:D017114 Liver Failure, Acute Acetaminophen 3.4617185352 16871587
MESH:D008113 Liver Neoplasms Tamoxifen 2.2916684651
MESH:D055370 Lung Injury Lipopolysaccharides 4.3121114838
MESH:D008175 Lung Neoplasms Tamoxifen 1.7418625569
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 4.1019428831
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 10.9511408345 17203775 11807958 16891317
MESH:D008325 Mammary Neoplasms, Experimental Ibuprofen 10.9510697514
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 10.9514580682 16827153 11731420 19196722 19196723
MESH:D020149 Manganese Poisoning Estradiol 13.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 13.9419453300
MESH:D008527 Medulloblastoma Tretinoin 2.8617453147
MESH:D008545 Melanoma Tamoxifen 3.3912393984 19393235
MESH:D008545 Melanoma Tretinoin 3.3916752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.5215990972
MESH:D008546 Melanoma, Experimental Acetaminophen 3.8719513568
MESH:D008591 Meningomyelocele Tretinoin 4.7316940565
MESH:D009190 Myelodysplastic Syndromes Tretinoin 3.2017596541
MESH:D015428 Myocardial Reperfusion Injury Estradiol 3.4616810080
MESH:D009362 Neoplasm Metastasis Tamoxifen 2.6319393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.5819410462
MESH:D009369 Neoplasms Tretinoin 2.5116594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 4.3819189210 19196722 19200415
MESH:D009389 Neovascularization, Pathologic Estradiol 4.0717289903
MESH:D009395 Nephritis, Interstitial Ibuprofen 5.366375363
MESH:D009410 Nerve Degeneration Ibuprofen 4.5710961664
MESH:D009421 Nervous System Malformations Estradiol 10.6316427766 11399458
MESH:D009421 Nervous System Malformations Tretinoin 10.639125849
MESH:D009436 Neural Tube Defects Tretinoin 3.209142499
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.0718514411
MESH:D010003 Osteoarthritis Ibuprofen 4.267009135
MESH:D010051 Ovarian Neoplasms Estradiol 5.0219401270
MESH:D010051 Ovarian Neoplasms Tretinoin 5.0216936753
MESH:D010146 Pain Acetaminophen 12.5316870215
MESH:D010146 Pain Ibuprofen 12.533291741
MESH:D010146 Pain Tretinoin 12.5316870215
MESH:D010149 Pain, Postoperative Ibuprofen 5.5216678543
MESH:D010190 Pancreatic Neoplasms Ibuprofen 5.8912384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 5.8915976015
MESH:D011014 Pneumonia Lipopolysaccharides 4.8912224865 11605937
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 4.1320887781
MESH:D011471 Prostatic Neoplasms Estradiol 2.6316740699
MESH:D011471 Prostatic Neoplasms Ibuprofen 2.6317409433
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.6315067354
MESH:D011507 Proteinuria Ibuprofen 10.396375363
MESH:D011507 Proteinuria Tretinoin 10.3916636307
MESH:D011625 Pterygium Tretinoin 5.1316723453
MESH:D012130 Respiratory Hypersensitivity Lipopolysaccharides 3.8810835634
MESH:D012208 Rhabdomyosarcoma Tretinoin 4.3616116481 16283617
MESH:D012878 Skin Neoplasms Tretinoin 2.7016467112
MESH:D013088 Spermatocele Tamoxifen 4.6716709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 4.3819457130
MESH:D013274 Stomach Neoplasms Tretinoin 1.8017261132
MESH:D013921 Thrombocytopenia Lipopolysaccharides 4.3915821434
MESH:D013964 Thyroid Neoplasms Tretinoin 3.2117045167 16026305
MESH:D013978 Tibial Fractures Estradiol 5.0619048282
MESH:D014062 Tongue Neoplasms Tretinoin 4.0216051514
MESH:D014376 Tuberculosis Tretinoin 3.3616040207
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 2.4316712894 8653321 17572228
MESH:D014581 Urticaria Acetaminophen 3.2410982225
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.9016129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.9916752155
MESH:D020301 Vasospasm, Intracranial Ibuprofen 5.5319057314
MESH:D014820 Vitiligo Tretinoin 4.3416761959
MESH:D009396 Wilms Tumor Tretinoin 4.1816287080
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA36362
    • No data
    Releated disease ID Related disease Name
    PA443450Asthma
    PA447278Depression
    PA447321Depressive Disorder, Major
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA448681budesonide
    PA450601nedocromil
    PA449233desipramine
    PA449673fluoxetine
    PA448068salbutamol
    PA134687887selective beta-2-adrenoreceptor agonists
    PA164713253Selective beta-2-adrenoreceptor agonists
    Drug Bank Top

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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