AutismKB 2.0

Annotation Detail for HIST1H1C


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Basic Information Top
Gene Symbol:HIST1H1C ( H1.2,H1C,H1F2,MGC3992 )
Gene Full Name: histone cluster 1, H1c
Band: 6p22.2
Quick LinksEntrez ID:3006; OMIM: 142710; Uniprot ID:H12_HUMAN; ENSEMBL ID: ENSG00000187837; HGNC ID: 4716
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of HIST1H1C proteinaffects expression 20106945
D017638 Asbestos, Crocidolite Asbestos, Crocidolite results in increased expression of HIST1H1C mRNAincreases expression 18687144
D001554 Benzene Benzene results in decreased expression of HIST1H1C mRNAdecreases expression 15122651
15120971
D019324 beta-Naphthoflavone beta-Naphthoflavone results in increased expression of HIST1H1C mRNAincreases expression 19737606
D001564 Benzo(a)pyrene Benzo(a)pyrene results in increased expression of HIST1H1C mRNAincreases expression 20106945
20064835
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HIST1H1C mRNAdecreases expression 17944540
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of HIST1H1C mRNAincreases expression 20382639
D016572 Cyclosporine Cyclosporine affects the expression of HIST1H1C mRNAaffects expression 20106945
C014347 decitabine [decitabine co-treated with vorinostat] affects the expression of HIST1H1C mRNAaffects cotreatment|affects expression 17330099
D004317 Doxorubicin HIST1H1C protein affects the susceptibility to Doxorubicinaffects response to substance 16217747
D004958 Estradiol Estradiol results in increased expression of HIST1H1C mRNAincreases expression 20106945
D004958 Estradiol [Progesterone co-treated with Estradiol] results in increased expression of HIST1H1C mRNAaffects cotreatment|increases expression 17404688
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of HIST1H1C mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in decreased expression of HIST1H1C mRNAdecreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HIST1H1C mRNAaffects cotreatment|decreases expression 17942748
C056933 fumonisin B1 fumonisin B1 results in increased expression of HIST1H1C mRNAincreases expression 16221962
C029424 hydrazine hydrazine results in increased expression of HIST1H1C mRNAincreases expression 15282401
C027185 indirubin indirubin results in decreased phosphorylation of HIST1H1C proteindecreases phosphorylation 18344322
C027185 indirubin [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]affects cotreatment|decreases phosphorylation|increases reaction 18344322
C027185 indirubin tanshinone promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]decreases phosphorylation|increases reaction 18344322
C027185 indirubin tetraarsenic tetrasulfide promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]decreases phosphorylation|increases reaction 18344322
D007529 Isoflavones Isoflavones affects the expression of HIST1H1C mRNAaffects expression 16365062
C452423 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in increased expression of HIST1H1C mRNAincreases expression 16052530
D010634 Phenobarbital NR1I3 protein affects the reaction [Phenobarbital results in increased expression of HIST1H1C mRNA]affects reaction|increases expression 19482888
D010634 Phenobarbital Phenobarbital results in increased expression of HIST1H1C mRNAincreases expression 19482888
C006253 pirinixic acid pirinixic acid results in increased expression of HIST1H1C mRNAincreases expression 20059764
18445702
C006253 pirinixic acid PPARA protein promotes the reaction [pirinixic acid results in increased expression of HIST1H1C mRNA]increases expression|increases reaction 20059764
D011374 Progesterone [Progesterone co-treated with Estradiol] results in increased expression of HIST1H1C mRNAaffects cotreatment|increases expression 17404688
