Gene Symbol:	ANXA2 ( ANX2,ANX2L4,CAL1H,LIP2,LPC2,LPC2D,P36,PAP-IV )
Gene Full Name:	annexin A2
Band:	15q22.2
Quick Links	Entrez ID:302; OMIM: 151740; Uniprot ID:ANXA2_HUMAN; ENSEMBL ID: ENSG00000182718; HGNC ID: 537
Relate to Another Database:	SFARIGene; denovo-db

Desease ID	Desease Name
1701	Antiphospholipid syndrome
1795	Amnionitis
1858	Hemorrhagic disorder
1896	Adrenoleukodystrophy
1934	Cancer
2074	Asthma
2115	Muscular dystrophies
2232	Aseptic necrosis of bone
2236	Cardiovascular disease

Chemical ID	Chemical Name	Interaction	Interaction Action	Publication
C063002	2,3-dimethoxy-1,4-naphthoquinone	2,3-dimethoxy-1,4-naphthoquinone results in increased expression of ANXA2 mRNA	increases expression	17547211
C023514	2,6-dinitrotoluene	2,6-dinitrotoluene results in increased expression of ANXA2 mRNA	increases expression	20406850
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of ANXA2 mRNA	increases expression	14600272
C009505	4,4'-diaminodiphenylmethane	4,4'-diaminodiphenylmethane results in increased expression of ANXA2 mRNA	increases expression	18648102
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ANXA2 mRNA	increases expression	14600272
C430898	AGN 194204	AGN 194204 results in decreased expression of ANXA2 mRNA	decreases expression	16339527
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of ANXA2 mRNA	affects expression	16483693
D001151	Arsenic	Arsenic affects the expression of ANXA2 mRNA	affects expression	18414638
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ANXA2 mRNA	decreases expression	19642359
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of ANXA2 protein	decreases expression	19642359 19781379
C006632	arsenic trioxide	arsenic trioxide results in increased expression of ANXA2 mRNA	increases expression	17547211
C006780	bisphenol A	bisphenol A results in increased expression of ANXA2 mRNA	increases expression	15223131
D002104	Cadmium	Cadmium results in increased expression of ANXA2 mRNA	increases expression	17547211
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of ANXA2 mRNA	increases expression	17547211
D002118	Calcium	ANXA2 protein binds to Calcium	affects binding	18508775
D002392	Catechin	Catechin results in increased expression of ANXA2 mRNA	increases expression	15465739
D002713	Chlorine	Chlorine results in increased expression of ANXA2 mRNA	increases expression	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of ANXA2 mRNA	affects cotreatment\|decreases expression	18636392
D002857	Chromium	Chromium results in increased expression of ANXA2 mRNA	increases expression	17547211
C019304	ciprofibrate	ciprofibrate results in increased expression of ANXA2 mRNA	increases expression	12771043
D002995	Clofibric Acid	Clofibric Acid affects the expression of ANXA2 mRNA	affects expression	17602206
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of ANXA2 mRNA	increases expression	17654400
C014347	decitabine	[decitabine co-treated with vorinostat] affects the expression of ANXA2 mRNA	affects cotreatment\|affects expression	17330099
C014347	decitabine	[trichostatin A co-treated with decitabine] results in increased expression of ANXA2 protein	affects cotreatment\|increases expression	19294695
D004041	Dietary Fats	Dietary Fats results in increased expression of ANXA2 mRNA	increases expression	18042831
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ANXA2 mRNA	increases expression	12771043
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of ANXA2 mRNA	increases expression	19638242
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of ANXA2 mRNA	increases expression	17547211
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of ANXA2 mRNA	increases expression	14600272
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of ANXA2 mRNA	increases expression	16314067
D004958	Estradiol	Estradiol promotes the reaction [Progesterone results in increased expression of ANXA2 protein]	increases expression\|increases reaction	17446234
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of ANXA2 mRNA	affects expression	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ANXA2 mRNA	increases expression	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA2 mRNA	affects cotreatment\|increases expression	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of ANXA2 mRNA	increases expression	17557909
C020326	ferric nitrilotriacetate	ferric nitrilotriacetate results in increased expression of ANXA2 mRNA	increases expression	10854235
D005472	Fluorouracil	ANXA2 mRNA results in decreased susceptibility to Fluorouracil	decreases response to substance	15152939
D005472	Fluorouracil	Fluorouracil results in increased expression of ANXA2 mRNA	increases expression	15152939
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in increased expression of ANXA2 mRNA]	affects reaction\|increases expression	15152939
C056933	fumonisin B1	fumonisin B1 results in increased expression of ANXA2 mRNA	increases expression	16221962
C039281	furan	furan results in increased expression of ANXA2 mRNA	increases expression	15120968
D006830	Hydralazine	[Hydralazine co-treated with Valproic Acid] results in increased expression of ANXA2 mRNA	affects cotreatment\|increases expression	17183730
