AutismKB 2.0

Annotation Detail for H2AFZ


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Basic Information Top
Gene Symbol:H2AFZ ( H2A.z,H2A/z,H2AZ,MGC117173 )
Gene Full Name: H2A histone family, member Z
Band: 4q23
Quick LinksEntrez ID:3015; OMIM: 142763; Uniprot ID:H2AZ_HUMAN; ENSEMBL ID: ENSG00000164032; HGNC ID: 4741
Relate to Another Database: SFARIGene; denovo-db
Related Pathway Information Top
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Related Diseases/Disorders Top
Comparative Toxicogenomics Database Top
Chemical ID Chemical Name Interaction Interaction Action Publication
C518576 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate 2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate results in decreased expression of H2AFZ mRNAdecreases expression 17327690
C019499 2-nitrofluorene 2-nitrofluorene results in increased expression of H2AFZ mRNAincreases expression 15890375
C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of H2AFZ mRNAdecreases expression 12958071
C009505 4,4'-diaminodiphenylmethane 4,4'-diaminodiphenylmethane results in increased expression of H2AFZ mRNAincreases expression 18648102
C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of H2AFZ mRNAdecreases expression 15890375
D016604 Aflatoxin B1 Aflatoxin B1 affects the expression of H2AFZ proteinaffects expression 20106945
D016604 Aflatoxin B1 Aflatoxin B1 results in increased expression of H2AFZ mRNAincreases expression 15890375
D000643 Ammonium Chloride Ammonium Chloride affects the expression of H2AFZ mRNAaffects expression 16483693
C015001 arsenite arsenite results in decreased expression of H2AFZ mRNAdecreases expression 18929588
D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of H2AFZ mRNAincreases expression 19150397
C095105 bexarotene bexarotene results in decreased expression of H2AFZ mRNAdecreases expression 16648578
C006780 bisphenol A bisphenol A results in increased expression of H2AFZ mRNAincreases expression 16474171
D016572 Cyclosporine Cyclosporine results in increased expression of H2AFZ mRNAincreases expression 20106945
D004054 Diethylstilbestrol Diethylstilbestrol results in increased expression of H2AFZ mRNAincreases expression 15890375
D004128 Dimethylnitrosamine Dimethylnitrosamine results in increased expression of H2AFZ mRNAincreases expression 15890375
D004958 Estradiol Estradiol results in increased expression of H2AFZ mRNAincreases expression 16474171
D004997 Ethinyl Estradiol Ethinyl Estradiol affects the expression of H2AFZ mRNAaffects expression 17555576
D004997 Ethinyl Estradiol Ethinyl Estradiol results in increased expression of H2AFZ mRNAincreases expression 17942748
D004997 Ethinyl Estradiol [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of H2AFZ mRNAaffects cotreatment|increases expression 17942748
C070081 fulvestrant fulvestrant results in decreased expression of H2AFZ mRNAdecreases expression 20543978
D019833 Genistein Genistein results in increased expression of H2AFZ mRNAincreases expression 16474171
D017313 Fenretinide Fenretinide results in decreased expression of H2AFZ mRNAdecreases expression 16671099
D008701 Methapyrilene Methapyrilene results in increased expression of H2AFZ mRNAincreases expression 15890375
C014707 nitrosobenzylmethylamine nitrosobenzylmethylamine results in increased expression of H2AFZ mRNAincreases expression 17616710