D013629 Tamoxifen Tamoxifen affects the expression of HIST1H1C mRNAaffects expression 17555576
C021751 tanshinone [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]affects cotreatment|decreases phosphorylation|increases reaction 18344322
C021751 tanshinone tanshinone promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]decreases phosphorylation|increases reaction 18344322
C534735 tetraarsenic tetrasulfide [tanshinone co-treated with tetraarsenic tetrasulfide] promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]affects cotreatment|decreases phosphorylation|increases reaction 18344322
C534735 tetraarsenic tetrasulfide tetraarsenic tetrasulfide promotes the reaction [indirubin results in decreased phosphorylation of HIST1H1C protein]decreases phosphorylation|increases reaction 18344322
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of HIST1H1C mRNAincreases expression 20106945
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of HIST1H1C mRNAaffects cotreatment|decreases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in decreased expression of HIST1H1C mRNAdecreases expression 17942748
19465110
D014212 Tretinoin Tretinoin results in increased expression of HIST1H1C mRNAincreases expression 16249480
D014747 Vinblastine HIST1H1C protein affects the susceptibility to Vinblastineaffects response to substance 16217747
C111237 vorinostat [decitabine co-treated with vorinostat] affects the expression of HIST1H1C mRNAaffects cotreatment|affects expression 17330099
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Phenobarbital 7.596195326
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 7.5915322242 14514962 11752688
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Benzo(a)pyrene 9.7120127859 20464547
MESH:D000230 Adenocarcinoma Doxorubicin 9.7117418594
MESH:D000230 Adenocarcinoma Estradiol 9.7111473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 9.7114692618
MESH:D000236 Adenoma Benzo(a)pyrene 6.416695378
MESH:D000236 Adenoma beta-Naphthoflavone 6.4119389873
MESH:D018248 Adenoma, Liver Cell Phenobarbital 16.0617620307
MESH:D018248 Adenoma, Liver Cell pirinixic acid 16.0616434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 16.0616835633
MESH:D000419 Albuminuria Doxorubicin 4.3421441931
MESH:D000505 Alopecia Isoflavones 9.0317569567
MESH:D000505 Alopecia Tretinoin 9.0315955085
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D000741 Anemia, Aplastic Benzene 4.2111369114 14761424 17661222
MESH:D017544 Aortic Aneurysm, Abdominal Benzo(a)pyrene 3.8719183758
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 6.7815885639
MESH:D001169 Arthritis, Experimental Tretinoin 6.7816412693
MESH:D001172 Arthritis, Rheumatoid Tretinoin 2.2216292516
MESH:D001249 Asthma Tretinoin 2.2816456186
MESH:D001471 Barrett Esophagus Tretinoin 4.2016935849
MESH:D001778 Blood Coagulation Disorders pirinixic acid 14.1719483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 14.1712125929
MESH:D001778 Blood Coagulation Disorders Tretinoin 14.1716206674 16197459
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001855 Bone Marrow Diseases Benzene 5.0216183116
MESH:D019046 Bone Marrow Neoplasms Doxorubicin 4.4914601052
MESH:D020201 Brain Hemorrhage, Traumatic Progesterone 5.1317868700
MESH:D001930 Brain Injuries Progesterone 4.0515665606 15845082 15380490
MESH:D001932 Brain Neoplasms Doxorubicin 3.6317150277
MESH:D001943 Breast Neoplasms marker/mechanism 17659439
MESH:D001943 Breast Neoplasms Benzene 8.0717162533 11921183
MESH:D001943 Breast Neoplasms Benzo(a)pyrene 8.0720146248 17474063
MESH:D001943 Breast Neoplasms decitabine 8.0719208741 18320071
MESH:D001943 Breast Neoplasms Doxorubicin 8.0718695136 16322301 15136595 15994142 15939500 17983394 16264153 15634643 18628466 16826403 19526202 16935488 16096432 18382427 18234424 17369602 15993339 11325840 16115903 15668708 15692762 17426702 16595493 15567936
MESH:D001943 Breast Neoplasms Estradiol 8.0717289903 19861407 16675129 17018787 12948864 18497071 17261762 14630087
MESH:D001943 Breast Neoplasms Progesterone 8.0716175315 15562024 17614352
MESH:D001943 Breast Neoplasms Tamoxifen 8.0715565566 20390343 20135344 20065188 19011961 16818667 19155303 17261762 21138602 21152245 18855134 19200415 19189210 17440819 11161223 16873071 19221464 19487384 17893378 19410462 18351453 20005174 16202921 17242785 19189212 18425577 18815881 18984771 19084267 19289846 19115204 17049068 20544844 18997820 19142967 20859285 15668708 19288272 18629630 19103187 19244106 18821012 19059307 19066611 16273361
MESH:D001943 Breast Neoplasms tanshinone 8.0715849732 19885617
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 8.0720435547
MESH:D001943 Breast Neoplasms Tretinoin 8.0716166294 16443354 16873071
MESH:D001943 Breast Neoplasms vorinostat 8.0716144943
MESH:D001997 Bronchopulmonary Dysplasia Tretinoin 4.3816813970
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002276 Carcinoid Tumor Doxorubicin 4.6016051944
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 2.6316835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D018236 Carcinoma, Embryonal Tretinoin 4.9516168501
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 10.9321507988 12619106 12907637
MESH:D006528 Carcinoma, Hepatocellular Doxorubicin 10.9318059187 17876044 16234567 16023760
MESH:D006528 Carcinoma, Hepatocellular Estradiol 10.9316924424
MESH:D006528 Carcinoma, Hepatocellular Phenobarbital 10.9317173139 20935162 1701930 6705139 20007298
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 10.9316924424
MESH:D006528 Carcinoma, Hepatocellular Tretinoin 10.931917145
MESH:D002292 Carcinoma, Renal Cell Doxorubicin 6.6316201981 1485588
MESH:D002292 Carcinoma, Renal Cell Vinblastine 6.631485588
MESH:D002294 Carcinoma, Squamous Cell Benzo(a)pyrene 10.2920419170
MESH:D002294 Carcinoma, Squamous Cell decitabine 10.2919215824
MESH:D002294 Carcinoma, Squamous Cell Doxorubicin 10.296189445
MESH:D002294 Carcinoma, Squamous Cell Tretinoin 10.2916051514 16096774
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D009202 Cardiomyopathies Doxorubicin 3.3916278810 17308081 16952015 16109756 17382496 16364871 17974986 17351982 17924179 18627295 16455267 15476868 15792986 16269455 17928571 16731534 15811867 16651473 16242529 17519947 17329180 15505089 17131338 16612575 17007740
MESH:D002311 Cardiomyopathy, Dilated Doxorubicin 2.8716243910 17334414
MESH:D002318 Cardiovascular Diseases Isoflavones 4.0117689850
MESH:D002386 Cataract Tretinoin 2.9717460283
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 10.3120889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 10.3112371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 10.3118566989
MESH:D002493 Central Nervous System Diseases Phenobarbital 4.044080065
MESH:D018290 Cervical Intraepithelial Neoplasia Tretinoin 4.3816129372
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis Cyclosporine 12.4519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 12.4517681005 11677210 16105132 15861022 16919318 17333356 17110522
MESH:D002779 Cholestasis pirinixic acid 12.4519176532
MESH:D002822 Choriocarcinoma Tretinoin 4.9516461808
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 5.4712621046 15340226 15668235 8697196 16354765
MESH:D002972 Cleft Palate Tretinoin 5.479407595
MESH:D003092 Colitis Tretinoin 3.5017035595
MESH:D003110 Colonic Neoplasms decitabine 2.3017616700
MESH:D015179 Colorectal Neoplasms decitabine 4.7318981723
MESH:D015179 Colorectal Neoplasms Doxorubicin 4.7318802399 18259882
MESH:D015179 Colorectal Neoplasms Isoflavones 4.7317116718