D007052	Ibuprofen	Ibuprofen affects the expression of ANXA2 protein	affects expression	18351690
C051890	irinotecan	irinotecan results in increased expression of ANXA2 mRNA	increases expression	15152939
D007501	Iron	Iron deficiency results in increased expression of ANXA2 mRNA	increases expression	20368581
D008628	Mercury	Mercury results in increased expression of ANXA2 mRNA	increases expression	17547211
D008701	Methapyrilene	Methapyrilene results in increased expression of ANXA2 mRNA	increases expression	15120968
C029938	nickel sulfate	nickel sulfate results in increased expression of ANXA2 mRNA	increases expression	16314067
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of ANXA2 mRNA	increases expression	17616710
C484027	oligofectamine	oligofectamine results in decreased expression of ANXA2 mRNA	decreases expression	14668052
C030110	oxaliplatin	oxaliplatin results in increased expression of ANXA2 mRNA	increases expression	15152939
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of ANXA2 mRNA	affects cotreatment\|decreases expression	18636392
C041786	palm oil	palm oil results in increased expression of ANXA2 mRNA	increases expression	18042831
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of ANXA2 mRNA]	affects reaction\|increases expression	19482888
D010634	Phenobarbital	Phenobarbital results in increased expression of ANXA2 mRNA	increases expression	19482888
D010634	Phenobarbital	Phenobarbital results in increased methylation of ANXA2 promoter	increases methylation	19482888
C006253	pirinixic acid	pirinixic acid results in increased expression of ANXA2 mRNA	increases expression	20059764 16221962 18301758
C006253	pirinixic acid	PPARA protein affects the reaction [pirinixic acid results in increased expression of ANXA2 mRNA]	affects reaction\|increases expression	16221962
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in increased expression of ANXA2 mRNA]	increases expression\|increases reaction	20059764
C443641	poly(propyleneimine)	poly(propyleneimine) analog results in increased expression of ANXA2 mRNA	increases expression	16308212
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of ANXA2 mRNA	increases expression	17547211
D011374	Progesterone	Estradiol promotes the reaction [Progesterone results in increased expression of ANXA2 protein]	increases expression\|increases reaction	17446234
D011374	Progesterone	Progesterone results in increased expression of ANXA2 mRNA	increases expression	17446234
D011374	Progesterone	Progesterone results in increased expression of ANXA2 protein	increases expression	17446234
D011794	Quercetin	Quercetin results in increased expression of ANXA2 protein	increases expression	15221776
D011794	Quercetin	Quercetin results in decreased expression of ANXA2 protein	decreases expression	18095365
C037219	quinoline	quinoline analog results in increased expression of ANXA2 protein	increases expression	18645022
C068874	raltitrexed	raltitrexed results in increased expression of ANXA2 mRNA	increases expression	15152939
C068874	raltitrexed	TYMS protein inhibits the reaction [raltitrexed results in increased expression of ANXA2 mRNA]	decreases reaction\|increases expression	15152939
C017947	sodium arsenite	sodium arsenite affects the expression of ANXA2 mRNA	affects expression	16507464
D013629	Tamoxifen	Tamoxifen affects the expression of ANXA2 mRNA	affects expression	17555576
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ANXA2 mRNA	affects cotreatment\|increases expression	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of ANXA2 protein	decreases expression	19201780
D013864	Thioglycolates	Thioglycolates results in increased expression of ANXA2 protein	increases expression	14504107
D014212	Tretinoin	Tretinoin results in decreased expression of ANXA2 mRNA	decreases expression	16140955 19642359
D014212	Tretinoin	Tretinoin results in decreased expression of ANXA2 protein	decreases expression	16197459 19642359
C012589	trichostatin A	[trichostatin A co-treated with decitabine] results in increased expression of ANXA2 protein	affects cotreatment\|increases expression	19294695
C012589	trichostatin A	trichostatin A results in increased expression of ANXA2 protein	increases expression	19294695
D014502	Uranyl Nitrate	Uranyl Nitrate results in increased expression of ANXA2 mRNA	increases expression	16316344
D014502	Uranyl Nitrate	Uranyl Nitrate results in increased expression of ANXA2 protein	increases expression	16316344
D014635	Valproic Acid	[Hydralazine co-treated with Valproic Acid] results in increased expression of ANXA2 mRNA	affects cotreatment\|increases expression	17183730
D014635	Valproic Acid	Valproic Acid results in increased expression of ANXA2 mRNA	increases expression	19101580
C025643	vinclozolin	vinclozolin affects the expression of ANXA2 mRNA	affects expression	19015723
D014807	Vitamin D	Vitamin D affects the expression of ANXA2 mRNA	affects expression	20368581
C111237	vorinostat	[decitabine co-treated with vorinostat] affects the expression of ANXA2 mRNA	affects cotreatment\|affects expression	17330099
D015032	Zinc	Zinc results in decreased expression of ANXA2 mRNA	decreases expression	17074742
D019287	Zinc Sulfate	Zinc Sulfate results in decreased expression of ANXA2 mRNA	decreases expression	17074742