D010882 Piperonyl Butoxide Piperonyl Butoxide results in increased expression of H2AFZ mRNAincreases expression 15890375
C006253 pirinixic acid pirinixic acid results in decreased expression of H2AFZ mRNAdecreases expression 18445702
C006253 pirinixic acid pirinixic acid results in increased expression of H2AFZ mRNAincreases expression 15890375
D011078 Polychlorinated Biphenyls Polychlorinated Biphenyls analog results in increased expression of H2AFZ mRNAincreases expression 16474171
D013629 Tamoxifen Tamoxifen results in decreased expression of H2AFZ mRNAdecreases expression 20543978
D013629 Tamoxifen Tamoxifen affects the expression of H2AFZ mRNAaffects expression 17555576
D013749 Tetrachlorodibenzodioxin AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of H2AFZ mRNA]affects reaction|increases expression 19465110
D013749 Tetrachlorodibenzodioxin [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of H2AFZ mRNAaffects cotreatment|increases expression 17942748
D013749 Tetrachlorodibenzodioxin Tetrachlorodibenzodioxin results in increased expression of H2AFZ mRNAincreases expression 19465110
17942748
Disease ID Disease Name Direct Evidence Inference Chemical Name Inference Score Publication
MESH:D000008 Abdominal Neoplasms Tamoxifen 4.3414745880
MESH:D000014 Abnormalities, Drug-Induced Tetrachlorodibenzodioxin 2.6415322242 11752688 14514962
MESH:D000138 Acidosis Ammonium Chloride 3.3518287403
MESH:D000152 Acne Vulgaris Ethinyl Estradiol 3.7317505938
MESH:D055371 Acute Lung Injury pirinixic acid 2.9218653653
MESH:D000230 Adenocarcinoma Dimethylnitrosamine 12.9916033868
MESH:D000230 Adenocarcinoma Estradiol 12.9911473722
MESH:D000230 Adenocarcinoma Ethinyl Estradiol 12.9914692618
MESH:D000230 Adenocarcinoma Fenretinide 12.9910697514
MESH:D000230 Adenocarcinoma Genistein 12.9911473722
MESH:D000236 Adenoma 4,4'-diaminodiphenylmethane 10.693712494
MESH:D000236 Adenoma 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.6916176798
MESH:D000236 Adenoma Dimethylnitrosamine 10.6919555203
MESH:D018248 Adenoma, Liver Cell pirinixic acid 9.2016434500
MESH:D018248 Adenoma, Liver Cell Tetrachlorodibenzodioxin 9.2016835633
MESH:D000686 Amyloidosis Diethylstilbestrol 4.2815469931
MESH:D000740 Anemia Tetrachlorodibenzodioxin 2.7611748828
MESH:D001161 Arteriosclerosis Ethinyl Estradiol 3.2611256880
MESH:D001169 Arthritis, Experimental Ethinyl Estradiol 2.5415885639
MESH:D001284 Atrophy fulvestrant 4.6511514358
MESH:D001660 Biliary Tract Diseases 4,4'-diaminodiphenylmethane 4.8111289319 1440618
MESH:D001778 Blood Coagulation Disorders pirinixic acid 8.1419483382
MESH:D001778 Blood Coagulation Disorders Tetrachlorodibenzodioxin 8.1412125929
MESH:D001836 Body Weight Changes Tetrachlorodibenzodioxin 3.5815340226
MESH:D001848 Bone Diseases, Developmental Tetrachlorodibenzodioxin 2.6315746008
MESH:D001862 Bone Resorption bisphenol A 3.6711985600
MESH:D001932 Brain Neoplasms Fenretinide 4.1716187019
MESH:D001943 Breast Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 6.8020146248
MESH:D001943 Breast Neoplasms bexarotene 6.8016818667 16344269
MESH:D001943 Breast Neoplasms bisphenol A 6.8017123778
MESH:D001943 Breast Neoplasms Diethylstilbestrol 6.8015324884 17129689
MESH:D001943 Breast Neoplasms Estradiol 6.8017018787 12948864 17261762 14630087 16675129 19861407 18497071 17289903
MESH:D001943 Breast Neoplasms Fenretinide 6.8016601279
