AutismKB 2.0

Annotation Detail for GZMM


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Basic Information Top
Gene Symbol:GZMM ( LMET1,MET1 )
Gene Full Name: granzyme M (lymphocyte met-ase 1)
Band: 19p13.3
Quick LinksEntrez ID:3004; OMIM: 600311; Uniprot ID:GRAM_HUMAN; ENSEMBL ID: ENSG00000197540; HGNC ID: 4712
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D000082 Acetaminophen Acetaminophen affects the expression of GZMM mRNAaffects expression 17562736
D000082 Acetaminophen MAP3K5 protein affects the reaction [Acetaminophen results in increased expression of GZMM mRNA]affects reaction|increases expression 18700144
D000643 Ammonium Chloride Ammonium Chloride affects the expression of GZMM mRNAaffects expression 16483693
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000138 Acidosis Ammonium Chloride 4.4418287403
MESH:D000799 Angioedema Acetaminophen 4.9110982225
MESH:D001321 Autistic Disorder Acetaminophen 1.3918445737
MESH:D006528 Carcinoma, Hepatocellular Acetaminophen 1.413084413
MESH:D002386 Cataract Acetaminophen 2.8310977129
MESH:D056486 Drug-Induced Liver Injury Acetaminophen 1.6816081117 16485898 16781746 2444490 14725611 15619225 11421492 11743745 17522070 11529661 17906064 19370779 19085960 10774834 15968718 12392966 12958197 12153990 16177239 18713872 12705907 16393943 10915739 17562736 14986274 10663392 18071297 19164858 16227642 14550746 11834606 16109766 11287661 12594235 11461765 19420014 19416960 19923254 12540782 11739529 19739265
MESH:D056487 Drug-Induced Liver Injury, Chronic Acetaminophen 5.1719426721
MESH:D005756 Gastritis Acetaminophen 4.7416983495
MESH:D006930 Hyperalgesia Acetaminophen 3.1116870215
MESH:D007674 Kidney Diseases Acetaminophen 2.4415629191 12587719
MESH:D008107 Liver Diseases Acetaminophen 1.7119784758 16610002 19460945 12587719 12969438 11587558 19014921 16611625
MESH:D017114 Liver Failure, Acute Acetaminophen 3.7417185352 16871587
MESH:D008546 Melanoma, Experimental Acetaminophen 4.3319513568
MESH:D019636 Neurodegenerative Diseases Acetaminophen 3.3118514411
MESH:D010146 Pain Acetaminophen 2.8216870215
MESH:D014581 Urticaria Acetaminophen 3.5810982225
No data
Pharmacogenomics Knowledge Base Top
  • PharmGKB Accession:PA29090
  • No data
    Releated disease ID Related disease Name
    PA446155Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Releated drug ID Related drug Name
    PA450379mercaptopurine
    PA450428methotrexate
    Drug Bank Top

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    AutismKB Statistics

    • Studies: 1,036
    • Genes: 1,379
    • CNVs/SVs: 5,420
    • SNVs/Indels: 11,669
    • de novo Mutations: 5,669
    • Mosaics: 789
    • Linkage Regions: 172
    • Paper Collected: 6/30/2018
    • Last Update: 8/26/2018