AutismKB 2.0

Annotation Detail for GZMB


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:GZMB ( CCPI,CGL-1,CGL1,CSP-B,CSPB,CTLA1,CTSGL1,HLP,SECT )
Gene Full Name: granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
Band: 14q12
Quick LinksEntrez ID:3002; OMIM: 123910; Uniprot ID:GRAB_HUMAN; ENSEMBL ID: ENSG00000100453; HGNC ID: 4709
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
No data
Pathway IDPathway Name
hsa05332Graft-versus-host disease
hsa04650Natural killer cell mediated cytotoxicity
hsa05320Autoimmune thyroid disease
hsa05330Allograft rejection
hsa04940Type I diabetes mellitus
No data
No data
Pathway IDPathway Name
P00006Apoptosis signaling pathway
No data
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C035207 4-amino-2,6-dinitrotoluene 4-amino-2,6-dinitrotoluene affects the expression of GZMB mRNAaffects expression 21346803
C430898 AGN 194204 AGN 194204 results in increased expression of GZMB mRNAincreases expression 16339527
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GZMB mRNAaffects expression 16483693
D001374 Azacitidine Azacitidine inhibits the reaction [IL2 protein results in increased secretion of GZMB protein]decreases reaction|increases secretion 19394699
D003436 Croton Oil Croton Oil results in increased expression of GZMB mRNAincreases expression 18652873
D003520 Cyclophosphamide Cyclophosphamide results in increased expression of GZMB mRNAincreases expression 15331540
D004041 Dietary Fats Dietary Fats affects the expression of GZMB mRNAaffects expression 18457598
D004137 Dinitrochlorobenzene Dinitrochlorobenzene results in increased expression of GZMB mRNAincreases expression 18652873
D000431 Ethanol Ethanol inhibits the reaction [IL2 protein results in increased expression of GZMB mRNA]decreases reaction|increases expression 12700414
C070081 fulvestrant fulvestrant results in decreased expression of GZMB mRNAdecreases expression 20145137
C070081 fulvestrant fulvestrant results in decreased expression of GZMB proteindecreases expression 20145137
C070081 fulvestrant [fulvestrant results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNAincreases expression 20145137
D010081 Oxazolone Oxazolone results in decreased expression of GZMB mRNAdecreases expression 11379042
D010081 Oxazolone Oxazolone results in increased expression of GZMB mRNAincreases expression 18652873
C008776 pelargonic acid pelargonic acid results in decreased expression of GZMB mRNAdecreases expression 11379042
C008776 pelargonic acid pelargonic acid results in increased expression of GZMB mRNAincreases expression 18652873
C006253 pirinixic acid pirinixic acid results in decreased expression of GZMB mRNAdecreases expression 17426115
C025299 polyphenols polyphenols results in decreased expression of GZMB mRNAdecreases expression 16293270
D011374 Progesterone Progesterone affects the expression of GZMB mRNAaffects expression 17251523
C020972 pyrrolidine dithiocarbamic acid pyrrolidine dithiocarbamic acid inhibits the reaction [IL2 protein results in increased expression of GZMB mRNA]decreases reaction|increases expression 12700414
D013629 Tamoxifen Tamoxifen results in decreased expression of GZMB mRNAdecreases expression 20145137
D013629 Tamoxifen Tamoxifen results in decreased expression of GZMB proteindecreases expression 20145137
D013629 Tamoxifen [Tamoxifen results in increased expression of TGFB1 protein] which results in increased expression of GZMB mRNAincreases expression 20145137
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in decreased expression of GZMB mRNAdecreases expression 11379042
D014051 Toluene 2,4-Diisocyanate Toluene 2,4-Diisocyanate results in increased expression of GZMB mRNAincreases expression 18652873
D014107 Tosyllysine Chloromethyl Ketone Tosyllysine Chloromethyl Ketone inhibits the reaction [IL2 protein results in increased expression of GZMB mRNA]decreases reaction|increases expression 12700414
D014212 Tretinoin Tretinoin results in decreased expression of GZMB proteindecreases expression 17107666
C088658 zoledronic acid IL2 protein affects the reaction [zoledronic acid affects the expression of GZMB mRNA]affects expression|affects reaction 19446661
C088658 zoledronic acid zoledronic acid affects the expression of GZMB mRNAaffects expression 19446661
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.4414745880
MESH:D000014 Abnormalities, Drug-Induced 4-amino-2,6-dinitrotoluene 8.517525203
MESH:D000014 Abnormalities, Drug-Induced Ethanol 8.5118926900 17676605
MESH:D000138 Acidosis Ammonium Chloride 10.1118287403
MESH:D000138 Acidosis Ethanol 10.1111192467
MESH:D058186 Acute Kidney Injury zoledronic acid 4.3619715164
MESH:D055371 Acute Lung Injury pirinixic acid 3.0118653653
MESH:D000210 Acute-Phase Reaction zoledronic acid 5.3720200999
MESH:D018248 Adenoma, Liver Cell pirinixic acid 3.3716434500
MESH:D020268 Alcohol-Induced Disorders, Nervous System Ethanol 5.2115451040 15451039
MESH:D000505 Alopecia Tretinoin 3.5315955085
MESH:D000853 Anophthalmos Ethanol 4.7115513904
MESH:D001008 Anxiety Disorders Ethanol 3.9211141031
MESH:D001161 Arteriosclerosis Cyclophosphamide 9.9615014928
MESH:D001161 Arteriosclerosis Dietary Fats 9.9615238619
MESH:D001169 Arthritis, Experimental Tretinoin 3.0116412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2416292516
MESH:D001249 Asthma Toluene 2,4-Diisocyanate 5.1615590890 11742282 6091946 8156442 10934080 12762349 3040596 16792590 18394133 12585506 17015710 16210060 170078 15855793 7684630 10797510 15590891 12684321 19187332 6091945 11077013 11467998 20032816
MESH:D001249 Asthma Tretinoin 5.1616456186
MESH:D001284 Atrophy fulvestrant 4.7411514358
MESH:D001321 Autistic Disorder marker/mechanism 18762240
MESH:D001471 Barrett Esophagus Tretinoin 4.2916935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.6419483382
MESH:D001778 Blood Coagulation Disorders Tretinoin 8.6416206674 16197459
MESH:D001859 Bone Neoplasms zoledronic acid 4.8517312309 19442620 16778634 11697798 15867366 16121404
MESH:D001862 Bone Resorption zoledronic acid 4.6018404659 18496637 15845617 16769263 11869084 8053405
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.2317868700
MESH:D001930 Brain Injuries Progesterone 4.1515665606 15380490 15845082
MESH:D001943 Breast Neoplasms marker/mechanism 19446661
MESH:D001943 Breast Neoplasms Cyclophosphamide 4.6617388661 11325840 18234424 15136595 17020986 16978400 18323546 12006526 15093573
MESH:D001943 Breast Neoplasms Dietary Fats 4.6620435547
MESH:D001943 Breast Neoplasms fulvestrant 4.6618984771
MESH:D001943 Breast Neoplasms Progesterone 4.6615562024 17614352 16175315
MESH:D001943 Breast Neoplasms Tamoxifen 4.6619189212 17261762 19221464 18984771 19115204 16818667 18351453 20390343 18815881 17049068 17893378 18425577 19011961 19289846 19084267 19244106 11161223 17440819 20544844 20005174 19155303 15565566 19189210 19410462 20135344 16273361 18855134 18821012 19142967 19066611 18629630 21138602 16202921 19288272 17242785 19200415 21152245 19487384 18997820 19103187 15668708 16873071 19059307 20859285 20065188
MESH:D001943 Breast Neoplasms Toluene 2,4-Diisocyanate 4.6611921183
MESH:D001943 Breast Neoplasms Tretinoin 4.6616873071 16443354 16166294
MESH:D001943 Breast Neoplasms zoledronic acid 4.6616096432 18695136
MESH:D016535 Bronchial Hyperreactivity Toluene 2,4-Diisocyanate 4.458156442 15590891 12507178
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.4816813970
MESH:D002056 Burns Ethanol 4.5416374292
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.4019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 5.0516168501
MESH:D006528 Carcinoma, Hepatocellular Cyclophosphamide 6.5019701751
MESH:D006528 Carcinoma, Hepatocellular Ethanol 6.5018788625 15763234 15289165
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 6.5016924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 6.501917145
MESH:D018827 Carcinoma, Lewis Lung Cyclophosphamide 4.7816152834
MESH:D002289 Carcinoma, Non-Small-Cell Lung zoledronic acid 3.5019233551
MESH:D002292 Carcinoma, Renal Cell Cyclophosphamide 6.9516201981
MESH:D002292 Carcinoma, Renal Cell zoledronic acid 6.9518507039
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 2.2616096774 16051514
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.5217572228
MESH:D006332 Cardiomegaly Ethanol 3.3819332462
MESH:D002386 Cataract 4-amino-2,6-dinitrotoluene 7.4014694615
MESH:D002386 Cataract Tretinoin 7.4017460283
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.4816129372
MESH:D002779 Cholestasis pirinixic acid 2.7419176532
MESH:D002822 Choriocarcinoma Tretinoin 5.0516461808
MESH:D002971 Cleft Lip Ethanol 3.5315513904
MESH:D002972 Cleft Palate Ethanol 6.0115513904
MESH:D002972 Cleft Palate Tretinoin 6.019407595
MESH:D003092 Colitis Tretinoin 3.6017035595
MESH:D003093 Colitis, Ulcerative Dinitrochlorobenzene 3.8219159591 17373747
MESH:D003110 Colonic Neoplasms polyphenols 2.6616293270
MESH:D015179 Colorectal Neoplasms Azacitidine 2.7219934284
MESH:D000013 Congenital Abnormalities 4-amino-2,6-dinitrotoluene 4.0615095906
MESH:D019465 Craniofacial Abnormalities Ethanol 2.8115451040 19302082 10194807 15451039 11873399 11198716 15513904
MESH:D019465 Craniofacial Abnormalities Tretinoin 2.8110589399 9211117 16925845 9224671 9125849 14991402 17551590 8800419 9664655 9142499
MESH:D003556 Cystitis Cyclophosphamide 4.8818710439 18372110 18483878 18433785 18295254 12913760 16989017 18093676 16651033 10498854 16413132 16614059 12388444 15276878 17010015 15643279 17979934 12161096 11948286 10700343
MESH:D003711 Demyelinating Diseases Tamoxifen 4.2519031437
MESH:D017449 Dermatitis, Allergic Contact Dinitrochlorobenzene 7.4515491423
MESH:D017449 Dermatitis, Allergic Contact Toluene 2,4-Diisocyanate 7.4512956900 15491423 18759878
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3818249437
MESH:D003877 Dermatitis, Contact Oxazolone 9.8312811023 15944321
MESH:D003877 Dermatitis, Contact Toluene 2,4-Diisocyanate 9.8317010967
MESH:D003921 Diabetes Mellitus, Experimental Cyclophosphamide 3.9711751995 10990075 15331540
MESH:D003922 Diabetes Mellitus, Type 1 Cyclophosphamide 3.1918772604
MESH:D003928 Diabetic Nephropathies Tamoxifen 3.3819279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.3817187935
MESH:D056486 Drug-Induced Liver Injury 4-amino-2,6-dinitrotoluene 6.3221346803
MESH:D056486 Drug-Induced Liver Injury Ethanol 6.3211566570
MESH:D056486 Drug-Induced Liver Injury polyphenols 6.3219370779
MESH:D050171 Dyslipidemias Dietary Fats 3.3718367378
MESH:D004487 Edema pirinixic acid 2.3812083418
MESH:D004489 Edema, Cardiac Tretinoin 4.3618230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 8.8117692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.8119031437
MESH:D016889 Endometrial Neoplasms Tamoxifen 7.2020544844 16202921 17893378 19155303
MESH:D016889 Endometrial Neoplasms Tretinoin 7.2016569247
MESH:D004715 Endometriosis Progesterone 3.6716134523
MESH:D004751 Enteritis Croton Oil 6.248982514
MESH:D004802 Eosinophilia Cyclophosphamide 9.0911006010
MESH:D004802 Eosinophilia Toluene 2,4-Diisocyanate 9.098156442
MESH:D004938 Esophageal Neoplasms Ethanol 2.7316704527
MESH:D005124 Eye Abnormalities Tretinoin 3.4916938888 9664655
MESH:D005128 Eye Diseases Toluene 2,4-Diisocyanate 5.6418447907
MESH:D005234 Fatty Liver Dietary Fats 17.9619004024 19551842 18296743 17967931
MESH:D005234 Fatty Liver Ethanol 17.9618620774 19236843 16409862
MESH:D005234 Fatty Liver pirinixic acid 17.9619236843 20131406
MESH:D005234 Fatty Liver Tamoxifen 17.9619224547 14986274
MESH:D005235 Fatty Liver, Alcoholic Ethanol 5.5617920746
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1716709447
MESH:D005264 Femoral Fractures zoledronic acid 5.7216234978
MESH:D005310 Fetal Alcohol Syndrome Ethanol 5.1915451040 16946407 10194807 15513904
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.4214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 4.0719069698
MESH:D005355 Fibrosis Dietary Fats 8.4718296743
MESH:D005355 Fibrosis Tretinoin 8.4717994277
MESH:D005756 Gastritis Ethanol 4.5915046732
MESH:D005909 Glioblastoma Tretinoin 2.9317312396
MESH:D018316 Gliosarcoma Cyclophosphamide 5.4011389073
MESH:D006086 Graft vs Host Disease Cyclophosphamide 4.9316376943 15172196 11014644
MESH:D006258 Head and Neck Neoplasms Tretinoin 3.1116096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 5.0516084493
MESH:D006330 Heart Defects, Congenital Tretinoin 2.8414991402 9664655
MESH:D006333 Heart Failure pirinixic acid 2.4720558911
MESH:D006467 Hemophilia A Cyclophosphamide 5.1811918545
MESH:D006504 Hepatic Veno-Occlusive Disease Cyclophosphamide 5.4314986274
MESH:D006529 Hepatomegaly pirinixic acid 2.8916221962 19176532 19772884 18467677
MESH:D006689 Hodgkin Disease Cyclophosphamide 3.6917606976 16135485
MESH:D006930 Hyperalgesia Ethanol 12.7718783367
MESH:D006930 Hyperalgesia Tretinoin 12.7716870215
MESH:D006930 Hyperalgesia zoledronic acid 12.7716769263
MESH:D006934 Hypercalcemia zoledronic acid 4.9419622757 18089816
MESH:D006937 Hypercholesterolemia Dietary Fats 3.4921332399
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.4616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0820558911
MESH:D006949 Hyperlipidemias Dietary Fats 3.5121332399
MESH:D006967 Hypersensitivity Toluene 2,4-Diisocyanate 4.5010880147 11019492
MESH:D006996 Hypocalcemia zoledronic acid 6.0912669777
MESH:D007154 Immune System Diseases Cyclophosphamide 5.2316076520
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.2915869954
MESH:D007248 Infertility, Male Cyclophosphamide 7.0916517039 7193160