MESH:D015179 Colorectal Neoplasms Vinblastine 4.7318802399
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Benzene 3.7015643154
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 3.7020055451 10048152 15322242
MESH:D019465 Craniofacial Abnormalities Tretinoin 3.708800419 17551590 9664655 10589399 14991402 16925845 9211117 9224671 9142499 9125849
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D003872 Dermatitis Benzene 4.5615902427
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 1.6217107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2519279558
MESH:D003929 Diabetic Neuropathies Progesterone 4.2817187935
MESH:D003967 Diarrhea vorinostat 4.3020479100
MESH:D056486 Drug-Induced Liver Injury Doxorubicin 5.9917416283
MESH:D056486 Drug-Induced Liver Injury fumonisin B1 5.9916221962
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9920420201
MESH:D004362 Drug Toxicity Doxorubicin 7.6018602426
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 7.6011462148
MESH:D004421 Dystonia Phenobarbital 3.811851702
MESH:D004487 Edema pirinixic acid 5.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9211000095 12711302
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 11.2318230668 15322242 16714409
MESH:D004489 Edema, Cardiac Tretinoin 11.2318230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 14.1512538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Progesterone 14.1517692515
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 14.1519031437
MESH:D004701 Endocrine Gland Neoplasms decitabine 4.9019294695
MESH:D016889 Endometrial Neoplasms Doxorubicin 16.6717359293
MESH:D016889 Endometrial Neoplasms Estradiol 16.6718566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.6719155303 20544844 17893378 16202921
MESH:D016889 Endometrial Neoplasms Tretinoin 16.6716569247
MESH:D004715 Endometriosis Progesterone 8.3216134523
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 8.3210568697 9294722
MESH:D004719 Endomyocardial Fibrosis Doxorubicin 4.9418037988
MESH:D004831 Epilepsies, Myoclonic Phenobarbital 3.903659116
MESH:D004828 Epilepsies, Partial Phenobarbital 3.6611558140 3922381
MESH:D004827 Epilepsy Phenobarbital 2.7820417680
MESH:D004832 Epilepsy, Absence Phenobarbital 3.376401628
MESH:D017029 Epilepsy, Complex Partial Phenobarbital 4.047750514
MESH:D004830 Epilepsy, Tonic-Clonic Phenobarbital 3.813659116
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 4.1620426865
MESH:D004938 Esophageal Neoplasms Benzo(a)pyrene 4.1616530937
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 8.3211564622
MESH:D005124 Eye Abnormalities Tretinoin 8.3216938888 9664655
MESH:D005221 Fatigue vorinostat 5.3820479100
MESH:D005234 Fatty Liver Cyclosporine 17.1719224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 17.1715345470
MESH:D005234 Fatty Liver pirinixic acid 17.1720131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 17.1714986274 19224547
MESH:D052776 Female Urogenital Diseases Tamoxifen 3.1116709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Doxorubicin 10.7419069698
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 10.7419069698
MESH:D005355 Fibrosis Cyclosporine 13.5212639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5220067830
MESH:D005355 Fibrosis Tretinoin 13.5217994277
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Doxorubicin 6.7917150277
MESH:D005909 Glioblastoma Tretinoin 6.7917312396
MESH:D005910 Glioma tanshinone 3.9416955220
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006258 Head and Neck Neoplasms decitabine 12.1819215824
MESH:D006258 Head and Neck Neoplasms Doxorubicin 12.1815692506
MESH:D006258 Head and Neck Neoplasms Tretinoin 12.1816096774
MESH:D006317 Hearing Loss, Noise-Induced Tretinoin 4.9516084493
MESH:D006330 Heart Defects, Congenital Benzo(a)pyrene 10.4620471113
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 10.4610048152 11294989
MESH:D006330 Heart Defects, Congenital Tretinoin 10.4614991402 9664655
MESH:D006331 Heart Diseases Doxorubicin 3.3416495754 17888722 18006777 16244371 14766674 18674790 16244372 16144979 17875725 16330681 16879835 12587719 16707910
MESH:D006333 Heart Failure Doxorubicin 6.6217481944
MESH:D006333 Heart Failure pirinixic acid 6.6220558911
MESH:D006394 Hemangiosarcoma Doxorubicin 3.7115692506
MESH:D006402 Hematologic Diseases Benzene 4.4616183116
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006529 Hepatomegaly fumonisin B1 19.0016221962
MESH:D006529 Hepatomegaly Phenobarbital 19.0016109766
MESH:D006529 Hepatomegaly pirinixic acid 19.0019772884 16221962 19176532 18467677
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 19.0015340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D006689 Hodgkin Disease Doxorubicin 7.2218501091 17606976 15147373
MESH:D006689 Hodgkin Disease Vinblastine 7.2218501091 18180244
MESH:D019584 Hot Flashes Estradiol 9.7117088409
MESH:D019584 Hot Flashes Isoflavones 9.7114716179 17290160
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.8318606429 15340226 16354765 8697196 16959395
MESH:D006930 Hyperalgesia Tretinoin 3.0516870215
MESH:D017681 Hypereosinophilic Syndrome Tretinoin 4.3616778211
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006968 Hypersensitivity, Delayed indirubin 5.7211275354
MESH:D006973 Hypertension Benzene 8.1417940673
MESH:D006973 Hypertension Cyclosporine 8.1410903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 8.1418670907 18850075
MESH:D017379 Hypertrophy, Left Ventricular tanshinone 5.0519662366
MESH:D007021 Hypospadias Ethinyl Estradiol 3.6016569931 16945680
MESH:D020244 Infarction, Middle Cerebral Artery Progesterone 4.1915869954
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male decitabine 6.2617581917
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.2617937319
MESH:D007249 Inflammation Progesterone 7.6715869954
MESH:D007249 Inflammation Tamoxifen 7.6719457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 7.6712200463 12878042
MESH:D007333 Insulin Resistance Estradiol 6.7516627594 16393666
MESH:D007333 Insulin Resistance pirinixic acid 6.7516306350
MESH:D007410 Intestinal Diseases Tretinoin 3.5617994277
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 9.3016580747
MESH:D007569 Jaw Abnormalities Tretinoin 9.3015992940 17551590
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 9.398314463 10903974 18776723
MESH:D007674 Kidney Diseases Doxorubicin 9.3915699352 16775033 15369732
MESH:D007674 Kidney Diseases Estradiol 9.3915618244
MESH:D007676 Kidney Failure, Chronic Doxorubicin 3.9616707910
MESH:D007680 Kidney Neoplasms Cyclosporine 11.3912371664
MESH:D007680 Kidney Neoplasms Estradiol 11.3915610895
MESH:D007680 Kidney Neoplasms Tamoxifen 11.3918625569
MESH:D007938 Leukemia Benzene 9.9814694614 17119257 18335105 15935818
MESH:D007938 Leukemia decitabine 9.9819235587 18980019
MESH:D007938 Leukemia Tretinoin 9.9817143497
MESH:D004915 Leukemia, Erythroblastic, Acute Doxorubicin 4.9416085563
MESH:D015464 Leukemia, Myelogenous, Chronic, BCR-ABL Positive tetraarsenic tetrasulfide 4.8919208803
MESH:D007951 Leukemia, Myeloid Benzene 14.9817506065
MESH:D007951 Leukemia, Myeloid decitabine 14.9818454857 19117987 17236224
MESH:D007951 Leukemia, Myeloid Tretinoin 14.9819285840 16482212 16932348
MESH:D015470 Leukemia, Myeloid, Acute marker/mechanism 17330099
MESH:D015470 Leukemia, Myeloid, Acute Benzene 5.9919478238
MESH:D015470 Leukemia, Myeloid, Acute decitabine 5.9919387464 18206229 18704418 19010910 18460780 17679729
MESH:D015470 Leukemia, Myeloid, Acute Tretinoin 5.9916294345 17596541 19850784
MESH:D015477 Leukemia, Myelomonocytic, Chronic decitabine 5.2518055864