MESH:D001943 Breast Neoplasms fulvestrant 6.8018984771
MESH:D001943 Breast Neoplasms Genistein 6.8017200150 16873071 16541309
MESH:D001943 Breast Neoplasms Tamoxifen 6.8019059307 19115204 17440819 18855134 17261762 19084267 20005174 19189210 18984771 19142967 16873071 18815881 19410462 18629630 21138602 15565566 18997820 17893378 18821012 15668708 19288272 19011961 20065188 20390343 19066611 16202921 19289846 19189212 18425577 19155303 19200415 11161223 16818667 20135344 21152245 19221464 19487384 20544844 17242785 19103187 20859285 19244106 17049068 18351453 16273361
MESH:D001943 Breast Neoplasms Tetrachlorodibenzodioxin 6.8020435547
MESH:D002181 Candidiasis, Vulvovaginal Estradiol 4.2516111702
MESH:D002277 Carcinoma Dimethylnitrosamine 7.8119555203
MESH:D002277 Carcinoma Tetrachlorodibenzodioxin 7.8116835633
MESH:D018270 Carcinoma, Ductal, Breast Tamoxifen 4.3019066611
MESH:D006528 Carcinoma, Hepatocellular 4,4'-diaminodiphenylmethane 13.557296757 3581430
MESH:D006528 Carcinoma, Hepatocellular Aflatoxin B1 13.5521507988 12907637 12619106
MESH:D006528 Carcinoma, Hepatocellular Diethylstilbestrol 13.5516924424 15948411
MESH:D006528 Carcinoma, Hepatocellular Estradiol 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Fenretinide 13.5517159502 16270382
MESH:D006528 Carcinoma, Hepatocellular Genistein 13.5516924424
MESH:D006528 Carcinoma, Hepatocellular Tamoxifen 13.5516924424
MESH:D002278 Carcinoma in Situ bisphenol A 4.7817123778
MESH:D002289 Carcinoma, Non-Small-Cell Lung bexarotene 3.1616247446
MESH:D002292 Carcinoma, Renal Cell 4,4'-diaminodiphenylmethane 2.587296757
MESH:D002294 Carcinoma, Squamous Cell Dimethylnitrosamine 5.0216033868
MESH:D002294 Carcinoma, Squamous Cell Fenretinide 5.0216274795
MESH:D002295 Carcinoma, Transitional Cell Tamoxifen 3.4317572228
MESH:D006332 Cardiomegaly Tetrachlorodibenzodioxin 2.2518850075 18670907 16120746
MESH:D002318 Cardiovascular Diseases Genistein 3.1616332659
MESH:D002471 Cell Transformation, Neoplastic 4,4'-diaminodiphenylmethane 14.827505956
MESH:D002471 Cell Transformation, Neoplastic 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14.8220889678
MESH:D002471 Cell Transformation, Neoplastic Cyclosporine 14.8212371664
MESH:D002471 Cell Transformation, Neoplastic Estradiol 14.8218566989
MESH:D018290 Cervical Intraepithelial Neoplasia Fenretinide 5.2616154183
MESH:D018281 Cholangiocarcinoma Tetrachlorodibenzodioxin 2.9916835633
MESH:D002779 Cholestasis 4,4'-diaminodiphenylmethane 17.9519486331 9022650
MESH:D002779 Cholestasis Cyclosporine 17.9519486331
MESH:D002779 Cholestasis Ethinyl Estradiol 17.9517681005 11677210 16105132 15861022 16919318 17110522 17333356
MESH:D002779 Cholestasis pirinixic acid 17.9519176532
MESH:D002972 Cleft Palate Tetrachlorodibenzodioxin 2.0216354765 8697196 12621046 15340226 15668235
MESH:D003110 Colonic Neoplasms arsenite 3.8515037631
MESH:D003110 Colonic Neoplasms Genistein 3.8517182828
MESH:D015179 Colorectal Neoplasms Fenretinide 3.0717273769
MESH:D015179 Colorectal Neoplasms Polychlorinated Biphenyls 3.0715531428
MESH:D000013 Congenital Abnormalities Tetrachlorodibenzodioxin 2.8814669216 17141729
MESH:D019465 Craniofacial Abnormalities Tetrachlorodibenzodioxin 1.2510048152 20055451 15322242
MESH:D003456 Cryptorchidism Diethylstilbestrol 4.3512952375 16002989
MESH:D003704 Dementia Polychlorinated Biphenyls 4.5116140633
MESH:D003711 Demyelinating Diseases Tamoxifen 4.1519031437
MESH:D017449 Dermatitis, Allergic Contact 4,4'-diaminodiphenylmethane 2.6118759878 11298694 12868966 8970840 8156756 2524372 11906362 14531868
MESH:D003876 Dermatitis, Atopic pirinixic acid 2.3318249437
MESH:D003877 Dermatitis, Contact 4,4'-diaminodiphenylmethane 3.303621924 2952479
MESH:D003924 Diabetes Mellitus, Type 2 Genistein 4.1516647724
MESH:D003924 Diabetes Mellitus, Type 2 Tetrachlorodibenzodioxin 4.1517107852
MESH:D003928 Diabetic Nephropathies Estradiol 8.2519279558
MESH:D003928 Diabetic Nephropathies Tamoxifen 8.2519279558
MESH:D056486 Drug-Induced Liver Injury 4,4'-diaminodiphenylmethane 5.9018692083 6482804 18289764 7440962 11289319 9653073 8291058 6679447 16192314 1440618 9022650 18648102 9328219
MESH:D056486 Drug-Induced Liver Injury Dimethylnitrosamine 5.908172417
MESH:D056486 Drug-Induced Liver Injury Tetrachlorodibenzodioxin 5.9020420201
MESH:D004362 Drug Toxicity Tetrachlorodibenzodioxin 2.6111462148
MESH:D004487 Edema pirinixic acid 5.9212083418
MESH:D004487 Edema Tetrachlorodibenzodioxin 5.9212711302 11000095
MESH:D004489 Edema, Cardiac Tetrachlorodibenzodioxin 3.6916714409 15322242 18230668
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Ethinyl Estradiol 8.2812538720
MESH:D004681 Encephalomyelitis, Autoimmune, Experimental Tamoxifen 8.2819031437
MESH:D004714 Endometrial Hyperplasia Diethylstilbestrol 11.1916402032
MESH:D004714 Endometrial Hyperplasia Genistein 11.1916402032
MESH:D016889 Endometrial Neoplasms Diethylstilbestrol 16.6816804899 15700306
MESH:D016889 Endometrial Neoplasms Estradiol 16.6818566989 11473722 19148513
MESH:D016889 Endometrial Neoplasms Genistein 16.6811473722
MESH:D016889 Endometrial Neoplasms Tamoxifen 16.6819155303 17893378 20544844 16202921
MESH:D004715 Endometriosis Tetrachlorodibenzodioxin 2.8410568697 9294722
MESH:D004938 Esophageal Neoplasms 4,4'-diaminodiphenylmethane 9.983581430
MESH:D004938 Esophageal Neoplasms 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 9.9820426865
MESH:D004938 Esophageal Neoplasms Dimethylnitrosamine 9.9817016578
MESH:D004938 Esophageal Neoplasms nitrosobenzylmethylamine 9.9815264214 15878914 15547721 15547733 16805852 16704527 16510608 15623463 15150132
MESH:D005124 Eye Abnormalities Tetrachlorodibenzodioxin 2.8611564622
MESH:D005234 Fatty Liver arsenite 22.6318296743
MESH:D005234 Fatty Liver Cyclosporine 22.6319224547
MESH:D005234 Fatty Liver Ethinyl Estradiol 22.6315345470
MESH:D005234 Fatty Liver pirinixic acid 22.6320131406 19236843
MESH:D005234 Fatty Liver Tamoxifen 22.6314986274 19224547
MESH:D052776 Female Urogenital Diseases Diethylstilbestrol 7.7916534752 16513791 15751030 16611131 16002989
MESH:D052776 Female Urogenital Diseases Tamoxifen 7.7916709447
MESH:D005313 Fetal Death Tetrachlorodibenzodioxin 3.2511858732
MESH:D005350 Fibroma 4,4'-diaminodiphenylmethane 4.816705139
MESH:D018221 Fibromatosis, Abdominal Tamoxifen 4.3214745880
MESH:D018222 Fibromatosis, Aggressive Tamoxifen 3.9719069698
MESH:D005355 Fibrosis arsenite 13.5918296743
MESH:D005355 Fibrosis Cyclosporine 13.5912639820 12168785
MESH:D005355 Fibrosis Tetrachlorodibenzodioxin 13.5920067830
MESH:D005833 Genital Neoplasms, Female Diethylstilbestrol 4.7416452187
MESH:D005885 Gingival Hyperplasia Cyclosporine 4.018708960
MESH:D005909 Glioblastoma Fenretinide 7.0916187019
MESH:D005909 Glioblastoma Genistein 7.0916598420
MESH:D006042 Goiter 4,4'-diaminodiphenylmethane 3.847505956
MESH:D006058 Gonadal Disorders Tetrachlorodibenzodioxin 4.3810696789
MESH:D006330 Heart Defects, Congenital Tetrachlorodibenzodioxin 2.2210048152 11294989
MESH:D006333 Heart Failure pirinixic acid 2.4120558911
MESH:D006457 Hemoglobinuria, Paroxysmal Cyclosporine 4.2115720958
MESH:D006470 Hemorrhage Tetrachlorodibenzodioxin 3.1511000095
MESH:D006505 Hepatitis 4,4'-diaminodiphenylmethane 3.316705139
MESH:D006529 Hepatomegaly pirinixic acid 7.5718467677 16221962 19176532 19772884
MESH:D006529 Hepatomegaly Tetrachlorodibenzodioxin 7.5715340226 12621046 16120746
MESH:D006558 Herpes Genitalis Estradiol 4.8215709030
MESH:D019584 Hot Flashes Estradiol 3.5417088409
MESH:D006869 Hydronephrosis Tetrachlorodibenzodioxin 3.838697196 18606429 15340226 16959395 16354765
MESH:D006943 Hyperglycemia pirinixic acid 3.0020558911
MESH:D006965 Hyperplasia 4,4'-diaminodiphenylmethane 10.1415034207
MESH:D006965 Hyperplasia Diethylstilbestrol 10.1412960047 14722030
MESH:D006973 Hypertension Cyclosporine 4.6810903974
MESH:D006973 Hypertension Tetrachlorodibenzodioxin 4.6818670907 18850075
MESH:D007021 Hypospadias Diethylstilbestrol 10.5516002989
MESH:D007021 Hypospadias Ethinyl Estradiol 10.5516945680 16569931
MESH:D007246 Infertility Diethylstilbestrol 4.1515036965
MESH:D007247 Infertility, Female Ethinyl Estradiol 3.2712013081
MESH:D007248 Infertility, Male Ethinyl Estradiol 6.4617937319
MESH:D007248 Infertility, Male fulvestrant 6.4611514358
MESH:D007249 Inflammation Tamoxifen 4.5319457130
MESH:D007249 Inflammation Tetrachlorodibenzodioxin 4.5312200463 12878042
MESH:D007333 Insulin Resistance bisphenol A 11.5316393666
MESH:D007333 Insulin Resistance Estradiol 11.5316393666 16627594
MESH:D007333 Insulin Resistance pirinixic acid 11.5316306350
MESH:D007565 Jaundice 4,4'-diaminodiphenylmethane 4.818074119 9022650
MESH:D007569 Jaw Abnormalities Tetrachlorodibenzodioxin 3.1516580747
MESH:D007638 Keratoconjunctivitis Sicca Cyclosporine 4.2315604871
MESH:D007674 Kidney Diseases Cyclosporine 5.548314463 10903974 18776723
MESH:D007674 Kidney Diseases Estradiol 5.5415618244
MESH:D007680 Kidney Neoplasms 4,4'-diaminodiphenylmethane 21.526582329
MESH:D007680 Kidney Neoplasms Cyclosporine 21.5212371664
MESH:D007680 Kidney Neoplasms Diethylstilbestrol 21.5215003126 14681315 16762066
MESH:D007680 Kidney Neoplasms Estradiol 21.5215610895
MESH:D007680 Kidney Neoplasms Tamoxifen 21.5218625569
MESH:D007859 Learning Disorders Diethylstilbestrol 3.8617184923
MESH:D007938 Leukemia Genistein 2.9218980019 17468513
MESH:D007972 Leukoplakia, Oral Fenretinide 5.8316707609
MESH:D008064 Lipidoses Tamoxifen 3.0117567588 15342952
MESH:D008103 Liver Cirrhosis arsenite 3.3118296743
MESH:D008105 Liver Cirrhosis, Biliary 4,4'-diaminodiphenylmethane 3.079327722 15034207
MESH:D008106 Liver Cirrhosis, Experimental Dimethylnitrosamine 8.3918364076 15577212 15864749 18629640 18095165 17203207 15942678 16603200 17719030 17348192 18371158 15744066 15366600 16169303 17666798 15571005 18672772 15591649 15492853 18637143 17036385 17534399 17640959 18239293 15733078 15383259 15099470 15504291 15842777 16009107 12918455 15161499 15479170 17724770 12925901 14568256 17465448 14709902 16544323 14726149 17432682 15723089 15763062 16570917 15067225 17201889 16270385 15793283 15298665 18567088 15339415 14643895 17196135 16627068 16042886 17198567 15081153 15369754 15086199 15798949 18210741 18237412 17881167 15138612 14659978
MESH:D008106 Liver Cirrhosis, Experimental Estradiol 8.3914659978 14716833
MESH:D008106 Liver Cirrhosis, Experimental Genistein 8.3917823541
MESH:D008106 Liver Cirrhosis, Experimental pirinixic acid 8.3915474484
MESH:D008106 Liver Cirrhosis, Experimental Tamoxifen 8.3918564211
MESH:D008106 Liver Cirrhosis, Experimental Tetrachlorodibenzodioxin 8.3912878042
MESH:D017114 Liver Failure, Acute Dimethylnitrosamine 4.2217457977
MESH:D008113 Liver Neoplasms 2-nitrofluorene 32.7815890375
MESH:D008113 Liver Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 32.7815890375
MESH:D008113 Liver Neoplasms Aflatoxin B1 32.7815890375 2125692 18177683 9163691
MESH:D008113 Liver Neoplasms Diethylstilbestrol 32.7815890375 16712894
MESH:D008113 Liver Neoplasms Dimethylnitrosamine 32.783113478 15890375
MESH:D008113 Liver Neoplasms Methapyrilene 32.7815890375
MESH:D008113 Liver Neoplasms Piperonyl Butoxide 32.7820101389 15890375 19690152 18648771
MESH:D008113 Liver Neoplasms pirinixic acid 32.7816377806 20007298 15890375
MESH:D008113 Liver Neoplasms Tamoxifen 32.7816684651
MESH:D008113 Liver Neoplasms Tetrachlorodibenzodioxin 32.7816984957
MESH:D008114 Liver Neoplasms, Experimental 4,4'-diaminodiphenylmethane 17.29598648 3712494 6587162 1399818
MESH:D008114 Liver Neoplasms, Experimental Aflatoxin B1 17.298603461
MESH:D008114 Liver Neoplasms, Experimental Dimethylnitrosamine 17.291848544 15603536 6150874
MESH:D008114 Liver Neoplasms, Experimental Polychlorinated Biphenyls 17.291423854
MESH:D008114 Liver Neoplasms, Experimental Tetrachlorodibenzodioxin 17.2912151625
MESH:D008175 Lung Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 10.3016061637 14755239 16401635 18508827 17139156 15893417 15172992 19931552 18813816 9255578 12438228
MESH:D008175 Lung Neoplasms Aflatoxin B1 10.3014755239
MESH:D008175 Lung Neoplasms arsenite 10.3016809336
MESH:D008175 Lung Neoplasms bexarotene 10.3017849452
MESH:D008175 Lung Neoplasms Dimethylnitrosamine 10.3019555203 16061637 11884234
MESH:D008175 Lung Neoplasms Tamoxifen 10.3018625569
MESH:D008175 Lung Neoplasms Tetrachlorodibenzodioxin 10.3011884234 19555203
MESH:D008181 Lupus Nephritis Diethylstilbestrol 4.9415166399
MESH:D008223 Lymphoma Diethylstilbestrol 3.3315700306
MESH:D016410 Lymphoma, T-Cell, Cutaneous bexarotene 4.9411161223
MESH:D052801 Male Urogenital Diseases Diethylstilbestrol 5.3016002989
MESH:D015674 Mammary Neoplasms, Animal Tamoxifen 3.5519428831
MESH:D008325 Mammary Neoplasms, Experimental bexarotene 17.4319196723 19196722 15591091
MESH:D008325 Mammary Neoplasms, Experimental Estradiol 17.4316891317 11807958 11408345 17203775
MESH:D008325 Mammary Neoplasms, Experimental Fenretinide 17.4310697514
MESH:D008325 Mammary Neoplasms, Experimental Genistein 17.4312929590 14578162
MESH:D008325 Mammary Neoplasms, Experimental Tamoxifen 17.4311731420 19196723 14580682 16827153 19196722
MESH:D020149 Manganese Poisoning Estradiol 11.9419453300
MESH:D020149 Manganese Poisoning Tamoxifen 11.9419453300
MESH:D008545 Melanoma Fenretinide 3.4916270382
MESH:D008545 Melanoma Tamoxifen 3.4919393235 12393984
MESH:D018328 Melanoma, Amelanotic Tamoxifen 3.9715990972
MESH:D008664 Metal Metabolism, Inborn Errors Cyclosporine 4.5816801185
MESH:D009062 Mouth Neoplasms Fenretinide 4.1616274795
MESH:D009135 Muscular Diseases pirinixic acid 3.3016239165
MESH:D009203 Myocardial Infarction Genistein 5.3917141266
MESH:D009203 Myocardial Infarction pirinixic acid 5.3919151258
MESH:D017202 Myocardial Ischemia Tetrachlorodibenzodioxin 2.8512213967
MESH:D015428 Myocardial Reperfusion Injury Estradiol 13.2516810080
MESH:D015428 Myocardial Reperfusion Injury Genistein 13.2517141266
MESH:D015428 Myocardial Reperfusion Injury pirinixic acid 13.2516411023
MESH:D009362 Neoplasm Metastasis 4,4'-diaminodiphenylmethane 5.413581430
MESH:D009362 Neoplasm Metastasis Tamoxifen 5.4119393235
MESH:D009364 Neoplasm Recurrence, Local Tamoxifen 2.4519410462
MESH:D009369 Neoplasms Diethylstilbestrol 7.7915313581
MESH:D009369 Neoplasms Fenretinide 7.7915958647 17353921
MESH:D009369 Neoplasms pirinixic acid 7.7917405874
MESH:D009376 Neoplasms, Hormone-Dependent bexarotene 10.2219196722
MESH:D009376 Neoplasms, Hormone-Dependent Tamoxifen 10.2219189210 19200415 19196722
MESH:D009389 Neovascularization, Pathologic arsenite 9.4515738583
MESH:D009389 Neovascularization, Pathologic Estradiol 9.4517289903
MESH:D009402 Nephrosis, Lipoid Cyclosporine 4.2317954296
MESH:D009404 Nephrotic Syndrome Cyclosporine 3.1119348381 18481113
MESH:D009421 Nervous System Malformations bisphenol A 28.5911399458 16427766
MESH:D009421 Nervous System Malformations Diethylstilbestrol 28.5911399458
MESH:D009421 Nervous System Malformations Estradiol 28.5916427766 11399458
MESH:D009421 Nervous System Malformations Genistein 28.5916427766
MESH:D009421 Nervous System Malformations Tetrachlorodibenzodioxin 28.5914600291
MESH:D009436 Neural Tube Defects 4,4'-diaminodiphenylmethane 2.786679447
MESH:D009472 Neuronal Ceroid-Lipofuscinoses Fenretinide 5.4716303764
MESH:D009765 Obesity pirinixic acid 1.7620558911
MESH:D009784 Occupational Diseases 4,4'-diaminodiphenylmethane 3.246482804 4026338
MESH:D009902 Optic Neuritis 4,4'-diaminodiphenylmethane 4.813988306
MESH:D010024 Osteoporosis Genistein 3.1319401787
MESH:D015663 Osteoporosis, Postmenopausal Genistein 3.8916169203
MESH:D010049 Ovarian Diseases bisphenol A 4.7811985600
MESH:D010051 Ovarian Neoplasms Estradiol 7.6219401270
MESH:D010051 Ovarian Neoplasms Fenretinide 7.6216133793
MESH:D010051 Ovarian Neoplasms Genistein 7.6219005980
MESH:D010190 Pancreatic Neoplasms 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone 5.7012384795
MESH:D010190 Pancreatic Neoplasms Fenretinide 5.7015580305
MESH:D016584 Panic Disorder Ethinyl Estradiol 3.4911578682
MESH:D010212 Papilloma 4,4'-diaminodiphenylmethane 3.287296757
MESH:D010300 Parkinson Disease Polychlorinated Biphenyls 3.3216702228
MESH:D010382 Peliosis Hepatis Tetrachlorodibenzodioxin 4.0412520081
MESH:D010787 Photosensitivity Disorders 4,4'-diaminodiphenylmethane 4.266228378
MESH:D010900 Pituitary Diseases Diethylstilbestrol 4.9614722030
MESH:D010911 Pituitary Neoplasms Diethylstilbestrol 4.4616977796 15687265
MESH:D017119 Porphyria Cutanea Tarda Tetrachlorodibenzodioxin 3.3618163543
MESH:D011230 Precancerous Conditions Cyclosporine 3.0512371664
MESH:D011297 Prenatal Exposure Delayed Effects bisphenol A 15.0610548101
MESH:D011297 Prenatal Exposure Delayed Effects Diethylstilbestrol 15.0617184923
MESH:D011297 Prenatal Exposure Delayed Effects Tetrachlorodibenzodioxin 15.0611399792 11896295 11222880 11118676
MESH:D019048 Prostatic Intraepithelial Neoplasia bisphenol A 9.9220887781