MESH:D007248 Infertility, Male fulvestrant 7.0911514358
MESH:D007249 Inflammation Dietary Fats 11.5520412841
MESH:D007249 Inflammation polyphenols 11.5516366677
MESH:D007249 Inflammation Progesterone 11.5515869954
MESH:D007249 Inflammation Tamoxifen 11.5519457130
MESH:D007251 Influenza, Human pyrrolidine dithiocarbamic acid 5.4518473937
MESH:D007333 Insulin Resistance Dietary Fats 7.0118457598 11836018
MESH:D007333 Insulin Resistance pirinixic acid 7.0116306350
MESH:D007410 Intestinal Diseases Tretinoin 3.6617994277
MESH:D007569 Jaw Abnormalities Ethanol 9.9915513904
MESH:D007569 Jaw Abnormalities Tretinoin 9.9917551590 15992940
MESH:D007680 Kidney Neoplasms Tamoxifen 2.9518625569
MESH:D007859 Learning Disorders Ethanol 4.1015451040
MESH:D007938 Leukemia Azacitidine 10.3619148494
MESH:D007938 Leukemia Cyclophosphamide 10.3610602166
MESH:D007938 Leukemia Tretinoin 10.3617143497
MESH:D015451 Leukemia, Lymphocytic, Chronic, B-Cell Cyclophosphamide 3.4517802794 18172266 17658394 17008537 17296974 18587576
MESH:D015459 Leukemia-Lymphoma, Adult T-Cell zoledronic acid 4.6718089816
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive Cyclophosphamide 4.0010373061
MESH:D007951 Leukemia, Myeloid Azacitidine 9.4519077051
MESH:D007951 Leukemia, Myeloid Tretinoin 9.4516482212 19285840 16932348
MESH:D015470 Leukemia, Myeloid, Acute Azacitidine 4.1317596541 18720364
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 4.1317596541 16294345 19850784
MESH:D054429 Leukemia, Myelomonocytic, Juvenile Azacitidine 5.0919299654
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0817712046 16823087 17339181 17649720 17107899 16891316 16331271 17294898 12679006 19035177 16140955 19642359 17361223 19075265 16766008 9834237 17301526 16788101 19225113 17506722 19029980 16935935 17217047 17368321 15748426
MESH:D007970 Leukopenia Cyclophosphamide 4.8610052129 11830472
MESH:D017880 Limb Deformities, Congenital Ethanol 8.0517676605
MESH:D017880 Limb Deformities, Congenital Tretinoin 8.059224671
MESH:D008064 Lipidoses Tamoxifen 3.0817567588 15342952
MESH:D008103 Liver Cirrhosis Dietary Fats 6.6418296743
MESH:D008103 Liver Cirrhosis Ethanol 6.6415289165
MESH:D008104 Liver Cirrhosis, Alcoholic Ethanol 4.9918295389
MESH:D008106 Liver Cirrhosis, Experimental Ethanol 6.6218166357
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 6.6215474484
MESH:D008106 Liver Cirrhosis, Experimental pyrrolidine dithiocarbamic acid 6.6215078482
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 6.6218564211
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 6.6218397230 16248980
MESH:D008107 Liver Diseases polyphenols 2.7616698588
MESH:D008108 Liver Diseases, Alcoholic Ethanol 4.5417207112 17347304
MESH:D008113 Liver Neoplasms pirinixic acid 4.3020007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 4.3016684651
MESH:D055370 Lung Injury pyrrolidine dithiocarbamic acid 4.8816129981
MESH:D008175 Lung Neoplasms Azacitidine 2.7621224363
MESH:D008175 Lung Neoplasms Tamoxifen 2.7618625569
MESH:D008223 Lymphoma Cyclophosphamide 3.7612854902
MESH:D016393 Lymphoma, B-Cell Cyclophosphamide 4.4916675587
MESH:D008228 Lymphoma, Non-Hodgkin Cyclophosphamide 4.0811911406
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.6519428831
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 9.7211408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 9.7211731420 19196722 14580682 16827153 19196723
MESH:D008325 Mammary Neoplasms, Experimental zoledronic acid 9.7217312309
MESH:D020149 Manganese Poisoning Tamoxifen 4.4419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7417453147
MESH:D008545 Melanoma Dinitrochlorobenzene 5.1417334785 12202904
MESH:D008545 Melanoma Tamoxifen 5.1419393235 12393984
MESH:D008545 Melanoma Tretinoin 5.1416752155
MESH:D018328 Melanoma, Amelanotic Tamoxifen 4.0715990972
MESH:D008546 Melanoma, Experimental Cyclophosphamide 4.6916388313
MESH:D008569 Memory Disorders Ethanol 4.0815451040 18411066
MESH:D008591 Meningomyelocele Tretinoin 4.3216940565
MESH:D008654 Mesothelioma zoledronic acid 3.7116675582
MESH:D009006 Monosomy Azacitidine 5.9819299654
MESH:D009101 Multiple Myeloma Azacitidine 7.7019549372 18443271
MESH:D009101 Multiple Myeloma zoledronic acid 7.7016996129 18089719 19621390
MESH:D009135 Muscular Diseases pirinixic acid 3.4016239165
MESH:D009190 Myelodysplastic Syndromes Azacitidine 7.5018720364 17611569 19805378 17596541
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.5017596541
MESH:D009203 Myocardial Infarction pirinixic acid 2.1019151258
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 2.8616411023
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.9819393235
MESH:D009362 Neoplasm Metastasis zoledronic acid 5.9815867366 19139120 17312309
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4819410462
MESH:D009369 Neoplasms Cyclophosphamide 8.0118854779
MESH:D009369 Neoplasms pirinixic acid 8.0117405874
MESH:D009369 Neoplasms Tretinoin 8.0116946489 16594593
MESH:D009374 Neoplasms, Experimental Toluene 2,4-Diisocyanate 4.621670384
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.8919189210 19196722 19200415
MESH:D009421 Nervous System Malformations Tretinoin 3.679125849
MESH:D009436 Neural Tube Defects Tretinoin 2.989142499
MESH:D009447 Neuroblastoma Cyclophosphamide 3.588761367 15176712 16115947
MESH:D017599 Neuroectodermal Tumors Cyclophosphamide 4.788761367 12837982
MESH:D009503 Neutropenia Cyclophosphamide 4.228291058
MESH:D009765 Obesity Dietary Fats 4.3411836018 20132043 21332399 19632207 17217161 18457598 16723640 20518802 18674790
MESH:D009765 Obesity pirinixic acid 4.3420558911
MESH:D009784 Occupational Diseases 4-amino-2,6-dinitrotoluene 9.2814694615
MESH:D009784 Occupational Diseases Toluene 2,4-Diisocyanate 9.2811077013 18394133 6091946 12585506 8156442 3040596 6091945
MESH:D009845 Oligospermia Cyclophosphamide 4.6016517039
MESH:D010014 Osteolysis zoledronic acid 5.2615867366
MESH:D010024 Osteoporosis zoledronic acid 3.9717882678
MESH:D010051 Ovarian Neoplasms Progesterone 4.8017393432 16525653
MESH:D010051 Ovarian Neoplasms Tretinoin 4.8016936753
MESH:D010146 Pain Cyclophosphamide 10.9718093676 12161096
MESH:D010146 Pain Tretinoin 10.9716870215
MESH:D010146 Pain zoledronic acid 10.9716475674
MESH:D010190 Pancreatic Neoplasms Cyclophosphamide 8.5511332152
MESH:D010190 Pancreatic Neoplasms Ethanol 8.5512384795
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.5515976015
MESH:D010212 Papilloma Croton Oil 5.6816517061
MESH:D054198 Precursor Cell Lymphoblastic Leukemia-Lymphoma Cyclophosphamide 3.7421297632
MESH:D011471 Prostatic Neoplasms AGN 194204 1.9116000583
MESH:D011471 Prostatic Neoplasms Azacitidine 1.9118324645
MESH:D011471 Prostatic Neoplasms Cyclophosphamide 1.9117136230
MESH:D011471 Prostatic Neoplasms pyrrolidine dithiocarbamic acid 1.9116139439
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.9115067354
MESH:D011471 Prostatic Neoplasms zoledronic acid 1.9112438248 19103299
MESH:D011507 Proteinuria Tretinoin 3.5016636307
MESH:D011625 Pterygium Tretinoin 4.6816723453
MESH:D011657 Pulmonary Eosinophilia Toluene 2,4-Diisocyanate 5.5214606601
MESH:D011658 Pulmonary Fibrosis Cyclophosphamide 3.2416636934
MESH:D015427 Reperfusion Injury pirinixic acid 2.3319058328
MESH:D012128 Respiratory Distress Syndrome, Adult pyrrolidine dithiocarbamic acid 4.8916129981
MESH:D012130 Respiratory Hypersensitivity Toluene 2,4-Diisocyanate 4.3616940033 20219652 7692837
MESH:D012140 Respiratory Tract Diseases Toluene 2,4-Diisocyanate 5.0118447907
MESH:D012208 Rhabdomyosarcoma Tretinoin 3.9916116481 16283617
MESH:D012220 Rhinitis Toluene 2,4-Diisocyanate 4.4819050374
MESH:D012221 Rhinitis, Allergic, Perennial Toluene 2,4-Diisocyanate 5.1712617775 15015336
MESH:D006255 Rhinitis, Allergic, Seasonal Toluene 2,4-Diisocyanate 5.4119075512
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.8218045962
MESH:D012512 Sarcoma, Ewing's zoledronic acid 4.8316121404
MESH:D012595 Scleroderma, Systemic Cyclophosphamide 4.7216636934
MESH:D012640 Seizures Ethanol 3.109754883
MESH:D012878 Skin Neoplasms Croton Oil 6.3916517061
MESH:D012878 Skin Neoplasms Tretinoin 6.3916467112
MESH:D012912 Sneezing Toluene 2,4-Diisocyanate 5.4119075512 19050374
MESH:D013088 Spermatocele Tamoxifen 4.1916709447
OMIM:102530 SPERMATOGENIC FAILURE 6 Cyclophosphamide 5.4016517039
MESH:D013119 Spinal Cord Injuries Progesterone 10.5116503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.5119457130
MESH:D013274 Stomach Neoplasms Ethanol 2.5918456281
MESH:D013274 Stomach Neoplasms Tretinoin 2.5917261132
MESH:D013276 Stomach Ulcer Ethanol 3.4311906479 9562338 16755016 9211565 17918041 17189318
MESH:D013375 Substance Withdrawal Syndrome Ethanol 4.169754883
MESH:D015173 Supratentorial Neoplasms Cyclophosphamide 4.9512837982
MESH:D013705 Temporomandibular Joint Disorders polyphenols 5.1517997062
MESH:D013964 Thyroid Neoplasms Tretinoin 2.9417045167 16026305
MESH:D014062 Tongue Neoplasms Tretinoin 3.6916051514
MESH:D014376 Tuberculosis Tretinoin 3.1616040207
MESH:D001749 Urinary Bladder Neoplasms Cyclophosphamide 5.2114692829
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 5.218653321 16712894 17572228
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.5816129372
MESH:D014604 Uveal Neoplasms Tretinoin 4.5016752155
MESH:D014820 Vitiligo Tretinoin 3.9516761959
MESH:D015430 Weight Gain Dietary Fats 3.6416723640
MESH:D009396 Wilms Tumor Tretinoin 3.8716287080
Pathway ID Pathway Name
KEGG:05330 Allograft rejection
REACT:578 Apoptosis
KEGG:05320 Autoimmune thyroid disease
KEGG:05332 Graft-versus-host disease
KEGG:04650 Natural killer cell mediated cytotoxicity
KEGG:04940 Type I diabetes mellitus
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29087
    • No data
    Releated disease ID Related disease Name
    PA446047Vitiligo
    No data
    Drug Bank Top
    Drugbank ID Action Drug Name Description
    DB02944 - Alpha-D-Mannose
    No data
    No data
    No data

    Simple Query:


      (e.g. CHD8)

    Syndromic Genes

    Non-syndromic Genes

    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018


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