MESH:D015473 Leukemia, Promyelocytic, Acute Tretinoin 3.0219075265 16935935 17339181 17301526 17649720 19029980 17361223 19225113 17107899 16140955 9834237 17506722 17712046 12679006 16823087 15748426 16788101 17217047 17294898 16331271 16891316 16766008 19642359 17368321 19035177
MESH:D017880 Limb Deformities, Congenital Tretinoin 3.169224671
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008103 Liver Cirrhosis Phenobarbital 2.7821047994
MESH:D008106 Liver Cirrhosis, Experimental Doxorubicin 8.3816439617 16595196
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3814716833 14659978
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3815474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3818564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3812878042
MESH:D008106 Liver Cirrhosis, Experimental Tretinoin 8.3818397230 16248980
MESH:D008107 Liver Diseases Phenobarbital 2.1219363144
MESH:D008113 Liver Neoplasms Aflatoxin B1 20.6718177683 9163691 15890375 2125692
MESH:D008113 Liver Neoplasms Benzo(a)pyrene 20.6721137059 20195826
MESH:D008113 Liver Neoplasms beta-Naphthoflavone 20.6719389873 21295105
MESH:D008113 Liver Neoplasms Phenobarbital 20.6719812893 15975961 19482888 19073162 8742319 21047994
MESH:D008113 Liver Neoplasms pirinixic acid 20.6720007298 15890375 16377806
MESH:D008113 Liver Neoplasms Tamoxifen 20.6716684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 20.6716984957
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 21.698603461
MESH:D008114 Liver Neoplasms, Experimental Benzene 21.6912562636
MESH:D008114 Liver Neoplasms, Experimental beta-Naphthoflavone 21.6918164116
MESH:D008114 Liver Neoplasms, Experimental Doxorubicin 21.6916842330 17085340
MESH:D008114 Liver Neoplasms, Experimental Phenobarbital 21.696150874 18308698 2563599 17172636 1399818
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 21.6912151625
MESH:D017563 Lung Diseases, Interstitial Benzene 4.6014698565
MESH:D055370 Lung Injury Asbestos, Crocidolite 3.8217365036
MESH:D008175 Lung Neoplasms Aflatoxin B1 8.2114755239
MESH:D008175 Lung Neoplasms Benzene 8.2112562636
MESH:D008175 Lung Neoplasms Benzo(a)pyrene 8.2117053015 18569708 18520028 20464547 6695378 18816296 20135361 20869020 20064080
MESH:D008175 Lung Neoplasms Doxorubicin 8.2117418594 6189445
MESH:D008175 Lung Neoplasms Tamoxifen 8.2118625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 8.2119555203 11884234
MESH:D008223 Lymphoma Benzene 11.8117584886 17119257
MESH:D008223 Lymphoma decitabine 11.8119470736
MESH:D008223 Lymphoma Doxorubicin 11.8116098063
MESH:D008228 Lymphoma, Non-Hodgkin Doxorubicin 3.6217654614
MESH:D016399 Lymphoma, T-Cell Doxorubicin 4.3615621674
MESH:D016410 Lymphoma, T-Cell, Cutaneous vorinostat 5.4820479100
MESH:D015674 Mammary Neoplasms, Animal Benzene 9.3712562636
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 9.3719428831
MESH:D008325 Mammary Neoplasms, Experimental Benzene 17.4111921183
MESH:D008325 Mammary Neoplasms, Experimental Doxorubicin 17.4115458769
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.4111807958 16891317 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Progesterone 17.4117203775 11408345
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.4119196722 14580682 19196723 11731420 16827153
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008527 Medulloblastoma Tretinoin 2.7017453147
MESH:D008545 Melanoma decitabine 9.4016505122 17785578
MESH:D008545 Melanoma Doxorubicin 9.4016827129
MESH:D008545 Melanoma Tamoxifen 9.4012393984 19393235
MESH:D008545 Melanoma Tretinoin 9.4016752155
MESH:D008545 Melanoma Vinblastine 9.4018176117 16809738 12374674 16432458 18332650 15577323 15577320 18505091 17761969 16248763
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008591 Meningomyelocele Tretinoin 4.2216940565
MESH:D008654 Mesothelioma Asbestos, Crocidolite 6.1616966607 16166281 18303189
MESH:D008654 Mesothelioma Doxorubicin 6.1617638057
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D028361 Mitochondrial Diseases Doxorubicin 4.3115792986
MESH:D009062 Mouth Neoplasms Benzo(a)pyrene 3.0316381670
MESH:D052016 Mucositis Doxorubicin 4.5817415656
MESH:D009101 Multiple Myeloma Benzene 7.0917119195
MESH:D009101 Multiple Myeloma decitabine 7.0918172295
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009190 Myelodysplastic Syndromes decitabine 7.0819010910 16882708 19157545 18608210
MESH:D009190 Myelodysplastic Syndromes Tretinoin 7.0817596541
MESH:D009203 Myocardial Infarction Doxorubicin 5.4215857846 19429709
MESH:D009203 Myocardial Infarction pirinixic acid 5.4219151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 7.7216810080
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 7.7216411023
MESH:D020191 Myoclonic Epilepsies, Progressive Phenobarbital 4.2617484760
MESH:D009325 Nausea vorinostat 5.3120479100
MESH:D009362 Neoplasm Metastasis Doxorubicin 5.5918259882
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.5919393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Benzo(a)pyrene 11.0011141357
MESH:D009369 Neoplasms decitabine 11.0019116145 17925555 19470736
MESH:D009369 Neoplasms pirinixic acid 11.0017405874
MESH:D009369 Neoplasms Tretinoin 11.0016594593 16946489
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 3.7919200415 19189210 19196722
MESH:D009389 Neovascularization, Pathologic Estradiol 3.5217289903
MESH:D009401 Nephrosis Doxorubicin 4.5616899518 16636307
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 8.7118481113 19348381
MESH:D009404 Nephrotic Syndrome Doxorubicin 8.7116889571 15640375
MESH:D009421 Nervous System Malformations Estradiol 15.1611399458 16427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 15.1614600291
MESH:D009421 Nervous System Malformations Tretinoin 15.169125849
MESH:D009436 Neural Tube Defects Benzene 7.0615643154
MESH:D009436 Neural Tube Defects Tretinoin 7.069142499
MESH:D009447 Neuroblastoma Doxorubicin 3.1615555623
MESH:D009503 Neutropenia Vinblastine 4.3817378895
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases Benzene 4.0015935809 17119257 15612468 15576619 15727169 17178637 16737584 17479406 15913788
MESH:D010018 Osteomalacia Phenobarbital 4.1517016548
MESH:D010024 Osteoporosis Isoflavones 3.9716562857
MESH:D012516 Osteosarcoma Doxorubicin 3.9515930896
MESH:D010051 Ovarian Neoplasms Benzene 14.2712562636
MESH:D010051 Ovarian Neoplasms decitabine 14.2719331143 19259094
MESH:D010051 Ovarian Neoplasms Estradiol 14.2719401270
MESH:D010051 Ovarian Neoplasms Progesterone 14.2716525653 17393432
MESH:D010051 Ovarian Neoplasms Tretinoin 14.2716936753
MESH:D010146 Pain Tretinoin 2.7416870215
MESH:D010190 Pancreatic Neoplasms decitabine 8.2119294695
MESH:D010190 Pancreatic Neoplasms Phenobarbital 8.2116965848
MESH:D010190 Pancreatic Neoplasms Tretinoin 8.2115976015
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D003557 Phyllodes Tumor Doxorubicin 4.9417983394
MESH:D010995 Pleural Diseases Asbestos, Crocidolite 4.6910923243
MESH:D010997 Pleural Neoplasms Doxorubicin 4.9417638057
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 8.3812371664
MESH:D011230 Precancerous Conditions Phenobarbital 8.382563599
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 2.9811896295 11399792 11118676 11222880
MESH:D055728 Primary Myelofibrosis decitabine 4.5217616702
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 3.6920887781
MESH:D011471 Prostatic Neoplasms Benzo(a)pyrene 1.8917292933
MESH:D011471 Prostatic Neoplasms Doxorubicin 1.8916868541 15897917 16888761 16729912 15749863 18437689
MESH:D011471 Prostatic Neoplasms Estradiol 1.8916740699
MESH:D011471 Prostatic Neoplasms Isoflavones 1.8917219775 17571952 17374662 16365062
MESH:D011471 Prostatic Neoplasms Tamoxifen 1.8915067354
MESH:D011471 Prostatic Neoplasms vorinostat 1.8917218635
MESH:D011507 Proteinuria Tretinoin 3.4116636307
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D019310 Pseudolymphoma Phenobarbital 4.2812752131
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011625 Pterygium Tretinoin 4.5816723453
MESH:D011658 Pulmonary Fibrosis Asbestos, Crocidolite 2.9517322281 17365031 15814490 17975199
MESH:D051437 Renal Insufficiency Doxorubicin 4.0117922066
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012208 Rhabdomyosarcoma decitabine 10.3019155313
MESH:D012208 Rhabdomyosarcoma Tretinoin 10.3016116481 16283617
MESH:D012468 Salivary Gland Neoplasms Progesterone 2.7818045962
MESH:D012509 Sarcoma Doxorubicin 3.8116767912 15675481 15625365 17710206 17203757 18313854
MESH:D012512 Sarcoma, Ewing's Doxorubicin 4.0414601052 16326096
MESH:D012514 Sarcoma, Kaposi Doxorubicin 4.5817846226
MESH:D012640 Seizures Phenobarbital 2.563137016 4039156 11442880 16876388
MESH:D003294 Seizures, Febrile Phenobarbital 4.616407741
MESH:D012878 Skin Neoplasms Benzo(a)pyrene 12.7519755658 10029692
MESH:D012878 Skin Neoplasms Doxorubicin 12.7515692506
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 12.7516192470
MESH:D012878 Skin Neoplasms Tretinoin 12.7516467112
MESH:D012983 Soft Tissue Neoplasms Doxorubicin 4.3617203757 15625365 16767912
MESH:D013088 Spermatocele Ethinyl Estradiol 10.8516709447
MESH:D013088 Spermatocele Tamoxifen 10.8516709447
MESH:D013119 Spinal Cord Injuries Progesterone 10.1716503802 15862959
MESH:D013119 Spinal Cord Injuries Tamoxifen 10.1719457130
MESH:D013274 Stomach Neoplasms Benzene 4.5712562636
MESH:D013274 Stomach Neoplasms Benzo(a)pyrene 4.572093021 20155912
MESH:D013274 Stomach Neoplasms decitabine 4.5719037991
MESH:D013274 Stomach Neoplasms Tretinoin 4.5717261132
MESH:D013921 Thrombocytopenia vorinostat 4.7920479100
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013953 Thymus Neoplasms Benzene 4.7410850423
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms decitabine 20.8317967635
MESH:D013964 Thyroid Neoplasms Doxorubicin 20.8317909728 16010429
MESH:D013964 Thyroid Neoplasms N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine 20.8316940797
MESH:D013964 Thyroid Neoplasms Phenobarbital 20.831399818
MESH:D013964 Thyroid Neoplasms Tretinoin 20.8317045167 16026305
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D014062 Tongue Neoplasms Tretinoin 3.6016051514
MESH:D014376 Tuberculosis Tretinoin 3.1016040207
MESH:D001749 Urinary Bladder Neoplasms Benzo(a)pyrene 11.2717053015
MESH:D001749 Urinary Bladder Neoplasms decitabine 11.2719087683 17616700
MESH:D001749 Urinary Bladder Neoplasms Doxorubicin 11.2717653716
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.2716712894 17572228 8653321
MESH:D002583 Uterine Cervical Neoplasms Tretinoin 3.4916129372
MESH:D014594 Uterine Neoplasms Benzene 8.9012562636
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.9014692618
MESH:D014604 Uveal Neoplasms decitabine 12.1217785578
MESH:D014604 Uveal Neoplasms Tretinoin 12.1216752155
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Vinblastine 4.8415577323
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D018487 Ventricular Dysfunction, Left Doxorubicin 4.0116364871 17678736 17638931 17334414
MESH:D014820 Vitiligo Tretinoin 3.8516761959
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D009396 Wilms Tumor Tretinoin 3.7916287080
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
REACT:578 Apoptosis
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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