MESH:D019048 Prostatic Intraepithelial Neoplasia Estradiol 9.9220887781
MESH:D011471 Prostatic Neoplasms bisphenol A 2.0716740699
MESH:D011471 Prostatic Neoplasms Diethylstilbestrol 2.0717136230 15846301 15046698
MESH:D011471 Prostatic Neoplasms Estradiol 2.0716740699
MESH:D011471 Prostatic Neoplasms Fenretinide 2.0717024972
MESH:D011471 Prostatic Neoplasms Genistein 2.0715378649 15256057 16925846
MESH:D011471 Prostatic Neoplasms Polychlorinated Biphenyls 2.0715721890
MESH:D011471 Prostatic Neoplasms Tamoxifen 2.0715067354
MESH:D011537 Pruritus Ethinyl Estradiol 3.1015861022 16919318
MESH:D011565 Psoriasis Cyclosporine 2.1616882103
MESH:D011629 Puberty, Precocious bisphenol A 4.5710548101
MESH:D015427 Reperfusion Injury pirinixic acid 2.2919058328
MESH:D015619 Respiratory System Abnormalities Tetrachlorodibenzodioxin 3.6418990726
MESH:D012162 Retinal Degeneration 4,4'-diaminodiphenylmethane 8.593692021
MESH:D012162 Retinal Degeneration Fenretinide 8.5916303925
MESH:D012878 Skin Neoplasms Fenretinide 5.5616467112
MESH:D012878 Skin Neoplasms Tetrachlorodibenzodioxin 5.5616192470
MESH:D013088 Spermatocele Diethylstilbestrol 18.9016002989 16709447
MESH:D013088 Spermatocele Ethinyl Estradiol 18.9016709447
MESH:D013088 Spermatocele Tamoxifen 18.9016709447
MESH:D013119 Spinal Cord Injuries Tamoxifen 3.8319457130
MESH:D013158 Splenic Diseases Dimethylnitrosamine 5.0612587719
MESH:D013274 Stomach Neoplasms Dimethylnitrosamine 2.8216033868
MESH:D013274 Stomach Neoplasms nitrosobenzylmethylamine 2.8212958204 17575124
MESH:D019966 Substance-Related Disorders bisphenol A 3.7716684133 16045194
MESH:D019851 Thrombophilia Ethinyl Estradiol 3.4211994571
MESH:D013927 Thrombosis Ethinyl Estradiol 2.9815669648
MESH:D013959 Thyroid Diseases Tetrachlorodibenzodioxin 3.6912697716
MESH:D013964 Thyroid Neoplasms 4,4'-diaminodiphenylmethane 2.736587162 6582329 3712494 7505956 1399818
MESH:D013978 Tibial Fractures Estradiol 4.4719048282
MESH:D001749 Urinary Bladder Neoplasms 4,4'-diaminodiphenylmethane 11.308074119
MESH:D001749 Urinary Bladder Neoplasms Diethylstilbestrol 11.3017306315 16452187 16712894
MESH:D001749 Urinary Bladder Neoplasms Fenretinide 11.3016720286
MESH:D001749 Urinary Bladder Neoplasms Tamoxifen 11.3016712894 8653321 17572228
MESH:D002583 Uterine Cervical Neoplasms Diethylstilbestrol 9.2316175088
MESH:D002583 Uterine Cervical Neoplasms Fenretinide 9.2316154183
MESH:D014591 Uterine Diseases bisphenol A 13.1114652134
MESH:D014591 Uterine Diseases Diethylstilbestrol 13.1114652134
MESH:D014594 Uterine Neoplasms Diethylstilbestrol 8.8015809267 16690809
MESH:D014594 Uterine Neoplasms Ethinyl Estradiol 8.8014692618
MESH:D014605 Uveitis Cyclosporine 3.771336536
MESH:D014625 Vaginal Neoplasms Diethylstilbestrol 4.2316513791 16002989
MESH:D054079 Vascular Malformations Tetrachlorodibenzodioxin 4.3812125929
MESH:D020246 Venous Thrombosis Ethinyl Estradiol 3.3514671159 15869587
MESH:D019282 Wasting Syndrome Tetrachlorodibenzodioxin 4.0415886252
MESH:D014985 Xerophthalmia Cyclosporine 4.2317120751
Pathway ID Pathway Name
REACT:22172 Chromosome Maintenance
REACT:27271 Meiotic Recombination
REACT:27235 Meiotic Recombination (mouse)
KEGG:05322 Systemic lupus erythematosus
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Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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