Disease ID	Disease Name	Inference Chemical Name	Inference Score	Publication
MESH:D000008	Abdominal Neoplasms	Tamoxifen	3.89	14745880
MESH:D000014	Abnormalities, Drug-Induced	Phenobarbital	10.52	6195326
MESH:D000014	Abnormalities, Drug-Induced	Tetrachlorodibenzodioxin	10.52	14514962 15322242 11752688
MESH:D000014	Abnormalities, Drug-Induced	Valproic Acid	10.52	8875741
MESH:D000015	Abnormalities, Multiple	Valproic Acid	3.35	19490988
MESH:D000138	Acidosis	Ammonium Chloride	8.50	18287403
MESH:D000138	Acidosis	Zinc Sulfate	8.50	7265320
MESH:D000152	Acne Vulgaris	Ethinyl Estradiol	3.29	17505938
MESH:D000169	Acrodermatitis	Zinc	4.76	16889938 17202136 17190629
MESH:D058186	Acute Kidney Injury	Ibuprofen	3.88	6375363
MESH:D055371	Acute Lung Injury	Chlorine	11.95	20601635
MESH:D055371	Acute Lung Injury	nickel sulfate	11.95	16100012 11954676 12718980 19131640
MESH:D055371	Acute Lung Injury	pirinixic acid	11.95	18653653
MESH:D000210	Acute-Phase Reaction	Thioglycolates	5.71	9464241
MESH:D000230	Adenocarcinoma	arsenic trioxide	14.32	19825857 11798837
MESH:D000230	Adenocarcinoma	Dimethylnitrosamine	14.32	16033868
MESH:D000230	Adenocarcinoma	Estradiol	14.32	11473722
MESH:D000230	Adenocarcinoma	Ethinyl Estradiol	14.32	14692618
MESH:D000230	Adenocarcinoma	Fluorouracil	14.32	17638652
MESH:D000230	Adenocarcinoma	Ibuprofen	14.32	10697514
MESH:D000236	Adenoma	4,4'-diaminodiphenylmethane	12.70	3712494
MESH:D000236	Adenoma	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	12.70	16176798
MESH:D000236	Adenoma	Diethylnitrosamine	12.70	10737359 6695378
MESH:D000236	Adenoma	Dimethylnitrosamine	12.70	19555203
MESH:D018248	Adenoma, Liver Cell	Diethylnitrosamine	19.62	19052882 19061943 17620307 16434500 17162532 18056438
MESH:D018248	Adenoma, Liver Cell	Phenobarbital	19.62	17620307
MESH:D018248	Adenoma, Liver Cell	pirinixic acid	19.62	16434500
MESH:D018248	Adenoma, Liver Cell	Tetrachlorodibenzodioxin	19.62	16835633
MESH:D000310	Adrenal Gland Neoplasms	sodium arsenite	4.05	15276417
MESH:D018246	Adrenocortical Adenoma	Arsenic	11.62	17306315
MESH:D018246	Adrenocortical Adenoma	sodium arsenite	11.62	16712894 17306315
MESH:D000505	Alopecia	Tretinoin	3.10	15955085
MESH:D019896	alpha 1-Antitrypsin Deficiency	Iron	5.01	16640825
MESH:D000544	Alzheimer Disease	Ibuprofen	7.89	18351690
MESH:D000544	Alzheimer Disease	Iron	7.89	16563566 16640825
MESH:D000544	Alzheimer Disease	Ozone	7.89	15513908
MESH:D000544	Alzheimer Disease	Zinc	7.89	16410023 17119284 16325427 16580781
MESH:D000550	Amblyopia	Valproic Acid	4.58	17688650
MESH:D000707	Anaphylaxis	Ibuprofen	4.62	9532969
MESH:D000740	Anemia	Fluorouracil	11.65	16511603 17963324 15504547

AutismKB 2.0

Annotation Detail for ANXA2

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics